Zofran ODT and Headaches: What Users Say

• Pic...
• Taken for 1 to 2 years
• April 20, 2021

For Nausea/Vomiting "This medication makes me more nauseous than before taking it. After 3 surgeries and multiple nausea-filled days due to a chronic health condition, I've concluded that this drug makes things worse for me. I kept hoping it was all in my head, but other anti-nausea meds (and even peppermint) work almost immediately, at least to a certain extent. Whereas this always makes me 10x worse to the point of vomiting. It also gives me really bad headaches, and I don't ever get headaches in general. It's the only medication that gives me this side effect. So I think this either works very well for people or makes it worse. I'm wondering if it has to do with brain chemistry since it's a serotonin blocker? I'm severely ADHD with mild OCD and depression. Perhaps certain brain wiring just doesn't benefit. I'd love more research to be done on this since it's the standard anti-nausea treatment given in hospitals."

• Uni...
• Taken for less than 1 month
• February 3, 2016

For Nausea/Vomiting "Today I went to the doctor for some common flu symptoms. They prescribed me Zofran for my nausea and upset stomach. About 10-15 minutes after taking it, there was a tremendous relief of everything. It works rapidly and does wonders. I have not experienced any side effects like headaches or nothing yet, so everything's good so far."

• car...
• February 2, 2008

For Nausea/Vomiting "My doctor prescribed this to me for pregnancy-induced nausea and vomiting. All of my pregnancies were horrible with nausea and vomiting. Well, this time I'm about seven weeks pregnant, and I have been taking the generic brand ondansetron orally dissolving tablets, they are small with a minty flavor. It melts quickly, and I must say I have not vomited one time this pregnancy. I have had mild tiredness, headache, dizziness, and much better than nausea and vomiting and being unable to eat."

• Anonymous
• Taken for less than 1 month
• August 20, 2012

For Nausea/Vomiting "Whole family in the hospital for stomach virus with severe nausea and vomiting every half hour. This medicine completely stops the nausea within minutes! It definitely gives you headaches and makes you sleepy, but this is a small price to pay to stop the nausea when you are in that situation."

• Cin...
• June 11, 2021

For Nausea/Vomiting "I've been using Zofran for a couple of years after it was given to me in the hospital for nausea following surgery. It has always worked beautifully in combating those days when I or a friend have felt nauseated. But the last time I took one, in February, during the night when awakened by stomach pain and nausea, it actually made things worse by adding an immediate headache and extreme heart palpitations that lasted a good half hour, without helping my initial nausea at all. I've been afraid to use it ever since. Turns out I was experiencing a gallbladder attack, and I'm not certain that wasn't the reason the Zofran failed. Today, I'm having one of those icky nauseated days, two doses of Emetrol have not helped, so I took a Zofran and cut it in half, yes, they are already small, but I was nervous. I'm happy to report it seems to have worked. Nausea is nearly gone now. No headache, no increased heart rate. I'm hoping Zofran is once more my friend."

• Anonymous
• November 4, 2009

For Nausea/Vomiting, Postoperative "Best anti-nausea medication available. Very effective for those undergoing chemotherapy. Also good for conditions when you are nauseous and require a narcotic analgesic - nausea will still subside. If you are allergic to other nausea medications such as Compazine and/or Reglan, like I am (severe panic attacks), Zofran is your safest bet (only side effect I have occasionally noticed is a slight headache). The only real downfall is the price of the orally disintegrating tablet because there is no generic. The non-ODT tablet does have a generic and is also very effective, but if you need relief FAST, ODT is the best way to go."

• Oak...
• August 2, 2017

For Nausea/Vomiting "I take Zofran ODT to relieve the severe medication withdrawal symptoms I experience when I accidentally miss a dose of my prescribed daily medication. Severe medication withdrawal symptoms such as brain zaps, nausea, vomiting, headaches, and dizziness."

• lwa...
• Taken for 5 to 10 years
• March 8, 2019

For Nausea/Vomiting, Chemotherapy Induced "The brand Zofran worked perfectly. Generics (Mylan, Rising, Glenmark) began coming out 2 years later. These made me sicker and caused headaches. Zofran contains 0.03 mg of aspartame. Generics have 0.51 mg. Naturally, insurance won't cover Zofran. I'm just glad I got it when I first started chemo when I was sickest."

• Anonymous
• April 20, 2012

For Nausea/Vomiting "I am/was taking this medicine to combat nausea from post-chemo treatments, and I found that it did give me a headache, and I could not stand the taste it left in my mouth when the medicine disintegrated on my tongue."

• Anonymous
• Taken for 6 months to 1 year
• November 30, 2021

For Nausea/Vomiting "Zofran is a miracle drug for me. I always have some on hand. I suffer from GERD, IBS, gastritis, malabsorption, endometriosis, and the list goes on. Nausea is a nagging symptom that I have often, and I vomit on a regular basis. Zofran has kept me out of the ER on many occasions due to severe vomiting. It also gets me through the occasional rounds of antibiotics as they really mess with my stomach. It does cause some pretty bad headaches when taken on a regular basis, but I will take a headache over vomiting any day. Could not recommend enough! It has been a total lifesaver!"

• vit...
• Taken for 1 to 2 years
• November 8, 2024

"I had hyperemesis gravidarum during my pregnancy, and Zofran was the only medication that allowed me to feel 'okay.' I was prescribed 8 mg ODT every 6 hours. This medication truly kept me and my child alive during that time. I also have had it prescribed for kidney infections and kidney stones. Side effects include severe constipation, and it can cause headaches. Benefits include not vomiting all over the place."

• Bre...
• Taken for less than 1 month
• April 23, 2022

For Nausea/Vomiting, Postoperative "I was prescribed this drug a few weeks back when I had an upper respiratory infection. The coughing fits got so bad they would make me throw up, and I had post-nasal drip, and the mucus made me feel sick to my stomach constantly. My Dr. gave me this to try because I couldn't really eat anything, and it works like a charm. 30 minutes after taking the ODT, I'm able to eat with no issues. I still have some left over from my URI, and I keep it on hand just in case. It's wonderful to have. I didn't have any side effects besides a slight headache, but it was completely worth it to finally be able to stomach some food and not have to get up 4 or 5 times a night feeling like I had to throw up."

• Cha...
• August 18, 2016

For Nausea/Vomiting "This medicine did nothing except constipated me and give me a headache!"

• Anonymous
• July 12, 2010

For Nausea/Vomiting "Medicine serves its purpose, but gives me severe headaches. Like 'hangover' headaches in the morning or shortly after I take them (1 hour or so)."