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Mirtazapine for Major Depressive Disorder User Reviews (Page 3)

Brand names: Remeron, Remeron SolTab

Mirtazapine has an average rating of 7.1 out of 10 from a total of 175 reviews for the treatment of Major Depressive Disorder. 58% of reviewers reported a positive experience, while 19% reported a negative experience.

Reviews for Mirtazapine

  • Mary
  • Taken for 1 to 6 months
  • January 7, 2022

Remeron (mirtazapine) "I was in another deep dark place. Have been on lexapro for years because I struggle w MDD. It seems the lex doesn’t help much like it used to. When I go downhill, my stomach is affected. I lose my appetite and can barely eat. I get these gnawing hunger pains, and eat to get rid of them, but then shortly after I’m hungry again but nothing sounds good or tastes good. I’m afraid of trying new meds. It’s so hard. So many don’t help and you have to be on them for quite awhile to know if they work. I’ve tried several in the past and they gave me chest pressure/pain. Unusual, but it happens. Didn’t want to try remeron but I was desperate. God heard my many prayers and many who were praying for me! Started feeling better and eating normal within a week! Crazy dreams and shaky for awhile, but that got better. Also, am gaining weight back that I lost."

9 / 10
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  • Taina
  • Taken for 1 to 2 years
  • October 15, 2020

Remeron (mirtazapine) "I have suffered from major depression for the past 20 years which caused severe insomnia Remeron has been a lifesaver . I have been able to sleep , but it causes weight gain . My doctor decreased it from 45 mg to 30 mg . There is no major difference between the dosage . I will be following a diet suggested by my dietician to lose 7 pounds gained from the meds"

9 / 10
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30 Report
  • John...
  • Taken for 1 to 6 months
  • January 24, 2015

"I've had major depression mostly everyday for the last 2 years and this medication is a lifesaver. After being on mostly every SSRI and on several different dosages I never got complete relief from them. They helped to give me a slightly better mood on most days but the depression was always there. After doing a lot of research I told my psych I wanted to try mirtazapine. After roughly two and a half weeks on 30 mg (15mg didn't help) I've never felt better. It also took away most of the night sweats that I was getting from SSRIs. I've read some people complaining about weight gain as a side effect, I would advise to not worry about weight gain if you actually have major depression, once the depression lifts you will be able to eat healthy."

10 / 10
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59 Report

Frequently asked questions

  • Magnu...
  • December 30, 2015

"Normally antidepressants work on me within a few days to a week if they are going to work at all. Not so with mirtazapine! It took about 4 weeks to work and when it did, it improved my depression and anxiety symptoms more than any other antidepression/antianxiety drug I have ever taken (Lexapro, Wellbutrin, Cymbalta, Effexor, Klonopin). I am glad I didn't give up on it after a short time, for I never would have discovered how well it worked for me!"

10 / 10
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  • Alive
  • December 16, 2020

"I wanted to share my experience because I have been an avid review reader and often only negative experiences are shared. I tried Zoloft, Prozac, Wellbutrin and lamictal and the side effects from all of these were too much for me. Remron helps me sleep and gives me a feeling of general wellness and an ability to cope. It takes away that crushing depression that tells you you aren’t good enough and doesn’t allow you to get out of bed. The big story on this drug is about the weight and I want to share with you that I may be a pound or two heavier with this drug than without it, but this drug actually helps me eat less. I used to feel hungry all the time and wake up at night from hunger but now I can sleep through. Take the lowest dose you can if you are worried about this side effect and know that not all people gain weight on this drug."

9 / 10
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Are you taking this medicine?

  • Mama...
  • Taken for less than 1 month
  • May 22, 2016

"I have fallen in love with this med! My cyclic depression was at an all time high, suicidal ideation, hopelessness, severe anxiety and paranoia, insomnia, and ready to literally give up on life. I started on 15 mg for the first 2 days. It knocked me out and I slept very well. Bad side effect was being super groggy all day long and a little foggy. Not a big change in depression until the third or fourth day. I upped the dosage to 30 mg on the third day, and after a week I am feeling so much better! It doesn't completely knock me out right away like the first night but just makes me a little tired. I wake up ready to face the day and happy. The dreams are a little crazy but they're kind of just like fun adventures. I recommend this drug!"

9 / 10
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  • Emily
  • Taken for less than 1 month
  • July 13, 2023

Remeron (mirtazapine) "After an injury that left me with chronic sciatica, I was so depressed and anxious that I had episodes of crying uncontrollably and panic attacks that lasted hours. I kept having insomnia, and I had no appetite even when I was hungry. I was having intense bouts of suicidal ideation multiple times per week. Between being on this drug at 7.5 mg every night for just over a week and starting an intensive outpatient program, I'm sleeping 8 hours every night, down to only minimal suicidal thoughts. While I'm still grieving for my old life, I'm no longer crying uncontrollably for hours at a time or overwhelmed by tiny things. It's like the difference between 3-foot waves and 6-foot waves. Without my pain level changing, this has made my life feel doable. And I actually feel like eating again. The only side effect has been minor morning sleepiness. I do advise making sure you have healthy food around when starting this drug if you tend to gain weight."

9 / 10
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  • Remil...
  • Taken for 6 months to 1 year
  • November 25, 2017

Remeron (mirtazapine) "I have had several bouts of depression in the last 30 years. SSRIs don't work for me. Tried them all. Remeron was a lifesaver. Started at 15 mgs and now up to 45 mgs. Didn't sleep well before this med. It cured my depression, anxiety, and insomnia. Only con, is weight gain which I'm working on with walking and eating a healthy diet. My husband said he rather see me chubby and happy and I totally agree. I'm so glad my doctor out me on this tricyclic antidepressant."

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  • Kiwic...
  • Taken for 10 years or more
  • December 14, 2019

"I have struggled with depression all my life and mirtzapine is the one of the few medications that seems to level me out and make life a little bit more bearable. I started on 15mg probably about ten years ago and quickly went to 30mg which made a big difference. If you suffer from severe depression like me I truly believe the dosage is crucial. Eventually increased to 45mg recently but after being on 30mg for several years the extra 15mg seemed to reignite my urge to eat everything in sight which I don’t like as you just end up over eating. But overall once you get used to the dosage you have been prescribed you can generally control the food cravings but if you increase the dosage the cravings will increase. Still I would rate this drug much higher that other meds as doesn’t interfere with your libido like the others!"

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  • Brit2...
  • Taken for 1 to 6 months
  • September 8, 2020

"I have been a small women all my life. I exercise 6 days a week and eat very healthy. Mirtazapine made me gain 10 pounds in the first 3 weeks of using it. It also makes me very irritable. I’m going to discontinue use."

9 / 10
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  • Pinak...
  • Taken for 1 to 2 years
  • June 11, 2021

"When Escitalopram 20+10=30mg failed to cope MDD after 9 years then also failed trazodone, desvenlafaxine..but Mirtazapine 15mg saved me. It's a life saver for me..now I'm taking escitalopram 20+10mg with Mirtazapine 15mg and Lithium carbonate 400 mg. Suicidal thoughts are gone.Love you remeron. In treatment resistant depression Mirtazapine showed wonder. Please don’t stop your drug after showing negative reviews. Remember all antidepressants are different. I didn't have any weight gain, make sure you have a healthy diet."

10 / 10
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  • Willu...
  • Taken for 6 months to 1 year
  • November 3, 2023

"Second time around on mirtazapine after taking myself off it. Have to say, it works well for me. After trying sertraline (godawful and never again), I was put on mirtazapine after being told it's likely I don't get along with SSRIs. Quality of sleep has improved, depression is 100x easier to deal with. PTSD symptoms have eased (though not disappeared - and they won't by just taking medication). But overall I'm very happy starting this drug again. I will say the increased appetite and cravings for sugar can get overwhelming at times, so please try and be kind to yourself and regulate food within reason. As someone with an ED, it's difficult at times to cope with. If you struggle with sertraline or citalopram, try mirtazapine; my GP told me it works completely differently from the above, and if, like me, you don't get along with the above, mirtazapine will hopefully be the best alternative. Everything works differently for everyone, however, so take this with a pinch of salt!"

9 / 10
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  • James...
  • Taken for 2 to 5 years
  • September 12, 2015

"Found this to be the best medicine for depression, I was treated with lots of different medications before I was put on 15mg of martazapine. Now I'm on 45mg due to the level of depression I have. I would recommend this to anyone with severe depression."

9 / 10
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48 Report
  • MrLak...
  • Taken for 2 to 5 years
  • September 7, 2019

"Works well for depression and helps me sleep. Also makes food utterly delicious! So be careful out there. Been taking 30mg for about three years. Good luck. Hope this medicine works for you. Always have the attitude that this drug will help me, when you start on something new."

9 / 10
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30 Report
  • Mano
  • Taken for 1 to 6 months
  • October 19, 2020

Remeron SolTab (mirtazapine) "I have MDD and my anxiety used to be really bad. The first week I took remeron, I was knocked out on the first night and really groggy in the morning and I remember being really hungry. I used to have a problem with my appetite and I could never finish my food. I was at least 42kg. But now I can finish my food, my appetite is really good and I get enough sleep! Dreams are kinda weird tho. I read some bad reviews but my experience has been great and I’m on my 13th week and the dosage is 30mg. Just give it a few more weeks and everything starts to get okay and moods will start regulating like normal. If anyone else is taking this, do know that your appetite will increase so get more exercise and watch what you eat!"

7 / 10
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  • Anonymous
  • Taken for less than 1 month
  • December 24, 2021

Remeron (mirtazapine) "Wow. I have always refused taking medication after a bad experience years ago with citalopram. This time around I spiralled after a bad breakup and had brief psychotic disorder. I hardly left my bed. Couldn't eat. Couldn't sleep. My doctor prescribed me this medication and it has worked wonders. Slept a full night and 3 days in I was eating again. I'm on day 9 now and I am already experience positives to my mood. I have hardly had any side effects which is also a bonus! Everyone is different but for me this medication saved my life."

10 / 10
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  • Choue...
  • Taken for 6 months to 1 year
  • May 22, 2016

Remeron (mirtazapine) "I slept like the dead when I took this which was great cuz I had horrible PPD and hadn't slept in weeks. But I gained 60 lbs in two months. I would retain so much water I felt like I was going to explode. Plus, anorgasmia so I discontinued it after 9 months. Horrible withdrawal."

6 / 10
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  • Gloria
  • Taken for less than 1 month
  • May 4, 2023

Remeron (mirtazapine) "I am battling severe insomnia and I took this because it helps with sleep according to some people but for me, it did not work at all. Insomnia persists and I feel like a zombie. Not a good medicine for me."

1 / 10
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  • Ringo
  • Taken for 1 to 2 years
  • August 20, 2020

"I take Viibryd for morning sadness. One side effect if that is insomnia. But it works so well. So I take mirtazapine to help me sleep. It works great. And, yes, some of the visuals occurred while adapting. However, I have an issue where one manufacturer's pills allow me to wake refreshed. Another manufacturer's has me waking feeling all creepy. Kaiser just sends me what they have in stock. I know there shouldn't be a difference. But there is."

10 / 10
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  • Anonymous
  • Taken for 1 to 2 years
  • October 10, 2015

"Been on it for 1.5 years now. 45 mg at bedtime. Before taking it I couldn't sleep, massive mood swings bad anxiety. Had trouble being in crowds or around people. Since taking been good able to deal with whatever comes up in life. I sleep 8 hrs a night. Takes a bit to wake up but once awake I'm good all day. Down side don't miss more than two days of it or I don't sleep and everything goes into hyper drive. I function very well on it and it keeps me a lot more stable"

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  • Rockel
  • Taken for 1 to 6 months
  • July 9, 2018

Remeron (mirtazapine) "I've been on Remeron and Abilify for a month now and I can say it is true to what the doctor says it is. I paid 8 a piece for them both, at my insurance's expense. When I first started , the first two days were horrible. I was drained and hungry as heck, but my body adapted quick. I lost 25 lbs before taking remeron and so far my weight has increased by 5 to 6lbs. I have nightmares almost every night and mood swings when I don't eat.. but thats just the downside. Overall the medicine helps me sleep, eat and feel better. I just have to get my rump back into the act of working out to avoid weight. Stay positive lovebugs <3"

8 / 10
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  • Zaphod
  • Taken for less than 1 month
  • August 11, 2020

"Started this med mirtazapine zonked me out . The following day I was like hyper very irritable and angry. Made me feel groggy and heavy headed all day and the next. I tried to persevere but once I guess I had got enough in my system the terrifyingly real nightmares began. I can barely believe the mind is capable of creating such intensely vision with little to no separation from reality. It kind of felt as though one moment you were thinking logically and the next you were still in the same place as you were in reality I.e in bed asleep but it was as though I had awoken from sleeping and then was lost in my own bedroom in this awful terrifying nightmare. I could not risk going back to sleep for a long time I was so scared of being transported back to hell. Sounds crazy and I would not have believed it had I not experienced it. Never again. But I think it would have been effective but for that, and increased pain. It may be ok for you."

3 / 10
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  • Miche...
  • September 3, 2017

Remeron (mirtazapine) "After years of being on depression medication and mood stabilizers my body stopped responding to my typical medications. My doctor called me in Remeron to try out. I took this drug for 2 days and had to stop due to extreme anger andk dar thoughts that are not typically me. My other half also went on this drug for a very short time because of the same issues. This medication is horrible"

1 / 10
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33 Report
  • Sleepy
  • February 16, 2016

Remeron (mirtazapine) "The first night I took it I slept for 16 hours straight (15 mgs). When I finally forced myself to get out of bed, I had this insatiable appetite. I also walked around like a zombie feeling groggy for the next day and a half. I took it on a Saturday night knowing that I didn't have to be anywhere the following day (good thing) Needless to say, I stopped taking it."

3 / 10
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  • blick
  • Taken for 1 to 6 months
  • October 15, 2015

"Best anti depressant I have taken. After trying different drugs for my severe depression, including citalopram which gave me constant diarrhea then sertraline which gave me diarrhea as well I was switched to mirtazapine. This has lifted my mood greatly and I sleep better at night too."

10 / 10
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38 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.

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