Differin Alternatives Compared
| Differin (adapalene) | Spironolactone | Doxycycline |
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| Differin (adapalene) | Spironolactone | Doxycycline |
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Prescription and OTC
Prescribed for Acne. Differin may also be used for purposes not listed in this medication guide. |
Prescription only
Spironolactone is a diuretic that may be used to remove excess fluid (edema) from the body, lower blood pressure, or treat hyperaldosteronism. It does not cause potassium loss from the body; however... View more |
Prescription only
Doxycycline is an effective antibiotic that treats a wide range of infections. However, it is not usually recommended for children aged less than eight or pregnant women in the last half of their... View more |
Related suggestions |
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| More about Differin (adapalene) | More about Spironolactone | More about Doxycycline | ||||||||||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||||||||||
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Differin has an average rating of 6.0 out of 10 from a total of 344 ratings on Drugs.com. 52% of reviewers reported a positive effect, while 37% reported a negative effect. |
Spironolactone has an average rating of 6.9 out of 10 from a total of 698 ratings on Drugs.com. 59% of reviewers reported a positive effect, while 24% reported a negative effect. |
Doxycycline has an average rating of 6.4 out of 10 from a total of 1628 ratings on Drugs.com. 50% of reviewers reported a positive effect, while 26% reported a negative effect. |
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| Side Effects | ||||||||||||||||||||||||||
| Generic Availability | ||||||||||||||||||||||||||
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Lower cost generic |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all Differin prices |
View all Spironolactone prices |
View all Doxycycline prices |
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| Dosage Forms Available | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
| Other adapalene brands include: Plixda | Aldactone, CaroSpir | Acticlate, Adoxa, Adoxa CK, Adoxa Pak, Adoxa TT, Alodox, Avidoxy, Doryx, Doryx MPC, Doxy 100, Doxy 200, Doxy-Caps, Doxy-D, LymePak, Mondoxyne NL, Monodox, Morgidox, Okebo, Oracea, Oraxyl, Targadox, Uracil, Vibramycin View more | ||||||||||||||||||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||||||||||
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51 hours |
37 hours |
23 hours |
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| CSA Schedule ** View glossary of terms | ||||||||||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category D
Positive evidence of risk
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 12 drugs are known to interact with Differin:
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A total of 384 drugs are known to interact with Spironolactone:
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A total of 210 drugs are known to interact with Doxycycline:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | ||||||||||||||||||||||||||
| First Approval Date | ||||||||||||||||||||||||||
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May 31, 1996 |
January 21, 1960 |
December 05, 1967 |
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| WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||||||||||
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N/A |
N/A |
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| Patient resources | ||||||||||||||||||||||||||
| Professional Resources | ||||||||||||||||||||||||||
| Related Treatment Guide | ||||||||||||||||||||||||||
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.