Diclofenac Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Diclofenac	Nurtec ODT (rimegepant)	Sumatriptan	Enter another drug to compare

Diclofenac

Nurtec ODT (rimegepant)

Sumatriptan

Prescription only

Diclofenac is an effective medicine for relieving pain but may be associated with an increased risk of cardiovascular and gastrointestinal side effects compared with some other NSAIDs. Prescribed... View more

Prescription only

Nurtec ODT may be placed onto or under the tongue to treat the symptoms of migraine in adults, and it may also be used to prevent episodic migraine when taken every second day. Nurtec ODT works by... View more

Prescription only

Sumatriptan may be used to quickly relieve the symptoms of a migraine but may not be suitable for everyone including those with pre-existing cardiovascular conditions. Prescribed for Migraine... View more

More about Diclofenac

More about Nurtec ODT (rimegepant)

More about Sumatriptan

Ratings & Reviews

Diclofenac has an average rating of 7.3 out of 10 from a total of 695 ratings on Drugs.com. 67% of reviewers reported a positive effect, while 21% reported a negative effect.

Nurtec ODT has an average rating of 6.3 out of 10 from a total of 320 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 30% reported a negative effect.

Sumatriptan has an average rating of 7.7 out of 10 from a total of 549 ratings on Drugs.com. 71% of reviewers reported a positive effect, while 17% reported a negative effect.

View all 695 reviews

View all 320 reviews

View all 549 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Upset stomach (4.9%)
Diarrhea (3.3%)
Nausea (3.3%)
Dizziness (2.9%)
Stomach pain (2.2%)
Drowsiness (2.0%)
Headaches (1.7%)

View all Diclofenac side effects

Nausea (18.4%)
Dizziness (4.4%)
Headaches (4.1%)
Tiredness (4.1%)
Migraine (3.4%)
Vomiting (3.1%)
Brain fog (2.8%)

View all Nurtec ODT side effects

Nausea (13.5%)
Drowsiness (6.6%)
Pain (6.4%)
Chest pain (5.1%)
Dizziness (5.1%)
Vomiting (4.4%)
Tiredness (4.2%)

View all Sumatriptan side effects

Drug Class

Nonsteroidal anti-inflammatory drugs

CGRP inhibitors

Antimigraine agents

Generic Availability

Lower cost generic

No lower cost generic approved

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	10 delayed release tablet
Strength	sodium 75 mg
Per unit^*	$1.53
Cost^*	$15.34

View all Diclofenac prices

Quantity	8 tablet, disintegrating
Strength	75 mg
Per unit^*	$138.56
Cost^*	$1,108.47

View all Nurtec ODT prices

Quantity	0.5 mL
Strength	6 mg/0.5 mL
Per unit^*	$41.00 - $105.76
Cost^*	$20.50 - $52.88

View all Sumatriptan prices

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Dosage Forms

Oral capsule
Oral delayed release tablet
Oral powder for reconstitution
Oral tablet
Oral tablet, extended release

Oral tablet, disintegrating

Nasal spray
Oral tablet
Subcutaneous solution

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

1.8 hours

11 hours

6 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category D Positive evidence of risk

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Drug Interactions

A total of 442 drugs are known to interact with Diclofenac:

97 major drug interactions (408 brand and generic names)
328 moderate drug interactions (1287 brand and generic names)
17 minor drug interactions (83 brand and generic names)

A total of 167 drugs are known to interact with Nurtec ODT:

57 major drug interactions (174 brand and generic names)
109 moderate drug interactions (310 brand and generic names)
1 minor drug interactions (2 brand and generic names)

A total of 100 drugs are known to interact with Sumatriptan:

70 major drug interactions (279 brand and generic names)
30 moderate drug interactions (166 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Ask your doctor before using diclofenac together with alcohol. Do not drink alcohol while taking... View more

If you are receiving therapy with rimegepant you may want to avoid the regular consumption of large... View more

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Disease Interactions

First Approval Date

July 28, 1988

February 27, 2020

January 28, 2016

WADA Class View classifications

N/A

More Information

Patient Resources

Nurtec ODT uses

Professional Resources

Prescribing information

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Diclofenac Alternatives Compared

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