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Progesterone User Reviews & Ratings (Page 3)

Brand names: Prometrium, Endometrin, Crinone, Cyclogest, Gestone, First Progesterone MC10 First Progesterone MC5 Milprosa

Progesterone has an average rating of 6.5 out of 10 from a total of 78 reviews on Drugs.com. 49% of reviewers reported a positive experience, while 21% reported a negative experience.

Reviews for Progesterone

Commonly mentioned side effects
  • 617...
  • September 24, 2017

For Perimenopausal Symptoms "I take progesterone 100 mg once a day and estradiol 1 mg once a day. I have bad headaches and start bleeding again when my period stopped almost 2 years ago. My hot flashes slowed down but are still there. Am I supposed to do these things? I need to know more from someone who takes those meds."

5 / 10
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16 Report
  • crs...
  • Taken for less than 1 month
  • March 13, 2023

For Endometriosis "I read all the reviews prior to taking this medication. I was quite concerned with the side effects a lot of people were experiencing. I decided to give myself a week of taking the meds and then I would re-evaluate my decision. I was placed on this medication to help with symptoms of endometriosis, adenomyosis, fibroid, and cysts, and to help reduce the inflammation in my uterus. I started taking (Errin .35) medication at dinnertime. The first three days, I did experience some pretty heavy fatigue, and on days four and five, I had some facial acne. I am now on day ten and don't have any side effects. I also weighed myself on day seven and had no weight change. My mood hasn't changed much from where I was before. I have not had a cycle yet as I am on week two. All in all, I am doing well on this medication. I will try to update you if anything changes in the future."

7 / 10
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5 Report
  • eta...
  • February 19, 2012

Progesterone for Endometrial Hyperplasia, Prophylaxis "I am taking this med without any estrogen for endometrial hyperplasia. I am in my first cycle of taking this and already started a period on day 9 of the 12 pills. I really hope this will eradicate my hyperplasia."

8 / 10
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30 Report

Frequently asked questions

  • Anonymous
  • Taken for less than 1 month
  • April 18, 2016

For Uterine Bleeding "I am 44 years old and taking AK2 generic for Prometrium for unusual uterine bleeding. The doctor put me on this to stop my irregular bleeding, but so far, after 4 days of taking it, I am still bleeding with some clots. I am supposed to take this for 12 days. He said my progesterone levels were really low, and the endometrium had built up too much in my uterus. The first time I took it, I got really dizzy and sleepy, so now I am taking it at night. I have had a bad headache on two different occasions and a fast heartbeat and definitely feel brain fog and can't think. This medicine is no fun. I had a normal cycle up until a month and a half ago, but a few months before that, I noticed a reduced cycle, so I am having low hormonal levels, I guess."

3 / 10
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15 Report
  • MDD...
  • Taken for 1 to 6 months
  • December 13, 2021

For Perimenopausal Symptoms "The neurologist wanted me to consult with a menopause expert to consider HRT. She declined. Estrogen hormone replacement therapy is contraindicated, as I have liver problems, migraines with aura (newer research busted that myth), and a family history of stroke. Nine months ago, I started having hot flashes every day around 2 PM for 3 hours. Intense long flashes, then chills, nausea, migraine attack. Brutal! Couldn’t work, couldn’t go out without a change of clothes and hair ties! New GYN started me on low-dose progesterone (Incassia). Unbelievable difference. Hot flashes are lesser, shorter, but vary in time."

8 / 10
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7 Report

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  • sav...
  • July 9, 2016

For Endometrial Hyperplasia, Prophylaxis "I take this med because I use Vivelle estrogen patch and need progesterone every 3 months to prevent uterine lining buildup. I take 200 intravaginally, every other day for 12 days - 6 doses total - every 3 months. At first dose, I was slammed with drowsiness, lower back pain, hot flashes at night, restless sleep, and weakness in legs. I had cramps, but did not get a period. By the last dose, the side effects were better, but still, it was no picnic. It's a small price to pay, however, for being able to take Vivelle dot and get estrogen, and as far as I understand, the easiest way to take progesterone as I don't want a uterine implant."

7 / 10
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12 Report
  • Amb...
  • Taken for less than 1 month
  • September 30, 2012

For Progesterone Insufficiency "I am using this in my FET cycle for IVF. I am 4 weeks, 4 days pregnant. I was taking 2 vaginal inserts (100 mg) each per day, but after blood tests came back showing a very low progesterone level, my Dr. is having me take an additional 600 mg per day in pill form (200 mg, 3x per day). My Dr. warned me that I would be very tired and possibly dizzy. I have been on the pills for 3 days now and have noticed that my breasts are very tender and swollen, which they weren't before, and it does make me a little drowsy, but not bad, it's manageable. I go back on Tuesday to check my levels."

8 / 10
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21 Report

More FAQ

  • She...
  • Taken for 1 to 6 months
  • December 12, 2016

Progesterone for Premature Labor "Mild side effects such as fatigue and hunger, horrible headaches if not taken at all. Seems to work, however, for the price paid for the medication, seems like they could include an applicator like the ones they give with gels and OTC yeast meds, etc. It's not fun or very easy trying to shove pills in your VAGAY with your fingers every single time you must use this medication."

6 / 10
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13 Report
  • Sad...
  • December 1, 2020

For Amenorrhea "Ultimate point: progesterone makes me self-harm and have suicidal tendencies. I have been on progesterone three different times. For two years as a teen, I attempted suicide three times. (Depo-Provera once monthly shot) I didn’t put the pieces together then. For three months at age 22 (Depo-Provera 3-month shot) I instantly realized that Depo was the cause and vowed to never take it again. 1.5 years from age 23-25 I was put on the progesterone-only mini pill. I didn’t realize that Depo and progesterone were the same drug. I attempted suicide for the fourth time. I’ve since been permanently surgically sterilized."

1 / 10
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18 Report
  • Bab...
  • Taken for less than 1 month
  • January 27, 2017

For Progesterone Insufficiency "I was prescribed progesterone in early pregnancy due to insufficiency. I switched pharmacies and this p-2 progesterone pill was a new brand that I was switched to. Two hours after taking the first pill (vaginally, as directed), I had spotting. This spotting continued for three days while I was on this pill. One day I didn't take it until the late afternoon and all morning had no bleeding. Then, two hours after taking the pill, I started bleeding again. I was far enough along in my pregnancy that when I brought this up to my doctor, he said that I could safely stop taking it. Ever since I stopped taking this pill, the bleeding had since stopped too! I would not recommend this brand of progesterone."

1 / 10
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  • qaf...
  • Taken for less than 1 month
  • June 12, 2022

For Female Infertility "Repeat miscarriages in the first trimester. Given 200 mg of progesterone to take after ovulation until the period to support pregnancy. Took it for one cycle and became suicidal, depressed, and now am not experiencing a period. I used to have irregular periods and then had regular periods for almost 3 years, during which I've had multiple losses. Now am back to being irregular after this progesterone treatment. I stopped taking it because of the suicidal ideations."

2 / 10
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3 Report
  • Min...
  • June 13, 2020

For Amenorrhea "I’ve been taking this progesterone pill for nine days orally. The first few days were fine, just had a bit of nausea. Then around my 5th night, when I took it at night, about an hour and a half later, I had dizziness and felt like I was in another world. It feels like laughing gas. I also am noticing bloating and, on the next day, headaches. It also makes me have mood swings once the dizziness has left my body. It makes me very tired, and I sleep great. I’ve had these symptoms since then. No sign of bleeding since then and I am not sure if it will work for me. But it says if you have these symptoms, you will get results, so I’m hopeful."

5 / 10
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  • Kan...
  • March 18, 2020

For Gender Dysphoria "My gender clinic doctor recommended that I take a progesterone-only based birth control pill to stop my period before and while I start testosterone. I’ve been on it for about a week, and I’ve had spontaneous bleeding even though I started the pill at the very end of my cycle. I’m also getting really tired during the day and having a hard time staying asleep at night."

7 / 10
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  • Anonymous
  • June 8, 2011

For Premature Labor "After each injection, I would be exhausted the next day. I would have severe depression, which seemed to get worse with each injection. I'm only 25 weeks and have to continue taking it until I'm 34 weeks. We'll see if it helps me go full term."

5 / 10
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  • Anonymous
  • May 17, 2011

For Premature Labor "I'm taking this medication to prevent premature delivery. With every injection, I have gotten a debilitating migraine, not to mention soul-crushing depression. With no other options, I have to stay on the medication until I reach 32 weeks."

3 / 10
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6 Report
  • Loi...
  • Taken for less than 1 month
  • November 10, 2020

For Perimenopausal Symptoms "This medicine smells strongly chemical and made me bleed for weeks. I had to switch to Dr. Reddy's brand. Would not recommend. 200 mg I had to pay $100 out of my own money because my insurance had already paid for this one. But I really didn't like it so much, I paid for the Dr. Reddy’s."

1 / 10
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  • Mar...
  • Taken for less than 1 month
  • May 1, 2024

For Uterine Bleeding "Progesterone 5mg 2x per day... After 0.35 mg for 90 days did not stop my menses, and may have even caused a 90-day bleed, I stopped it. However, I was then put on this 5 mg two times a day and within three or four days the bleeding stopped. It did its job! So for that, I give it a 10. Unfortunately, after a few days, I had body aches like I was getting the flu, I hurt from head to toe. It took me a few days to figure it out over the weekend while no doctor was in the office, but the cause of my body aches, fatigue, and actual jitteriness was this medication. Due to needing my menses completely stopped for proper OBGYN testing, I still have to take this medication, it makes me feel awful! So for the feeling of yuckiness, for lack of a better word, I give it a 2. Overall, a 6 since it did the job I needed."

6 / 10
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  • San...
  • Taken for 1 to 2 years
  • April 21, 2025

Progesterone for Perimenopausal Symptoms "The effect of Prometrium for perimenopausal symptoms alongside application of Estrogel is as intended. I am a shift worker who had to get clarification from a second doctor as to when to take on a 24/7 rotating roster. My biggest problem is swallowing the capsule, I have never had problems swallowing anything, but the capsule more often than not is hard to swallow and seems to make its way back up my esophagus, causing discomfort. I now have to take it well before bedtime and drink up to 2 liters of water to avoid the feeling of this well into the night. After Googling this problem, I have found many posts describing the same problem."

7 / 10
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  • Sat...
  • Taken for 1 to 6 months
  • April 22, 2024

Progesterone for Progesterone Insufficiency "I am postmenopausal and take this product at night to help my symptoms and for sleep. For the first time in years, I've been getting 6 hours of continuous sleep and now feel nearly normal. Love it!"

9 / 10
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12 Report
  • Anonymous
  • March 10, 2011

Progesterone for Uterine Bleeding "It saved my baby. I was showing signs of miscarrying because of my hormone levels. I took this for 12 weeks. The bleeding stopped the next day, and I now have a healthy little girl!"

10 / 10
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56 Report
  • joj...
  • Taken for 1 to 6 months
  • April 7, 2023

Progesterone "Two months into taking this med, I have found it's making me feel ill. Dizziness, shortness of breath, lethargy. I've had test after test. Then realized this all happened after starting this med."

1 / 10
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11 Report
  • Anonymous
  • December 31, 2008

Progesterone for Progesterone Insufficiency "I experienced a few mild side effects - mainly mild nausea and irritability. Well worth the improvement in my overall health."

8 / 10
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52 Report
  • Fem...
  • Taken for less than 1 month
  • October 2, 2020

Progesterone for Perimenopausal Symptoms "I developed severe tinnitus, and after 1 week, couldn't take generic progesterone for Prometrium anymore."

1 / 10
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18 Report
  • Anonymous
  • Taken for less than 1 month
  • August 24, 2015

Progesterone for Progesterone Insufficiency "After a few days of use, I had such horrible itching, it prevented me from sleeping. The itching took about a week after discontinued use to subside."

4 / 10
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21 Report
  • Nic...
  • Taken for 1 to 6 months
  • November 8, 2018

Progesterone for Progesterone Insufficiency "I used it for IVF/frozen embryo transfer. I’m due with our baby any day now, it was super easy and convenient to use. I’d much rather do this than an intramuscular shot into the butt every day."

10 / 10
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16 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.