Leflunomide Interactions
There are 675 drugs known to interact with leflunomide, along with 7 disease interactions, and 2 alcohol/food interactions. Of the total drug interactions, 546 are major, 119 are moderate, and 10 are minor.
- View all 675 medications that may interact with leflunomide
- View leflunomide alcohol/food interactions (2)
- View leflunomide disease interactions (7)
Most frequently checked interactions
View interaction reports for leflunomide and the medicines listed below.
- Aspirin Low Strength (aspirin)
- Benadryl (diphenhydramine)
- Celebrex (celecoxib)
- CoQ10 (ubiquinone)
- Cymbalta (duloxetine)
- Eliquis (apixaban)
- Enbrel (etanercept)
- Fish Oil (omega-3 polyunsaturated fatty acids)
- Flexeril (cyclobenzaprine)
- Humira (adalimumab)
- Lyrica (pregabalin)
- Metoprolol Succinate ER (metoprolol)
- Metoprolol Tartrate (metoprolol)
- Nexium (esomeprazole)
- Norco (acetaminophen / hydrocodone)
- Orencia (abatacept)
- Ozempic (semaglutide)
- Plaquenil (hydroxychloroquine)
- ProAir HFA (albuterol)
- Protonix (pantoprazole)
- Singulair (montelukast)
- Synthroid (levothyroxine)
- Tylenol (acetaminophen)
- Vitamin B12 (cyanocobalamin)
- Vitamin C (ascorbic acid)
- Vitamin D2 (ergocalciferol)
- Vitamin D3 (cholecalciferol)
- Xanax (alprazolam)
- Zofran (ondansetron)
- Zyrtec (cetirizine)
Leflunomide alcohol/food interactions
There are 2 alcohol/food interactions with leflunomide.
Leflunomide disease interactions
There are 7 disease interactions with leflunomide which include:
- immunosuppression
- liver disease
- peripheral neuropathy
- pulmonary toxicity
- renal dysfunction
- tuberculosis
- hypertension
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More about leflunomide
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- Reviews (115)
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- Side effects
- Dosage information
- During pregnancy
- Drug class: antirheumatics
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Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
