Premarin User Reviews & Ratings

• Hap...
• Taken for less than 1 month
• May 27, 2019

For Postmenopausal Symptoms "At 50 years old and being perimenopausal, I started feeling crazy. I was very angry, bitter, and agitated every day. I was never this way before. My periods were longer than usual. I went to a doctor who found a fibroid. I started on Premarin 0.625, which saved my life. Before starting on Premarin, I was thinking about not wanting to live anymore - so sad. After 1 month on Premarin, I am back to myself! Very happy and loving life."

• Sta...
• October 30, 2020

For Postmenopausal Symptoms "Premarin is a miracle for me. I'd been menopausal for 11 years, the last 2-3 of which I'd been suffering deep major clinical depression. The pandemic made it worse. My last menstrual period was more than 10 months ago. Still depressed, summer came, and the hot flashes started! And a bunch of difficult personal things happened that I really had to deal with and be present for, and finally I just had nothing left. I had no reserve, I had no buffer. I got to the point where a broken pencil might send me to bed for the whole day. I hardly ate. I was living on a knife's edge emotionally. I nearly cracked. I couldn't handle it anymore. Premarin saved my life! After just a week on the starter dose of 0.3mg, I felt like a new person, my old self. It is a miracle. It's been about a month and I'm still feeling great on that low dose; we're just going to stick with it for now. I am hoping it will bring my ability to orgasm back. That just went away one day, a few months ago... poof! Bummer."

• dev...
• Taken for 1 to 2 years
• January 14, 2015

For Postmenopausal Symptoms "Hormone Replacement Therapy (HRT) - I took Prempro for two years after becoming menopausal at age 40. When it stopped working a year ago, I was changed to a daily combination of Premarin 1.25 and medroxyprogesterone 2.5. Without HRT, I experience irritability and irrational rage, hot flashes, and a non-existent sex drive. The current HRT, which includes Premarin, works very well for me. It is frustrating how difficult it is for a woman in her 40s to be taken seriously by the medical community for complaints of low libido. (Consider Viagra, etc., for men.) Every year, my doctors suggest I give up this medication therapy that increases my quality of life by 100%. I'm 43, and so far, I'm winning, but I expect that I will have to keep fighting."

• Luc...
• Taken for less than 1 month
• June 22, 2016

For Postmenopausal Symptoms "I was in the DEEPEST pit of depression. I felt that it was hormonal. Had labs drawn and was shown to be in menopause. Had a hysterectomy which left me with one ovary. The depression started this year in March and spiraled out of control. I was seriously deciding whether or not to stick around not because I didn't want to live, but the mental pain was too much. I noticed in a study of women that were treated successfully for severe hormonal depression using Premarin and mirtazapine. Within 24 hours, the depression was GONE GONE GONE! I believe it is mostly the Premarin because ADs take longer than that to work. I want to start a campaign for the horses that are being treated too poorly. Why can't we get this from pg. humans and pay them?"

• Din...
• Taken for less than 1 month
• February 8, 2020

For Postmenopausal Symptoms "I was given Premarin for hot flashes and vaginal irritation from vaginal dryness. It helped with my sex drive. I still have vaginal irritation and dryness from time to time. Now I'm wondering if I have a yeast infection because I have some burning. I've only been on it for one month. I suffer from depression and all this has caused me to lose weight, about 40 lbs. My night sweats have improved but during the day they are bad. I don't know what is going on with this vaginal irritation. It's the worst. I'm 47. I'm irritated and moody and get annoyed quickly. My poor husband doesn't know what to do. I've changed my soap and detergents. I'm scared. My mind is all over and I forget things. That's not me at all. Any advice."

• Anonymous
• September 27, 2011

For Osteoporosis "Have been on hormones for 25 years. Mom died at 59, Dad at 55. I am 79, still play active tennis = weight training- golf and do not have the usual aches and pains. If you do not have any serious illness get on the hormones."

• ove...
• October 13, 2017

For Postmenopausal Symptoms "So I just started this yesterday and wonder, I am feeling a little bit worked up (sexually charged). Has anyone else experienced this? My main concern was dryness. I had a hysterectomy 11 years ago and was taking Estradiol. I didn't really feel anything different, I would still get the hot flashes mostly during the day. But BOY oh BOY, today definitely increased libido! Just looking to see if this is normal?"

• Dre...
• Taken for 10 years or more
• September 9, 2016

For Postmenopausal Symptoms "I took Premarin daily since 1975, with no problems, and felt great, young at heart, and full of energy. Last year, the insurance company decided they would not pay for it anymore and suggested Estradiol. I don't feel the same. No energy, hair thinning, and bloated all the time. Next doctor's appointment, I'm going back on Premarin even though it'll cost me a pretty penny."

• Wes...
• Taken for 1 to 6 months
• August 29, 2020

For Atrophic Vaginitis "Premarin is a complete game changer. I had a 10 cm mass on my ovary and uterine hyperplasia. I thought things couldn't get any worse with pain and discomfort. This resulted in a full hysterectomy and oophorectomy. Then, it went from bad to worse. Atrophy. Sex was so painful I gave up. Even urination was a challenge some days. This went on for a year. Then I started using Premarin. Within a week, things started to improve. I hesitated to use Premarin because of some bad advice from the internet. Premarin is a complete game changer. I wish I would have tried it sooner. I have my sex life back and feel like my old self. Incredible!"

• Anonymous
• July 5, 2011

For Postmenopausal Symptoms "I had surgery in 1995 and the other half in 2004. I have been taking Premarin since then. I am now going through a divorce. Because of depression, I stopped taking my medicines. NEVER AGAIN. The past two months have been hell without my Premarin. Not sleeping because of night sweats, hot flashes all day and just feeling like I have no energy. I have started back for 6 days now and can already feel the difference. I will never stop taking Premarin again."

• Boz...
• May 6, 2010

For Postmenopausal Symptoms "I had a hysterectomy in 1998. I had a horrible 2 years prior with night sweats, mood swings (huge swings), irritability. Then after my hysterectomy, I started taking Premarin 1.25. I have been on it ever since. For me, it is a lifetime therapy that, quite honestly, I cannot be without. I forgot to take them once for 2 weeks. I went into such a rage and cried until I realized I had forgotten to get it filled. NEVER AGAIN. In my 50s, my hot flashes no longer exist, my mood is even most of the time, and I enjoy the physical side of a relationship more than I did when I was younger."

• Anonymous
• August 12, 2019

For Postmenopausal Symptoms "Wake up America!!! This drug comes from the urine of pregnant mares hooked up to a catheter their entire life!!!! The horses have to have foals and what happens to them? Choose a synthetic form. Educate yourself. "

• lem...
• January 24, 2015

For Postmenopausal Symptoms "I had a hysterectomy 9 years ago and have been suffering with hot flashes, tired, no energy, and lots of other symptoms. Went to my doctor, and he did not want to give me any HRT, but I could not cope anymore with some of the hot flashes, tiredness, no energy, and numerous other symptoms. So decided to go back to my doctor and ask again for something to help me. This time he has prescribed me Premarin. It's early days yet, but already my hot flashes are starting to subside. Seems to be starting to help. Great to at last get a tablet to help. I am very pleased with the Premarin and no side effects."

• Mag...
• July 7, 2013

For Hypoestrogenism "I had a hysterectomy in 1980 and have been on Premarin 1.25 mg for 33 years and have no problems at all. I love my Premarin. I hope I can keep getting Premarin because there have been times doctors give you a hard time and I need to keep taking it. I have terrible withdrawals. So I need it. I get awful headaches and pain."

• SOS...
• Taken for 10 years or more
• December 18, 2022

For Postmenopausal Symptoms "Very few doctors will prescribe HRT. It’s obvious they’re afraid of liability, so attorneys now run healthcare. The UK just permitted HRT to be purchased OTC because menopausal women went on a campaign there. I’m running very low on my Premarin and can find NO doctor in two states who will prescribe it. I’m now cutting my pills in half. I have been on HRT for over ten years and feel and look great. I’m a woodworker who just put in a porch ceiling by myself. I’m 63. I run 5K’s regularly. I will be darned if I let an attorney or the frightened medical community leave me to shrivel up in my estrogen-depleted years by depriving me of my HRT. I’ll start a campaign here like in the UK. All these women who wrote glowing 10 out of 10 reviews are endangered that they will soon be unable to get their HRT. This is an outrage by the medical community. It’s my body and I want my HRT."

• Bor...
• Taken for less than 1 month
• September 25, 2018

For Postmenopausal Symptoms "Doc prescribed it, but asked her to switch to Estrace and have good results. Y'all do realize that Premarine is a shortened version of Pregnant Mare Urine which is what it's made from? They take large (most commonly Belgium Draft Horses) and confine them in small stalls for their 11-month gestation with their tails tied up and catheters on to harvest their urine. Female foals are cycled back into the program. Males are useless so sold off to auction houses, some are lucky to get purchased by rescues, others are sold to end up as horsemeat in other countries. The mares are bred again once they've foaled to continue the cycle. Ironic that a drug developed to help post productive human females is derived from horrific treatment of female horses during their productive years. It is an awful life. Please find an alternative."

• ann...
• August 24, 2016

For Postmenopausal Symptoms "I have taken Premarin in the 1.25 strength for over 40 years. It has not stopped the hot flashes and night sweats, but it reduces them by at least 50%. I do not have osteoporosis (my mother and all of my aunts did) and my bone density is better than most women half my age, a lot of which I attribute to the Premarin. I have never taken Prempro or any progestin product, just the Premarin alone. I tried the half strength and was miserable with all-day hot flashes, so overheated that I looked like I had a sunburn with heat rash and nasty skin breakouts. I changed doctors and now back to the 1.25 strength. My only complaint is that a product like this, which has been on the market for over 50 years, I do not understand why there is no generic as it is very expensive."

• TIR...
• Taken for 10 years or more
• July 30, 2020

For Postmenopausal Symptoms "21 years old, had two babies, endometriosis, was told I won't have anymore babies. Uterus was tilted and prolapsed. Didn't use birth control, due to ob-gyn saying it would be a miracle to get pregnant. Got pregnant two more times, had a hysterectomy with the last baby. I was put on many different hormones, and none seemed to help my extreme moods, dry skin, and wrinkles. Finally, I was told to try Premarin. It is very expensive, and insurance doesn't cover it, but it was like a dream come true. I became at peace, happy, and my skin became soft, wrinkles disappeared, and my sex life wasn't dormant anymore. I've got so many friends now using it, due to me telling them about my 'happy pill', Premarin!"

• kul...
• Taken for 1 to 6 months
• November 19, 2014

For Atrophic Vaginitis "I went on the medicine at age 65 due to extreme dryness and constant yeast infections. The fantastic side effect is now I fall asleep within one hour of going to bed. For six years, ever since menopause, I have had trouble falling asleep (averaging only 4 hours of rest). The only change in my life was the Premarin pill. It helped the dryness and now I can function with 8 hours of sleep!"

• cur...
• September 19, 2009

For Postmenopausal Symptoms "I had a hysterectomy in 1998 and was on Premarin 0.0625 for many years. Then the doctor decided not good to prescribe anymore. I was so very miserable! If I have to live like that, I don't want to. It was terrible. No doctor knows your body like you do! And just for the record, one of my sisters is 73 years old and still has terrible hot flashes! Sometimes it looks as if she just stepped out of the shower! My mother was the same way! I am not willing to live like that! There are pros and cons to everything!"

• sou...
• October 14, 2010

For Hypoestrogenism "I have taken 0.9 Premarin (natural estrogen) for 23 years (after my uterus was removed at 34 and symptoms developed), and I am just fine (unless I don't take it). Any attempt to use any oral artificial estrogen made me very sick, and the patches left red welts that lasted for months. So I have stayed with oral Premarin, and although I don't appreciate the way horses are treated in order to produce it, I am very grateful that it stops the severe sweating, hot flashes, shakiness, and weakness that comes if I miss it for a day or two. It did not prevent osteoporosis. I do look 15 years younger than I should - a possible good side effect. 23 years and no problems."

• Mag...
• Taken for 1 to 6 months
• May 24, 2017

For Postmenopausal Symptoms "I am 57 years old. My sister-in-law mentioned that she took Premarin for 5 years with no side effects. I was intrigued; I had never heard of this medication. I went to my doctor and asked for Premarin; she prescribed me 0.3 mg. Wow, amazing results! No side effects. I just finished my 30-day supply, went back to my doctor, and asked for a little higher dosage because I was still having hot flashes and vaginal dryness, so she prescribed another 30 days at 0.45. Of course, my doctor does not recommend this medication because of all the possible side effects, especially heart attack. I told her to let me try and see how I feel. Now I will have one more month at 0.45 mg; I will see what the results are. I will keep everyone posted."

• blo...
• Taken for 5 to 10 years
• February 21, 2014

For Postmenopausal Symptoms "Complete Hysterectomy: I was on Premarin started about 6 weeks after hysterectomy because I couldn't handle the restless leg syndrome and having to move all the time. I was put on 0.625 mg, was on it from 2007 until 8 months ago. 5 weeks after doc took me off, my whole body and life went to double hockey sticks!! Anxiety, Severe! OCD crazy uncontrollable, and panic disorder through the roof. I am on Celexa 20mg daily and 1.75 mg broken into 6 doses. It works, but I don't understand why it just doesn't work the same. I never had such bad OCD, anxiety, or panic like this while on it and I want it back! I am gonna go get mammo, if it comes back clean, I'm going back on Premarin! Will my life go back to normal? Will I feel like me again, and want to enjoy life? I have two appointments."

• hap...
• August 28, 2011

For Oophorectomy "Had oophorectomy 8 years ago. On the second week, I started to have terrible hot flashes, couldn't sleep anymore. The doctor started me on all you can name before trying Premarin. Since taking Premarin, I got my life back. Several times, the doctor tried to decrease the dose and wean it off completely. I went into deep depression, crying all the time, and back to the nightmare again. Thanks to Premarin, I feel like a normal human being again. As a floor nurse on a cardiac floor, I have talked to several ladies in their seventies still taking Premarin daily. My actual dose for years has been 0.65 mg daily."

• Fbu...
• March 12, 2018

For Primary Ovarian Failure "Had a hysterectomy at age 35 with ovaries left intact. Night sweats appeared gradually, and by age 53 were intolerable. I was awake most of the night and kept my husband up as well. Was prescribed Premarin at the lowest dose. I experienced relief after 2 days. I can’t believe how much better I feel. Now, 2 weeks in, my brain fog is gone, and I am so happy. I didn’t realize how depressed I was. No side effects at all. Just look forward to peaceful sleep at night."