Rybelsus and Tiredness: What Users Say

• joa...
• Taken for 1 to 6 months
• August 15, 2020

For Type 2 Diabetes "Dr put me on Rybelsus since I had bad luck with Trulicity and feeling sick every time I took the shot. The first month of the dose 3mg, I noticed I never ate. I had a complete lack of appetite. I was exhausted, had weird dreams, and a constant feeling of anxiety, and sometimes insomnia. I put up with it. The second round with the 7 mg, the first day I was sicker than heck. I felt like I was on a cliff dangling, my anxiety turned into panic, rapid heartbeat, and I was unable to sleep. I stopped after day 4. I called the doctor but she never got back to me. I am debating trying to take 7mg every other day or go back to the 3mg and see if there is a difference now that it is almost out of my system. It is brutal to the body. The warnings say nothing about the feelings of anxiety or the insomnia."

• Mis...
• Taken for 6 months to 1 year
• August 14, 2020

For Type 2 Diabetes "Started Rybelsus when it first came out in October 2019. Took 3 mg at first and my glucose levels started to rise. Changed to 14 mg and was on that for 6 months. Glucose went very low - I was tired and weak. A1C went from 10.1 to 5.2. Changed to 7 mg and feel so much better, glucose levels are still within normal limits. I've had no side effects and great results. I do take this with 5 mg of Glipizide - once a day. Have tried many diabetic drugs and Rybelsus has worked the best. I've had a slight weight loss... under 10 lbs. So glad I tried this drug. It's a winner in my book."

• Bir...
• Taken for 1 to 6 months
• August 12, 2020

For Type 2 Diabetes "Bad news: I started taking the 3 mg Rybelsus for 30 days, did well. Have been taking the 7 mg for the past 3 weeks, and I have had diarrhea, stomach bloating, nausea, and can barely eat anything or drink. Even the smell of food makes me sick. I am extremely exhausted and hate feeling like this. Calling doctor tomorrow. Good news: dropped A1C from 8.4 to 7.3 in 6 weeks and lost 10 pounds, and also cut back on my 24 hr insulin and fast acting due to not eating. — Is it really worth it though???"

• Joe...
• Taken for less than 1 month
• June 3, 2020

For Type 2 Diabetes "1st, I did not take Rybelsus to lose weight, only trying to get A1C down. For 10 days on this, I did not vomit, but the feeling is there, sometimes I have to gag myself to get that feeling to go away. Felt tired all the time, trouble sleeping, and my stomach always feels full. I don't have much of an appetite either, and oh boy, diarrhea the first 3 days almost seems like you can't leave the house and almost like uncontrollable, need to stay near the throne. 4-5 days later, the diarrhea seems to be better, but the nausea and vomiting feelings keep me away from this med. Also, if anyone likes to try this med, I suggest getting some ginger chew candy, it does help the nausea feelings. One more thing: if you are a guy, beware of this, your libido will go down :-("

• AJa...
• July 4, 2021

For Type 2 Diabetes "I have been taking 3 mg Rybelsus since June 4th. I am not experiencing nausea nor diarrhea, however, I am experiencing constipation and loss of appetite. Since I have been taking this medication, I notice I get tired very quickly. Overall, I notice that it has helped my diabetes tremendously, and I have lost 8 lbs with very little exercise. I also take metformin 750 ER. Before starting Rybelsus, my A1C was 8.1, I do expect it to be much lower on my next visit in September."

• CRK...
• Taken for less than 1 month
• July 16, 2021

For Type 2 Diabetes "My doctor gave me a sample box of 3 mg Rybelsus for T2D. I could only tolerate it for 10 days. The first thing I noticed was my appetite was gone. As days went on, I felt like I was in my first trimester of pregnancy, although I didn’t ever feel like vomiting. Continuous nausea, lack of appetite, lethargy, and horrible constipation were my friends during the time I took the drug and for about a week afterward. I ended up in the ER with terrible IBS with very painful cramps. I thought I had a blockage from no BMs for 12 days. After being off the drug for about a week, one day I woke up and the symptoms were gone (about a week after I stopped taking it). I felt like myself again. During that short time period, the pounds just started melting off me, and I only weighed 138 going into this. I dropped down to 130. I really wanted this drug to work for me. My doctor tried to prescribe Trulicity after this. No way. It’s too similar. My A1C is 8. Not sure where to go from here."

• Ann...
• Taken for 1 to 6 months
• April 7, 2023

"I started this medication on Dec 20th, 2022, 3 mg when my doctor told me I was diabetic. I weighed 206 lbs. A1C 6.5. The first month on this, I was nauseous and felt sick. At 30 days, I told him what I felt. He said, 'I am putting you on 7 mg now. Your body will get used to it.' Here I am now, 3 months later, and I am so sick. I get nauseous still, have constipation, diarrhea, and loss of appetite, and the smell of food at times is so nasty. I am constantly feeling sick, dizziness, and I feel lightheaded, always exhausted, no energy, which scares me. My A1C is lower now, 6.1. I have pretty much stopped having sweets, carbs, or anything bad. Weight loss is out of control. My current weight is 157 lbs today when I went to the doctor. I have lost 49 lbs in 4 months. I told him I can’t take this anymore. He changed me to metformin 500 mg, let’s see how this one works. This medication hurt me more than it helped me."

• Mar...
• Taken for 1 to 6 months
• November 28, 2021

For Type 2 Diabetes "I was on Metformin and had an A1c of 8. The doctor told me to get off Metformin and gave me a sample of 3 mg Rybelsus and prescribed the 7 mg dose after 1 month. My morning blood sugars with Metformin were 111 to 88. With Rybelsus, my blood sugar in the morning has been 148 to 208! I had diarrhea with Metformin, but that went away with Rybelsus, however, my stomach has become bloated, lots of burping, slightly nauseous, no appetite, a tightness in my chest, and now that I am using the 7 mg dose, I have become exceedingly tired with zero appetite. Today my blood sugar was 177. This is unacceptable. It was way lower with Metformin. I am quitting this. I can't be this tired and feeling so ill. I used to have energy with Metformin, but Rybelsus has completely drained it. I feel the doctor had just been visited by the Big Pharma salesman and gave her the sales pitch, and she started prescribing it. Is she getting a kickback? This Rybelsus is not good and causes cancer."

• Chr...
• Taken for less than 1 month
• July 21, 2022

For Type 2 Diabetes "I went to a weight loss clinic, and I was prescribed Rybelsus 3 mg plus diet and exercise. After the first day, I noticed I'm really tired, the next day was worse. On the third day, I can barely drag myself from the bed. I only cut the bread and beer out of my diet, and I had my morning coffee and two normal meals every day. I'm stopping taking this right away. I'm fat but active, I have stuff to do. I can't walk around holding to the furniture, so I won't fall in my face."

• Tin...
• Taken for 1 to 6 months
• July 5, 2022

For Type 2 Diabetes "I have been on Rybelsus for over three months now. Initially, I saw multiple doctors with a complaint of chronic diarrhea while on Metformin. No one would consider taking me off of the Metformin. Finally, I went to a teaching facility, and they did stop it, and they put me on the Rybelsus. No problems at all with a 3 mg, and then we went to 7 mg. My taste buds suddenly changed, and I could not eat anything that was greasy or sweet, and I could not eat any meat. From the diarrhea, I lost 30 pounds. I have also been weak and tired every day. I have weird nightmares, and I am now walking and talking in my sleep. I have been on the 14 mg for two weeks now, and I was fine up until yesterday. It was as though I could feel my belly swelling up with gas, and it was very painful. Diarrhea has now turned to constipation. I used to drink three bottles of water a day, now I can’t even get down one because I can’t stand the taste of anything. I did not take my pill today because I am sick."

• SuT...
• Taken for less than 1 month
• August 4, 2021

For Type 2 Diabetes "I have been on Rybelsus for 11 days now. The first few days were horrible. I had diarrhea and stomach pains, even threw up twice. I am still having side effects on day 11 but not as bad. I’m taking Zofran for the nausea. I have already lost 8 lbs, which I’m sure is not healthy, but I don’t have an appetite on this medication. Before this medication, I would eat all the time, it seemed like I never was full. My sugar levels are as low as they’ve ever been. I am tired and have lower energy. I'm hoping after another week on it the side effects will subside. I have been struggling with weight loss my whole adult life and can never break through the plateau phase. I think this medication will help if I can withstand the side effects."

• Kik...
• Taken for less than 1 month
• October 23, 2021

For Type 2 Diabetes "I've been taking this drug at 3 mg for 3 weeks, and I am so bone-weary and exhausted I can barely move. I have severe body aches and am literally starving all the time! I will stop using it immediately."

• bcs...
• Taken for 1 to 6 months
• April 17, 2025

For Type 2 Diabetes "I tolerated the 3 mg course. I'm 12 days into the 7 mg pills, and I've had nausea, dizziness upon standing, and tired for the last four days. I'm getting ready to email my doctor for his advice."