Lupron Depot for Uterine Fibroids User Reviews (Page 2)

• Anonymous
• January 25, 2012

"I was bleeding 24/7 and anemic due to a large fibroid. First I tried Depo Provera shots, which didn't work. All bleeding stopped about a week and a half after my first Lupron shot. At this point, it's only been a month, so I don't know if I'll still need a hysterectomy. "

• cmfsos
• Taken for 1 to 6 months
• August 19, 2015

"I had the 3 month 11.25mg on 3/30/2015 to shrink my giant fibroid to the size that the laparoscopic myomectomy can be performed. I had no symptom of side effects for the first month and also having my period but ever since the second month (May) the side effects were really hitting me hard; including hot flashes and night sweat. Had my surgery at the end of June and my doctor confirmed that I had reacted to the Lupron more thanexpected as the fibroid not only shrink but part of it was degenerated. So Instead of a 2 hours operation, it ends up to be a 6 hours. Now, it's been 5 months and the Lupron still lasting (period still not back yet), don't know when it will be gone..."

• Vesta
• Taken for less than 1 month
• October 14, 2020

"I developed several fibroids in my late 40s that caused very heavy bleeding. I opted for a hysterectomy and was given one shot of Lupron about 3 months prior in the hope that it would shrink the fibroids before I had surgery. I cannot say that it shrunk them (my uterus size was comparable to a 5-month pregnancy), but it did stop my periods immediately and that it made it worth it to me. The only side effect I ever experienced were extremely painful cramps a few times (once so bad I had to pull off the road because I was driving). Still worth it."

• Hopef...
• Taken for 6 months to 1 year
• October 14, 2019

"I am 48 yrs old. I was bleeding nonstop for over a year due to a large fibroid.....and I was in much pain. In Jan 2019 I started my Lupron 3 month shot, and I’ve had two more shots since then (every three month). I have not bled since Jan. My 6cm centrally located fibroid shrunk to 5cm within 6 months. My uterus reduced in size from 10cm to 8cm. I was anemic but my blood levels are back to normal now. I do get hot flashes often. My hair is thinning and dry. My biggest problem is bone pain in my fingers /toes. But that’s nothing compared to how bad I felt when I was bleeding. I have been very moody at times over the past 10 months. I’m supposed to schedule one more dose of the shot before my doctor will decide what to do next, hoping I can just start menopause so I don’t have to have surgery. I also have multiple sclerosis. But so far the MS flair up, due to this fibroid, is minimal."

• Angeal
• April 10, 2010

"I love that it completely stopped my outrageous heavy bleeding, which in turn made me anemic. So I am happy for that. However, the only side effect that I am experiencing is super dry skin on my arms, neck and face...I feel it is aging me overnight. Some constipation, and not really hot flashes but warm spells every now and then. Can't wait for surgery to get my hormones back to work."

• Linda
• Taken for 1 to 6 months
• January 11, 2021

"This ruined my life! I don't recommend it. Get a surgery, and if you get pregnant, get a C-section. This drug (6 injections) was recommended by my doctor. The only choice he gave me and he didn't tell me the lifetime side effects. There was just the 6 months suspension of periods, (sweats, moods). In 2005 I was 32 years old, recently married, and we wanted to have children. Now, I'm 47 yrs old, we didn't have children anyway and I don't lubricate, it hurts when have sex, and my libido its gone, all this for the last 15 years, and I think for the rest of my life."

• KYRAAW
• February 2, 2016

"This drug was the worse form of treatment for my multiple symptoms - Daytime hot flashes and steady period was not worth it. I was administered this drug in 2008 and since then my life has never been the same. Forgetfulness covered in laughter by co-workers; poor cognitive skills, no sex drive & no desire to be touched. Headaches, blurred vision; quick weight gain and most of all I quit my job and I'm still try'n to figure out why when I was financially stable. Who was I? Something in my brain is out of sync, I was not a person that took medicines. The Male-doctor pushed this on me & I was a patient with that organization for over 10yrs and I was the only 32yrs old & super active!"

• Kelisa
• Taken for 1 to 6 months
• February 11, 2019

"I got the LUPRON 3 month shot in January. I’ve had so far now the hot flashes and some abdomen pain and depression and now these headaches I keep getting. The bleedings stopped which that’s the good part. But the headaches gots to go. I don’t like to have to keep taking medication. Those are my only issues."

• Anon
• Taken for less than 1 month
• May 4, 2016

"Received 3-month shot two weeks ago to stop heavy menstrual bleeding in preparation for a hysterectomy next month. My period started and the bleeding is just as extreme as usual. No relief in blood or pain with this drug. Have experience hot flashes (minor), headaches (minor), night sweats, nausea (moderate), and have pain in upper right back area. Will be seeing doctor later this week to get checked on. I know it's early in the process, but I'm disappointed. I took it knowing about the side effects, but was willing to go along with them to get my bleeding under control and to build up my iron stores."

• Mlh
• Taken for 1 to 6 months
• March 24, 2022

"I wanted to share my story also for people who are considering trying this out. I had big fibroids and was scheduled for a laproscopic hysterectomy. My doc put me on Lupron for 4 months before the hysterectomy. She felt it would help me in hopefully shrinking my fibroids down to help with surgery. She wanted me to take the 3 month dose. I am very scared of side effects and really don't like taking anything. I did my research and decided I only felt comfortable taking the once a month lower dose Lupron shot. I was afraid to even try that. I was on Lupron for 4 months and I did bleed for the first month on it and then my bleeding and periods stopped after the first month. My only side effect was HOT FLASHES! But as time went by they seemed to get a little better and they calmed down some. It wasn't too bad, but definitely uncomfortable at times. Thats all though! So happy that I moved past my fear and tried it. It helped stop my periods and I was able to get the laproscopic hysterectomy done."

• Hano
• Taken for 1 to 6 months
• July 25, 2019

"I’ve been on Lupron depot for 4 months for heavy bleeding from a fibroid and extreme pain due to endometriosis. It has stopped my uterine and heavy bleeding and I have increased energy from not being anemic any longer. However, I have experienced hair loss, generalized whole body muscle pain and stiffness. As well as hot flashes, extreme jaw tension and teeth grinding at night and occasional insomnia."

• Meli...
• Taken for less than 1 month
• December 16, 2016

"My rating is based SOLELY on symptoms, I am unsure about the effectiveness being that I haven't checked my fibroid size yet to see if it has suppressed. To furthermore explain, I was diagnosed with a large fibroid about 10cm (outside my uterus) through a CT scan. I'm 28, no children, but hoping to conceive in my early 30s, therefore I chose to go on with the Lupron shot (3.75) to hopefully shrink the fibroid for surgery early next year. After reading the side effects, I was terrified and put this off for a year and a half. I have had ONE symptom and that is I do notice that my (face) is a bit clammy/dry. Just wishing I never put it off due to fear. I just finished my first month. Will update how month 2 went in January!"

• Jenash
• Taken for less than 1 month
• August 20, 2020

"This is user Jennybean from the review below (August 12, 2020). I could not log in with that username so here's my update: I got my first injection on 08/14/20. Ultimately I am getting the 3 month 11.25MG Kit. So I assume I will get 2 more shots. I got the shot in my butt cheek & did not hurt or flare up. The side effects for me so far: A couple short lived hot flashes here and there. Fatigue & my boobs are sore (like before a period and wearing a bra sucks as a result). These effects are medium-mild & are not overwhelming. I'd say the fatigue and breast tenderness are the most bothersome. I expect I will be adding to my list of side effects as we go on. The last thing I'll add is that my biggest fibroid is 7cm and my uterus never shrunk after I had my preemie son at 28 weeks pregnant. So basically, I STILL look six months pregnant 6 years later. That's why I'm on this medicine. I need to shrink my uterus and fibroid in order to have a less invasive partial hysterectomy (leaving my ovaries)."

• Kiano
• June 30, 2018

"My experience was horrible. My Obgyn recommended lupron for my fibroids. I have 1 large one the size of grapefruit, 3 the size of tennis balls and many pea size. Surgery not an option. I get lupron shots 1 time a month for 6 months. I had 13 acne cysts in total on my face that I had to have sugerically removed (over time). I gained 30 pounds almost overnight and it took me 3 years of intense dieting to get this weight off. My body thought I was going thru menopause so I had the hot flashes as well. I would not do it again. I spent a fortune only to find out after 6 months and all of this that the tumors were the same size. Years later I am having health issues and wondering if related to lupron usage."

• rubyt
• Taken for 1 to 6 months
• July 11, 2018

"I had 8 tumors in my uterus and the doctors told me there was no way to remove them. They gave me 2 shots of lupron and I started losing my memory and the bleeding increased. I did a search for doctors that remove the tumors and I found one. He took out the tumors, I was able to keep my uterus and have had no problems since. I thank God everyday for this doctor! The only bad thing is thanks to the drug my memory is damaged for life."

• SickN...
• Taken for 1 to 6 months
• September 24, 2020

"My experienced with Lupron Depot has been challenging, I have side effects of memory loss, trouble breathing (did not have this before), heart palpitations just about everyday (worst at night) nausea, extreme tiredness (daily), periods had stopped before but started up when taking Lupron Depot (very light to spotting). I am in my second month of the 3 month injection and I now have body aches, hot flashes every 15 minutes all day, as subsided to every 30 min to an hour as getting close to wearing off. I will not know if the fibroid has shrunk until after the 3 months have passed. Not interested in sex, so not want to be touched. Very sensitive since shot and not having a taste for really anything. Feet swollen like Ms. Piggy. Would I get again...heck NO! I would stop eating Red Meat First and drink healthy smoothie with raw veggies and fruit first."

• Trin
• November 29, 2019

"I started the shot in June 2018 due to having multiple fibroids on my uterus. I was bleeding very bad for months non stop. I had the Nexplanon (BC) in and took that out to see If the bleeding would stop as well. I took the shot for 6 months and then the doctor removed my fibroids located outside uterus on November 29, 2018. The doctor stated that he could not remove two fibroids in my uterine cavity and that he would keep an eye on them. As time went on I was still bleeding bad and got back on the Lupron injection in August 2019. I had another surgery on November 7, 2019 and my fibroids located in the uterine cavity shrunk. I did not get the shot in November and had a cycle November 23, 2019. It was heavy at first but it stopped after 5 days. My fibroids have grown back since last year and are located on the outside of my uterus. The shot may help some and it may not."

• KStar
• September 25, 2022

"Do not be afraid of this drug. I am in my forties and have several fibroids. I was bleeding continuously for 8 months and needed a hysterectomy. My hemoglobin at the time was too low for a successful surgery so my doctor suggested Lupron. It worked wonders. Bleeding stopped. Bloating went down. I'm sure my fibroids shrunk also. Hemoglobin recovered from a 6 to a 12 in just 4 months. Soon I will have my laparoscopic hysterectomy. Lupron saved me."

• Jenny...
• Taken for less than 1 month
• August 12, 2020

"I am getting my first injection 11.25mg/3 month at the end of this week for Uterine Fibroids. I am scared of flipping my body into fake, sudden menopause. I need to shrink a fibroid in order to have a partial hysterectomy and this is the route I chose despite being wary. I will come back to update. So far, just getting the approvals to get this stuff has been quite challenging! I should be ending my 3rd month on Lupron but it took that long just to get it. Good thing I didn't lose too much blood in the meantime on a period (which is what prompted me to seek this treatment in the first place). Again, I will come back and provide my experience once I get my shot this week."

• Love...
• Taken for 1 to 6 months
• March 10, 2017

"I was on lupron a few years ago. For chronic pain multiple cysts I was bed ridden a week or two of of every month. This injection saved my life back then. I lost coverage so i stopped. Now I have coverage and decided to try it again... its not working this time!. I'm in pain all the time still. I have trouble sleeping at night or staying asleep my libido is gone..and I'm in the 4th month of treatment and started bleeding and have really bad pains again.. and my got flashes are back. The first month is the worst! Worst period of my life.. but there was no bleeding until now.. so I would recommend trying the once a month doses first"

• Anne
• Taken for 1 to 6 months
• November 19, 2021

"Lupron did not work for me. I took this medication as a last resort prior to having surgery to try and stop further growth of my already large fibroids and stop the hemorrhage level bleeding that I was regularly experiencing. This was a injection taken once every 3 months. While taking, my bleeding continued to get heavier. I had all the side effects and none of the stated good effects. The doctors don’t tell you that this medication may not work and when I told my doctor that it’s not effective and I continued to have heavy bleeding she still wanted me to continue taking this very expensive medication. For me it wasn’t worth it. The mood swings alone made me feel awful, I had memory fog, and the hot flashes were so intense. Take with extreme caution."

• Chocl...
• Taken for 1 to 6 months
• March 8, 2018

"I have had like 8 fibroids super big started 2015 March started bleeding blood clots. I was close to 50 years old so I found a study and she recommended lupron, I'm not gonna lie had 3 shots, my hair fell out - its gone, but for the pain I'm in right now might have to get my 4th shot. This situation changes your life style 100%. Horrible uterus pain is unbelievable. My hot flash/ cold flash worst are without lupron."

• chiom...
• May 15, 2021

"I took luprodex 3.75mg injection for 5 months on monthly basis to reduce the severe cramp.and pain associated with monthly flow. First month of injection was still painful but the subsequent months were normal and I also ovulated well on month 4. Then after the last dose, it took just 6 weeks before my period returned. It was quite normal but with a very light right abdominal cramp. I will do scan to check if the bulky uterus has reduced because I want to conceive too. One important observation is that it did not stop my period for those months . I usually see my period each month but did not see the next month when I stopped the injection. It was a beautiful experience though I had severe leg cramp/ arthritis..."

• Flori...
• Taken for 1 to 2 years
• August 9, 2021

"The Lupron injection was a lifesaver. In November 2019, I was 50 years old and I had been bleeding for 75 days, due to uterine fibroids. My hemoglobin was down to 5.1 and I had to have blood transfusions in the hospital. So far so good, no bleeding at all, until today, when I started bleeding again the first time, since November 2019. I'm now almost 53 years old and I'm scared to death, I have to go to the doctor on Thursday. Has anyone else had their periods restart after so much time, not having them following the Lupron injection? I know the injections wear off I'm not sure if they will administer more to stop the bleeding now ?"

• Mon
• Taken for 6 months to 1 year
• March 30, 2023

"I’ve had Lupron Depot for six months with no reduction in the size of my fibroids. It wasn’t hell with Lupron Depot, but my sex life was non-existent, the heat flashes were constant and it didn’t help the various pains I was experiencing from my large uterine fibroid (>10 cms). I also noticed that my knees got weak, and I constantly had back pain. I’m 29 years old, so this is alarming."