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Sumatriptan and Tiredness: What Users Say

Brand names: Imitrex, Imitrex Statdose, Zembrace SymTouch, Tosymra, Onzetra Xsail, Imitrex Nasal

Tiredness: mentioned by 23 users (4.2%)

Based on user experiences from 549 Sumatriptan reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

nausea 13.5%
drowsiness 6.6%
pain 6.4%
chest pain 5.1%
dizziness 5.1%
vomiting 4.4%
tiredness 4.2%
weakness 3.5%
headaches 3.3%
fatigue 2.7%

Reviews for Sumatriptan

Commonly mentioned side effects
  • Rai...
  • July 16, 2019

Sumatriptan for Migraine "I have had migraines since I was a kid. Diagnosed as sinus for many years until one doctor asked me to try Imitrex. It was like a miracle. I thought I would have to suffer with 3 to 4-day long headaches that feel like a knife in my temple the rest of my life. But Imitrex knocks it out in 30-40 minutes. There are side effects: muscle aches, tiredness, sensitive skin, and the need to pee constantly. Annoying, but if you've had migraines for years, it is a good trade-off. I take a naproxen at the same time to help with body aches."

9 / 10
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30 Report
  • xza...
  • June 26, 2013

Sumatriptan for Migraine "I completely rely on Imitrex. Once I had this, the daylong headaches are gone. I now know that what I used to call 'sinus headaches' were migraines I had since a teenager, though not bad until into my 40s. My side effects are a little sleepiness and maybe some tiredness, but nothing compared to the debilitation of a migraine. However, I am much more aggressive with eliminating triggers, particularly MSG and processed foods, and this helps. My better diet has reduced my need for Imitrex down to 2-3 times a month."

9 / 10
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36 Report
  • Anonymous
  • Taken for less than 1 month
  • November 1, 2012

Sumatriptan for Migraine "This medicine kept the migraine from becoming full-blown. It made me sleepy and out of sorts, but this is better than an agonizing migraine. I took it as soon as I saw the visual effect, and within 30 minutes, my vision was back to normal. However, I still had a mild migraine with very little nausea. Imitrex made me tired, and my body felt heavy. It also made my tongue feel swollen, but it wasn't. But I'd take this over a full-blown migraine any day! It seemed to fast-forward the headache rather than it being debilitating like last time. I still lay around all day though."

7 / 10
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18 Report

Frequently asked questions

  • mer...
  • December 6, 2018

Sumatriptan for Migraine "After I had my son, I had horrible migraines, sometimes daily. I tried every over-the-counter medication, including Excedrin, Tylenol, and Ibuprofen. I recently started taking Imitrex. It's amazing. It does take a while to kick in, probably about an hour to two. The pain goes away within about 20 minutes, but I still have a pressure-like feeling until about an hour or two later. It also has really helped my depression, maybe because of the serotonin element in the medication. It doesn't make me tired or dizzy, luckily. I do feel relaxed, but not in a bad way. I really love it."

9 / 10
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10 Report
  • Anonymous
  • Taken for 10 years or more
  • June 25, 2013

For Migraine "This medication works for me. I did have slight chest discomfort the first few times using it. I no longer experience it. Sometimes it makes me feel tired, but I continue on, and it goes away. Headache disappears within 30 mins to 1 hr of taking the tablet. I have been taking Imitrex and sumatriptan for over 25 years and am thankful the neurologist prescribed it."

10 / 10
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15 Report

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  • Anonymous
  • January 25, 2010

Sumatriptan for Cluster Headaches "I consider Imitrex to be the greatest medicine in the world, at least as far as my health is concerned. I am never without the auto injector. When a chronic headache comes on, I inject myself, and 3 to 4 minutes later ... no pain. My muscles are fatigued, and I'm somewhat tired for about 30 minutes, but NO PAIN! ... Yes!"

9 / 10
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17 Report
  • Jma...
  • Taken for less than 1 month
  • September 16, 2019

For Migraine "I've been having migraines, so the doc put me on 25 mg of Imitrex. It makes you very tired and drowsy, so I wouldn't suggest taking it at work or when driving. It got rid of the migraine, but had horrible side effects. I took it Saturday at noon, and here it is Monday morning, and I still feel panicky, nauseous, very tired, and feel like I'm having a panic attack. I won't be taking it again."

2 / 10
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6 Report

More FAQ

  • pip...
  • Taken for 1 to 6 months
  • April 16, 2019

For Migraine "Sumatriptan works amazing to take away my migraine as soon as I feel the telltale pain above my eyebrow. However, I experience severe side effects such as jaw pain that prevents me from opening my mouth very far and chewing/swallowing. I also get tired and spaced out after taking this. The drug takes maybe 30 minutes to kick in and removes the migraine pain entirely, which is why I still rated it as effective. Works first time and every time, I never have to take a second dose."

10 / 10
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  • CLS...
  • Taken for less than 1 month
  • April 3, 2019

For Migraine "This drug works, but not sure if it’s worth the scary side effects. It usually takes around 40-45 minutes for the drug to actually get rid of the headache. In that time, my neck will get very stiff. It’ll feel like my head is like a bowling ball. I’ll feel pretty weak and unfocused. Today I took it and had a numb, tingling feeling in my left hand. That went away after a few minutes, then I started feeling heavy in my tongue. Next, the left side of my mouth and cheek started going numb. For a minute there, I thought I was having a stroke! Luckily, the numbness didn’t last more than 10 minutes, but talk about freaky. The rest of the day I’ve been absolutely exhausted. Basically, don’t plan on being able to have a productive day at work if you’re going to take this, at least in my experience. I’ve only taken it twice, but the side effects have been the same."

5 / 10
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5 Report
  • Amb...
  • July 11, 2019

For Migraine "I have suffered with migraines for over 30 years, nothing helped. Now tried the 50 mg sumatriptan. Took it at 5 PM, within 30 mins, my nose had a tingling sensation, left shoulder started to ache, nauseous, but pain gone. Now, 4 hours later, pain is back, I am very tired."

1 / 10
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4 Report
  • Anonymous
  • March 7, 2012

Sumatriptan for Migraine "Took the pain away in 15 min. The injection site bruises and bleeds. But still worth it. I felt the nausea associated with this medication for about the first 10 mins and extreme tiredness. Got it as a sample but will for sure fill the prescription. Most effective and fastest working migraine medicine so far."

9 / 10
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7 Report
  • teg...
  • October 18, 2011

Sumatriptan for Migraine "I was nervous about the pain, and even though it's needle-free, I have a bit of a needle phobia, and the idea of any injection (even without a needle) was pretty rough for me to get over. After talking myself up for about 30 minutes, I was finally able to give myself the dose. It hurt a lot more than I was expecting and bled more than my neurologist and pharmacist said it would, so immediately after administering it, I was pretty apprehensive. I felt the side effects most people have reported (weakness, dizziness, heaviness, etc.), but I also had some nausea, and I was really tired. I felt near-immediate relief of about 50% of my migraine, and then took a power nap for about 45 minutes. When I woke up, I felt like a completely new person."

9 / 10
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9 Report
  • LML...
  • Taken for 10 years or more
  • September 22, 2022

For Migraine "I suffer from debilitating occipital migraines since I was 19. I am now 52. I get them approximately 4 times a month. The only medication that has been my holy grail is Imitrex, aka sumatriptan 100 mg. It works within 2 hours, and the only side effect for me is occasional malaise/lethargy for 24 hours... but I can get back to life instead of suffering through the indescribable pain you all know if you are reading this. I HIGHLY recommend it. Affordable and non-habit forming."

10 / 10
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  • Ang...
  • February 8, 2013

For Cluster Headaches "This is the first time I have used Sumatriptan, it was Arrow-Sumatriptan injection. I immediately felt a slight pressure in my chest and a pushing in my temples and the base of my skull, and I felt tired and weak. There was a tingling sensation in my nose, and my throat was ultra-sensitive. It is an hour since I injected, and my cluster headache has eased but not gone away yet. My eye has stopped streaming, and my nose is not running so fast, and I look slightly more human. I had hoped for better than this, but it is an improvement."

5 / 10
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7 Report
  • Cwa...
  • March 29, 2018

For Migraine "I was prescribed this medication for migraine. I took it at work during my lunch for the first time... big mistake. My head felt like a swollen balloon, I was disoriented, loopy, delusional, heavy, weird as ever, and very tired. I wanted to lay down on my desk and cry or go home, but I could not. My dosage was 100 mg. The next time I took it, I cut it in half, and it was not as bad of a feeling as before. I recommend trying it at home first to see how your body reacts first... not at work, lol."

7 / 10
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3 Report
  • Ste...
  • Taken for 6 months to 1 year
  • September 10, 2018

For Migraine "I love this medicine! It has given me back my life. When I first started taking it, I would get super tired and have to sleep for an hour, but I have been taking it for a year and have no side effects anymore. For me, it starts working within 10 minutes, and the migraine is gone within an hour. Most of the time, I don't even need to take a full dose... just half of a pill. The only bummer is my insurance company will only let me have so many of these pills every 20 days, and because I suffer from migraines all but maybe 4 days a month, I run out."

10 / 10
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3 Report
  • Dan...
  • Taken for less than 1 month
  • May 7, 2018

For Migraine "Every time I take this medicine, my throat and neck become so tense and sore. I also feel tired and loopy. It does make the migraine better. Currently trying to decide if it's worth the side effects or not."

4 / 10
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  • Lee...
  • May 10, 2017

For Migraine "Just tried sumatriptan for the first time, I got it over the counter in a UK chemist. I'm a 39-year-old man who has suffered from debilitating migraines since a teenager. They have become less frequent with age, but when I get the early signs (aura), it still sends me into a panic about what's to come, lying helplessly in hell for hours. So, when I heard of a new effective drug, I jumped at the chance. This was my experience: you get two pills, I took one with water and lay down in a dark room. After about 40 minutes, I could feel the drug starting to take effect. It was as if the migraine was still happening, but it had been dulled down or masked by the drug. You feel tired, sick, and a bit weird, but it's better than the migraine pain."

6 / 10
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1 Report
  • Anonymous
  • August 31, 2012

For Migraine "I recently was diagnosed with complex migraine. I feel like I am having some kind of seizure that I am awake for: numbness and facial twitching, slurred speech, ocular pain, and all kinds of bizarre visuals. Sumatriptan definitely takes the edge off. It only works if I am already having a severe migraine, though, and takes some time to work as well. In addition, I cannot take this medicine if I am at work because it makes me rather tired. However, it is quite helpful for when I am at home and does significantly reduce the disorienting pain and eye pressure. It does not make aura disappear, but it makes it less bright. Not perfect but pretty good!"

7 / 10
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  • It...
  • Taken for 1 to 2 years
  • March 11, 2018

For Migraine "Just started having migraines at 45 (gee, wonder why... lol). Tried all the OTC and homeopathic treatments I could find. Gave up and started with Relpax. My insurance wouldn’t help, so it was $115 for 6. Then my doctor had me try 50 mg sumatriptan (generic Imitrex) and very inexpensive. Always works within an hour, and normally my migraines last 36 hours on any OTC med. I can’t take more than 2 doses in a 5-day stretch, or I’m up for days with leg cramps, though. In desperation, I’ve started Topamax 50 mg as preventative, but it’s about 20% effective and not worth the side effects for me (lack of focus; numbness; tired)."

10 / 10
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  • hea...
  • Taken for 10 years or more
  • April 2, 2015

Sumatriptan for Migraine "Three days on medicine caused extreme muscle pain, tiredness, and weakness. Also, facial flushing, tingling, hot and cold flashes, blurred vision, malaise, increased urination, lack of concentration."

9 / 10
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15 Report
  • Ell...
  • September 6, 2017

For Migraine "I have had migraines since my teenage years. Sumatriptan is the only medication that works every single time, with no side effects besides being a little tired. Thank goodness for this pill!"

10 / 10
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9 Report
  • Bar...
  • April 4, 2016

Sumatriptan for Migraine "I don't like it at all. Have taken 2 times and causes me to yawn a lot and jaw tightness. Makes me feel really weird."

1 / 10
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8 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.