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Orlistat and Liver Damage: What Users Say

Brand names: Xenical, Alli

Liver damage: mentioned by 4 users (1.0%)

Based on user experiences from 400 Orlistat reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

diarrhea 11.0%
gas 5.0%
upset stomach 5.0%
constipation 3.3%
bloating 1.8%
oily skin 1.5%
cramps 1.3%
headaches 1.3%
liver damage 1.0%
bowel movements 0.8%

Reviews for Orlistat

  • Mor...
  • Taken for less than 1 month
  • August 6, 2015

Orlistat for Weight Loss (Obesity/Overweight) "Recently purchased Alli tablets from the chemist. After two weeks, my liver and kidneys started hurting so much that I had to stop taking them. I emailed GlaxoSmithKline, who said that they were aware that possible liver failure may result, as they originally removed them back in 2012. And they wanted me to sign a consent form (basically wanting me to keep on taking them as their guinea pig) for their research."

3 / 10
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33 Report
  • Tro...
  • October 17, 2017

For Weight Loss (Obesity/Overweight) "I had massive leakage by cheating and eating a butterfly cake -- DO NOT DO THIS!! I thought I was farting, but I sharted instead and had to go home and change my trousers as a ton of orange fluid soaked through! I also had white-colored stools, which can indicate liver damage, which is one of the side effects."

4 / 10
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9 Report
  • Cha...
  • Taken for less than 1 month
  • May 16, 2016

For Weight Loss (Obesity/Overweight) "Just on the obesity cusp by less than 2 lbs, was prescribed Orlistat. I got a terrible stomach ache within a week, kept passing out, and couldn't eat. My liver levels were tested, they came in at 138. Liver disease occurs at 110 for a non-drinker, not good. I could not eat at all for a week, the medication I had obviously abruptly discontinued. Eventually, I started to improve. In total, I lost 7 lbs. Unsure as to whether it was Orlistat, starvation, or illness through Orlistat. I thought I was going to die, but I have restarted the medication in the hope to lose weight. Worth the risk? Only if the obesity is going to result in your death. Weigh up your health issues due to obesity against liver damage to make an informed decision."

2 / 10
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7 Report

Frequently asked questions

  • Sal...
  • March 1, 2017

For Nonalcoholic Steatohepatitis "I don't recommend this medicine for anyone. I stopped taking Alli (which is over-the-counter orlistat) after experiencing pain in my upper abdomen. This medication causes liver damage! I wish someone would have told me. I have seen specialists after specialists to determine what is wrong with me. You shouldn't take it! Also, I was diagnosed with H. pylori. This bacteria, in rare cases, causes stomach."

1 / 10
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13 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.