L-methylfolate for Depression User Reviews (Page 4)

• Pay...
• April 21, 2017

"As mentioned in other reviews Deplin is designed to augment other medications to increase their efficacy. All Deplin is is L-methylfolate packaged as a Prescription medication by Drug manufacturers to make money on a supplement that is readily available for much less cost. If you are paying more than $30/month check out other brands It sells L-Methylfolate 15 mg 30 capsules for $30. They also have 7.5 mg capsules. Methylpro is not a generic Deplin. Methylpro is L-methylfolate. Deplin is L-Methylfolate. No difference. Naturopaths and savvy Doctors (not the medication only white coats) have been using L-methylfolate years and years before it was packaged as an expensive prescription "drug". Do your homework, save money and stick it to the man"

• sting...
• September 29, 2009

Deplin (l-methylfolate) "I have had partial response to my antidepressant. I have had a hard time finding one as my chemistry responds unfavorably to many drugs. Deplin was advised by my Doctor who has actually participated in clinical trials. She had seen no adverse effects and thought it would work great for me. On 3rd day I felt like my old self for first time in 1 year. Unfortunately, that night I had auditory hallucinations... first time in my life... and a very restless night. Went off and slept okay. Tried just doing folic acid and Vitamin B6 and had the same response, only worse. Didn't sleep the whole night. Both my Psychiatrist and Psychologist say I am the only person who they have ever seen have a negative reaction. Like I said, I felt great. Good luck."

• Laura...
• Taken for 1 to 6 months
• May 31, 2017

Deplin (l-methylfolate) "I started this supplement with high hopes. I was given it to boost the effectiveness of the Pristiq I'm taking. After using it for over a month I'm disappointed. Really have experienced no change. I'll keep searching for the right combination of meds."

• Jonat...
• Taken for 2 to 5 years
• February 26, 2020

Deplin (l-methylfolate) "I took this for a while at the recommendation of my psychiatrist. I have the double mthfr mutation. It did nothing for me and is prohibitively expensive. I’m not sure if I buy into their mthfr serotonin theory, but it seems to work for some. For me, I would get these weird sensations in my hands and feet, almost like they were heavier or more sensitive, and I felt like my sleep was less restful (even I got 8 hours consistently) because I was always tired. It made me feel off as well, but I assume that is just depression medication in general."

• Seeking
• Taken for less than 1 month
• December 16, 2017

Deplin (l-methylfolate) "MUST take Deplin and not a generic and definitely not over the counter folic acid or folate! These can make things worse! My C spinal fluid showed that I have a less prominent type of folate abnormality. Wasn't detected in a gene swab test. Anyway, just started taking 15mg as an Anti-depressant add-on. Made my depression & anxiety worse!!! I would stop taking it, but my doc has me taking a lower dose as she recognizes that Deplin can cause a worsening of symptoms in certain folks. It just needs to be started low and gradually increased. So, please start with a low dose if it makes you MORE anxious/depressed at 15mg. Too early to say it helps, but the lower dose is needed, to start, for some. And it may take many months to work--for some!"

• Julz
• October 24, 2019

"So, I've been on a litany of meds for 40 years. I have BPD1, major depressive disorder with psychotic features. I sometimes have delusions and hallucinations. Both suicidal and homicidal ideations. This has been utterly unbearable because no antidepressants or antipsychotics have ever helped me. The antidepressants cause me to feel suicidal. About a year ago, doctor gave me Deplin. I take it when I need to and it works. Just 3 days ago, I felt suicidal and was hearing the voices inside my head. Day 3 of Deplin and I feel better again. I only use Deplin and nothing else. Yes it's tough managing the other symptoms by myself but they're nothing next to my depressive episodes. All I can say is that L-methylfolate is helping me. It is the only thing that has ever helped. There are some side effects like palpitations, insomnia and some restlessness but I don't care."

• Cindy...
• July 14, 2009

Deplin (l-methylfolate) "I've been on Deplin for 20 days now, along with Zoloft. I had great success with Cymbalta, but it messed badly with my blood pressure (going from 112/65 to 175/100) so I had to go off it. I was put on Zoloft as a stop gap, but have tried it in the past without much success, as with all the others. They say it can take 4-6 weeks before Deplin has its full effect. I'm still hopeful, but I do so wish I'd seen the overnight change like others. "

• Lynne...
• Taken for 1 to 6 months
• September 18, 2022

Deplin (l-methylfolate) "I took Deplin during a former depressive episode but in a much smaller dose. I cannot say if it helped with the effects of depression. During this episode my doctor recommended tailgating 15 mg. I was taking Deplin for 3 months. I was having unbearable anxiety and began looking carefully at the side effects of my meds. Deplin can cause severe anxiety along with other negative side effects. There is an article online called ‘ Anxiety Nutrition Solutions’ by Trudy Scott with Dr. Benjamin Lynch. He is a major supporter of methyl folate. He talks in the article about the different side effects patients can experience on Deplin, severe anxiety among them. If you’re taking Deplin and are feeling anxiety, please read."

• Anonymous
• October 10, 2009

Deplin (l-methylfolate) "I am hearted by the 6 reviews. I have just started on Deplin. I have been on Remeron for two years. I cannot tolerate serotonin type medicines such as Prozac, Lexapro. Remeron worked beautifully at first but effects have slowly worn off and my anxiety and mild depression returned. I pray Deplin will work for me and I can regain my enthusiasm and joy in life. I am happy for those of you who have been helped. Wish me luck."

• Jinx
• Taken for 1 to 6 months
• August 23, 2023

Deplin (l-methylfolate) "I have a genetic mutation which lowers my body's ability to convert folic acid into its active form, but had never been prescribed Deplin for my bouts with depression and lifelong insomnia. This spring, my mood started to decline and my sleep was worse. At one point, I was taking three medications for sleep. I told my new psychiatrist about my old genetic test results regarding folic acid, and he thought I should try 15 mg of Deplin. Within two weeks, my sleep improved dramatically - I was able to discontinue a sleeping medication, and within 3-4 weeks, my mood also became much more stable and consistent. I've now been taking Deplin for almost six months and have been able to discontinue another sleep medication (I still take one for sleep). Although I still get short bouts of lower moods, they are nothing compared to what they were prior to Deplin. I tried at least five add-on antidepressants prior to Deplin with no results. I had no side effects, and it's very easy to take - a real lifesaver!"

• Rose
• Taken for 1 to 6 months
• August 14, 2018

"I’ve been on so many antidepressants. None made me feel great. Improved the depression for a while then poop out. Or the dose was raised and had no emotions at all. I started Enlyte. I’m in month 3. It’s subtle and gradual for me. But I’m napping less. Back to reading and doing art work again. I feel much less of the “ugh this is too hard” I’m putting one foot in front of the other on automatic instead of such a forced effort. Well worth the $30 a month. I don’t miss any work as work is less of a drag so it pays for itself. I’m living my life for the first time since I was a teenager. At age 60!"

• jonny...
• November 12, 2016

Deplin (l-methylfolate) "I am taking 225 mg of Lamictal for depression. The Dr. wanted me to try this along with the Lamictal. I took it once, at bedtime and woke up with the worst headache I've had in my entire life, and it lasted all day. Also had very loud ringing in my ears which lasted all day. Not good. Needless to say, I did not take it again, so I cannot comment on its effectiveness."

• TZT
• Taken for 1 to 2 years
• April 9, 2018

Deplin (l-methylfolate) "If you are taking Deplin because of the MFTHR genetic abnormality, you were misled by your doctor(s). This genetic test is being pushed by the pysch field even though it has not been proven. Look up the studies on MFTHR and you will soon learn that most of what you read about are myths. That being said Deplin does have its benefits. "

• ktexas
• October 27, 2014

Deplin (l-methylfolate) "For the past several years I have been trying to find the right balance to deal with the anxiety and depression of Post Traumatic Stress Disorder. I have been on Citalopram for the depression and that seems to work well. It has been hard to find an antipsychotic that works and currently I'm on Latuda. I'm also on a mood stabilizer Lamictal. My Dr added Deplin. Long story I wound up without my Latuda and Deplin for about 6 weeks. In 6 weeks I was off the charts on the ups and my old patterns were popping up. Not good. I went back on the Latuda and began evening out but still had too much up. Now I've been back on the Deplin for a week and I feel completely numb. Trouble sleeping at the right times, trouble being awake or at least alert at the right times."

• Ablack
• Taken for less than 1 month
• April 27, 2018

"I've had depression for most of my life and have been suffering from premenstrual dysphoric disorder (PMDD) the last five. I was prescribed l-methylfolate by my psychiatrist to go along with my anti-depressants a year ago but for some reason I didn't take them. If only I knew!!!! I took those and noticed a difference right away but when I ran out, my insurance wouldn't cover it (different insurance company at the time) so I had to go OTC. I have felt so much better since taking the MethylPro at 10mg. I am actually happy, content and I laugh. My PMDD is calming down. I've only been on it about two weeks consistently. Yesterday I woke up and exercised!!!!!!! I've been doing some type of exercise the past week almost every day. Yoga, dance, kickboxing (not actual kickboxing but as exercise). It's amazing how much energy I have, but it isn't that caffeine-driven energy feeling, if that makes sense. I haven't been tested for the gene mutation and am going to inquire about it when I speak with my doctor next."

• KTgreen
• Taken for 6 months to 1 year
• November 15, 2017

"I started taking MethylPro after I was prescribed Deplin and could not afford the monthly cost once my insurance discontinued it. MethylPro has actually made me feel better than ever, I believe I was having a reaction to one of the additives in Deplin and it was making my skin itch. I no longer have that issue and I feel the effects more quickly on the MethylPro. It has allowed me to no longer be on antidepressants and two months ago I started taking one with cofactors, I'm now training for a half marathon in March. Life is now fulfilling and I'm full of energy, L-methylfolate has been a game changer for me!"

• Snowpea
• Taken for less than 1 month
• May 7, 2019

"Tried Neurofolin today As was considering giving it to my late teen with low mood and energy I though I would be the guinea pig first. Had a positive experience. Felt focused and alert all day with sustained results and improved mood and outlook. A little jittery but personally managed ok with that.."

• Amybee
• Taken for 1 to 6 months
• October 2, 2022

"I thought Deplin was helping my depression at first, but soon realized that the severe anxiety and insomnia I was experiencing coincided with when I started taking it. Granted, I take other meds, but I had zero anxiety and practically no trouble sleeping before I added Deplin. It’s a shame because at first I thought it was helping me, but the side effects were intolerable."

• maxm
• August 20, 2010

"I am a 63 year old man (a psychologist) who has had treatment-resistant depression for many years. In the past ten years I also have had frequent (10-15/month) migraines--migraine and mood disorders often appear together. I started on Deplin 7.5 mg/day along with Zoloft 50 mg./day last month. I had been on Zoloft alone previously with no improvement. After 3-4 weeks of no change in mood or functioning, my psychiatrist increased the Deplin to 15 mg./day and the Zoloft to 75 mg./day (not a high dose). Within a few days, I experienced an increase in energy and sharp decrease in depressed mood--to the point where I'm feeling back to what "normal" was decades ago. I have been through numerous antidepressants and never experienced this."

• Finally
• Taken for 1 to 6 months
• February 1, 2020

"Hi I've suffered from depression since my early thirties . At that was when it was diagnosed. I've tried most of the antidepressants and for short periods of time they certainly have assisted me come out of some pretty dark places. Now in to my 50s I'm tired of taking the medication and do not feel that it has been assisting me. Recently I have tried Nurofolin and I can't believe the difference. I weaned myself off the antidepressants and then began taking your folin within two weeks my mood was lighter and my anxiety reduced considerably. I have now been taking it for well over 3 months. I would definitely recommend this for anyone who has work done the work and now just wants something to keep their mood balanced. Of course this is not for everyone but in my experience I am so grateful to finally find something that truly helps without the chemical side affects."

• Frust...
• December 6, 2019

"tl;dr: 5-MTHF, methyl folate calcium salt, whatever it's called by the manufacturer, some forms work better for some people than others. My depression responded poorly to nearly every antidepressant on the market for 10+ yrs. Turns out I'm homozygous for the MTHFR mutation. Started taking 1mg L-methyfolate pills by Superior Source, increasing every few days to hit the recommended 15mg/day for depression. Had an immediate improvement in energy, and my other meds, like Allegra, started working better. I also tried OptiFolate 7.5mg, MD Life 5mg, and NOW 5mg. My depression symptoms and skin-picking came back on each of those. My psych finally wrote me a prescription and now I'm on 15mg pills made by Breckenridge. They work as well for me as Opti Folate: not very well at all. YMMV (your mileage may vary), I've seen reviews on Amazon where people responded much better to Opti Folate than Superior Source. Do your research, & try different makers if one doesn't work for you. I'm waiting for a new prescription."

• John_...
• October 16, 2014

"I'm 47 and heterozygous for both MTHFR mutations. I just came out of a deep, dark depression with the help of Effexor. I started taking 0.5 milligrams of methyl folate (yes, a very low dose) about a month ago. Even this small amount of methyl folate (in combo with methyl B12) affects me deeply and immediately. I take it before 8 in the morning, and it still influences my sleep that night. I have never been an active dreamer, but on methyl folate, I dream A LOT. I seem to feel more awake and active in the afternoons, as well. I agree with the commenter about being on methyl folate for a period of time before deciding if it works for you. You may feel the effects immediately, or later on. There may be ups and downs."

• NotDy...
• Taken for 1 to 6 months
• January 24, 2022

"I have a double mutation with the MTHFR situation. It took a long time to get my insurance to cover this. I take 15 mg twice a day and just like all these other reviews - I am no longer dying. I see that a lot of people are taking 15 mg once a day so I don't know why I'm on it twice a day but I went from feeling like somebody who was literally being swallowed up by quicksand to somebody who is alive. I've been on it for 5 months. I have no side effects. It feels crazy to feel normal."

• Brian
• September 2, 2021

Deplin (l-methylfolate) "I was having major anxiety and insomnia stemming from shoulder surgery. I wasn’t sure what was wrong with me. I eventually found a psychiatrist and he prescribed klonopin. That made me more depressed. I decided I needed a better psychiatrist. After meeting with this doctor, he decided to do the genetic testing. Three days later I find I have MTHFR. Compound heterozygous. Been on Deplin 15mg for over a year. I also take 10 mg Lexapro per day. Anxiety is better and I’m not nearly as angry. Changed my life for the better. Better late than never. I’m 54"

• Lennie
• April 8, 2011

"I have battled depression and anxiety for 15 years and was prescribed Klonopin. Over the years I have remained on Klonopin, in addition to Paxil which was added 6 years ago. I didn't see any significant changes in my depression, but my anxiety was under control. After trying several antidepressants with no significant change in my depressive mood, I was frustrated. My doctor, prescribed Methylfolate and today is my 2nd day taking the medicine. I woke up this morning with hope, energy, and excitement. It has been years since I have felt excited about what a day in my life would unfold, and it happened today. I feel like I am participating in life today as opposed to being a spectator."