Leflunomide Alternatives Compared
Leflunomide | Otezla | Upadacitinib |
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Leflunomide | Otezla (apremilast) | Upadacitinib |
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Prescription only
Prescribed for Rheumatoid Arthritis, Psoriatic Arthritis. leflunomide may also be used for purposes not listed in this medication guide. |
Prescription only
Otezla is a PDE4 inhibitor that may be used to treat adults with plaque psoriasis, psoriatic arthritis, and oral ulcers associated with Behçet’s Disease. It may also be used to treat plaque psoriasis... View more |
Prescription only
Prescribed for Crohn's Disease, Ankylosing Spondylitis, Atopic Dermatitis, Non-Radiographic Axial Spondyloarthritis, Polyarticular Juvenile Idiopathic Arthritis, Psoriatic Arthritis, Rheumatoid... View more |
Related suggestions Psoriatic Arthritis
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More about Leflunomide | More about Otezla (apremilast) | More about Upadacitinib | ||||||||||||||||
Ratings & Reviews | ||||||||||||||||||
Leflunomide has an average rating of 5.2 out of 10 from a total of 111 ratings on Drugs.com. 42% of reviewers reported a positive effect, while 45% reported a negative effect. |
Otezla has an average rating of 5.1 out of 10 from a total of 433 ratings on Drugs.com. 35% of reviewers reported a positive effect, while 41% reported a negative effect. |
Upadacitinib has an average rating of 6.7 out of 10 from a total of 184 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 22% reported a negative effect. |
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Drug Class | ||||||||||||||||||
Side Effects | ||||||||||||||||||
See also: leflunomide side effects in more detail. |
See also: Otezla side effects in more detail. |
See also: upadacitinib side effects in more detail. |
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Generic Availability | ||||||||||||||||||
Lower cost generic |
N/A |
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Pricing and Coupons * Prices are without insurance | ||||||||||||||||||
View all leflunomide prices |
View all Otezla prices |
We could not find an exact match for this medicine. Try searching the Price Guide directly. |
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Dosage Forms Available | ||||||||||||||||||
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N/A |
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Brand Names | ||||||||||||||||||
Arava |
N/A |
Rinvoq, Rinvoq LQ | ||||||||||||||||
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||
336 hours |
9 hours |
14 hours |
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CSA Schedule ** View glossary of terms | ||||||||||||||||||
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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Pregnancy Category | ||||||||||||||||||
Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Summary unavailable. See the full pregnancy warnings document. |
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Drug Interactions | ||||||||||||||||||
A total of 659 drugs are known to interact with leflunomide:
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A total of 87 drugs are known to interact with Otezla:
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A total of 579 drugs are known to interact with upadacitinib:
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Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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Disease Interactions | ||||||||||||||||||
First Approval Date | ||||||||||||||||||
September 10, 1998 |
March 21, 2014 |
August 16, 2019 |
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WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||
N/A |
N/A |
N/A |
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More Information | ||||||||||||||||||
Patient resources | ||||||||||||||||||
Professional Resources | ||||||||||||||||||
Related Treatment Guide | ||||||||||||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.