Comparing Prolia vs Reclast
| Prolia (denosumab) | Reclast (zoledronic acid) |
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| Prolia (denosumab) | Reclast (zoledronic acid) |
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Prescription only
Prolia is an injection that can be self-administered once every six months for the treatment of osteoporosis. It has been associated with an increased risk of fractures on discontinuation and... View more |
Prescription only
Reclast may be used to treat or prevent osteoporosis caused by menopause, steroid use, or gonadal failure, in the treatment of Paget's disease, and to increase bone mineral density in men. Reclast... View more |
Related suggestions Osteoporosis
Popular comparisons
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| More about Prolia (denosumab) | More about Reclast (zoledronic acid) | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Prolia has an average rating of 2.9 out of 10 from a total of 374 ratings on Drugs.com. 16% of reviewers reported a positive effect, while 76% reported a negative effect. |
Reclast has an average rating of 5.1 out of 10 from a total of 275 ratings on Drugs.com. 37% of reviewers reported a positive effect, while 43% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
View all Prolia side effects |
View all Reclast side effects |
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| Drug Class | |||||||||||||||||
| Generic Availability | |||||||||||||||||
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N/A |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Prolia prices |
View all Reclast prices |
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| Dosage Forms | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Other denosumab brands include: Bomyntra, Conexxence, Jubbonti, Osenvelt, Ospomyv, Stoboclo, Wyost, Xbryk, Xgeva View more | Other zoledronic acid brands include: Aclasta, Zometa | ||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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609.6 hours |
N/A |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
Category D
Positive evidence of risk
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 306 drugs are known to interact with Prolia:
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A total of 123 drugs are known to interact with Reclast:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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June 01, 2010 |
August 17, 2007 |
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| WADA Class View classifications | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
| Patient Resources | |||||||||||||||||
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| Related Treatment Guide | |||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.