L-methylfolate for Depression User Reviews (Page 3)

• Anonymous
• November 17, 2011

Deplin (l-methylfolate) "I have been on Deplin for over a year now. At first I was on 7.5 mg and that was helpful but when that stopped working the Psych doctor increased the dosage up to 15 mg and it really works. What it does is helps your other antidepressants work better. Deplin will affect each person differently depending on which antidepressant you are taking."

• KQano
• Taken for 1 to 6 months
• May 5, 2021

Deplin (l-methylfolate) "My child has been on antidepressants for three years. I read about MTHFR gene mutations and felt this might be the case with my daughter. Her psychiatrist recommended a trial of Deplin rather than testing since Deplin would be the treatment. The results are nothing short of amazing. I have my daughter back!"

• Anonymous
• April 30, 2011

Deplin (l-methylfolate) "I just took my second dose of Deplin. I love the fact that there are no side effects. I went all through the day without getting so angry at someone I would get an anxiety attack. It's a start and I'm hoping I can return to my normal self. Wish me luck."

• just...
• March 26, 2014

Deplin (l-methylfolate) "I thought I would share my experience as it may be helpful to others. I have been on this for over 2 years now... and depression wise (which is what I'm basing my rating off of because that is what this rating is supposed to pertain to) it hasn't done anything for me at all. At least nothing at all that I have ever noticed. I have stayed on the medication because of the fact IT DOES help bring down my homosistine levels. I have a condition referred to as MTHFR. Basically it's a liver enzyme condition that makes it so the body doesn't convert proteins/peptides very well. Common condition (1/10 americans) but rarely tested for. The lab had to look up what to do for drawing blood and testing for it."

• whizb...
• Taken for less than 1 month
• July 8, 2013

Deplin (l-methylfolate) "I have been taking Deplin for 18 days and I do notice a slight change in my depression/brain fog and energy levels. I think it is being inhibited by my Adderall withdrawal but am hoping it is helpful since I've tried many medications and nothing has really helped."

• Ravioli
• Taken for less than 1 month
• January 5, 2020

"After 40 years of SSRIs & counseling failing, I felt hopeless. Many days were torture. I tired too easily, felt sad, hopeless, unmotivated & anxious more than I should have most of my life. Finally I took l methyl folate at 15 mg and got an immediate rash. Then, based on internet info, I took 1mg. I noticed an immediate reduction in sadness, improved energy and interest...but by day 4 I had an unbelievable panic attack with dry heaving and misery. Thankfully, I knew to take niacin and, within the hour, I was normal. This happened 4 times and I had had enough. But I was beyond despair, so I tried it again at between 0.25 and 0.5 mg and added a small amount of niacin (and will add methyl b12 because I think the problem occurred because I’m building up nitrous oxide). This tiny amount, taken carefully, has completely made me normal. NOTHING else did. I have the MTHFR gene mutation, severe form. To me, it’s like a miracle for which I waited too long."

• Jenni...
• Taken for less than 1 month
• August 4, 2014

Deplin (l-methylfolate) "Added Deplin 15mg to 150 mg dose of Wellbutrin when the Wellbutrin no longer worked as well. It did help for a few days but then I developed severe muscle weakness, stiffness and pain particularly in my neck and shoulders. Bad enough that I could not turn my head or look up or down without great discomfort. Kind of felt like I had whiplash. I did some research and found that the muscle pain can be a side effect of both medications. I have not ever had this problem on Wellbutrin alone, so I'm inclined to think the Deplin caused this. I quit taking both medications because I couldn't function with the pain and stiffness any longer and 2 days later the pain is still there but is slowly subsiding."

• chris...
• April 18, 2010

Deplin (l-methylfolate) "I hope this helps to all the depressed people out there. I have been seeing a psychiatrist for drug induced depression. I abused meth, Vicodin, coke, and any other drug you can think of for years and that has left me a basket case. I have tried many antidepressants but I suffer too many adverse reactions for the stronger stuff. I am currently on 300mg Wellbutrin and 15 mg Deplin and I have to say I feel GREAT! However I had taken Wellbutrin/Deplin combo in the past and it stopped working for me after 6 months. The results with the antidepressants were a little funny because I went back to abusing Vicodin. Now I am clean of any drugs and just taking what is prescribed by my doctor. 300mg Wellbutrin and 15 mg Deplin. "

• Lskmjk
• Taken for less than 1 month
• July 10, 2016

Deplin (l-methylfolate) "Terrible! I was on it 3 days while also on Viibryd and it caused me SEVERE anxiety. I was found to have a compound heterozygous gene mutation and the psychiatrist thought this should help. Wrong. I also found out through the gene test I cannot take SSRI's. Viibryd is a hydrid SSRI. The combination was bad news for me and I had to stop the AD cold turkey bc the blast of Deplin apparently caused me serotonin overload. Still struggling 4 weeks later. From what I've researched, l-methyl folate should be started at SMALL doses, like 400mg, NOT 15mg (Deplin).... Lord!"

• ladyk...
• May 2, 2014

"Wow. Where to even start. I've been on several cocktails of antidepressants from ago 13-28. Finally, my doctor prescribed Methylfolate in conjuction with Celexa. Within 10 days, I felt more alive, motivated, energetic, and at peace then I had EVER felt in my life. Absolutely a miracle. If you have given up on the endless trial and error, please, please give this a chance."

• jerry...
• Taken for 1 to 6 months
• July 12, 2019

Deplin (l-methylfolate) "Have taken Paxil for years, had a poop out with the Paxil so the doctor added Deplin 15 MG, that did not work had lots of confusion out of touch feelings. I cut the Deplin back to 7.5 MG and in three days it is doing the same thing as the 15 MG. I would assume if you had a folic deficiency it would work. However, I must have enough and this just overloads my system. Not for me cannot get off of it fast enough."

• sprytle
• December 15, 2010

Deplin (l-methylfolate) "I started taking Deplin yesterday and recently tapered myself off of Cymbalta and Wellbutrin. I still have the Cymbalta withdrawal "brain zaps" but have regained my crying reflex that I lose everytime I get back on medication. I have been pregnant several times and needed to come off all medications for the duration. Today I had more natural energy than I've had in a long time. I had been taking Hydroxycut just to get myself moving and to the gym as I had reached my maximum weight of 188 last week. Now I don't feel like I need it anymore. My OCD is almost non-existent now. I can complete multiple tasks without spending an eternity detailing every aspect of a small task. This is how I feel after day 2, hopeful this will continue."

• skytrex
• Taken for less than 1 month
• June 5, 2017

Deplin (l-methylfolate) "Like many others I took the Genomind test which told me that SSRI's were not optimal and that SNRI's were a better choice. After 16 years and 20 different meds, I have had MUCH better success with SSRI's than SNRI's. The test results also said that I was deficient in what Deplin could provide. I have been taking 15mg of Deplin for almost 3 weeks now and have been experiencing some of the lowest depression that I have ever felt. Today I woke up feeling just as miserable as I have been for the past 3 weeks so I decided not to take Deplin. As I slumped through he morning I started to feel a wave of happiness and excitement for life come over me around 10:30am and I still feel great. I feel like "my" normal self again. $60 wasted!"

• Seeking
• September 4, 2018

Deplin (l-methylfolate) "Update to my previous post: I've now been taking Deplin for close to a year. It serves as an add on to my anti depressant meds. It hasn't been a magical booster to improve my severe, resistant depression as well as my horrible anxiety. However, over a year's time, Deplin has helped me feel just enough better to justify its cost. A very subtle improvement that is difficult to describe. I'm glad that I stuck with it; not at all noticeable until at least 9 or 10 months. And that time frame ( for subtle change ) isn't acceptable if you are miserable. But, I was improving just enough with my other meds to allow me to continue taking Deplin--just in case it began making a difference ....whenever? Plus, my dr. told me it was good for my overall health, regardless if it touched the depression. This made it easier for me to continue taking it despite feeling no benefit for a long time."

• Hello...
• Taken for 5 to 10 years
• July 10, 2019

"I had been prescribed this by the same psychiatrist who gave me Wellbutrin. It was originally covered by my drug plan and I wasn't sure it was working. But then my plan stopped covering it (because they said it was a "vitamin" and I ran out. That's when I found the fog of depression setting in deeply. Deplin is ridiculously overpriced for what it is, and many other manufacturers make l-methylfolate equivalents. I have switched to one of those. I use 15mg tablets and cut them in half, so a bottle lasts for 180 days. This is much cheaper than Deplin (the generic costs about 40 cents a day. Deplin without prescription plan is about 4 dollars a day.) Honestly, I think the methylfolate helps me, and the generic is affordable and it works!"

• Former...
• Taken for less than 1 month
• July 11, 2016

"Normally I only peruse these listings, but this time I thought I owed it to all my fellow readers to give a detailed review. I began taking 10mg methyfolate around 10 days ago at the urging of my father, who, for obvious reasons, shares a very similar genetic predisposition toward depression and anxiety. The results? All I can say is wow. Within 1 day, I felt like my internal motor that had been idling along at a 5 out of 10 had been turned up to a 10 for the first time in a long time. I had more energy, clearer thoughts, happier disposition, appetite and libido returned full force. My only regret is not trying this stuff sooner. If it feels like nothing has ever really solved the problem before, please try this. It's a miracle."

• Male...
• Taken for 1 to 2 years
• February 15, 2015

"Depression sufferer my whole life. On Deplin for last year and my lows vanished within first week on 15mg/day. It's all I'm taking and the benefit is absolutely profound. Zero side effects. Most psychiatrists downplay the lack of studies but it definitely works for me better than anything else I've tried. Good luck."

• Zarat...
• Taken for less than 1 month
• March 1, 2018

Deplin (l-methylfolate) "I had the swab genetic test done. I lack the MFTHR gene that creates the enzyme that breaks down folic acid to folate. Without folate depression is very likely. My DR prescribed Deplin as it would take 60 bottles of over the counter folate to equate to the convenient orange capsule. The first three weeks my depression and anxiety got worse. My doctor wasn't helpful but I kept taking it. I’m around week 5 and I am able to see my compulsive eating as not good for me as I am morbidly obese. I don't feel overly happy but more in control in a chaotic World and able to focus more. I'll chat to my doctor about getting off Lamictal once I've had a couple months on Deplin. I am far less paranoid and explosive but I have routine scary dreams being out of control. I can't put my finger on it but I think I am better off with Deplin and apprehensive to go off it. This is not the placebo effect talking. I think I can lose weight and get off the bipolar meds. I pay $160 for three months supply."

• Anxio...
• Taken for 1 to 6 months
• October 12, 2018

"L-methylfolate is a great. I spent the last 3 years with increasingly crippling anxiety and it was starting to limit my ability to work and live. At the point of attempting anti-depressants. Luckily I came across an article for an l-methylfolate product. Given it's just processed folate and B12, I gave it a try, because the side effects are so limited. WOW. AMAZING. Within a week (15mg per day) I had my life back. I still get anxious but it's like all of a sudden it's not so bad. I can laugh, smile and be happy. I'm a better husband and father. Anyone who is struggling with thoughts of low self worth, anxiety or depression, it is worth considering trialling this drug. I wouldn't say that if the side effects weren't so limited: it's just folate after all!"

• CK1210
• May 26, 2016

Deplin (l-methylfolate) "I have been on Deplin 15mg for about 3.5 months. I have the mutation and was hopeful that this would help. I noticed no change whatsoever in my anxiety or depression. I also started having severe joint pain and nothing had changed but adding Deplin. My doctor recommended that I stop the Deplin. I have been off for 3 days and continue to have joint pain. Would love to hear from others with a similar experience."

• Goodue
• November 11, 2016

Deplin (l-methylfolate) "I've gone through deepshit, to the wall depression - had ECT et al while on meds. Went off and have NOOOO regrets b/c I finally started having feelings again (after 25 years on meds).... But I went through deep retaliation at work for speaking out against a bully, and the PTSD from that became deeply real only after two lawsuits were settled and every state/federal complaint was successfully settled. I won... but the PTSD won even more. And ya think you can find a shrink who looks at alternatives to antidepressants? HA! My only salvation came in the form of my doctor, an internist, who suggested I go to ER b/c of thyroid stuff. While 5 days on a med/surg unit was not free from shit... I got connected with a shrink who prescribed THIS."

• Elsie...
• February 24, 2012

"I have suffered from depression for about 30 years.. crippling depression with anxiety since 1992. I am 62. I have taken nearly every antidepressant and none really worked. I read this forum about four months ago and decided to order 5-MTHF,10 mg. After about three weeks, I realized I was coming up from the deep depression. I was taking 20 mg of Lexapro and cut that down to 10 mg a day. I am excited that this might be what I need but will wait a while before foregoing with the Lexapro because I'm not ready to enter that deep depression if this doesn't work by itself. I am so excited even if I do have to continue the Lexapro. To feel like getting out of bed, doing normal things and feeling good is great. I will post updates."

• Jon...
• Taken for less than 1 month
• May 14, 2019

"I have been struggling with depression and anxiety for 4 years. I used trintellix helped me a lot with memory and anxiety but I was extremely flat for emotions, I then started modafinil and got a huge improvement. Then I was changed to methylphenidate 20 mg ER and the trintellix was reduced to 10 mg. I was using B Vit combo includes methyl folate and methylcobalamine, I suspected it make me anxious but one of my friend told me that it gives extreme energy on high dose so I started 10 mg Methylfolate on first day I was so happy in the morning in the afternoon I was extremely angry yet felt powerful. A friend recommended that I should use niacin with it, so I added 500 mg niacin. Now I cry when listen music or reading what I like. It gives huge boost to methylphenidate, also anger went away when I added niacin I feel emotions so deep and cry with happiness. I am not hyperactive anymore but I have high energy levels, I can go work, then the gym after meet with friends and slept like a baby. I hope this will not change in time."

• JDmom...
• Taken for 1 to 6 months
• January 12, 2015

"After YEARS of depression & anxiety I'd been on countless combinations of medicines. The past few years severe health problems (open heart surgery @ 37 and a bowel resection @ 39 over 200 days in hospital) have contributed to the lowest lows of my life. I've spent the vast majority of the past two years in pajamas. EVERYTHING felt overwhelming. Living a normal life again seemed impossible. I had absolutely NO energy & believed I'd feel tired forever which made me sad all the time. After adding Deplin to the Celexa I've been taking for years, I am amazed by the results. It's been like flipping a switch in my brain. The darkness has been flooded with light. I have the motivation to live life again. Deplin is nothing short of a miracle!"

• stgecko
• Taken for less than 1 month
• February 4, 2015

Deplin (l-methylfolate) "I've been using antidepressants for quite a few years now. I seem to have gone through the entire list of antidepressants. My latest script is Escitalopram Tabs, 10mg. We recently added Abilify and this Deplin Caps, 15mg. I've been feeling a bit better. One of these two give me an awful case of Heartburn! Painful it is. I'll mention it during my next appointment. Now, as before, I can't watch anything with intense emotions as I'll breakdown and start crying. At age 52 I find it a bit annoying. Before I added these last two medicines I found myself crying more frequent than not. The movie "UP" really freaked me out. Anyway I'm disabled with intractable pain. That's what started all the depression stuff."