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Doxycycline Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Doxycycline Spironolactone Accutane (isotretinoin)
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Doxycycline Spironolactone Accutane (isotretinoin)
Prescription only

Doxycycline is an effective antibiotic that treats a wide range of infections. However, it is not usually recommended for children aged less than eight or pregnant women in the last half of their... View more

Prescription only

Spironolactone is a diuretic that may be used to remove excess fluid (edema) from the body, lower blood pressure, or treat hyperaldosteronism. It does not cause potassium loss from the body; however... View more

Prescription only

Prescribed for Acne, Rosacea, Acute Nonlymphocytic Leukemia, Granuloma Annulare. Accutane may also be used for purposes not listed in this medication guide.

More about Doxycycline More about Spironolactone More about Accutane (isotretinoin)
Ratings & Reviews

Doxycycline has an average rating of 6.5 out of 10 from a total of 1634 ratings on Drugs.com. 51% of reviewers reported a positive effect, while 26% reported a negative effect.

Spironolactone has an average rating of 6.9 out of 10 from a total of 702 ratings on Drugs.com. 59% of reviewers reported a positive effect, while 24% reported a negative effect.

Accutane has an average rating of 8.0 out of 10 from a total of 657 ratings on Drugs.com. 74% of reviewers reported a positive effect, while 14% reported a negative effect.

View all 1634 reviews

View all 702 reviews

View all 657 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

View all Doxycycline side effects

View all Spironolactone side effects

View all Accutane side effects
Drug Class
Generic Availability

Lower cost generic

Lower cost generic

 Lower cost generic approved
Pricing and Coupons * Prices are without insurance
Quantity 2 tablet
Strength hyclate 100 mg
Per unit* $6.37
Cost* $12.73

View all Doxycycline prices

Quantity 100 each
Strength 25 mg
Per unit* $0.22 - $0.27
Cost* $22.35 - $27.20

View all Spironolactone prices

Quantity 30 each
Strength 10 mg
Per unit* $4.43
Cost* $133.04

View all Accutane prices

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Dosage Forms
  • Injectable powder for injection
  • Oral capsule
  • Oral delayed release capsule
  • Oral delayed release tablet
  • Oral powder for reconstitution
  • Oral tablet
  • Oral suspension
  • Oral tablet
  • Oral capsule
Brand Names
Acticlate, Adoxa, Adoxa CK, Adoxa Pak, Adoxa TT, Alodox, Avidoxy, Doryx, Doryx MPC, Doxy 100, Doxy 200, Doxy-Caps, Doxy-D, LymePak, Mondoxyne NL, Monodox, Morgidox, Okebo, Oracea, Oraxyl, Targadox, Uracil, Vibramycin View more Aldactone, CaroSpir Other isotretinoin brands include: Absorica, Absorica LD, Amnesteem, Claravis, Myorisan, Sotret, Zenatane
Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

23 hours

37 hours

32 hours
CSA Schedule 1 View glossary of CSA terms
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
Pregnancy Category
D
Category D Positive evidence of risk

See the full pregnancy warnings document.
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.
X
Category X Not for use in pregnancy

See the full pregnancy warnings document.
Drug Interactions

A total of 222 drugs are known to interact with Doxycycline:

  • 22 major drug interactions (60 brand and generic names)
  • 195 moderate drug interactions (2211 brand and generic names)
  • 5 minor drug interactions (21 brand and generic names)

A total of 382 drugs are known to interact with Spironolactone:

  • 51 major drug interactions (248 brand and generic names)
  • 311 moderate drug interactions (1485 brand and generic names)
  • 20 minor drug interactions (145 brand and generic names)

A total of 138 drugs are known to interact with Accutane:

  • 24 major drug interactions (95 brand and generic names)
  • 114 moderate drug interactions (819 brand and generic names)
Alcohol/Food/Lifestyle Interactions

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.
  • Spironolactone and alcohol may have additive effects in lowering your blood pressure. You may... View more
  • Ask your doctor before using ISOtretinoin together with alcohol. Do not drink alcohol while you... View more
Disease Interactions
First Approval Date

December 05, 1967

January 21, 1960

May 07, 1982
WADA Class View classifications

N/A

N/A
More Information
Patient Resources
Professional Resources
Related Treatment Guide

1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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