Zofran ODT and Nausea: What Users Say

• Pic...
• Taken for 1 to 2 years
• April 20, 2021

For Nausea/Vomiting "This medication makes me more nauseous than before taking it. After 3 surgeries and multiple nausea-filled days due to a chronic health condition, I've concluded that this drug makes things worse for me. I kept hoping it was all in my head, but other anti-nausea meds (and even peppermint) work almost immediately, at least to a certain extent. Whereas this always makes me 10x worse to the point of vomiting. It also gives me really bad headaches, and I don't ever get headaches in general. It's the only medication that gives me this side effect. So I think this either works very well for people or makes it worse. I'm wondering if it has to do with brain chemistry since it's a serotonin blocker? I'm severely ADHD with mild OCD and depression. Perhaps certain brain wiring just doesn't benefit. I'd love more research to be done on this since it's the standard anti-nausea treatment given in hospitals."

• Anonymous
• Taken for less than 1 month
• April 20, 2013

For Nausea/Vomiting "I've been taking ondansetron ODT 8mg tablets for about 2 days due to nausea caused by a kidney infection. When I take the tablet, it doesn't help and makes me more nauseous than I was before. I just took it half an hour ago to be sure, and I immediately became more nauseous. So I'm pretty sure it just doesn't work for me, and I'm wondering if anyone else has this problem?"

• Wil...
• September 23, 2013

For Nausea/Vomiting "I suffer from chronic lower back pain due to scoliosis and arthritis (42 yrs old). I also suffer from irritable bowel syndrome. I take Zofran almost daily to deal with the miseries of both lower back pain and digestive issues. I still have regular bouts of vomiting, however, Zofran will stop the pain and nausea that would continue for days and land me in the hospital with an IV delivering morphine into my system to stop the cycle of vomiting, nausea, and severe pain. I love my Zofran! It makes life 'livable.'"

• Cat...
• Taken for less than 1 month
• February 22, 2021

For Nausea/Vomiting "Horrible drug for me. Actually makes me nauseous and throws up. Nothing tastes right on this medication. One dose had me throwing up and nauseous, not able to eat for a couple of days. One dose had me constipated for about 5 days before I was back to normal (with taking stool softeners Rx after surgery). May work for some, but for me, it’s a NO go."

• Anonymous
• April 7, 2008

For Nausea/Vomiting "My mother was down to 78 lbs due to nausea. Phenergan had been the only drug her Dr. would prescribe. This continued for 3 months until someone told me about Zofran. I asked if we could please try it, it was amazing. I'm positive, if we hadn't asked about this drug, she would be dead from starvation due to nausea."

• cat...
• October 1, 2010

For Nausea/Vomiting "I was given this in the ER when I went in with nausea/vomiting problems. I've taken a couple of the 4 mg tabs since I've been home, and they work great. The problem is that I only was prescribed 5 tabs, and I'm having trouble getting more. I suffer from anxiety and am feeling nauseous on a daily basis. I also think this is pre-menopausal nausea since I've suffered from gastric problems in the past. Hoping to get more. Don't want to have to take it, but I sure want it available to me."

• Mrs...
• January 11, 2013

For Nausea/Vomiting "I have severe nausea and vomiting due to an extreme case of endometriosis. I have to be hospitalized because of pain, weakness, and dehydration because of severe vomiting. I can't even hold down a tiny sip of water for 2 minutes. I have tried every medication possible, and Zofran ODT is the only thing that gives me relief! It is a prescription I always have on hand at all times."

• EGS...
• January 8, 2009

For Nausea/Vomiting "The medicine saved my second pregnancy (with twins). It enabled me to eat normally most of the time, although I did have a bit of nausea. There was no adverse effect on my twins, both are healthy 18 months later. Great drug."

• sil...
• Taken for 1 to 6 months
• September 18, 2012

For Nausea/Vomiting "I am pregnant and have been suffering from severe nausea and vomiting. I have been taking Zofran for about 25 weeks. The dissolving tablet doesn't have an effect on me. I can't keep it down, even after half an hour, I will throw up the medication. The rare times I can hold it down, it has no effect on me."

• Mis...
• Taken for less than 1 month
• September 20, 2015

For Nausea/Vomiting "Had a kidney stone and was given a Zofran prescription to take home for nausea - it only made it worse. Every time I took it, I found myself more nauseous after only 1/2 hour. I chose to stop and had my doctor switch me to a different drug. I think some people's systems are more sensitive to it than others, especially if they are taking pain medications with the Zofran."

• Sad...
• Taken for 1 to 6 months
• April 20, 2016

For Nausea/Vomiting "I feel like I've been sick for a very long time. It began around early February. I started feeling tired and nauseous. I had other symptoms, but the nausea was the worst. It just got worse and more frequent. My mother talked me into going in, and I was diagnosed with 'migraine with aura' about a month ago. I don't feel like migraines have anything to do with the nausea, but that's all I have to go on for now. The nausea comes in waves, and I've had to stop doing schoolwork because of it. I was hoping the Zofran would help, but it doesn't seem to do anything. I still wake up at night because I'm so nauseous, and it never seems to end."

• Oak...
• August 2, 2017

For Nausea/Vomiting "I take Zofran ODT to relieve the severe medication withdrawal symptoms I experience when I accidentally miss a dose of my prescribed daily medication. Severe medication withdrawal symptoms such as brain zaps, nausea, vomiting, headaches, and dizziness."

• Ren...
• Taken for 10 years or more
• March 9, 2022

For Nausea/Vomiting "I have been taking Ondansetron, 4 mg ODT for years to treat severe nausea after I eat too many carbs during a meal. When I feel the nausea starting, I put 2 tablets under my tongue followed by a Chewy Tum and a Prilosec ODT. I was given Promethazine before Zofran was available to me, which worked fantastic because it puts you to sleep, and you sleep through the nausea episode, which is not practical when you are working. Zofran saved me by allowing me to recover from nausea episodes, taking 30 minutes out of my day versus half or an entire day off work. Great drug!!!"

• Dmp...
• April 11, 2017

For Nausea/Vomiting "This stuff works like a dream and quickly! I take over 20 meds a month, and sometimes I just get flat-out nauseated from my 'cocktail from hell.' I have also had it administered in an IV, and it can't be beat. The only downfall is the cost...the last I heard, it is $20 per pill, and Medicaid balks at paying for it."

• Tls...
• Taken for 6 months to 1 year
• April 6, 2018

For Nausea/Vomiting "I get debilitating migraines that cause vomiting, and I have several GI issues. My doctor ordered Zofran pills to begin with, and they did nothing for me. Although I still feel a little nauseous at times, I can stop the vomiting with the Zofran ODT by putting it under my tongue."

• Lit...
• Taken for less than 1 month
• December 12, 2016

For Nausea/Vomiting "I was rxed the ODT for extreme nausea and vomiting, due to a norovirus. The minty flavor really drove me over the edge and only made matters worse. Then my doc gave me the regular tablets that you swallow with a tiny bit of water, but it didn't help at all either. I remember being awed by the knowledge that they give this med to sick cancer patients when it is so horribly ineffective. Evidently, it does work like gangbusters for some people, but I'm not one of them."

• JUS...
• Taken for less than 1 month
• September 11, 2022

For Nausea/Vomiting "I've been traveling and taking Zofran. In the past, if I took Zofran once, it seemed to be okay. But after taking multiple doses these last few days of travel, I've been having nausea, vomiting, diarrhea, muscle spasms, and numbness/tingling in my limbs. When I would feel a little off, I would take Zofran, not realizing that it was making things worse for me! I also looked up any possible drug interactions, and it appears that it has a major negative interaction with Zoloft (which I take!). It's ruined the first part of my trip, and I'm praying that I can start feeling better so I can enjoy the trip that I have dreamed about for decades now!"

• Sto...
• Taken for less than 1 month
• January 8, 2022

For Nausea/Vomiting "Took for a few days after getting food poisoning, which turned into a stomach virus. It worked for an hour or two, but the nausea came back worse. No vomiting, surprisingly, but didn’t really help my nausea."

• Dis...
• Taken for less than 1 month
• November 22, 2021

For Nausea/Vomiting "I took ondansetron swallow pill at 4 mg, and it was starting to help. My physician increased the dose to 8 mg, but it was now a mouth-dissolving format and made my nausea far worse. Pharmacy says they can distribute 8 mg in the swallow pill form, but the doctor has to prescribe it in that format."

• Ery...
• August 19, 2014

For Nausea/Vomiting "Only thing that works! I have MSK and vertigo, and BOTH cause nausea with flare-ups, and this is my lifesaver!"

• Goo...
• July 10, 2016

For Nausea/Vomiting "Had kidney stones. Took pain meds for it. Got super nauseous at night. Took Zofran, and within 10 minutes I was not nauseated at all. Amazing medicine."

• poo...
• September 1, 2012

For Nausea/Vomiting "After surgery, long-term nausea due to pain medicines."

• Win...
• July 29, 2019

For Nausea/Vomiting "I have nausea and vomiting from the flu, and this medication either did nothing or made me more nauseous."

• Mad...
• March 12, 2023

For Nausea/Vomiting "I took this for a bad stomach bug, and it actually made me feel worse. I wish it had worked for me, but I got extremely nauseous to the point of vomiting. I’ll stick with Phenergan."