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Comparing Metformin vs Trulicity

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Metformin Trulicity (dulaglutide)
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Metformin Trulicity (dulaglutide)
Prescription only

Metformin improves how the body responds to insulin and it is used to treat type 2 diabetes. Taste disturbances, diarrhea, and other stomach-related side effects are common side effects. Metformin is... View more

Prescription only

Trulicity mimics the effects of GLP-1, a naturally occurring hormone that stimulates insulin secretion and lowers glucagon secretion from the liver. It lowers blood glucose levels in people with... View more

More about Metformin More about Trulicity (dulaglutide)
Ratings & Reviews

Metformin has an average rating of 6.8 out of 10 from a total of 655 ratings on Drugs.com. 54% of reviewers reported a positive effect, while 19% reported a negative effect.

Trulicity has an average rating of 5.3 out of 10 from a total of 971 ratings on Drugs.com. 38% of reviewers reported a positive effect, while 40% reported a negative effect.

View all 655 reviews

View all 971 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

View all Metformin side effects

View all Trulicity side effects
Drug Class
Generic Availability

Lower cost generic

N/A
Pricing and Coupons * Prices are without insurance
Quantity 100 each
Strength 500 mg
Per unit* $0.15 - $0.24
Cost* $15.37 - $24.08

View all Metformin prices

Quantity 2 mL
Strength 0.75 mg/0.5 mL
Per unit* $531.93
Cost* $1,063.85

View all Trulicity prices

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Dosage Forms
  • Oral solution
  • Oral tablet
  • Oral tablet, extended release
  • Subcutaneous solution
Brand Names
Glumetza

N/A
Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

4.5 hours

120 hours
CSA Schedule 1 View glossary of CSA terms
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
Pregnancy Category
B
Category B No proven risk in humans

See the full pregnancy warnings document.
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.
Drug Interactions

A total of 377 drugs are known to interact with Metformin:

  • 24 major drug interactions (129 brand and generic names)
  • 344 moderate drug interactions (1793 brand and generic names)
  • 9 minor drug interactions (35 brand and generic names)

A total of 271 drugs are known to interact with Trulicity:

  • 15 major drug interactions (34 brand and generic names)
  • 254 moderate drug interactions (1446 brand and generic names)
  • 2 minor drug interactions (14 brand and generic names)
Alcohol/Food/Lifestyle Interactions
  • MetFORMIN should be taken with meals, and excessive alcohol intake (either short-term binge... View more
  • Dulaglutide may affect the absorption of other medications that you take by mouth. In some cases... View more
  • Talk to your doctor before using alcohol together with dulaglutide. Alcohol may affect blood... View more
Disease Interactions
First Approval Date

March 03, 1995

September 18, 2014
WADA Class View classifications

N/A

N/A
More Information
Patient Resources
Professional Resources
Related Treatment Guide

1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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