Mirtazapine for Major Depressive Disorder User Reviews (Page 4)

• sha...
• Taken for 1 to 6 months
• March 30, 2015

"My life was about to end a few years back due to OCD. I wished to die a couple of times. I had lost all hopes of recovery, but this medicine came into my life as a miracle. I took it for 5 months and have now gotten rid of it. I have stopped taking it more than a year ago, and I am a completely healthy person now and enjoying a wonderful life. It does not have any special side effects except weight gain or dizziness."

• Zap...
• Taken for less than 1 month
• August 11, 2020

"Started this med, mirtazapine, zonked me out. The following day, I was hyper, very irritable and angry. Made me feel groggy and heavy-headed all day and the next. I tried to persevere, but once I guess I had got enough in my system, the terrifyingly real nightmares began. I can barely believe the mind is capable of creating such intensely vivid experiences with little to no separation from reality. It kind of felt as though one moment you were thinking logically, and the next you were still in the same place as you were in reality, i.e., in bed asleep, but it was as though I had awoken from sleeping and then was lost in my own bedroom in this awful, terrifying nightmare. I could not risk going back to sleep for a long time, I was so scared of being transported back to hell. Sounds crazy, and I would not have believed it had I not experienced it. Never again. But I think it would have been effective but for that, and increased pain. It may be okay for you."

• Sen...
• Taken for 1 to 6 months
• August 20, 2024

"The combination of 30 mg Mirt and 10 mg Trintellix saved my life. I attempted suicide while on Sertraline (had helped me in past MDD), and doctors and psychiatrists at the hospital changed my medication to the above combo. It really has worked wonders. I don't feel suicidal, I no longer dread getting out of bed wishing I didn't wake up, no more blackness, and I feel like I have now got control of my life again. It's 5 weeks into the combo, and while I am not fully recovered, this combination has really helped me think positively about the future again, and I can focus on my family and getting back to my old self."

• Emi...
• Taken for less than 1 month
• July 13, 2023

Mirtazapine "After an injury that left me with chronic sciatica, I was so depressed and anxious that I had episodes of crying uncontrollably and panic attacks that lasted hours. I kept having insomnia, and I had no appetite even when I was hungry. I was having intense bouts of suicidal ideation multiple times per week. Between being on this drug at 7.5 mg every night for just over a week and starting an intensive outpatient program, I'm sleeping 8 hours every night, down to only minimal suicidal thoughts. While I'm still grieving for my old life, I'm no longer crying uncontrollably for hours at a time or overwhelmed by tiny things. It's like the difference between 3-foot waves and 6-foot waves. Without my pain level changing, this has made my life feel doable. And I actually feel like eating again. The only side effect has been minor morning sleepiness. I do advise making sure you have healthy food around when starting this drug if you tend to gain weight."

• hos...
• July 15, 2021

"I am a 30-year-old female with no chronic health conditions. I started taking Remeron when I was hospitalized in May of 2021 due to increased frequency of panic attacks, suicidal ideation, and no appetite, I could no longer work. I tried several medications since 2010 - sertraline, paroxetine, duloxetine, citalopram, combined with lorazepam, diazepam, or clonazepam - bad side effects, and depressive symptoms returned. I eventually tried lamotrigine, which gave me a rash and swelling of lymph nodes. I tried lurasidone, which seemed to help but was too expensive to continue without health insurance. After 5 days in the hospital and taking Remeron, I felt stabilized in a way I didn't think was possible. I am now able to cope with day-to-day stressors, sleep well, have the energy to do things I used to avoid, haven't gained weight, and have no issues with sex drive at all. I have had none of the terrible side effects I had with SSRIs, anti-psychotics, or benzodiazepines. This drug truly changed my life, I feel like a different person."

• kat...
• Taken for 1 to 6 months
• April 17, 2019

"I have been on mirtazapine for approximately 4 weeks. In those 4 weeks, I have been able to sleep through the night for the first time in months. I've been able to eat healthy amounts. I've gained 7 pounds, which makes me no longer underweight, and have just had generally more upward moods. Although mirtazapine hasn't worked for my anxiety, after about 7+ medications, mirtazapine is the first one to significantly help me sleep through the night and be able to get up in the morning and have a routine. I can't believe how this antidepressant makes me feel. If you are afraid of the weight gain, try it anyway. The only negative things that have to do with this drug for me are that I get sweaty at night and have had a few nightmares, however, they are very tolerable as I've never been actually scared of my nightmares. Please try this medication, it may change your life as I've barely been on it a month, and it's changed mine."

• Anonymous
• Taken for 6 months to 1 year
• January 17, 2020

"Amazing drug, really helped with my depression and insomnia. Takes a good 4 to 6 weeks to fully kick in and start working. The first two weeks I had terrible headaches and stomach pains, but they lifted eventually. The only major side effect I've suffered from it is that I've put on 3 stone in six months while taking this medication. Even though it's the best drug I've ever taken for my major depressive disorder, I'm going to have to come off it as I can't afford to put on any more weight."

• Aar...
• March 20, 2015

"What can I say? I've suffered from major depression all my life, well, since I was 18. I had been on numerous medications, nothing seemed to work. Then my doctor said to try these, mirtazapine. The low levels didn't work. I'm on 45 mg and have been for 9 years. They help you sleep, give you a great appetite at night, basically, they stop you from thinking you're going off your rocker. I still get highs and lows throughout the day. I still think I'm bipolar with the mood swings, example: Jekyll/Hyde. They really do help in so many ways, but the withdrawals can be bad. I get severe stomach cramps, feel nauseous. Also, it feels like you're losing your mind, and your anxiety levels can go up."

• Sea...
• Taken for 1 to 6 months
• May 25, 2018

Mirtazapine "I took this because I was severely suicidal and depressed due to seasonal MDD. I started it because my mother was worried, and I thought if I went on medication, it would let her relax a little. It helped me sleep and completely erased my suicidal thoughts and urges. I got a restful full night’s sleep every night. At the start, the downsides were an inability to focus, feeling extremely tired during the day, and having my suicidal thoughts and urges increase drastically. These only lasted like a few days, then everything was okay again. The only side effect that didn’t go away was weight gain, but I’d rather be heavier and alive than skinny and dead. I only went off of it because my depression is seasonal, so I don’t need it at this time of year, but I will definitely start again in the fall."

• Bri...
• Taken for 1 to 6 months
• September 8, 2020

"I have been a small woman all my life. I exercise 6 days a week and eat very healthy. Mirtazapine made me gain 10 pounds in the first 3 weeks of using it. It also makes me very irritable. I’m going to discontinue use."

• bab...
• Taken for 1 to 2 years
• April 17, 2026

"Mirtazapine has not helped whatsoever with depression symptoms, but it's one of the few things that has consistently helped me with sleep. And poor sleep can amplify depression, so I have continued to take it for that reason alone. I would not recommend it as a first option for depression. Also, I am on the 7.5 mg dosage; 15 mg has been tested on me more than once, and the higher dose strangely makes my sleep terrible, so I have to stay on the lowest dosage."

• not...
• March 23, 2019

"I was given this med to deal with depression, insomnia, and anxiety. The first night I took 7.5 mg, and yes, I slept, and slept, too much. Was told to bump up to 15 mg, and the first day and night I felt good. Now a month later, I am more depressed than ever before, shaking, feel like I have the flu, and can't sleep more than 2 hours. Worst part is the horrendous heart palpitations, my heart literally skips beats now. I won't even talk about the 7 pounds of weight gain in a month. I wish it had worked as it seems to help some people."

• Jay...
• Taken for 6 months to 1 year
• October 23, 2021

"I've been on a bunch of antidepressants - sertraline, fluoxetine, fluoxetine + mirtazapine, venlafaxine + mirtazapine - but about 5 months ago, I changed to just mirtazapine and increased the dose to 45 mg, and it has been amazing! I didn't really believe that any antidepressants would actually work until I went on mirtazapine. I've been hospitalized about a dozen times for psych reasons in the last two years + a couple of suicide attempts, but I haven't even been to the emergency department since I've been on mirtazapine 45 mg. I hear a lot of people talking about weight gain on it, but I've actually lost a fair bit of weight on it because I actually want to get out of bed and go do things. I'd previously been on quetiapine, and that made me hungry & caused weight gain, but I haven't had that at all on mirtazapine. Love it so much, don't plan to ever stop taking it."

• Ell...
• Taken for less than 1 month
• January 21, 2016

"Have been prescribed 15 mg Mirtazapine with Lamotrigine for severe bipolar depression/unipolar disorder GAD. Just to say if you're taking this medication with another as I am, unwanted side effects may be greater. Restlessness in legs and arms, cold sweats, vivid nightmares/night terrors, no appetite, no mental stimulation/dullness. These unwanted side effects should weaken over time since this medication is still pretty new in my system. I wish lots of luck to those who are really trying to treat their depression (if you've mentally been to hell and back). You're not alone, look at all these reviews!"

• Wil...
• Taken for 6 months to 1 year
• November 3, 2023

"Second time around on mirtazapine after taking myself off it. Have to say, it works well for me. After trying sertraline (godawful and never again), I was put on mirtazapine after being told it's likely I don't get along with SSRIs. Quality of sleep has improved, depression is 100x easier to deal with. PTSD symptoms have eased (though not disappeared - and they won't by just taking medication). But overall I'm very happy starting this drug again. I will say the increased appetite and cravings for sugar can get overwhelming at times, so please try and be kind to yourself and regulate food within reason. As someone with an ED, it's difficult at times to cope with. If you struggle with sertraline or citalopram, try mirtazapine, my GP told me it works completely differently from the above, and if, like me, you don't get along with the above, mirtazapine will hopefully be the best alternative. Everything works differently for everyone, however, so take this with a pinch of salt!"

• Hol...
• Taken for less than 1 month
• March 5, 2016

Mirtazapine "So far, I'm very happy as my nausea, vomiting, stomach cramps, and anxiety have subsided. Not much relief from depression yet on day 5, but I understand it takes time. It does make my tongue numb for a bit after I take it, and I've had vivid dreams every night on it."

• Mic...
• September 3, 2017

Mirtazapine "After years of being on depression medication and mood stabilizers, my body stopped responding to my typical medications. My doctor called me in Remeron to try out. I took this drug for 2 days and had to stop due to extreme anger and dark thoughts that are not typically me. My other half also went on this drug for a very short time because of the same issues. This medication is horrible."

• Anonymous
• Taken for less than 1 month
• October 29, 2021

Mirtazapine "Just wanted to give an update on Remeron 15 mg taken nightly. I'm a diabetic type 2 and spoke to a few doctors regarding its safety and efficacy with diabetes. Although most SSRIs somehow interfere with diabetes, I took the plunge and decided to still try it again because it worked so well. Could not have made a better decision. I sleep much better, though using 75 mg Seroquel and Stilnox MR as well. I've had a bit of brain fog in the morning, but it subsides at about 10 in the morning, and then I'm great to go."

• lou...
• Taken for 1 to 6 months
• January 12, 2016

"This medication is brilliant. After trying various other antidepressants for depression over the last few years with no success and worsening of symptoms, I was giving up hope of ever getting better. Sleep has improved, appetite has increased, but after the first month, the sugar cravings have subsided. I have put on about 5 lbs, but it's a small price to pay to finally reach the light at the end of the tunnel! I am genuinely happy for the first time in a long, long time. There were some side effects at first, which subsided after a few weeks: fuzzy head, sleeping too much, massive appetite, dry mouth; all of which have subsided. Started on a 15 mg dose and now on 30 mg, as the lower dose made me drowsy through the day."

• Ano...
• Taken for less than 1 month
• July 6, 2025

"Saved my mom's life. She was on a deep depressive episode, took this one drug, and in 14 days she was back to being herself again!! Really a miracle drug. She got some side effects like upset stomach and very high appetite (which was good considering she lost weight due to her depression)."

• Ano...
• Taken for 1 to 6 months
• June 29, 2025

"Saved my life, effectively reduced depression and anxiety. Went from not moving, being in bed all day not doing anything to actively moving around and doing what needed to. Reduced social anxiety that I had to where I could power through it. Improved sleep, went from doing all-nighters to getting to sleep much earlier. 15mg helped partially, then was upped to 30mg which improved my mental state a lot. Intake is one pill at night every night."

• Emm...
• June 3, 2016

"Seemed to help the depression, but the tiredness left me unable to function. I was on this for a year and was unemployed for most of it, this meant it didn't matter that I found it impossible to wake up before lunchtime. No matter how early I took the pill (6 pm), I would be sound asleep 20 minutes later and could easily sleep 15-16 hours on these. I recently got a job and could not wake up enough to function at work. I had to stop taking them, and now I can easily wake at 7 am and last the entire day at work. I would consider these more of a sedative than an antidepressant."

• Bec...
• July 31, 2017

"I had been on quite a few SSRIs, and nothing helped my major depression and panic disorder. This was a last resort medication for me and ended up working like a dream. I was eased onto the meds slowly, which helped my doctor determine the correct dosage once I got used to it. I have experienced weight gain, but the weight gain does not increase with the dosage. Also, I've had some acne flare-ups. I take the medicine at night so the drowsiness doesn't ruin my day. The side effects are a small price to pay for the exchange of a happy life again! If you have had trouble with Prozac, Zoloft, etc., please ask your doctor to try this medication next! I wish I had found this years earlier!"

• JS8...
• Taken for less than 1 month
• July 19, 2019

"I was prescribed mirtazapine by my VA physician and took it yesterday evening for the first time. I slept for about 12 hours and woke up feeling awful. I felt lethargic and not myself. I was very irritable and felt like I was occupying someone else's body. I know it sounds strange, but that's the best I can describe it. The worst part was waking up at 1 a.m. after a terrifying dream that demons were attacking me. I seldom have dreams like that, but it scared the poop out of me. I also heard my phone alert me that I had an email from a co-worker, but when I woke back up, there was no email whatsoever. Am I losing my mind?"

• fat...
• October 18, 2016

"Nine months ago, I was prescribed this in combination with venlafaxine to treat major depressive disorder, anxiety, and complex PTSD. Initially, I did not notice any side effects, but about three months in, I suddenly gained so much weight that none of my clothes fit. It seemed to almost happen overnight, and whilst I was struggling with the fact that I had nothing to wear, I started to get hot flushes, pee my pants without realizing, and sweat like a sauna at random moments, especially in my groin area. Lovely. Add to that - memory loss, freaky (exhausting) dreams, fingernails that split if you look at them, and trembling hands... what do you get? A fat, sweaty, smelly, trembly lump who is now too depressed and anxious to even go out the front door. I quit."