Omeprazole Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Omeprazole	Pantoprazole	Nexium (esomeprazole)	Enter another drug to compare

Omeprazole

Pantoprazole

Nexium (esomeprazole)

Prescription and OTC

Omeprazole decreases stomach acid production which promotes the healing of gastric and duodenal ulcers and other inflamed areas of gastrointestinal tissue. The risk of interactions with omeprazole... View more

Prescription only

Pantoprazole is a proton pump inhibitor that decreases acid secretion in the stomach and may be given to relieve the symptoms of heartburn or to allow inflamed tissue in the gastrointestinal tract to... View more

Prescription only

Nexium effectively heals inflamed tissue in the gastrointestinal tract and relieves symptoms of heartburn. Nexium is available orally and as an IV preparation that may be used in adults and children... View more

More about Omeprazole

More about Pantoprazole

More about Nexium (esomeprazole)

Ratings & Reviews

Omeprazole has an average rating of 4.7 out of 10 from a total of 497 ratings on Drugs.com. 33% of reviewers reported a positive effect, while 52% reported a negative effect.

Pantoprazole has an average rating of 5.0 out of 10 from a total of 431 ratings on Drugs.com. 37% of reviewers reported a positive effect, while 47% reported a negative effect.

Nexium has an average rating of 6.1 out of 10 from a total of 211 ratings on Drugs.com. 52% of reviewers reported a positive effect, while 35% reported a negative effect.

View all 497 reviews

View all 431 reviews

View all 211 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Anxiety (24.7%)
Dizziness (15.7%)
Nausea (11.5%)
Headaches (8.9%)
Brain fog (7.8%)
Depression (7.8%)
Pain (7.4%)

View all Omeprazole side effects

Headaches (16.5%)
Anxiety (11.6%)
Dizziness (10.9%)
Nausea (10.2%)
Pain (9.3%)
Bloating (7.0%)
Stomach pain (6.7%)

View all Pantoprazole side effects

Anxiety (11.8%)
Diarrhea (10.9%)
Nausea (10.0%)
Headaches (9.0%)
Fatigue (7.1%)
Dizziness (5.7%)
Heart palpitations (5.7%)

View all Nexium side effects

Drug Class

Proton pump inhibitors

Proton pump inhibitors

Proton pump inhibitors

Generic Availability

Lower cost generic

Lower cost generic approved

Pricing and Coupons * Prices are without insurance

Quantity	50 each
Strength	20 mg
Per unit^*	$0.37
Cost^*	$18.67

View all Omeprazole prices

Quantity	50 each
Strength	40 mg
Per unit^*	$0.37 - $1.69
Cost^*	$18.42 - $84.31

View all Pantoprazole prices

Quantity	30 delayed release capsule
Strength	40 mg
Per unit^*	$9.89
Cost^*	$296.67

View all Nexium prices

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Dosage Forms

Oral delayed release capsule
Oral delayed release tablet
Oral tablet, disintegrating, delayed release

Intravenous powder for injection
Intravenous solution
Oral delayed release tablet
Oral granule, enteric coated

Oral delayed release capsule
Oral powder for reconstitution, delayed release

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

1.5 hours

1 hour

1.5 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Category B No proven risk in humans

See the full pregnancy warnings document.

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Drug Interactions

A total of 238 drugs are known to interact with Omeprazole:

25 major drug interactions (66 brand and generic names)
165 moderate drug interactions (1310 brand and generic names)
48 minor drug interactions (273 brand and generic names)

A total of 179 drugs are known to interact with Pantoprazole:

17 major drug interactions (44 brand and generic names)
143 moderate drug interactions (1223 brand and generic names)
19 minor drug interactions (142 brand and generic names)

A total of 212 drugs are known to interact with Nexium:

23 major drug interactions (62 brand and generic names)
155 moderate drug interactions (1285 brand and generic names)
34 minor drug interactions (187 brand and generic names)

Alcohol/Food/Lifestyle Interactions

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Food may interfere with the absorption of esomeprazole. Esomeprazole should be taken at least one... View more

Disease Interactions

First Approval Date

June 20, 2003

February 02, 2000

N/A

WADA Class View classifications

N/A

More Information

Patient Resources

Omeprazole uses

Nexium uses

Professional Resources

Prescribing information

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Omeprazole Alternatives Compared

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