Trintellix and Nausea: What Users Say (Page 3)

• Lov...
• Taken for 1 to 6 months
• May 19, 2017

For Major Depressive Disorder "I was diagnosed with major depression after years of dealing with terrible Rheumatoid arthritis that has limited my mobility. My doctor prescribed me 3 different antidepressants and after Cymbalta gave me head zaps and my anxiety was causing panic attacks, he switched me to Trintellix. I started on the 5 mg while I was weaning off 60 mg of Cymbalta. The nausea was so bad. I would like to think I have a pretty strong stomach, but this med made me sick like when I was pregnant. I stuck with it and 3 weeks in at 10 mg, I feel fantastic! I'm so glad I stuck with it! I'm laughing again and my motivation is incredible! It was so worth it! If you're debating it, stick with it through the nausea to see if it works for you. I'm truly thankful!"

• Kaf...
• June 7, 2015

For Depression "I am an R.N. and diagnosed 20 plus years ago with clinical depression. I have also been on just about every antidepressant. A week ago, I requested help from my physician due to the increasing depression and lack of help from Cymbalta. He prescribed Trintellix. I switched immediately, and some of the symptoms are withdrawal from the Cymbalta. The 'reverberations' in my head are distinctly withdrawal symptoms. My headaches appear to be from decreased sodium, which is a Trintellix side effect, and for me, are eliminated by drinking Gatorade, which is high in sodium. The nausea is a toss-up and eased with ginger ale and carbs. The itching responds to one Benadryl. Four weeks is the norm for side effects to subside. Identical to the original Prozac."

• Rac...
• Taken for less than 1 month
• July 27, 2016

For Depression "Only been on it for a week and a half so far. The first few days caused dizziness and a bout of nausea about an hour after taking it with food. I don't get nauseous taking it anymore. I still get dizzy every now and then but they're less intense now. I can already tell a difference in my mood. I'm excited to see my future progress."

• -Je...
• Taken for 1 to 6 months
• January 26, 2015

For Major Depressive Disorder "I am bipolar and have major depression issues and have been on tons of meds, to the point where I have felt like a pin cushion for these meds. Either they make me so tired I can't do nothing or they just don't work. I started taking Brintellix 3 months ago and I am on 10 mg a day. Side effects, whether I took it with food or not I would throw up almost every day ugh... but on the upside it has made me feel like me again, not miserable and naggy looking at everything in a negative way! The nausea is still there sometimes in the morning but I will take it. So I can cope with everyday issues without freaking out and to be somewhat at peace with myself."

• Anonymous
• September 25, 2015

For Depression "I was diagnosed with General Anxiety Disorder. My doctor prescribed Viibryd. I wasn't ready to start on any antidepressant. Physical symptoms had worsened, and I was experiencing symptoms of depression. It was when I was ready to take medication. I am glad I did! My doctor prescribed me Trintellix. I started with 5mg. It is my first week, and I have been feeling very good - much clarity, can focus now. The only side effect I'm experiencing is nausea on my 3rd day. I sleep well at night, get enough sleep, and wake up refreshed. I don't feel anxious anymore. When I was depressed, I was overeating. This medication suppresses my appetite. I lost 1.5 lbs in 5 days, and I noticed regular bowel movements. This drug does wonders for me!"

• Joh...
• Taken for 6 months to 1 year
• July 1, 2015

For Depression "I was on venlor for 6 months and couldn't take the nausea and dizziness. It messed with my blood sugar and cholesterol. I changed to Trintellix, 6 months now, and I'm feeling awesome. Life is back to normal and I'm much better now. No side effects."

• Mea...
• Taken for less than 1 month
• April 29, 2019

For Major Depressive Disorder "I tried getting off of Effexor for a while, but withdrawals were bad. Lowering the dosage while increasing with Trintellix helped. 5 mg was fine. 10 mg was hard to get used to: nausea, diarrhea, really tired. I was also very itchy, but all of these symptoms went away after a week or two. One thing to note, I was a smoker and after a week of being on 10 mg, I can't stand smoking and quit. I also can't stand soda anymore. So, I am in love with this drug."

• Tam...
• Taken for 1 to 6 months
• November 23, 2014

For Depression "I have had great results from this medication for my depression and also my anxiety. I did not experience the 'dumbing' down that I have felt with other antidepressants. My focus is good and I've not had memory problems. One side effect I've noticed is lack of motivation / procrastination. It may sound odd but being a full-time college student, I've never put things off until the last minute like I have been doing since starting this medicine. Other side effects I've had are gas and bloating, diarrhea, nausea. These have lessened over the past 8 weeks. All in all, I'm very pleased with the results. Insurance: I'm not sure how much our co-pay will be for this, as I've been using samples given to me by my physician."

• Sta...
• August 15, 2019

For Major Depressive Disorder "I have had MDD for over 10 years now, and I have been on Venlafaxine XR, Prozac, Cymbalta, and other medications. I have recently been switched to Trintellix because nothing else is helping. I tried to do yoga, Pilates, and daily exercise along with a keto diet. I read the other reviews, and I was very nervous before I started taking this. I thought this was not going to be a good medicine for me, but so far I have had zero side effects! I am on 10 mg for two weeks, and then I go to 20 mg. So we will see how long it takes to work out, but so far it’s not bad. I even got nausea meds just to be safe, but I have zero side effects! So that’s definitely a big plus! Other meds have made me gain 40 pounds and didn’t help. Every person is different, so I’m just trying to be a positive person based on my experience so far. Be safe and stay positive!"

• Anonymous
• Taken for 1 to 6 months
• November 3, 2016

For Depression "I've been on Trintellix for 10 weeks now, roughly. I was on 5mg for a while, now on ten. At first, the nausea was unbearable, and all it really did was stop me from getting overwhelmingly sad as often, but now I've found that I'm more outgoing and capable of trying my best even in uncomfortable situations. The nausea is still there, but it becomes super tolerable, and Gravol is a lifesaver. The only time it became a problem is when I was sick, I vomited non-stop. I had bronchitis, so apparently the throat pain mixed with nausea was to blame. Still, overall, Trintellix has done wonders for my mental health, and I'm hoping the majority of others can agree or find another medication that will do for you what Trintellix has done for me."

• Pat...
• Taken for less than 1 month
• April 24, 2015

For Depression "I am only on day two. I hesitated taking this drug because the last antidepressant I took (Cymbalta) was horrible. It took me a year to get rid of the withdrawal symptoms. To this day, I still have random 'brain zaps'. So back to the Trintellix, I was in the deepest and darkest depression of my life ever. I knew I had to do something, so yesterday I took my first pill. Later that evening, I was feeling much more calm and better. Today, my deep depression is gone. I still have room for improvement. I would have never thought in a million years it would start to work that fast. I was very nauseous yesterday after I took it, but I was nauseous before I took it. I just took pill #2. So far, I am very impressed. I will report back in the future."

• tam...
• May 19, 2014

For Depression "This has worked the best for me thus far. I have been on several SEVERAL antidepressants and by far this has been better with very little side effects. Nausea has been the only downside at this point. I missed two days due to my pharmacy being closed and didn't have the 'brain zaps' after missing. Big plus in my book."

• Jes...
• April 24, 2017

For Major Depressive Disorder "It was very difficult titrating up to 20 mg of Trintellix. I started at 5 mg one week, 10 mg the next week, 15 mg the following week until I reached 20 mg. The nausea, vomiting, and dizziness were almost unbearable, I missed 2 days each week for a month while starting it. Thankfully I was on FMLA and was able to muscle through it. I have been through almost every SSRI, SNRI, etc., and nothing but electroconvulsive therapy worked for me. After the first week on Trintellix, I felt happy for the first time, actually happy, which is why I muscled through the side effects. I have been on it for a year now, and it is a miracle pill. Make it through the first month, and all side effects go away."

• Mel...
• Taken for less than 1 month
• October 12, 2016

For Depression "Lots of nausea after moving from 5mg to 10mg. Days and days of headache and nausea, did get a Zofran RX and I feel much better! I believe this med is doing a good job at helping with my depression and anxiety. Just came off of Prozac after 10 years and I'm pretty happy with the results of Trintellix so far, 3 weeks in! Had to work the much hated job at work today - front desk...easiest day I've had up front in years, I believe due to new Trintellix...very promising!"

• Dru...
• January 2, 2015

For Depression "I'm still in the process of acclimating to Trintellix while weaning off of Paxil. However, I must say that my anxiety and depression seem to be much better, and my hunger (caused by Paxil) has reduced. One of the major side effects of Trintellix is nausea. So, instead of starting on a 5 mg dosage, I cut the 5 mg in half and took that for three days since I am very sensitive to medications. Today is my first day on the 5 mg dosage and I have not experienced any nausea. The only side effects that I have felt so far are a bit of heartburn/indigestion, mild sleepiness, and mild dizziness, which certainly haven't kept me from doing my day-to-day routine. People should at least give this medicine a chance."

• Apr...
• December 16, 2014

For Depression "I've been taking 10mg for 4 days now (today will be day 5) and I'm wondering if I can make it a full week like my doctor wants me to. The side effects have been horrible for me. I've been walking around like a nauseous zombie since day 1. Then there's the dizziness and headache that goes along with it. The only benefit I've experienced so far is weight loss, but that's not at all why I started taking this medication. Instead of the anxiety and depression I would normally feel, I feel no emotions."

• Kgi...
• February 25, 2020

For Depression "I went on this medication because I have a condition called PGAD (persistent genital arousal disorder). The condition I have is absolutely horrible. I was previously on Zoloft for over 10 years, 100 mg. It starts to flatten out, so my doctor also gave me Wellbutrin 150 mg in 2016/2017. In May 2019, my PGAD condition occurred (reasons are still unknown). I was then told to go off Zoloft due to its sexual side effects and try something else. My doctor gave me Trintellix 10 mg. At first, it worked okay. I felt super nauseous for a while. Then later, almost every night, I was throwing up an hour after taking Trintellix. I took Trintellix for 8 months with zero relief of the vomiting. I have to take domperidone before my Trintellix so I don't puke. My condition sort of got better, now it is terrible. I also have anxiety and panic attacks nearly every day and cry very easily. It just isn't the pill for me. It was used for my anxiety and did not work."

• Sun...
• August 15, 2015

For Depression "I have been taking Trintellix for about 2 months, after my Lexapro stopped working. The first day after taking Trintellix, I was nauseous. I stayed nauseous for 2 weeks. Now that the nausea has worn off, I LOVE this medication! I feel less anxious and more happy, and things don't bother me as much. Just try to tough out the nausea for 2-3 weeks. It gets better. After that, you'll love it. I highly recommend Trintellix!"

• Blu...
• May 14, 2017

For Depression "I have been on several antidepressants and/or anxiety meds over the past 15 years. This is the first one that I can actually tell a difference without having to take a cocktail of other drugs with it. The ONLY downside was the nausea. The first couple of days felt like morning sickness. Once I got through it, it's been well worth it. And unlike many other drugs, there isn't the overwhelming weight gain."

• Blu...
• May 14, 2017

For Depression "I have been on several antidepressants and/or anxiety meds over the past 15 years. This is the first one that I can actually tell a difference without having to take a cocktail of other drugs with it. The ONLY downside was the nausea. The first couple of days felt like morning sickness. Once I got through it, it's been well worth it. And unlike many other drugs, there isn't the overwhelming weight gain."

• Mel...
• November 21, 2015

For Depression "Started taking Trintellix 13 days ago and noticed an immediate difference. It helped with my GAD and depression. I had slight nausea after taking it on an empty stomach, so ate a bite of something before taking it until my body got used to it. I've tried EVERYTHING, and this is the only medication that did not cause severe side effects. Very happy, and the results are incredible. I can smile again! ☺️"

• Dir...
• Taken for 1 to 6 months
• April 29, 2019

For Major Depressive Disorder "I have been on 10 mg Trintellix for nine weeks. I also take Risperidone and Buspirone. I was on Viibryd before I started this drug. I have had MDD for 24 years and have been on many antidepressants. Trintellix is by far the best I've been on. I had a little bit of nausea and vomiting, but really no side effects other than that. The side effects went away after the first three days. Trintellix has regulated my sleep and given me so much more energy and zest for life."

• RGC...
• Taken for 1 to 6 months
• June 12, 2023

For Depression "Life threw me a number of BIG curveballs in a row, and I found myself in a deep depression. Tried several other SSRIs, and nothing helped. Life was pretty bleak. My psychiatrist recommended trying Trintellix. At over $400 a month, I was hesitant, but since nothing else was working, I figured I'd give it a try. This medication was a game changer for me. The lights turned back on. I'm enjoying my life again. My husband said he hasn't seen me this happy and playful in years. Yes, the nausea can be a little rough at first. Ask your doctor for a Zofran Rx if you start this med. It was a game changer and got me through until my body adjusted to it. No sexual side effects (which I've had with every other SSRI I've tried). If you feel like you're running out of options, this medication is worth a try."

• Moo...
• Taken for 1 to 6 months
• May 14, 2015

For Depression "I switched from Zoloft due to fogginess at higher doses. As others have mentioned, the nausea and dizziness were definitely difficult for me when I first started Trintellix. At the same time, I could tell this was working for my depression. I was so grateful for the antidepressant effects. I cut back from 10 mg to 5 mg (half a pill) for a couple of weeks, and the nausea began to subside. I went back up to 10 mg, and now nausea is only an occasional problem. My doc said to make sure to take it with food, which I do in the morning. I know others take it at night. The nausea was indeed difficult, but I am so glad I stuck with it. For me, it is a very effective antidepressant."

• Can...
• March 11, 2019

For Major Depressive Disorder "I'm a 25-year-old woman with major depressive disorder and social anxiety for 8 years (with episodes of agoraphobia). Trintellix solved my major depressive disorder in almost 3 weeks!!! I was very skeptical about the antidepressant meds, but this changed my view about it. I'm very happy with this antidepressant. I feel nauseated at times, but compared with the symptoms of depression, it's negligible. Of course, this is not a magic bullet, changes in your lifestyle are required: exercise, healthy food, no drinking or smoking... Hope this med helps you :)"