Prolia and Weakness: What Users Say

• Dog...
• March 9, 2020

For Osteoporosis "Density went from -1.2 to -2.8 in 2 years because of taking steroids for 2 years. Prior to Prolia, started weight-bearing exercise regime to intensify bone building and planned to continue after taking the drug. I can't because of pain! Fingers, thumb, and wrist, shoulders, shoulder blades, right groin, hips, and pelvic area with the worst in back and neck. Muscle soreness in biceps and thighs. Jaw pain for a month. Weakness in legs, arms, and hands. Major stiffness after short time sitting. Back cracks when I stand up, bend over, or stretch. Hearing loss, fatigue, and now take meds for insomnia. I was active: went to the gym, out with friends, walked 2 miles/day. No more. I awaken in the morning and can barely move. I'm depressed because of my situation. I had none of these issues prior to taking this drug! Common denominator and cause = Prolia! This drug is poison and shame on the FDA. The makers of Prolia have put aside billions of dollars for lawsuits. Hmm, wonder why. I will not take my next injection despite what my doc advises. My whole life has been turned upside down."

• PAI...
• Taken for 6 months to 1 year
• March 11, 2020

For Osteoporosis "I had my first injection in Aug 2019. I’ve had joint stiffness and muscle aches daily. I’ve also noticed my legs have gotten so weak! When I walk down stairs, I have to hold onto the railing for dear life, in case my legs collapse. I’m 58 years old but I feel like I’m 75. I just had my second shot yesterday and a few hours after I had it, I suddenly felt a horrible sharp pain in my lower leg that felt like a spasm, and it quickly spread down into my foot and then my foot became totally numb. I’ve never ever had this happen to me before, but the nurse believes it’s not related to the Prolia. I’m convinced that it is."

• Luc...
• Taken for 1 to 6 months
• February 21, 2020

For Osteoporosis "Had my first Prolia injection in Dec 2019. Within 10 days had severe rolling pain throughout my body. Would go on for hours at a time. It would hit my toes, shins, top of foot, bottom of foot, abdomen, thigh, groin, knees. No energy. Difficulty getting out of chair and walking. Since it is a 6-month injection, it takes time to get out of your body. It is now Feb 21, 2020. I am still having difficulty walking and so painful getting out of chair. Pain is intermittent and can hit any part of your body at any time. Have to take pain meds and muscle relaxer to get through the night. Will never take another injection. Do not know what drug to take next because if I don't take a drug for bones, I will have fractures of the spinal column. I have never had a fracture in my life."

• LMa...
• July 29, 2019

For Osteoporosis "I am a 45-year-old female with severe osteoporosis of the spine, osteopenia of the femur and hips. I took Prolia in September of last year and it will be the one and only time that I take it! I was sick within two months of taking this drug! I have been running a fever nonstop, terrible headaches, abdominal pain, nausea and vomiting, weakness in legs, joint pain, and rashes! This drug is so bad! My life has been turned upside down with this sickness from Prolia, numerous ER visits, doctor appointments, and missing work. I am a single mother who couldn’t afford any of this. PLEASE DO NOT TAKE THIS DRUG!"

• Sto...
• Taken for 2 to 5 years
• February 16, 2021

For Osteoporosis "Had my fifth shot of Prolia on December 8th, 2020. Will definitely not be taking this drug again. I found that with each passing injection, the symptoms became more severe. I have gone from being a very fit person to being totally disabled. Muscle weakness in thigh muscles and arms. Extreme pain in shoulders and arms. Very tight rib cage muscles. No energy. Extreme nausea. Discomfort in my throat. Dry cough at night. Muscle stiffness, twitching, cramps, and spasms. Severe right hip pain and sciatica pain. All of these started after taking Prolia."

• Ree...
• Taken for 1 to 6 months
• November 5, 2019

For Osteoporosis "On my last visit to the cancer center, they put me on a new injection for osteoporosis (Prolia) and had to sign a form to take it. Like a lot of you, I trusted my doctors and took the shot back in September 2019. OMG, I was not ready for what I was in for with the side effects. I have no energy, my legs feel like they give out after 10 steps, making me take a break. My bones hurt all the time, which they did anyway with the hormone blocker, but this just intensified it. I have no appetite, can't sleep, and my memory is horrible. I have a very multitasking job, and it has been tough keeping up with everything. It feels like it's all about the almighty dollars with these doctors, and I will not take this drug again. One thing I have found concerning osteoporosis is there are classes called Osteo Strong that help build bone naturally in your body, and you attend once a week."

• Jja...
• Taken for less than 1 month
• September 12, 2018

For Osteoporosis "DO NOT TAKE THIS! My grandmother took this needle on a Tuesday, her behavior changed almost immediately. She became very weak, could not stay awake, her breathing changed and as the week progressed, she got worse. Sunday of the same week, her heart rate was jumping between 70 and 120 bpm, and her oxygen went down to 90. She was rushed to the hospital and has rashes, water in the lungs, she can't talk because she is so congested, and has to be on a special mask for oxygen. She is definitely not the same in a matter of 5 days. I've also noticed she has developed a lot of involuntary movements all over her body - arms, legs, hands, and even eyes. We actually thought she was going to pass away on the Monday after being admitted to the hospital. We were called to have an emergency meeting with the doctor. She only has had one shot and WILL NOT have any more. Please do your research before taking this needle. Biggest mistake."

• Bre...
• Taken for 6 months to 1 year
• January 2, 2021

For Osteoporosis "Had a wedge compression fracture in August 2019, doctor ordered Prolia injection. Wish I had never had it, developed stomach and intestinal problems, reflux (never had any problems with that before), pain in groin (a cyst on ovary was found), increased pain in neck, had an increase in blood pressure, pulse rate increased, pain in arms, legs, and continue with pain in back, muscle soreness, and weakness. Was diagnosed with Barrett's Esophagus in January 2020. Never will allow another injection, and of course, doctors don't believe it caused these problems."

• Jas...
• Taken for 6 months to 1 year
• June 12, 2019

For Osteoporosis "I was on Boniva for 10 years with no improvement in my bones. My doctor switched me to Prolia shots. I took my first shot of Prolia in January 2018 and developed severe mouth ulcers, sloughing of my gums. I could not handle spice or salt, and my nutrition fell. At that time, I did not associate it with Prolia. I took my second shot in August, and my mouth ulcers flared up. Severe ulcers in the gums, upper palate, back of the throat, and nasopharynx area. My mouth had grey, purple, and white patches. I was unable to eat. I also developed severe jaw pain, bone pain, and muscle weakness. For three days, my low back, hips, and legs froze, and I was in excruciating pain and could not walk. I was in bed with ice packs and anti-inflammatories. I was frightened. I have stopped Prolia. It has been more than a year, and my mouth ulcers have not healed. I am now being treated at a university hospital. This is not a safe medicine and should not be prescribed."

• Cat...
• Taken for 2 to 5 years
• April 29, 2019

For Osteoporosis "I have had 6 Prolia injections. With the first 5 injections, I had muscle pain for a few weeks. This was relieved with ibuprofen. I had my 6th injection in February 2019. One week after the injection, I started experiencing severe hip pain. As the days went on, the pain appeared in my shoulders, hands, feet, ankles, knees, and elbows. The pain is so severe I am having trouble walking. It takes me a minimum of 30 minutes to get out of bed. I have been back to my doctor twice, and she says there is nothing she can do but prescribe pain medication. She said it will take 6 months for the medication to wear off. I have read comments from some saying even after 6 months, the pain does not go away. I have read comments from others saying they have not experienced side effects. You are not safe. Stop taking this drug now. Before this drug, I was a healthy, active woman."

• Jus...
• Taken for 1 to 6 months
• October 24, 2019

For Osteoporosis "I took my first shot of Prolia in July 2019. I sure wished that I had seen this site prior to taking the shot. I had just trusted my GP and did not do any research. My legs are so weak and I have so much pain in my legs that I am finding it difficult to do anything. I work for 5 minutes and then rest for 5 minutes. I have already told my GP that I will not take any more shots. I am praying that my legs will eventually heal as I have always been active, and now I hurt so much that I just can't do what I normally do."

• Nev...
• Taken for less than 1 month
• February 26, 2023

For Osteoporosis "On 12/16/22 I received my first Prolia injection as recommended by my doctor. Less than 44 hours later I was in the hospital with a subarachnoid brain aneurysm. 19 days in the hospital (16 of them in ICU). I am lucky to be alive and without any damage. Then on 2/10/23 I started experiencing severe body pain and weakness all over (in my joints, back, hands and fingers, forearms, front of legs, etc.). My arms get so weak I can barely lift my covers off me in bed, and it's painful to try. I would also wake up with pain in my forehead over both my eyes. On 2/22/23, I woke up in the morning, and my right eye was bloody. Obviously, a blood vessel had popped sometime in the night and bled a lot. The body pain and weakness change daily. I believe all of these things that have happened to me are caused by that Prolia injection I received. I won't be getting any more injections of it, and I will be warning others to investigate it and all drugs before they agree to take them."

• RBC...
• April 5, 2017

For Osteoporosis "For Osteoporosis: In 2014, the Dr. prescribed me Prolia due to its stronger potency, along with the continued Cal-VitD tablet. Though my bone density increased some % since taking Prolia, starting one year ago, I was feeling a constant back pain, from right to left of my hip, now and constantly 90% on the left side. I was diagnosed with weakness of the last 5 lumbar vertebrae. I do Pilates reformer as a therapy three times a week, walk almost every day 4-5 Km, and play golf 1-2 times a week. I used to be very active, but this back pain is really hurting and making me depressed."

• Bet...
• Taken for 1 to 2 years
• June 11, 2019

For Osteoporosis "Had a great rheumatologist who retired. New Dr. Continued Prolia but side effects got so bad, I refused 4th shot. Dr. became very defensive and refused to admit side effects were from Prolia (eczema, sore joints, sweats, nausea, weakness which I never had before) so I now have a new Dr. A woman who I hope will be more understanding. Are some doctors afraid to admit the horrible side effects? They also charged my insurance company for the drug and administration of it, even though I never got the shot. I called the insurance company and told them they need to disallow those charges."

• Kat...
• Taken for 6 months to 1 year
• September 7, 2018

For Osteoporosis "I have had 2 injections of Prolia and have now developed loose front teeth. My dentist is concerned that if there is a chance that I may lose these teeth, then the healing process will be inhibited while I am on Prolia. Also, I now have to take Vit D tablets daily as the Prolia has caused a drop in my Vit D levels. I also had severe itching, weakness, and unexplained fatigue. My doctor did not warn me of the possible side effects. I will not take Prolia again."

• Joa...
• Taken for 1 to 6 months
• April 21, 2019

For Osteoporosis "Within 4 days of the Prolia injection, I had severe skin reactions. Within one week, my body became weak, and I experienced sleep difficulties. I have continued to be weak, experience bone pain, and have fatigue. Now I feel like I have some cancer in my organs, none of them are functioning right. This is a hideous drug that should be removed from the market."

• Tob...
• August 6, 2018

For Osteoporosis "I had my first injection of Prolia 5 weeks ago. Two weeks later I was admitted to the hospital with severe headache, weakness, dehydration, and generally feeling dreadful. I was treated for meningitis, and I am still waiting for the results of X-rays, MRI scans, and CAT scans. The pain down the left side of my neck was unbearable. I am convinced all this was a result of Prolia. I won't be taking a second shot of it and would urge anyone thinking of taking it to think twice before you do."

• Gin...
• April 24, 2023

For Osteoporosis "I had my first injection on August 22 in 2022. I started having severe muscle spasms in my toes and calves. Headaches and fatigue. Then I started having pain in the lower and upper muscles in my legs. A little at first, and it has increased to where I am in tears when this happens. I had my second injection and now, along with that, I’m waking in the night with a severe rapid heartbeat. Can’t sleep and have such bad body weakness that it just overwhelms me. I would never recommend this poison to anyone. I have had test after test and been in the hospital several times. No answers. Not thinking about Prolia being so bad, I said let’s take a look at the side effects of Prolia. There it was in print: everything that was happening to me. It also said these side effects could continue on. Prolia is supposed to stay in your body for about four months, but it can be longer."

• Bar...
• November 19, 2019

For Osteoporosis "Two days after getting the Prolia shot (I have an allergic reaction to latex), I got hives so bad that after a prednisone shot plus pills, I ended up in the emergency room. Also, I felt very weak. Horrible medicine. I am on three different antihistamines and might have to go back on prednisone. Every time I think I am better, they come back even worse. Please do not take this medication. This was my second shot. Never again."

• Ann...
• Taken for 1 to 2 years
• August 23, 2018

For Osteoporosis "Where do I start, rash on face, loss of hair at one stage, fatigue, jumping out of bed at night with severe cramps in the legs, itchiness all over, pain in the knee, pain in the joints, pain in the side of the head, pain in the feet and big toes, sick in stomach, hearing loss, general weakness, mood change very angry, frequent urinating, weight gain, breathing difficulty, aware of heart rate changing, slight soreness in the mouth nose run-off and on like sinus problem, numbness in hands and arms, I have just had my third shot wish I never did"

• Gay...
• Taken for 2 to 5 years
• September 8, 2024

For Osteoporosis "I was on this medication for 12 months to 2 years. I'm now having numbness in my hands and weakness in my legs. Cannot walk properly. I don't know why my doctor stopped the injection. I'm going to ask him. Pain in shoulders now, having cortisone injections. Not sure if this was included. I'm 73 years."

• Lil...
• Taken for less than 1 month
• May 26, 2019

For Osteoporosis "I just had my first injection last week of Prolia. I already have psoriatic arthritis on Enbrel with some days of pain anyway, so at this point it would be hard to say any joint pain related to this drug, and I haven’t noticed any unusual increase. What is different is the last 2 days of a mild headache, dizziness and vertigo, weakness, and nausea. I am not yet convinced it is from this drug, but after reading these reviews, I am concerned that it is. I had two rheumatologists and my internist recommend I go on this drug, and they told me that they have not seen side effects in their patients."

• PAM...
• Taken for 1 to 2 years
• May 29, 2018

For Osteoporosis "After the 2nd and 3rd (the 3rd being my last), my life is a living hell. I have digestive issues, tons of mucus in stools, lots of severe pain in abdomen, both hips, both thighs, arms, cold sweats, jaw bone pain, and I feel weak, dizzy, and no appetite. It feels like I am dying. Don't take this prescription, it is very, very dangerous!!"

• Anonymous
• Taken for 1 to 2 years
• November 1, 2022

For Osteoporosis "I have had three doses of Prolia. Initially, I was skeptical, but the nurse assured me that she gave lots of these injections to patients and sure most people were okay. She then went on to say, sure, the common pain medications gave side effects, so you will be fine. I realize she thought she had my best interests at heart. But with hindsight, she probably didn't know the full extent of this very dangerous drug, as I sure doctors also are not well informed either. After the second injection, I had really bad headaches. Since the third one, my neck, shoulders, and arms are very painful. My hands and arms have muscle weakness. Despite the fear of stopping it and breaking bones, I won't get another injection. Shame on this pharma company for ruining so many lives worldwide."

• Joa...
• May 3, 2021

For Osteoporosis "After a severely painful experience with a Reclast infusion (which are once per year), I was put on Prolia injections every six months. After a yearly infusion of Reclast and two 6-month intervals of Prolia, I have pain in my joints, muscles, groin, tendonitis in my Achilles tendons and thumb, headaches, nausea, confusion, weakness, fatigue, at least 40 pounds of weight gain, and severe back and hip pain. Before, I was on the go all the time, walking, exercising, and busy constantly, now I don't feel like doing anything because I never feel good and hurt all the time. Needless to say, I canceled my next injection and will take nothing for the osteoporosis. Even though I have a pretty good chance, even more so now, of having a fracture since I took the injections. Can you believe this? When you stop taking Prolia, you are more at risk than you were before you took it! Thanks to all the doctors that only think of how much money they can make off of someone instead of thinking of their health."