Semaglutide and Fatigue: What Users Say (Page 2)

• Kda...
• September 20, 2019

Semaglutide for Type 2 Diabetes "This is the worst drug I have ever been prescribed. I took my first shot on Sat at 4 p.m. By 10 p.m. I had a horrible headache and acid indigestion unlike anything I have ever experienced. By Sunday morning, the fatigue was so bad I could not get out of bed. Following was total lock down of my digestive system and then uncontrollable diarrhea for 5 days. The fatigue and nausea I could not shake. I spent most of the next 5 days trying to sleep and not eating due to the nausea and overall horrible sick feeling. I am a person who works out and runs 3 miles a day and is very active. I feel like a week of my life has been sucked away from me. Today is Thursday and still feeling terrible. I can only hope it wears off soon. Think very long and hard before using this drug. Do your research and read about it, it is very concerning that this is actually approved to be injected into people."

• Anonymous
• Taken for 1 to 6 months
• June 11, 2024

Semaglutide for Type 2 Diabetes "2024 I am 75 years old and my doctor prescribed Ozempic for me. My A1C was 7.6 and climbing. I was overweight and could not keep the weight off even with exercise. My first dose was 0.5 mg, which I injected into my stomach. I was very sick after that - nausea and just feeling sick. So, I Googled the medication and found out I could inject it into my thigh, so I did that the next time - no symptoms this time. I have been on it for about 5 months now. My last A1C was 6.3, and I have lost weight. At times, I still have symptoms of nausea and constipation, but they go away. The worst one is low libido, and that's hard to fix. Also, muscle wasting - you must exercise to keep your muscles strong. Loss of energy might be due to eating less. I only eat small meals throughout the day. I hope this review was able to help."

• Lax...
• Taken for less than 1 month
• August 26, 2019

Semaglutide for Type 2 Diabetes "Update: since my last report, I have not taken another dose. I’m on day 11 of feeling sick and miserable. I have indigestion from the smallest amounts of food, steady low-grade headache, sweats, fatigue, nausea, but the worst is extreme dizziness every time I stand up. This drug may work for some, but my experience from one small dose was horrible."

• Avi...
• Taken for 1 to 6 months
• July 16, 2024

Semaglutide for Weight Loss (Obesity/Overweight) "I am 58, have IBS-D, no gallbladder, GERD, and am 60 lbs overweight. This is my second attempt at taking Wegovy. The first attempt was disastrous! I didn't make it through the first week before I was hit with diarrhea, nausea, acid reflux, dizziness, cramps, and had headaches. I missed four days of work and went to ER twice. The doctor did tell me to stop taking this, but I honestly did not think it was the Wegovy (I had not done any research on side effects). Once I got back to my normal state of digestive issues, I became proactive. I started back on Wegovy (.25 lowest dose) 6 weeks ago, but now I take a dose of Pepto-Bismol daily (twice a day the day of and day after the shot) and I take an OTC daily antacid. I still get mild side effects (nausea, headache, and fatigue) the day after the shot or if I overeat. I have not lost any weight at this dose so I am going up to the .5 dose next week. As others have said - everyone will react to this med differently."

• She...
• Taken for 2 to 5 years
• May 5, 2022

Semaglutide for Cardiovascular Risk Reduction "The medical weight loss program kicked me out because their drugs weren't helping. I lost minimal weight, and the weight I lost was trying to come back on. I had already been eating very moderately for years at this point. I would try to get in some walking, but exercise was limited due to fatigue, pain, and weight. When I went on Ozempic, I experienced a slight increase in fatigue (barely noteworthy), I experienced slight nausea (barely noteworthy), and acid reflux (I took an acid pill on shot day and kept my carbs minimal). Immediately, my feet and hands stopped hurting all the time, and the swelling I wasn't noticing went down, and I realized how swollen I had been. I lost about 20 lbs that stayed off and stable. I eat small amounts, and the reduction in pain made exercising easier, but I have stalled on weight loss. That said, my new weight seems stable. Reduce sugars and carbs, and the acid reflux stays at bay. I've been on it for about 3 years."

• Liz...
• Taken for less than 1 month
• December 16, 2019

Semaglutide for Type 2 Diabetes "On the fence. Took my first shot of Ozempic .25 last Wed at the doc's office. I was nervous as I couldn't tolerate Metformin's side effects. But she reassured me this was gonna be the answer to my prayers, so I agreed to try it. First day I was fine, then they hit. Woke up feeling dizzy, nauseous, and shaky. My fasting blood sugar was 157. Lower than it's been in quite some time. Ozempic does its job. My BS has been managed quite well. I definitely don't have an appetite. Have to make myself eat and drink. Have very low energy. Tired all the time. Aside from that, it's the other side effects I'm having trouble living with. Waking up in the wee hours of the morning clammy with severe nausea, mild headache, and dizzy. But it's only been 6 days. The constant nausea, dizziness, and headaches are almost unbearable. Not sure if I'm gonna continue. If the effects are like this now, what are they gonna be with the increased dose? There's gotta be a better way!"

• Jac...
• Taken for less than 1 month
• December 24, 2020

Semaglutide for Type 2 Diabetes "I am 70 and was diagnosed with type II diabetes about 7 years ago. I have always been on Metformin and have tried medications like Farxiga and Janumet, both of which give me bad leg pains after a while. I started Rybelsus, 3 mg, about 6 weeks ago, and after 3 weeks felt so bad I stopped taking it. The worst feeling was quite bad lower back pain and a sort of fatigue. It was a generally weird feeling of malaise, not just fatigue. So if an introductory dose of just 3 mg is any indication, a stronger dose would be terrible for me. So now I am on the max dosage of Metformin, and my last A1c was 7.6. 7 years ago it was 6.5. I would add that at most I have been about 15 lbs overweight, and there has never been any incidence of diabetes in my family."

• Jac...
• Taken for less than 1 month
• December 24, 2020

Semaglutide for Type 2 Diabetes "I am 70 and was diagnosed with type II diabetes about 7 years ago. I have always been on Metformin and have tried medications like Farxiga and Janumet, both of which give me bad leg pains after a while. I started Rybelsus, 3 mg, about 6 weeks ago, and after 3 weeks felt so bad I stopped taking it. The worst feeling was quite bad lower back pain and a sort of fatigue. It was a generally weird feeling of malaise, not just fatigue. So if an introductory dose of just 3 mg is any indication, a stronger dose would be terrible for me. So now I am on the max dosage of Metformin, and my last A1c was 7.6. 7 years ago it was 6.5. I would add that at most I have been about 15 lbs overweight, and there has never been any incidence of diabetes in my family."

• Chu...
• Taken for 1 to 6 months
• July 30, 2022

Semaglutide for Weight Loss (Obesity/Overweight) "Started Wegovy February 28, 2022, at 257 pounds. July 28, 2022, at 205 pounds on the 2.4 ml dose. Side effects at low dose were headaches, stiffness, fatigue, indigestion. 2.4 dose caused extreme gas. Sometimes I stayed an extra month on a dose because of side effects, but you get used to them. Sometimes side effects come the next day or 5 days later. Completely stopped drinking alcohol because it makes me very sick while taking Wegovy."

• kit...
• Taken for less than 1 month
• August 2, 2021

Semaglutide for Type 2 Diabetes "Rybelsus made me really sick. I didn't realize it until a couple of days ago. I thought I had a virus. I was practically leaning on the wall every day, trying to pull myself out of work to the car. Last week, I spent a lunch time lying on my office floor and then just left early. It is more than the nausea, it was fatigue, significant dehydration, confusion, dizziness, headaches... I'm still feeling sick after 2 days of not taking it. I just read that it can take a couple of weeks to get out of your system."

• Com...
• Taken for less than 1 month
• June 10, 2023

For Weight Loss (Obesity/Overweight) "Started on May 23 at a 0.125 mg dose and spent the entire Memorial Day weekend sicker than I've ever been. I didn't put two and two together until after I took my second dose on May 30. Two nights later, I woke up with my body uncontrollably shaking, and I had my hand on my phone, ready to call 911. I didn't take my third dose on June 6 and don't plan to ever again, despite my doctor telling me to take a two-week break and retry it. He says the side effects are typically more tolerable after a two-week break, but I'm not willing to chance it. Since day one, my symptoms have been extreme fatigue, making it impossible for me to function in daily life. I can't do my job and I'm hardly able to be there for my kids without pushing myself as if my life depended on it. I've been missing out on everything for over three weeks because all I can do is go from bed to couch. Additionally, I've experienced severe confusion, heaviness in my head, nausea, and vomiting, and I've lost 16 pounds."

• Odi...
• Taken for less than 1 month
• May 22, 2023

Semaglutide for Weight Loss (Obesity/Overweight) "This is my third week, and I feel absolutely horrid! I have constant dizziness, extreme fatigue, and generally feel like crap. I don't think I will continue. It's not worth it to lose maybe 20 lbs, but I can't get out of bed and function. I am tired of feeling like death warmed over. Unfortunately, because it is controlling my appetite, I'm full after a few bites. I am on a 25 mg dose."

• nau...
• December 30, 2020

Semaglutide for Type 2 Diabetes "I started Ozempic .25 mg subcut 8 days ago. I took my second dose yesterday. My first week, I ended up in the ED. I thought I had a bowel blockage or ileus. The ED visit was preceded by 6 hours of constant, sickening, odiferous belching, constant flatus, eruptive vomiting, cramping, and pain. A CT scan revealed gastric paresis. The event was precipitated by a fatty meal. I have since learned that the decreased gastric motility demands drastic changes in the volume of food intake, fat content, and most importantly, patience with what I consider to be major side effects. Now, I have no appetite. I am nauseated all the time, taking Zofran 4 mg before any meal. The belching is greatly reduced, same with flatus. I feel constipated, but that is easing off. I am avoiding high-fat foods and eating smaller portions. I am profoundly fatigued. Tomorrow, I am getting on the treadmill for 30 minutes each day to stimulate endorphin release to feel better. I have read the symptoms are reduced after 4-6 weeks."

• edw...
• Taken for 1 to 6 months
• January 28, 2025

Semaglutide for Type 2 Diabetes "Insurance is Medicare Advantage AARP United Health. The 1st 3-month supply was $130. The 2nd 3-month supply was $450. I expect the medication will not be affordable for the future. There was no advantage in the first 3 months taking the 3 mg dosage. A1C is 7.4% from 7.6%. Now taking the 7 mg dosage; waiting for my next doctor evaluation on Feb. 26, 2025. I get frequent headaches, dizziness, upset stomach, bloated feeling, and sleepy/low energy levels. No weight loss."

• Jer...
• Taken for less than 1 month
• March 28, 2023

Semaglutide for Weight Loss (Obesity/Overweight) "I am in my fourth week of Wegovy (at .25 mg). I am a female in my early 50s, 5'8", and have struggled to lose weight and need to lose 100 lbs. So far, I have not experienced any significant side effects but have seen a little more fatigue than normal, and after injection during the day only a slightly upset stomach. I have lost 13 pounds. I work out five times a week and watch/track my diet. I find that drinking a lot of water and watching what I am eating (staying at about 1,500 to 1,800 calories) with high protein helps. Because you feel full, it is a challenge to reach calories - smaller meals throughout the day help. Also, find a support group of others on the medication to get tips and ideas. I found this to be very helpful."

• Jca...
• Taken for less than 1 month
• June 25, 2019

Semaglutide for Type 2 Diabetes "Horrible, debilitating fatigue, needing naps that I’ve never needed daily! Painful intestinal pressure and gas that wakens me from sleep, that cannot be burped or passed out. No noticeable difference in my blood sugar levels (my A1C was already 5.6). A little vomiting. If this fatigue does not subside, I believe I will stop using and seek other alternatives. I hate this, I want my life back."

• Anonymous
• Taken for 1 to 6 months
• August 31, 2022

Semaglutide for Type 2 Diabetes "I did not have a good experience with Ozempic. Other than a 35 lb weight loss in 4 months, there is nothing else good I can say about it. From the first dose, I’ve had nausea and dizziness. The second dose has been a rollercoaster of constipation, stomach pain, fatigue, with continued nausea and dizziness. I’m constantly sick, I can’t eat anything more than a couple of bites of food. Nothing tastes the same, and the smell of food makes me head to the bathroom with nausea. So going out to eat is only a memory now. I do not recommend this medication. This cannot be healthy for anyone. I’ve stopped taking the Ozempic and am wondering if these side effects will end, they say it takes 5 weeks to leave your system. I’m counting the days!!"

• Rox...
• Taken for 1 to 6 months
• May 16, 2024

Semaglutide for Type 2 Diabetes "User, I followed the prescribed regimen of 3mg daily for two months, taking the pill with minimal water between 5 and 8 AM. However, I experienced persistent nausea, burping with a peculiar taste, and a sharp decline in appetite, particularly for sweets. I lost around 10-12 lbs and struggled to drink water, feeling as if my throat was constricted at times. This led to dehydration and widespread body cramps. Trying Gatorade alleviated the issue temporarily, but the discomfort persisted. Upgrading to 7mg exacerbated the symptoms, causing extreme fatigue, body aches, and lightheadedness. I stopped three pills short of completing the 30-day dose to restore my well-being. In total, I've shed 19 lbs."

• Swi...
• Taken for 1 to 6 months
• May 13, 2019

Semaglutide for Type 2 Diabetes "Started on Ozempic 5 months ago for diabetes 2. Started at 0.25, then 0.50, now at 1.00, and so far I lost weight - 35 lbs. But I’m feeling really fatigued, dizzy, and occasional stomach ache, diarrhea, and my eyesight has changed. Great drug for lowering A1C and losing weight, but the side effects are horrible. I think I’m done taking this drug. Side effects are getting worse."

• Lax...
• August 19, 2019

Semaglutide for Type 2 Diabetes "I just started this drug on Thursday. It’s now Monday, and I have lost 7 pounds, however, I feel miserable. Today it’s overwhelming dizziness, but previously it was nausea, bloating, and stomach pain. No appetite whatsoever, extreme fatigue, and insomnia! I had six stents placed in my heart arteries on July 22. I was hiking on the 20th and needed to be rescued from the trail. My blood glucose at rescue was 33. I was put on insulin in the hospital and prescribed a cardiac cocktail of six different meds, four of which caused some dizziness and light sensitivity, which had improved over four weeks to the point that I was walking an hour a day. I’ve barely left the house since Thursday. I will not take another dose of Ozempic. PS: the insulin was working well, I was down to 3 units, three times a day of Humalog (from 8 units x 3) and 9 units of Basaglar (from 25), plus 500 mg x 2 of Metformin."

• Kev...
• Taken for less than 1 month
• December 2, 2023

Semaglutide for Weight Loss (Obesity/Overweight) "It sure works. Even at the lower initial doses, it completely CURBS your appetite, and you are no longer hungry. It’s an interesting phenomenon. I’m going to have to plan means better and so forth. So far, side effects have been mild stomach upset and fatigue, but nothing substantially more…"

• Big...
• Taken for less than 1 month
• April 11, 2022

Semaglutide for Weight Loss (Obesity/Overweight) "Took my injection .25 mg Friday afternoon and had a very hard time eating dinner. By noon Saturday, I was violently ill with diarrhea, vomiting, and a fever. The symptoms subsided by Sunday, and I was left very achy and fatigued. On the upside, I guess I did go from 335 lbs to 318 lbs over the course of the weekend. This medication is not for the faint of heart. It is very depressing to see a full-course meal in front of you and only be able to eat a few bites. If you are serious about losing weight, this medication will get you there, but I wonder if it’ll work or if the side effects will at least subside with longer-term use. The nausea is horrible, but you do also have some beautiful dreams while taking it."

• Amy...
• Taken for less than 1 month
• January 15, 2023

Semaglutide for Type 2 Diabetes "Ozempic made me sick after the second week. I had to go to the emergency room for dehydration, fatigue, depression, and bloating and fluid! My doctor pretty much gave it for weight loss because I was pre-diabetes. Not to mention I gained more weight!"

• Ley...
• Taken for 1 to 6 months
• June 3, 2023

Semaglutide for Weight Loss (Obesity/Overweight) "From the initial starting dose until I went up to 1 mg, the whole 6 months was a roller coaster of nausea, headaches, and uncontrollable vomiting. The nausea was always followed by throwing up 5-7 times per day. If I ate or drank anything with too much sugar (including fresh orange juice), then I would throw it up within 30 mins. The sulfate mouth smell, along with the vomiting, was difficult and embarrassing. Exhausted and tired feeling, along with feeling depressed and hating/disgusted by food, is how I felt. I did lose about 8 kgs before moving on to Saxenda. Get ready for Ozempic to destroy your life for a few months if you want to lose weight with it."

• Chr...
• Taken for 1 to 6 months
• January 9, 2020

Semaglutide for Type 2 Diabetes "I am 70, and I have been using Ozempic for over 5 months. After having horrible nausea, things have gotten better. I have to use samples as the cost is greater than I can afford. Now, my joints are paining, reflux, and low energy. My A1c is better, and I have lost a little weight."