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Progesterone and Insomnia: What Users Say

Brand names: Prometrium, Endometrin, Crinone, Cyclogest, Gestone, First Progesterone MC10 First Progesterone MC5 Milprosa

Insomnia: mentioned by 6 users (7.7%)

Based on user experiences from 78 Progesterone reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

tiredness 17.9%
dizziness 14.1%
headaches 11.5%
sore breasts 11.5%
drowsiness 10.3%
vivid dreams 10.3%
depression 7.7%
insomnia 7.7%
weight gain 7.7%
brain fog 6.4%

Reviews for Progesterone

Commonly mentioned side effects
  • Lor...
  • April 22, 2012

For Perimenopausal Symptoms "I am soon to be 49 and I was feeling so bad, hot flashes, 30 pounds of weight gain in 2 years, insomnia, foggy brain and a very large appetite, to name a few. But I saw a doctor (alternative) and he did blood work and found my testosterone was so low and my progesterone. So I now take a small dose of testosterone cream and 200 mg of natural progesterone. Can I tell you I feel like I did in my 30s. Use progesterone at night, testosterone in the morning. I have lost 12 pounds in about 40 days and it continues to fall off. Sleeping like a baby, no hot flashes and I think more clearly and my memory is awesome too. I do take a lot of supplements that work with the hormones."

10 / 10
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200 Report
  • skr...
  • March 4, 2009

Progesterone for Progesterone Insufficiency "I'm 48, and found that this nicely balanced the issues I'm having with estrogen dominance. I've had no side effects that I can tell, but a real clearing up of the fuzzy brain, night sweats, and trouble sleeping. I love it!"

9 / 10
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197 Report
  • PLa...
  • Taken for 5 to 10 years
  • November 27, 2020

For Progesterone Insufficiency "I have a progesterone insufficiency, and one of its main symptoms is insomnia. Prometrium is too expensive in the US, and the doc switched me to the Bionpharma generic. Unfortunately, this is not natural progesterone but rather a progestin. After struggling with insomnia for weeks, I had to order actual progesterone from a compounding pharmacy. Now I am finally back to sleeping 8 hrs per night. My understanding is that US companies no longer use natural progesterone in their generics, so compounding pharmacies are the only viable alternative."

10 / 10
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28 Report

Frequently asked questions

  • Mau...
  • April 26, 2016

For Progesterone Insufficiency "The first two years on 100 mg were okay, with a very rough 3-month adjustment period of feeling emotionally and physically completely wacked out. After two years, I started feeling menopausal symptoms of brain fog again, so I started taking 200 mg. This is my second month, emotional roller coaster, angry outbursts, racing heartbeat, no sleep! I am giving it another month to see if things will get to normal like before. Maybe I have to go through this every several years, part of getting older."

6 / 10
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25 Report
  • Sno...
  • Taken for less than 1 month
  • June 10, 2012

For Progesterone Insufficiency "All day dizziness and general blah feeling. Sleep majorly disrupted, and when I get it, it doesn't do anything to help with the tiredness I already have. Nails grew weak and thin. Also had some numbness in places, which went away when I stopped the pill."

2 / 10
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33 Report
  • sav...
  • July 9, 2016

For Endometrial Hyperplasia, Prophylaxis "I take this med because I use Vivelle estrogen patch and need progesterone every 3 months to prevent uterine lining buildup. I take 200 intravaginally, every other day for 12 days - 6 doses total - every 3 months. At first dose, I was slammed with drowsiness, lower back pain, hot flashes at night, restless sleep, and weakness in legs. I had cramps, but did not get a period. By the last dose, the side effects were better, but still, it was no picnic. It's a small price to pay, however, for being able to take Vivelle dot and get estrogen, and as far as I understand, the easiest way to take progesterone as I don't want a uterine implant."

7 / 10
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12 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.