L-methylfolate for Depression User Reviews (Page 2)

• RNG...
• September 23, 2015

Deplin (l-methylfolate) "Within just days of my first dose, I could feel a huge, positive difference. My mind and speech were clearer, my anxiety was nearly unrecognizable, and I was just plain happy. I admit that the cost has been somewhat limiting at times. When I have chosen to delay filling a prescription for a week or two, not only can I feel the difference, but my coworkers, family, and friends quickly point out the changes. It's an amazing supplement and worth every penny (when I have it to spare). Plan to stay on it from now on!"

• Anonymous
• June 2, 2009

Deplin (l-methylfolate) "I have been depressed since 1998, after I had a fall at work and problems with the work doctors. My doctor had me try different types of medications like Prozac, Wellbutrin, Paxil, and Tofranil. Finally, the one that helped me was Effexor. At least, I thought so. Then the doctor put me on Deplin, and I felt like I hadn't felt in a very long time. That was 8 weeks ago, and now I feel great. Deplin has really changed my life. Thank you for letting me share this with you."

• Anonymous
• January 22, 2012

Deplin (l-methylfolate) "In about 1 week, I noticed a drastic change. I was feeling much happier, had fewer mood swings, and even my anxiety had lessened. I like this medication because it's natural and has almost no side effects. I highly recommend it."

• Che...
• Taken for 1 to 6 months
• March 30, 2019

Deplin (l-methylfolate) "I take L-methylfolate (this medical food) once a day with my antidepressant for my anxiety and panic disorder, and I feel great. I am always very positive, and I never have anxiety. My panic triggers are gone, it is amazing. Definitely recommend to anyone having depression. It works. It's not expensive. $58 a month. Worth it for me. Also helps my folate deficiency. 100% awesome med. Never want to be without it."

• CLM...
• November 20, 2011

Deplin (l-methylfolate) "I found the pamphlet for Deplin while sitting in the waiting room. I was very intrigued because all of the adjunct medicines for anti-depressants usually have many side effects. My doctor was skeptical, stating that it was just a vitamin but wrote me a script. Effexor is the only one that works for me. I tried Cymbalta for pain issues and spent most of the time in tears. Before my diagnosis, I was constantly suicidal. As of late, my dark moods were back too often. But after 3 days of Deplin, I woke up feeling motivated and hopeful. I am amazed but so grateful."

• Myl...
• Taken for 1 to 6 months
• October 14, 2015

Deplin (l-methylfolate) "I have suffered with depression as long as I can remember, high school and since. I'm 30 years old. I've tried everything to help my depression. Paxil, Lexapro, Prozac, 5-HTP, Wellbutrin, and now Celexa. Celexa did help more than the other antidepressants, but still I was suffering from depression. I lost my baby girl doggie, who was only 3 years old and was just like my child. My world fell apart, and my depression became severe, the worst I've ever experienced. I went to the doctor to talk about options as the severity of depression was overruling my life. The doctor gave me 30 Deplin 15 mg capsules samples. In 2 days, I felt alive again. I am so grateful. Look up Brand Direct Health and have your doctor send your prescription to them. Much cheaper. $65 for 30 caps."

• Anonymous
• April 10, 2013

Deplin (l-methylfolate) "I'm so happy for you all. It's just pure hell dealing with depression, no sleep, continual thoughts, obsessive compulsive disorder, and not happy at all. Maybe if we all get figured out that this is what we need. Imagine how cheap our health insurance could go to. This is wonderful, I take folic acid and it does make a big difference."

• Aun...
• March 9, 2017

Deplin (l-methylfolate) "I have taken antidepressants for years, with some improvement but mostly moderate to severe side effects, which makes me go off them. I only take Cymbalta now mostly for pain. When I began Deplin, I noticed a major improvement overnight. More energy, better disposition, and no sinking to the low lows of major depression. I have been taking it for about 3 months now and feel like a normal person for the first time ever. Best thing, no side effects."

• Anonymous
• February 9, 2012

Deplin (l-methylfolate) "This medicine has been amazing. I have been on it for about 6 weeks. I am also taking Nardil, which has been effective sporadically. Finally, I'm happy all the time! I've also had to greatly reduce my Levoxyl because my thyroid is speeding up. My depression is finally gone after years of treatment-resistant atypical depression."

• Aja...
• June 29, 2016

Deplin (l-methylfolate) "I started Deplin 8 months ago. I thought it was helping but I didn't notice drastic effects. I stopped taking it for 2 weeks due to the cost and quickly realized it had been working. I started feeling lethargic and unmotivated. Since I have been taking it daily, I am much more active, energetic, less moody, and I am happier. I think it is a subtle change but over time it is drastic."

• Anonymous
• June 18, 2011

Deplin (l-methylfolate) "I have very bad treatment-resistant depression/anxiety. I was on Prozac for a year and it worked wonders until I had to keep going up in dose, and the side effects were just too bad. Since I have been put on Lexapro, Wellbutrin, Vyvanse, and Lamictal, none worked like the Prozac. Recently, my doctor put me back on Prozac, 20mg, and added 15mg Deplin. Prozac usually takes a month or longer to feel the effects, especially on a low dose. After two weeks, I felt good already with no side effects! In fact, my sex drive has actually increased. 20mg was never enough for me before, and with Deplin, it's perfect. I'm so happy."

• Ell...
• August 25, 2014

Deplin (l-methylfolate) "I was so very excited when I found out that I could be helped after being diagnosed with MTHFR. I was on Deplin 15mg a day. I actually felt fantastic after about 2 months of treatment. After about 8 months, I slowly started getting severe muscle pain and weakness, also extreme joint pain to where I could barely work or do the slightest activities. Doctors ran a ton of blood tests but found nothing. I recently stopped taking Deplin and have found that the issues have disappeared! I loved Deplin and am very sad I can't take it any longer! It also really helps with depression and mood!"

• JoR...
• September 16, 2016

Deplin (l-methylfolate) "First, I want to advise others that Deplin is an adjunct to your antidepressant, not an antidepressant. I am on day 4, and already feel more clarity, better mood, and more energy. I have Narcolepsy, untreated due to being allergic to meds for this condition. So, greater energy and more awake felt great. In addition, I have been battling severe Irritable Bowel Syndrome, Gastritis, and severe upper gastric pain for 10 months. Most days I have been unable to eat other than breakfast. The evening of my first day of Deplin greatly reduced my irritable bowel issues, and since then little to no pain. I had a ham and cheese sub yesterday. It is like a miracle. Good luck to those prescribed this medication."

• Anonymous
• April 28, 2011

Deplin (l-methylfolate) "I've been on Deplin for about a year, and it has helped me drastically. I was originally diagnosed with bipolar and later, through blood tests, found out my bipolar was related to a condition known as MTHFR. I am compound heterozygous, meaning I have one of each genetic markers which contributes to a multitude of diseases, including mental disorders and circulatory conditions because I do not metabolize folate/folic acid. I was on Lithium for 2 years (with horrible side effects on minimal doses), and since being on 30mg of Deplin plus 5000mcg Methyl B12, I've been taken off the Lithium completely and have normal mood changes."

• cra...
• Taken for 1 to 6 months
• October 25, 2017

Deplin (l-methylfolate) "Who turned the lights on?! Oh hey Deplin, it's you! This oddly classified medical food has been a welcomed step towards victory I've needed far too long, and I'm only taking the Rx for about a month. This is nothing like anything I've taken. I have Bipolar 1 & have had a slippery disaster with any and all antidepressants and have just glided along life with mood stabilizers and atypicals. I have energy, but I'm in no way jittery or hyper and I sleep like a baby. I have tons of focus & can work more effectively and efficiently, not many at a manic pace, just really focused. I found a part of myself I lost, self-esteem and confidence. When I say or act, I say it like I mean it & it's well presented. Don't hesitate to try it"

• Sta...
• August 8, 2015

Deplin (l-methylfolate) "I have been taking Paxil/Paroxetine for approx. 15 years. About 2 years ago, I mentioned to my psychiatrist that I had long been very sensitive to noise. I would get really upset (angry) by the sound of the doorbell, or even my young daughter's playfulness. My Dr. recommended Deplin as an additional 'medicine'. After a couple of weeks of taking Deplin, my sensitivity improved greatly. I did not feel any different, nor have any side effects. I stopped for a couple of weeks, thinking that it didn't really do anything, and I DID notice a big difference. Although it is expensive, I will continue to take my 15mg every day (along with my Paxil). It works! My husband agrees!"

• Anonymous
• Taken for 1 to 6 months
• December 17, 2012

Deplin (l-methylfolate) "I have had treatment-resistant depression for 20 years and have tried Zoloft, Prozac, Effexor, Paxil, Celexa, Wellbutrin, Lexapro, and Viibryd. Lexapro (20 mg) and Wellbutrin (300 mg XL) seem to work best but even with talk therapy, good diet, and exercise, I still have never achieved full remission. After my psych doctor retired, I switched to another who had me tested for MTHFR mutations and started me on 15mg of Deplin. Within 7 days, I felt better than I could ever remember - it was like a light switch! Test results showed I am homozygous for the C677T MTHFR mutation. I stopped taking Deplin after some agitation and anxiety started; I restarted on a lower dose before ramping up to 15 again. I have yet to see the same improvement after 3 weeks."

• Lee...
• July 28, 2017

Deplin (l-methylfolate) "My doctor gave me a grocery bag full of samples because she said it was expensive. I never took them. I am bipolar with also anxiety. Depression will get very low spontaneously but is much more controlled with my Seroquel and fluoxetine and Xanax if needed. I had an appointment recently and she reminded me that I need to take the Deplin as it augments my antidepressant! I didn't realize this so I made sure to take it. Now I don't remember the last time I felt this good and functional. She gave me another grocery bag of samples. Deplin absolutely is great for me."

• Gla...
• Taken for less than 1 month
• April 5, 2017

Deplin (l-methylfolate) "I was struggling with major depression and OCD and tried several antidepressants before my endocrine doctor found out I had the gene mutation. The first dose of Deplin, 15 mg, was too much for me and I felt edgy and anxious. I then tried the 7.5 dosage and honestly felt like myself for the first time in months. Clarity, energy, and focus! One side effect was headaches, and then I went online to MTHFR.net and learned I needed to supplement with a few things to feel better. This has been an answer to prayer for me. I am on 2.5 mg of Lexapro and hope to get off of it in the next 6 months. Wish someone would have told me about this sooner!!"

• Fre...
• February 8, 2014

"I have suffered with some depression but mostly anxiety for the past 15 years. I have taken Celexa and then Lexapro off and on (mainly on) for most of those years. While the Lexapro helps some, I still always had difficulty with my energy levels and with coping during really stressful situations. I was recently tested for MTHFR gene mutation, and was found to have the 1298c mutation, which can affect my brain's ability to utilize folate in order to make needed serotonin, dopamine, and norepinephrine. My doctor prescribed Deplin (L-methylfolate), and even though I had read many good reviews, I was still hesitant. I have to say it has been a miracle for me. It's like this dark cloud has been lifted, and my anxiety has completely disappeared."

• Rev...
• Taken for less than 1 month
• May 23, 2017

Deplin (l-methylfolate) "I have the gene deficiency, & 25% ability to make l-methylfolate myself. I have had poor results taking a variety of antidepressants over decades. Only drugs like Klonopin help my anxiety & depression. My doctor prescribed 15 mg Deplin, but I had itchy, red skin & stopped. After reading online that I might need to start at a lower dose, I obtained 7.5 mg, which I cut into 6 parts, & took about 1.25 mg per day for 4 days. Today I realized that over these days I have been feeling consistently more energetic, & do not feel as easily overwhelmed (less crying, less agitation). I'm taken by surprise that this might be working at even this low dose. I'm excited to increase the dose & add B vitamins. WOW, this could be my cure at last"

• Anonymous
• March 21, 2011

Deplin (l-methylfolate) "I have been on Deplin for six days and I am amazed with the change in my emotions and feelings. I take 7.5mg of Deplin and 60 mg of Prozac, and I am pleased with my increased defenses to deal with my daily life. I feel like myself again for the first time in 10 years. I hope Deplin will continue to provide me with the positive attitude that I am now feeling. I feel like a whole new person."

• Anonymous
• February 20, 2012

Deplin (l-methylfolate) "I was diagnosed with depression 11 years ago. I can't remember all of the antidepressants I've been on, but for the last 5 years I've been on Wellbutrin 450mg. My psychiatrist prescribed Mirtazapine for its energizing effects when on high doses. It didn't work for me; then he prescribed Deplin 15mg. I took it for 6 weeks. I could not tell a huge difference, so I didn't refill my prescription right away. (It's expensive since insurance won't cover it!) After I stopped, my energy/motivation decreased, so I started taking it again. I've been on it for about a week now and have seen an increase in my energy again, but the motivation is still not as high as it should be. Hopefully, it will get better the longer I'm on it."

• usa...
• June 11, 2016

"I have suffered from anxiety and depression for the better part of 60 years. Anxiety was normal for me until a friend told me about Deplin's L-methylfolate. She explained that severe anxiety could be from an inability to absorb folate. I asked my Dr for an Rx and he said it wouldn't hurt to try this, it was a medical food and not a drug. I was on Ativan, Prozac, Doxepin, and Trazodone and still had anxiety 24/7. Within one week of taking L-methylfolate, I had absolutely NO anxiety. It was so quiet in my soul that I almost felt anxiety about not having anxiety! It was foreign to me, the steady drip, drip, drip of adrenaline rushing through my system was shut off. Within six months I was off all other medications. This was a miracle for me."

• Hay...
• Taken for 1 to 6 months
• August 1, 2015

Deplin (l-methylfolate) "I started taking Deplin 2 months ago in addition to the 300 mg of Wellbutrin I had already been taking for several years. I was experiencing a very low level of chronic depression but generally okay. The doctor recommended I try Deplin to see whether it would increase my level of well-being. I could swear I feel a lot more depressed with the Deplin. Nothing has changed in terms of lifestyle over the past few months, so I can't think of any other explanation. Needless to say, I'm going to stop taking it. I had no idea it might worsen my symptoms."