L-methylfolate for Depression User Reviews

• Ken...
• April 21, 2019

Deplin (l-methylfolate) "Deplin has changed my life. My doc did genetic testing for my severe anxiety and panic disorder and found I have the MTHFR gene mutation where I don’t break down folate. He prescribed me this with my antidepressant and it’s been a miracle. I’m no longer anxious, I do not have panic attacks, my depersonalization and derealization is completely gone. I praise the Lord in how good and healed I feel. I’m a RN and I suggest all those who are suffering to give this a try. Hang in there, God is with you. There is hope. You will feel better. Praying for all who read this post."

• joh...
• Taken for 2 to 5 years
• April 20, 2013

Deplin (l-methylfolate) "I want to really say people should wait at least 3 months before they rate Deplin or any psychiatric medicine, unless you have some major horrible reaction. Deplin gave me a kick start the first week I took it for some reason, but then the effects disappeared. I talked to the P-doc, and he said it takes something like 6 weeks to build up in your system. Well, after about 6 weeks or so, I started to notice the effects. It gave my Wellbutrin a huge boost, and my energy level rose through the roof. People rating a medicine after 2 days is just ridiculous and annoying. Even the SSRI's take a couple of weeks to work. Stop it, people."

• Tin...
• August 30, 2019

Deplin (l-methylfolate) "I’m a psychiatric nurse and have seen many medications work and many not. For me, Deplin has worked quite well. I’ve stopped taking it before with a marked increase in depression. With Deplin, I feel genuine happiness and want to smile. We all know people with depression are pros at the “fake smile,” but my smile is from the heart. At the risk of sounding like a marketer for Deplin, there have been a few times I’ve teared up because I’m afraid the happiness will go away. I enjoy being well and don’t take what I have right now for granted. I know the studies aren’t great concerning Deplin, but for the people who do respond well to it, Deplin can be a life-changer and a lifesaver."

• MsR...
• Taken for 2 to 5 years
• June 16, 2019

Deplin (l-methylfolate) "I was being treated for a mood disorder and the meds were kind of helping, but many days I still felt 'disconnected', rarely having a day where I felt great. I assumed it was normal for me to feel that way. My doctor decided to prescribe Deplin. This was years ago. Anyway, one day, after having been taking it for about 3 weeks, I woke up and realized I felt GREAT! Like the fog had lifted. I have so many great days now. I’ve been on it for years now and it really has changed the quality of my life."

• lad...
• December 14, 2013

Deplin (l-methylfolate) "In 28 years, after dozens of antidepressants, add-ons, ECTs...I've never felt so full of life. Ever. An absolute miracle this was. I was absolutely lifeless. I feel sorrow for having gone so long miserable, but blessed to have been lucky enough to have a doctor try this with me."

• Col...
• Taken for less than 1 month
• November 6, 2016

Deplin (l-methylfolate) "Deplin has saved my life. For two years, I have struggled with debilitating depression and anxiety. I have been on every antidepressant and antipsychotic, and went through sixteen sessions of ECT. A fourth visit to the hospital landed me under the care of a psychiatrist who finally ordered genetic testing for me, and we learned I have the gene mutation that impairs folate production. Started Deplin 15 mg eight days ago, and I feel absolutely wonderful. Mood is great, anxiety has improved significantly, and I feel so peaceful. My energy level is up, and I feel hopeful and full of life again. I am so relieved and happy I could cry."

• Mar...
• February 4, 2019

Deplin (l-methylfolate) "I am a 50-year-old medical professional and have struggled with mostly moderate depression for most of my life. I had struggled with, and eventually refused, taking antidepressants because the side effects were worse than the cure. Eventually, a counselor convinced me to try Deplin. After a few weeks, there was a noticeable shift in my mood. It was like a curtain had been lifted, and I felt normal. A few months later, I ran out of the Deplin but didn't want to spend the money to get it refilled. Approximately two weeks later, wham!, the curtain dropped, and the depression was back. Lesson learned."

• I...
• May 10, 2015

Deplin (l-methylfolate) "My sister was tested and has the MTHFR mutation. I have struggled with depression, anxiety, ADHD, and bowel problems since childhood. I have only been on Deplin for five days but I have never been so energized and just generally happy in my life. Finally I have hope for the future. Before I was unsure how long I could last because I knew all of my symptoms were slowly worsening. Now I feel like a little kid again. All I want to do is dance around and do handstands. Everything and everyone makes me laugh and life has never been so good. My ADHD, depression (obviously), and IBS have dissipated. I have increased sex drive and metabolism and even my liver is detoxing again. THANK YOU DEPLIN."

• The...
• Taken for 10 years or more
• June 27, 2020

Deplin (l-methylfolate) "This is a follow-up from a post years ago. I tried every med possible, both antidepressants as well as benzos, for panic, depression, and anxiety. Nothing ever worked, and the meds had intolerable side effects. In 2009, I took Deplin for the first time, and my life changed. Yes, I am Heterozygous with the C667T mutation, and 11 years later, I am still loving my Deplin. I am off benzos completely, after a long taper, and have lowered my SSRI to a very small dose."

• Mar...
• Taken for 6 months to 1 year
• January 5, 2013

Deplin (l-methylfolate) "Deplin worked for me but is not for everybody. I have the genetic mutation which others on this website have talked about, which keeps the body from processing folic acid into L-methylfolate which is needed by the brain for the other neurotransmitters to work properly. A blood test ($280) proved this. Before Deplin, I was on Bipolar meds (including Seroquel, which was miserable) and antidepressants. Now, I am only on Deplin and Clonazepam for chronic anxiety and am feeling re-energized."

• fee...
• May 10, 2011

Deplin (l-methylfolate) "Just turned 50 and I've fought with Bipolar Disorder and Depression my entire life. I've been taking 300mg of Lamictal to control mood swings and 1.5mg of Klonopin to treat chronic anxiety. Depression was still so overwhelming that I asked for an antidepressant. The MD prescribed 200mg of Wellbutrin SR which had a positive effect, yet did not get rid of the underlying thoughts of death and dying; many of you will understand that I'm talking about a coping mechanism, not actually wanting to harm myself. A pharmacist told me to ask my MD about Deplin, and that was the best medical advice I've ever received! I've been taking 15mg daily for over two months and have not felt this 'normal' for many years! Thanks for reading my opinion."

• Ray...
• Taken for less than 1 month
• November 12, 2018

Deplin (l-methylfolate) "Deplin! What can I say? Changed my life! I had been dealing with treatment-resistant depression for over a year. My psychiatrist finally gave me Deplin and in just days, I felt better than I had in a long time! I also started taking L-carnitine, which if you've been depressed for a long time, you are probably deficient in it. But I know it was the Deplin. You have nothing to lose, please try it! I had absolutely no side effects. I have more energy, but mainly the horrible painful depression lifted in 3 days! I am beyond thrilled and would pay any amount of money per month to keep this medicine. Please give it a try."

• Jea...
• June 12, 2016

Deplin (l-methylfolate) "I have suffered with depression since I was a child, but of course I didn't know it then. Alcohol and drugs became my only salvation. Eventually, I had to get sober. Still depressed. Had a relapse that lasted 4 years. Sobered up again. 18 years sober and still suffering that black cloud with anxiety on top. Tried Deplin 3 months ago. I didn't expect good results since I've taken so many antidepressants over the years. I felt better the first day. I feel like how normal people feel. I have hope, motivation, freedom. I am completely happy. I know this has not been everyone's experience, but it's mine, and for that, I'm eternally grateful. If your insurance doesn't cover it, file an appeal. If you can pay cash, it's only $178 for 3 months or pay monthly."

• Who...
• February 22, 2012

Deplin (l-methylfolate) "I have had depression for 8 years and nothing has ever pleased me. I just had a baby 5 weeks ago and my depression doubled. I felt so lost and I really thought I was losing my mind. I just wanted to end my life. I told my OBGYN and he gave me this medicine and I really haven't felt this good in years. It makes me feel relaxed and do nothing but laugh. My mom said she hasn't seen me this way in years. I was pushing my son's dad away because of how I've been feeling but I've just been so happy around him now. I can handle the baby's crying better and most of all myself. I just feel alive again. Thank you Deplin!"

• Mar...
• Taken for 1 to 6 months
• April 2, 2019

Deplin (l-methylfolate) "Like many, I have been clinically depressed since my 20s (30 years). Cymbalta has helped me the most, but I still get hit with very dark times. Last month, my doctor gave me Deplin samples. I took them, but with very low expectations. Three weeks into it, I began to notice a change...normalcy! It crept up on me. I stopped needing a 2-hour nap, I feel clear-minded. My mind doesn't feel like a Los Angeles freeway. I am calm and feel content. I can't wait to tell my doctor tomorrow. I also needed a D3 prescription. I am sure my father could have felt so much better with these good meds."

• Suz...
• April 13, 2012

Deplin (l-methylfolate) "I lost my only child four years ago and have battled grief and depression. I was put on Deplin, and it made a huge difference in my frame of mind. I went off of it a month ago because I started a new job and basically just forgot to get it filled. Big mistake. I have been extremely sad and depressed. I will be getting that prescription filled tomorrow. It was a lifesaver."

• Kar...
• October 20, 2016

Deplin (l-methylfolate) "I have struggled with depression almost all my life and have been on Zoloft for more than 20 years. I recently told my doctor that in addition to being overwhelmed with devastating family health issues, I had been becoming more and more fearful of losing my career because I couldn't seem to remember even the simplest of tasks. I was literally losing my mind! He prescribed DEPLIN. I've been on it for roughly four months. SUCCESS! My memory and mind are as sharp as they've ever been. Thank God for DEPLIN. Additionally, my overall mood has improved and I have a calm outlook on life and now take everything in stride. It's been years since I've been able to just 'go with the flow'. I FEEL LIKE A NEW PERSON. THANK YOU, DEPLIN!"

• Sad...
• February 5, 2009

Deplin (l-methylfolate) "I'm 47 and have had serious, treatment-resistant depression since my early 20s. Antidepressants have offered me some relief, though it has been far from complete. Although I have remained consistently on antidepressants since Prozac was released, my depression has been bad. I've been muddling along on Pristiq and Wellbutrin. Recently, my doctor had me on Ritalin as well, to give me the energy just to make it through the day. She put me on Deplin a week ago and its effect on me was felt the next day. After a night of extremely colorful dreams, I woke up feeling great. I took my medicine as usual and it was suddenly as if my brain could feel all the antidepressants for the first time. I spent a trippy weekend, got in touch with my doctor on Monday, immediately discontinued Ritalin. I'm still feeling great, full of energy, and still feeling overmedicated. I suspect the next step might be to reduce, if not discontinue, the Pristiq and Wellbutrin. This is the first time I've ever actually thought I may have found a 'cure' for lifelong depression. It's only been about a week now, but I remain cautiously optimistic."

• Muc...
• Taken for 1 to 6 months
• August 30, 2018

Deplin (l-methylfolate) "I have suffered from depression, anxiety, and PTSD for years. I tried most of the SSRIs and SNRIs. The best medicine for me was Lexapro and Klonopin. However, after 10 years on Lexapro, it lost its efficacy. My psychiatrist suggested Deplin. It took about 9 weeks for it to work. I hung in there because of him and posts like this. It has reduced my depression and, surprisingly, my anxiety. I am thrilled. Deplin is a true blessing. Don’t give up if it doesn't work for you quickly. I've read it can take much longer for some people, even 10 weeks. Have patience; it’s worth it!"

• glb...
• Taken for less than 1 month
• April 9, 2015

Deplin (l-methylfolate) "Because this is a food/medicine, there is no way it can cause side effects. I have only been on it for a little over a week, but I am thrilled!! I do not feel depressed, and I am feeling energized and better than I have in years! I have taken every kind of antidepressant there is, I think. I weaned off the last one, and right now I am not on anything but Deplin. I am amazed."

• Net...
• December 24, 2010

Deplin (l-methylfolate) "I have suffered with Major Depressive Disorder, Generalized Anxiety Disorder, and Obsessive-Compulsive Disorder for over twenty years. I have been on many types of antidepressants with moderate success. I started taking Deplin 7.5mg once a day and I can't believe the results. I feel 'normal.' My idea of normal is to go through a day without having feelings of hopelessness and wanting to stay out of social situations. I feel great. I started feeling the effects of Deplin on the second day. I am a mental health counselor (graduate student). I have learned how to survive and muddle through all that I want to accomplish in life. Deplin has given me new hope for the future."

• Anx...
• Taken for less than 1 month
• January 16, 2015

Deplin (l-methylfolate) "I have been taking Citalopram and Clonazepam (for panic attacks only) for MONTHS. My anxiety level, even on these medicines, was completely out of control. To the point where my muscles were twitching nonstop all day long (as well as other physical symptoms). I added the Deplin to my 20mg Citalopram at the request of my doctor. Within a few days, I felt like a completely new person! Better than I have felt in years. My muscle twitching completely went away, and I no longer have obsessive thoughts. I highly recommend this medicine for anyone suffering from severe anxiety or Generalized Anxiety Disorder. It is a life-changer. Well worth the $60 a month."

• Anonymous
• December 17, 2011

Deplin (l-methylfolate) "I've been on so many different medications for the past few years. A couple of weeks ago, my psychiatrist decided to try Deplin. I can't even begin to explain the change. I haven't felt this normal in five years. I'd forgotten what it was like to not be depressed. This is a miracle medicine."

• Spe...
• Taken for 1 to 2 years
• August 20, 2014

Deplin (l-methylfolate) "This is a great add-on medication for depression. I am compound heterozygous for the C677T and A1298C MTHFR mutations. I was taking Celexa and Wellbutrin and still having frequent depressive episodes when I first started taking Deplin. After about a month on Deplin, I weaned off Wellbutrin. We later lowered my dosage of Celexa too. I did try to wean off Celexa completely and use Deplin as monotherapy, but ran into issues. I've been taking Celexa 20mg and Deplin 15mg for over a year now, and it's still working great!"

• Ter...
• September 4, 2015

Deplin (l-methylfolate) "I was born with Spina Bifida L4-5 S1-2 along with a myelomeningocele. My birth issues were due to low folate. Throughout life, I have struggled with depression, always being told it was due to the Spina Bifida. I fought through a major depression my senior year in college. When I became employed following college and had insurance, I sought counseling and medication, taking imipramine. When Prozac became available, I began it. After a decline in my health from a stroke at 33, my depression became worse, requiring hospitalization. Five years ago, I returned to my hometown and sought medical care from my high school friend. He tested me for L-methylfolate deficiency. I was deficient, he put me on Deplin 15mg with Zoloft 100mg. I am finally emotionally healthy."