Prolia and Rash: What Users Say

• Anonymous
• Taken for 1 to 6 months
• February 22, 2020

For Osteoporosis "The Prolia side effects are real and devastating. My rapid heart rate is out of control. This is dangerous. Not only will I never ever take this drug again, nor will I go to the bone specialist again. The skin rashes, the gut problems, vision loss. So much more! I called Prolia support line. Guess what? No support!"

• LMa...
• July 29, 2019

For Osteoporosis "I am a 45-year-old female with severe osteoporosis of the spine, osteopenia of the femur and hips. I took Prolia in September of last year and it will be the one and only time that I take it! I was sick within two months of taking this drug! I have been running a fever nonstop, terrible headaches, abdominal pain, nausea and vomiting, weakness in legs, joint pain, and rashes! This drug is so bad! My life has been turned upside down with this sickness from Prolia, numerous ER visits, doctor appointments, and missing work. I am a single mother who couldn’t afford any of this. PLEASE DO NOT TAKE THIS DRUG!"

• Liz...
• September 3, 2014

For Osteoporosis "Received the first shot at the end of June. Within a week, I started with a rash on my neck. It was red, swollen, and itched day and night. Second week started with red blotches on either side of my mouth. They blistered and peeled, and were painful and itchy. It is now over 2 months later, and the redness is fading, but the itching is still awful, waking me up at night. I have tried everything with no relief. I will not be taking another shot."

• ang...
• August 25, 2015

For Osteoporosis "HORRIBLE side effects! Loose tooth, needed extraction. Dentist found a healthy root, no problem with tooth. Lumps formed in several places. Rashes, shortness of breath. Hoarseness, headaches, joint pain...many more complaints."

• Jan...
• Taken for 1 to 6 months
• May 20, 2023

For Osteoporosis "I have found my back pain is worse than ever, my immune system has declined, my cholesterol went way up, I developed a skin rash, and I still have a lack of appetite, muscle pain, headaches, nausea, swelling, jaw pain, chills, mouth and legs tingling, pain in my arms, sore throat, trouble sleeping, and more pain. I do not recommend the Prolia injection. It is bad, bad, bad, you start feeling miserable because the pain is unbearable."

• M H...
• Taken for 1 to 2 years
• April 17, 2016

For Osteoporosis "Prolia shot given July 26, 2012! Immediately had every dermatological problem listed in the ad: Itching, rash all over body except for face, extreme pain, dry skin, repeated biopsies, thousands of dollars for doctors, prescriptions, lotions, and potions. Left calf's skin completely peeled off like the bark of a tree and has never recovered four years later!! Even now it is again broken out in oozing rashes around the ankle, but the entire leg hurts. I must keep the hair on my legs shaved very close or when I am exercising in the Y pool, the leg is painful just with the movement of the tiny hairs in the water. The pain is inside as well as on the surface of my skin. These bad side effects continue! Have pictures of early rash available."

• Oh ...
• May 1, 2016

For Osteoporosis "I have been on Prolia for approximately two years. Just this year ( my 5th injection) I did experience sore muscle/joint pain in my hips. About 4 months ago I developed dermatitis around the corners of my eyes, nose, mouth, and along both sides of my neck. I've never had allergies before. Also, I'm dealing with a feeling of deep exhaustion. I'm not sure whether this is due to Prolia. If my next bone density doesn't show marked increase, I will ask my physician for a change in med. One note--I faithfully exercise 3-4 times weekly with a trainer, take calcium, and eat green veggies and foods with calcium/D."

• Jja...
• Taken for less than 1 month
• September 12, 2018

For Osteoporosis "DO NOT TAKE THIS! My grandmother took this needle on a Tuesday, her behavior changed almost immediately. She became very weak, could not stay awake, her breathing changed and as the week progressed, she got worse. Sunday of the same week, her heart rate was jumping between 70 and 120 bpm, and her oxygen went down to 90. She was rushed to the hospital and has rashes, water in the lungs, she can't talk because she is so congested, and has to be on a special mask for oxygen. She is definitely not the same in a matter of 5 days. I've also noticed she has developed a lot of involuntary movements all over her body - arms, legs, hands, and even eyes. We actually thought she was going to pass away on the Monday after being admitted to the hospital. We were called to have an emergency meeting with the doctor. She only has had one shot and WILL NOT have any more. Please do your research before taking this needle. Biggest mistake."

• XGy...
• Taken for 1 to 6 months
• November 25, 2019

For Osteoporosis "This is now 1 year, 1 month from my one and only Prolia injection. Reading the other comments from patients who have had poor to terrible side effects, I am certain that one dose of Prolia likely still lingers in my system and the side effects continue. My bone and muscle pain kicked in with a vengeance and has not abated. Walking became and remains difficult due to body pain and loss of strength/balance/pain in addition to which, my skin rashes causing both pain and itching continue. I regret being talked into taking Prolia even though my osteoporosis remains seriously advanced. All of the side effects continue although I only had the first injection due to the severe reaction that kicked in within a few days. Note: Amgen is recently promoting a 'new' drug 'Evenity' ... an almost identical to Prolia... which has major warnings, actual black boxed warning - some even worse than the Prolia warnings. Doctors continue to advise trying the drug. For me, that is not an option."

• Mar...
• Taken for 1 to 6 months
• May 26, 2016

For Osteoporosis "From the start, I began to experience side effects. The most bothersome are the extreme sweating episodes followed by chills at least 12 times a day or more. In addition, other side effects are more pain in my lower back and hips as well as a rash with associated itch on my upper back. I will never get another Prolia shot!!! Wish I knew there would be so much discomfort!"

• Slm...
• January 1, 2020

For Osteoporosis "I had one injection in 2018 and started having side effects the next day. Skin rash and itching, then mouth ulcers, swollen lips and tongue. Pain in feet, legs, and hip, and fatigue. I would never recommend nor have this drug again. It has been over a year, and I still have symptoms."

• Nom...
• Taken for 1 to 6 months
• September 7, 2019

For Osteoporosis "After one treatment, severe jaw and hip pain, rashes, and my hair has started falling out. I wasn't told by my doctor that I couldn't stop this medication without risking spinal fractures. This drug shouldn't be on the market. I only gave it a one because 0 wasn't an option."

• yog...
• August 30, 2016

For Osteoporosis "The Prolia is helping with my bone density. I am allergic to Actonel, Boniva, Evista, etc. I have taken my third shot three weeks ago. I have experienced blisters between my toes, the bottom of my feet peeling off, a rash, small pinpoint red dots on my skin, a cough, stomach discomfort, bleeding sores on my face, and my cholesterol has gone up to the highest point of my life! I have also gained 10 pounds that are almost impossible to lose. I'll see what my cholesterol level is in another 6 months. I believe it should be down by then."

• yog...
• August 30, 2016

For Osteoporosis "The Prolia is helping with my bone density. I am allergic to Actonel, Boniva, Evista, etc. I have taken my third shot three weeks ago. I have experienced blisters between my toes, the bottom of my feet peeling off, a rash, small pinpoint red dots on my skin, a cough, stomach discomfort, bleeding sores on my face, and my cholesterol has gone up to the highest point of my life! I have also gained 10 pounds that are almost impossible to lose. I'll see what my cholesterol level is in another 6 months. I believe it should be down by then."

• MR...
• July 1, 2017

For Osteoporosis "Will never take it again. Worst experience in my life. Took it twice, the first time, rashes all over my back, spent a lot of money going to the dermatologist. Second time, severe pain in the body, especially in both legs, still going to the doctor to try to solve the problems. On top of that, lots of headaches. Can't sleep at night due to pain in my legs. No one should have to go through that much suffering to treat an illness. FDA should stop this drug on the market. Not recommended for anyone."

• Jud...
• Taken for 1 to 6 months
• June 17, 2019

"I was diagnosed with Osteopenia and on Dec. 3, 2018, I was talked into a shot of Prolia. Within a couple of weeks, I started with a rash on my face. Red spots raised, red spots, some having white spots on them, quite severe. I also experienced knee joint pain. Sometimes when it hit both knees at once, it was difficult to walk. I also experienced back pain, muscle pain ongoing for 6 months. Most of the itchiness on neck and chest has dissipated. The rash on my face will not go away, blotchy and red. So, I am going to my dermatologist. Never again will I take this drug!! All of this has produced stress and depression. It is now June 17, 2019."

• Bar...
• November 19, 2019

For Osteoporosis "Two days after getting the Prolia shot (I have an allergic reaction to latex), I got hives so bad that after a prednisone shot plus pills, I ended up in the emergency room. Also, I felt very weak. Horrible medicine. I am on three different antihistamines and might have to go back on prednisone. Every time I think I am better, they come back even worse. Please do not take this medication. This was my second shot. Never again."

• Ann...
• Taken for 1 to 2 years
• August 23, 2018

For Osteoporosis "Where do I start, rash on face, loss of hair at one stage, fatigue, jumping out of bed at night with severe cramps in the legs, itchiness all over, pain in the knee, pain in the joints, pain in the side of the head, pain in the feet and big toes, sick in stomach, hearing loss, general weakness, mood change very angry, frequent urinating, weight gain, breathing difficulty, aware of heart rate changing, slight soreness in the mouth nose run-off and on like sinus problem, numbness in hands and arms, I have just had my third shot wish I never did"

• Maw...
• Taken for 1 to 2 years
• January 20, 2019

For Osteoporosis "I am scared to death now after I have read these posts. My doctor told me nothing of these. I have a rash and fever tonight that appeared very suddenly today. My jaw aches also. I have had 2 injections, no more."

• gui...
• Taken for 6 months to 1 year
• January 11, 2019

For Osteoporosis "Since I cannot take Fosamax and was so severe even after Forteo. I was told Prolia was the answer. I already suffer from autoimmune issues, which I was given shots to reduce pain in my back, only to find my lower discs are osteoporotic, and my knees and hips have lost bone density. I opted for Prolia. The first shot seemed to have no pain, after the second shot, loss of hair, pains throughout my body. Muscles knot up in shoulder and neck pain, toes hurt, legs and ankles swell. A rash lasted two months. I don't know how much longer I can go on without a bone-building medication. I was turned down for Tlymos because I took Forteo. My insurance company isn't worried about me being sick, or they would have approved Tlymos, a bone-building substance, and forgotten about the fact I took a bone builder. So far, that is what I have left to take, but even the insurance turned me away."

• CMc...
• Taken for 1 to 2 years
• October 14, 2023

For Osteoporosis "I’ve had 4 Prolia injections and have only experienced one negative (possible) side effect. After the third injection-about 2 weeks later-I got a peculiar rash (very itchy) on my lower back, right along my spine. It has almost gone away now-6 months later. I just got another Prolia injection yesterday. I’m waiting to see if the red, itchy rash returns. Other than that, no negative side effects. I wonder if the negative effects have anything to do with blood type? I’m A negative. It would be interesting to know blood type, previous diseases, whether patients had ever had hysterectomies before getting Prolia, etc. Certainly, with this number of negative responses, there needs to be much more research done."

• Joh...
• Taken for 6 months to 1 year
• August 18, 2018

For Osteoporosis "Developed hives after the first shot. Didn’t suspect Prolia. After the second shot, all hell broke loose with hives and bleeding blisters all over my body. I had bloody pajamas every morning for months. Had to use lots of ice packs day and night to help soothe the skin. Fourteen months after the last shot, bleeding blisters finally gone, but painful and itchy hives still there. Don’t know when I will be free of these Prolia-caused skin problems."

• JOh...
• Taken for 6 months to 1 year
• June 13, 2018

For Osteoporosis "Had a terrible experience with this drug. My doctor recommended it to treat my osteopenia condition as a preventive measure, more than 2 years ago. Within a few weeks of the first shot, I developed hives and what looked like insect bites. I had been swimming in the sea daily, so I thought I was bitten by sea lice. Six months later, after the second Prolia shot, all hell broke loose. I developed severe skin problems, itchy all over, hives appeared in any and every part of my body, and they turned into blisters that would break and bleed. Every morning, my pajamas would have blood spots in many places. I am now in my eleventh month since the last shot and the itchiness is not over. I cursed my own stupidity for trusting my doctor and not doing my own due diligence before taking Prolia. My doctor was totally helpless when I reported the problem to her and was not helpful. She kept saying that Prolia has little to no side effects, but she could not explain or treat my condition."

• Jud...
• May 9, 2018

For Osteoporosis "My side effects began after my 2nd of 3 injections. Terrible skin rashes on face, hands, legs. Sores in my mouth that prohibited me from eating, so I suffered weight loss. Terrible muscle pain in my shoulders, resulting in severe bursitis. The worst was infections in my teeth, resulting in the loss of a front tooth. It wasn't until I reread the side effects that others were experiencing that I connected my problems to Prolia. I no longer am taking it but am still dealing, 2 years later, with muscle pain which comes and goes, and huge dental bills re bone grafts and dental implants. I had previously taken Actonel with no problems and still wonder why I agreed to Prolia!"

• Mar...
• Taken for 1 to 6 months
• October 30, 2017

For Osteoporosis "Four months after the third injection, developed a gum abscess, followed by loose teeth, inability to chew semihard substances such as apples and chewy vegetables. Also developed a rash and bladder infection. Still has loose, sensitive teeth twelve months after the last injection. Prescribing doctor has denied association. Two dentists found nothing wrong with the teeth just prior to the abscess developing. Recommended root canal, but treated conservatively."