Doxycycline Alternatives Compared
| Doxycycline | Spironolactone | Accutane (isotretinoin) |
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| Doxycycline | Spironolactone | Accutane (isotretinoin) |
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Prescription only
Doxycycline is an effective antibiotic that treats a wide range of infections. However, it is not usually recommended for children aged less than eight or pregnant women in the last half of their... View more |
Prescription only
Spironolactone is a diuretic that may be used to remove excess fluid (edema) from the body, lower blood pressure, or treat hyperaldosteronism. It does not cause potassium loss from the body; however... View more |
Prescription only
Prescribed for Acne, Rosacea, Acute Nonlymphocytic Leukemia, Granuloma Annulare. Accutane may also be used for purposes not listed in this medication guide. |
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| More about Doxycycline | More about Spironolactone | More about Accutane (isotretinoin) | ||||||||||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||||||||||
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Doxycycline has an average rating of 6.4 out of 10 from a total of 1633 ratings on Drugs.com. 50% of reviewers reported a positive effect, while 26% reported a negative effect. |
Spironolactone has an average rating of 6.9 out of 10 from a total of 700 ratings on Drugs.com. 59% of reviewers reported a positive effect, while 24% reported a negative effect. |
Accutane has an average rating of 8.0 out of 10 from a total of 657 ratings on Drugs.com. 74% of reviewers reported a positive effect, while 14% reported a negative effect. |
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| Drug Class | ||||||||||||||||||||||||||
| Side Effects | ||||||||||||||||||||||||||
| Generic Availability | ||||||||||||||||||||||||||
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Lower cost generic |
Lower cost generic |
Lower cost generic approved | ||||||||||||||||||||||||
| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all Doxycycline prices |
View all Spironolactone prices |
View all Accutane prices |
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| Dosage Forms Available | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
| Acticlate, Adoxa, Adoxa CK, Adoxa Pak, Adoxa TT, Alodox, Avidoxy, Doryx, Doryx MPC, Doxy 100, Doxy 200, Doxy-Caps, Doxy-D, LymePak, Mondoxyne NL, Monodox, Morgidox, Okebo, Oracea, Oraxyl, Targadox, Uracil, Vibramycin View more | Aldactone, CaroSpir | Other isotretinoin brands include: Absorica, Absorica LD, Amnesteem, Claravis, Myorisan, Sotret, Zenatane | ||||||||||||||||||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||||||||||
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23 hours |
37 hours |
32 hours |
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| CSA Schedule ** View glossary of terms | ||||||||||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Category D
Positive evidence of risk
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 210 drugs are known to interact with Doxycycline:
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A total of 383 drugs are known to interact with Spironolactone:
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A total of 137 drugs are known to interact with Accutane:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | ||||||||||||||||||||||||||
| First Approval Date | ||||||||||||||||||||||||||
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December 05, 1967 |
January 21, 1960 |
May 07, 1982 |
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| WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||||||||||
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N/A |
N/A |
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| Related Treatment Guide | ||||||||||||||||||||||||||
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.