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Doxycycline Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Doxycycline Adalimumab Methotrexate
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Doxycycline Adalimumab Methotrexate
Prescription only

Doxycycline is an effective antibiotic that treats a wide range of infections. However, it is not usually recommended for children aged less than eight or pregnant women in the last half of their... View more

Prescription only

Adalimumab is a TNF-alfa inhibitor that may be used to treat a wide range of different inflammatory conditions, such as rheumatoid Arthritis, psoriasis, ankylosing spondylitis, Crohn's disease, and... View more

Prescription only

Methotrexate may be considered for the treatment of psoriasis, rheumatoid arthritis, polyarticular juvenile idiopathic arthritis (pJIA), mycosis fungoides, and certain cancers, such as ALL or... View more

More about Doxycycline More about Adalimumab More about Methotrexate
Ratings & Reviews

Doxycycline has an average rating of 6.4 out of 10 from a total of 1632 ratings on Drugs.com. 50% of reviewers reported a positive effect, while 26% reported a negative effect.

Adalimumab has an average rating of 6.4 out of 10 from a total of 725 ratings on Drugs.com. 55% of reviewers reported a positive effect, while 31% reported a negative effect.

Methotrexate has an average rating of 6.6 out of 10 from a total of 334 ratings on Drugs.com. 54% of reviewers reported a positive effect, while 23% reported a negative effect.

View all 1632 reviews

View all 725 reviews

View all 334 reviews

Drug Class
Side Effects

Doxycycline side effects

Adalimumab side effects

Methotrexate side effects
Generic Availability

Lower cost generic

Lower cost generic

Lower cost generic
Pricing and Coupons * Prices are without insurance
Quantity 2 tablet
Strength hyclate 100 mg
Per Unit* $6.36
Cost* $12.71

View all Doxycycline prices

Quantity 2 kit
Strength adbm 40 mg/0.8 mL
Per Unit* $697.26 - $1,979.13
Cost* $1,394.51 - $3,958.25

View all Adalimumab prices

Quantity 20 each
Strength 2.5 mg
Per Unit* $1.77
Cost* $35.42

View all Methotrexate prices

Get free Discount Card

Get free Discount Card

Get free Discount Card

Dosage Forms Available
  • Injectable powder for injection
  • Oral capsule
  • Oral delayed release capsule
  • Oral delayed release tablet
  • Oral powder for reconstitution
  • Oral tablet
  • Subcutaneous kit
  • Subcutaneous solution
  • Injectable powder for injection
  • Injectable solution
  • Oral tablet
Brand Names
Acticlate, Adoxa, Adoxa CK, Adoxa Pak, Adoxa TT, Alodox, Avidoxy, Doryx, Doryx MPC, Doxy 100, Doxy 200, Doxy-Caps, Doxy-D, LymePak, Mondoxyne NL, Monodox, Morgidox, Okebo, Oracea, Oraxyl, Targadox, Uracil, Vibramycin View more Abrilada, Amjevita, Cyltezo, Hadlima, Hulio, Humira, Hyrimoz, Idacio, Simlandi, Yuflyma, Yusimry View more Jylamvo, Methotrexate LPF Sodium, Otrexup, Rasuvo, Trexall, Xatmep
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

23 hours

480 hours

15 hours
CSA Schedule ** View glossary of terms
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
Pregnancy Category
D
Category D Positive evidence of risk

See the full pregnancy warnings document.
B
Category B No proven risk in humans

See the full pregnancy warnings document.
X
Category X Not for use in pregnancy

See the full pregnancy warnings document.
Drug Interactions

A total of 210 drugs are known to interact with Doxycycline:

  • 22 major drug interactions (60 brand and generic names)
  • 183 moderate drug interactions (2181 brand and generic names)
  • 5 minor drug interactions (21 brand and generic names)

A total of 542 drugs are known to interact with Adalimumab:

  • 294 major drug interactions (851 brand and generic names)
  • 240 moderate drug interactions (920 brand and generic names)
  • 8 minor drug interactions (35 brand and generic names)

A total of 709 drugs are known to interact with Methotrexate:

  • 144 major drug interactions (662 brand and generic names)
  • 551 moderate drug interactions (2692 brand and generic names)
  • 14 minor drug interactions (45 brand and generic names)
Alcohol/Food/Lifestyle Interactions

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.
  • Caffeine may reduce the effectiveness of methotrexate in the treatment of arthritis. If you are... View more
  • Methotrexate may cause liver problems, and using it with other medications that can also affect the... View more
Disease Interactions
First Approval Date

December 05, 1967

N/A

December 07, 1953
WADA Class View World Anti-Doping Agency classifications.

N/A

N/A

N/A
More Information
Patient resources
Professional Resources
Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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