Wegovy and Fatigue: What Users Say

• Mom...
• Taken for 1 to 6 months
• December 29, 2021

For Weight Loss (Obesity/Overweight) "Just took my last injection of month 5, 1.7. I have lost about 25-30 lbs along with 3-5 days a week at the gym. Definitely curbs your appetite. The nausea is very real! Each month I thought it would get easier. It never does. A couple times I puked for hours. Lots of belching. In the beginning, a little constipation. The first day or 2 after the injection, you can feel fatigue. It works for weight loss if you can tolerate the nausea. This will be my last month. I have a 6-month prescription but I can’t deal with the nausea anymore."

• RNi...
• Taken for 1 to 6 months
• May 4, 2022

For Weight Loss (Obesity/Overweight) "Wegovy does work, problem is... I feel like dirt all day long. I'm fatigued, nauseous, and even the smell of food makes me vomit. My heart races, and I'm quite dizzy. I lost 55 lbs. Do I look good? Yes. Do I feel good? No. I'm down to 153 lbs now. It's time to stop this medication."

• Jed...
• Taken for 1 to 6 months
• December 15, 2021

For Weight Loss (Obesity/Overweight) "Halfway through the 1.7mg dose. Been on for about 4.5 months. Have lost a total of 35 pounds. My weight loss has slowed down since on the 1.7 dose. Still losing but not as quickly as in the beginning. Have no real interest in food anymore. Sometimes have to eat when not hungry due to low blood sugar (had this prior to Wegovy use). Been trying to lose weight for months. Wegovy is the only thing to work for my obesity due to medical issues. Have noticed off and on fatigue, dizziness, constipation, stomach pain, gas, belching, and hair loss. Can no longer eat fried, greasy food without feeling sick, which is good. Now I want healthy food instead."

• usm...
• Taken for 1 to 6 months
• November 29, 2022

For Weight Loss (Obesity/Overweight) "At this time, I’m on my 5th week of the maintenance dose. The only side effect I’ve had is occasional constipation, but as a 25-year medical professional, I know how to deal with it medically and in conjunction with my VA doctor and pharmacist. At times, I would get hypoglycemic, but again I knew how to combat that. At this dose, I find myself somewhat more fatigued but I can deal with that. Cat naps usually do the trick. I started at 393 and 6’3”. I’m 56 years old. I’m down to 349 since I started, which for me is great. I have critical low testosterone and can’t take testosterone due to my history of pulmonary embolisms. So, I don’t mind losing only 2 pounds a week. I can now walk so much better and farther. I’m 95% VA disability rated, and I’ll tell you, I feel and look so much better after starting to use Wegovy. The VA truly cares for us veterans no matter what you hear. Stay blessed and hang in there."

• Gre...
• Taken for 1 to 6 months
• January 6, 2025

For Weight Loss (Obesity/Overweight) "I've been injecting Wegovy for the past three months on a weekly basis. I am at the 1 mg dosage. I have been having brief dizzy episodes. These could be related to my Lisinopril dosage. I have had stomach upsets and fatigue, but no trouble with the injecting. I have lost 25 pounds since starting - 220 - 195 lbs. I have been able to tolerate the side effects."

• Me ...
• Taken for 1 to 6 months
• January 25, 2022

For Weight Loss (Obesity/Overweight) "Nausea, diarrhea, constipation, sulfur burps, fatigue, loss of appetite, super sensitive to smells, I have to make myself eat enough. It's like morning sickness, only it's 24/7. Zofran helps for about 6 hours. Cannot tolerate much besides chicken broth and Brussels sprouts. No fried, fatty, oily, spicy foods. Need to stay hydrated with water. Ginger ale helps. I'm up to a 1 mg dose and 14th week. This nausea is constant and impacts my daily routine significantly. However, it is the only effective weight loss option that's worked in 26 years of diets and exercise and eating healthy. I will not give up. The weight is killing me, and I needed this medication. I started at 221 lbs. and now I'm at 194.3 lbs. BMI is close to pre-obesity, and I know I'll cry the day I hit it. Full disclosure, I'm disabled in part due to my weight. There is no way I could have worked and taken Wegovy with the severity of my nausea and fatigue. But the mobility and breathing issues are improving."

• Dan...
• Taken for 1 to 6 months
• April 5, 2023

For Weight Loss (Obesity/Overweight) "I wanted to warn people of the side effects, as my doctor did not prepare me for this med. I am very glad I didn't try to work, otherwise, I would have lost my job or, at the very least, been written up for various reasons. On it for a month. I tried spacing out the second shot and never ended up taking the last injection. Side effects: severe fatigue, severe hair loss, decreased hormones, severe headaches, changes in your sleep architecture, bad nightmares for all sleep, naps, and overnight. Warning: if you have PTSD, that may mess with you. Bladder urgency and UTI symptoms started on day 3 and were constant the whole time on the med, I had to take AZO. Bloating, burping, throwing up, and all food smells make you sick, severe constipation, hypoglycemia, and increased binge eating. I also had increased topical psoriasis and arthritis pain. Started having problems with my foot and wondering if it's impacting ligaments. I am getting that checked out. Did not reduce the need to eat, no weight loss."

• Ms ...
• Taken for 6 months to 1 year
• October 14, 2023

For Weight Loss (Obesity/Overweight) "I started on Wegovy in April 2023 with a weight of 271 lbs. My current weight is now 233 lbs, and this weight loss is with minimum mobility. I started at the lowest dosage and am now on 2.4. I didn’t experience any symptoms until I reached 1.7, I felt nauseous and fatigued on the first day of injection, but after, I was fine. I definitely eat differently, I cut out the starches like potatoes and pasta, which gave me that overly full feeling, and I have never been a fan of snacks and sweets. I have a new love for fruits and veggies now, though, and I eat mainly protein and veggies. I feel like Wegovy helped me to live a healthier lifestyle when it comes to food choices. On occasion, I may get a craving for something a bit more hearty and treat myself, but Wegovy has definitely helped me to lead a healthier lifestyle as I approach my 40s."

• Ano...
• Taken for 1 to 6 months
• April 8, 2025

For Weight Loss (Obesity/Overweight) "I am in week 10/injection 2 of 1 mg and taking Wegovy for weight loss. I started at 142 kg and am down to 132 kg, which is wonderful. My goal weight is 115 kg as I'm tall and solid build. The side effects, nausea, fatigue, headaches, and some bowel upsets tend to dissipate 3 days after the injection. Avoid big meals and heavy/fatty foods in particular to minimize side effects. Not enjoying food and the social side can be a bit tough, but the results far outweigh any downsides. You actually save money overall due to eating less. I intend to stay the course and highly recommend this life-changing experience."

• Flo...
• Taken for less than 1 month
• December 16, 2024

For Weight Loss (Obesity/Overweight) "I am on my 3rd injection today of Wegovy. Started at 234.5 pounds. Down 8 so far. I'm not sure it's all Wegovy, as I've been able to lose 40 lbs on my own 2 separate times, and I am still doing the things that gave me that success before. Eating close to 1200 a day calories, walking 10,000 steps a day, and lowering alcohol consumption. Still, I do believe it is helping me get a good start and get my mind right. The fear of the side effects is what is probably keeping me in line. So far though, I've only had headaches and fatigue a day or so after the shots. Otherwise, no other side effects, so I am pleased so far with how things are going."

• Avi...
• Taken for 1 to 6 months
• July 16, 2024

For Weight Loss (Obesity/Overweight) "I am 58, have IBS-D, no gallbladder, GERD, and am 60 lbs overweight. This is my second attempt at taking Wegovy. The first attempt was disastrous! I didn't make it through the first week before I was hit with diarrhea, nausea, acid reflux, dizziness, cramps, and had headaches. I missed four days of work and went to ER twice. The doctor did tell me to stop taking this, but I honestly did not think it was the Wegovy (I had not done any research on side effects). Once I got back to my normal state of digestive issues, I became proactive. I started back on Wegovy (.25 lowest dose) 6 weeks ago, but now I take a dose of Pepto-Bismol daily (twice a day the day of and day after the shot) and I take an OTC daily antacid. I still get mild side effects (nausea, headache, and fatigue) the day after the shot or if I overeat. I have not lost any weight at this dose so I am going up to the .5 dose next week. As others have said - everyone will react to this med differently."

• Chu...
• Taken for 1 to 6 months
• July 30, 2022

For Weight Loss (Obesity/Overweight) "Started Wegovy February 28, 2022, at 257 pounds. July 28, 2022, at 205 pounds on the 2.4 ml dose. Side effects at low dose were headaches, stiffness, fatigue, indigestion. 2.4 dose caused extreme gas. Sometimes I stayed an extra month on a dose because of side effects, but you get used to them. Sometimes side effects come the next day or 5 days later. Completely stopped drinking alcohol because it makes me very sick while taking Wegovy."

• Jer...
• Taken for less than 1 month
• March 28, 2023

For Weight Loss (Obesity/Overweight) "I am in my fourth week of Wegovy (at .25 mg). I am a female in my early 50s, 5'8", and have struggled to lose weight and need to lose 100 lbs. So far, I have not experienced any significant side effects but have seen a little more fatigue than normal, and after injection during the day only a slightly upset stomach. I have lost 13 pounds. I work out five times a week and watch/track my diet. I find that drinking a lot of water and watching what I am eating (staying at about 1,500 to 1,800 calories) with high protein helps. Because you feel full, it is a challenge to reach calories - smaller meals throughout the day help. Also, find a support group of others on the medication to get tips and ideas. I found this to be very helpful."

• Kev...
• Taken for less than 1 month
• December 2, 2023

For Weight Loss (Obesity/Overweight) "It sure works. Even at the lower initial doses, it completely CURBS your appetite, and you are no longer hungry. It’s an interesting phenomenon. I’m going to have to plan means better and so forth. So far, side effects have been mild stomach upset and fatigue, but nothing substantially more…"

• Big...
• Taken for less than 1 month
• April 11, 2022

For Weight Loss (Obesity/Overweight) "Took my injection .25 mg Friday afternoon and had a very hard time eating dinner. By noon Saturday, I was violently ill with diarrhea, vomiting, and a fever. The symptoms subsided by Sunday, and I was left very achy and fatigued. On the upside, I guess I did go from 335 lbs to 318 lbs over the course of the weekend. This medication is not for the faint of heart. It is very depressing to see a full-course meal in front of you and only be able to eat a few bites. If you are serious about losing weight, this medication will get you there, but I wonder if it’ll work or if the side effects will at least subside with longer-term use. The nausea is horrible, but you do also have some beautiful dreams while taking it."

• Sar...
• Taken for less than 1 month
• April 10, 2022

For Weight Loss (Obesity/Overweight) "Made me terribly sick. Took only 0.25 dosage one time, had terrible diarrhea, extreme exhaustion, and some nausea. Definitely not taking the second dose. Not worth the pain. Did not lose any weight either. It stops you from eating because it makes you feel so bad if you do. I also think this drug is meant for someone who doesn’t live an active lifestyle. I work out all the time, I eat healthy, and really just wanted to drop 15 lbs. This drug was very disappointing."

• 510...
• Taken for 1 to 6 months
• April 12, 2022

For Weight Loss (Obesity/Overweight) "I'm on my third month of Wegovy. The day after my injection, I usually puke at least once and sleep 10+ hours with extreme fatigue and nausea. I started in February 2022, and now it's April 2022. I went from 247 lbs to 222 lbs. 25 pounds. I get ill if I eat sugary foods with this. I eat three small meals a day, a plant-based diet, with around 5,000 steps a day and little to no exercise outside of work. I felt good usually a couple of days after injections, and by the third week at the same dose, I had no side effects. The first two injections at a new dose aren't easy for me. I have missed work and had a hard time watching my two-year-old due to puking and fatigue. I gave 10 stars because it does as it says with side effects you are aware of to begin with."

• Eve...
• Taken for less than 1 month
• May 21, 2022

For Weight Loss (Obesity/Overweight) "I was recently put on a generic form of Ozempic for weight loss. I’m prediabetic and have tried other forms of weight loss programs that were not sustainable. It’s day 3 now, and although I feel fatigued, my appetite is substantially reduced, and I don’t have nausea anymore. The nausea is actually almost non-existent. I only get it in the morning right after I wake up, and it goes away within minutes. I’m honestly amazed by this medication, but I’m just concerned about the long-term effects of it, such as cancer."

• Kay...
• Taken for 1 to 6 months
• May 18, 2023

For Weight Loss (Obesity/Overweight) "I’ve been on Wegovy for 3 months and have gained 2 lbs. I have had side effects such as severe constipation, fatigue, and issues with my menstrual cycle. I am glad other people have had positive experiences with this drug, but it’s definitely no miracle. I decided I can make healthy changes without this medication. I stopped using it."

• doi...
• Taken for less than 1 month
• June 21, 2023

For Weight Loss (Obesity/Overweight) "I am on my 3rd week of Wegovy. So far, the only side effect I have noticed is fatigue. Seems to be worse in the morning, but it's not a big deal at all. My kids keep me awake and busy. I lost 3 pounds in the first week and nothing in the second week. I just took my 3rd dose today and hoping to lose another 3+ pounds this week."

• Big...
• Taken for 1 to 6 months
• May 23, 2023

For Weight Loss (Obesity/Overweight) "I started Wegovy (2.4 mg) 5 months ago, weighing in at 417 lbs. Today I'm down 82 lbs. Not bad for no exercise and extreme dieting! Wegovy is NOT for the weak! My first dose almost canceled me completely out of the plan! I experienced severe nausea and vomiting the first 3 days, accompanied by fatigue. I felt horrible, but I chose to stick it out after I stepped on the scale and saw amazing results! After the first month, my vomiting stopped, however, if I ate anything that didn't agree with me, it would come up. I still experience nausea, for which I take Zofran to help keep it to a minimum. The most important thing I love about Wegovy is it makes me think about what I'm going to put in my mouth and if I'm even hungry. I have to remind myself to eat a little something, but most of the time I'm not hungry at all. Most of the time, I'll make a plate and only take a few bites, wrap it up for another time. If you are serious about losing weight, Wegovy is the way to go!"

• Bre...
• Taken for 1 to 6 months
• June 14, 2023

For Weight Loss (Obesity/Overweight) "I began using Wegovy injectable semaglutide exactly 8 weeks ago today and have had very few symptoms, until the 7 1/2 week mark. At first, my nose ran continually, but that was somewhat manageable with Robitussin (recommended by the pharmacist) for the cough it caused. At dinnertime, at the 7 1/2 week mark, fatigue hit very hard. We were on a trip, and I could barely walk to get back to the hotel and fall in bed. This continued for 48 hours with no desire for food or drink, except ice water. I slept for 5 or 6 hours and awoke with a headache, which lasted the rest of the night. Strange because I do not get headaches. Thankfully, we were headed home at that point, and I slept in the car most of the day for two days. I am much improved and can function somewhat, but not back to normal yet. I am due to double my dose today, but the medication not available for a while due to high demand. Easy to use and have lost 10 lbs in 8 weeks."

• lee...
• Taken for less than 1 month
• June 15, 2023

For Weight Loss (Obesity/Overweight) "This is my second week on Wegovy. During the first week, I felt fine, but this week, I am experiencing extreme fatigue, tachycardia, headache, and craving sweets. I find myself not eating anything other than meat and no sides. I think I might be done with it. I don't like feeling like this. It's just the second week, and I can't imagine what the third week would feel like."

• Tko...
• Taken for 1 to 6 months
• May 23, 2023

For Weight Loss (Obesity/Overweight) "I started approx. 3/29 and will begin my third step up to 1 mg this week. I have lost 23 lbs in 8 weeks. Very happy about that. My appetite is reduced. I can sometimes skip dinner because, after a light lunch and breakfast, I am not hungry. I have experienced fatigue, nausea, and constipation. However, if I eat something like an apple with peanut butter, that helps with the constipation. So far, these side effects are not bad enough for me to discontinue. I would like to feel better, but I am hoping it will improve. Fatigue is the worst for me because I also have another autoimmune disease that causes extreme tiredness. I am taking a multivitamin and see my doctor in a week, and I will discuss negative side effects. Right now, the benefits of losing weight are worth it."

• Cor...
• Taken for 1 to 6 months
• June 9, 2023

For Weight Loss (Obesity/Overweight) "Last night, I had my first injection of 1 mg strength (week 3). I have gastrointestinal issues of bloating, eructation, diarrhea, and abdominal pain, LUQ 3-4/10 pain. It feels like a stomach virus, chills, but afebrile. Fatigue and anorexia. Only lost 5 lbs, but think it’s due to significantly reduced food intake."