Inclisiran and Joint Pain: What Users Say

• Sue...
• Taken for 1 to 6 months
• May 17, 2023

Inclisiran for High Cholesterol, Familial Heterozygous "I have had my first and second doses of Leqvio, and unfortunately, I am having a lot of muscle and joint pain - primarily in my back, neck, and shoulders. It is quite similar to the pain I was having from taking statins, so not sure why that is. It has definitely improved my cholesterol numbers, which is a plus."

• Nai...
• Taken for 1 to 6 months
• June 7, 2023

For High Cholesterol, Familial Heterozygous "I am experiencing severe muscle and joint pain, nausea, headache, sweating, palmar erythema, hives, the soles of my feet are burning hot, painful urination, and abdominal pain! Inclisiran damaged my liver! Are the side effects ever gonna go away? I was stupid to agree to have this poison. I'm really scared."

• Jay...
• Taken for 1 to 6 months
• September 5, 2024

Inclisiran for High Cholesterol "Painful joints when moving around after sitting. Troublesome cough. Feeling nauseous frequently, especially in the morning before breakfast. Night cramps every night disturbing sleep, and therefore causing tiredness the next day. Extreme fatigue during the day needing an afternoon nap."

• Joo...
• Taken for 1 to 6 months
• February 28, 2025

For High Cholesterol "Had first injection of inclisiran September 2024. Twelve hours later, suffered stomach cramps, had to sit on the toilet for two hours! Felt bloated and sick, could not eat, loose stools. This lasted five weeks. Digestive system has not been right since. Have craved sugary foods. Now have joint pain in knees, hands, and feet. Severe pain that left me doubled up, now diagnosed with gallstones. It did lower LDL by half, but the side effects are too much. Still not right and coming up to six months after injection. Consultant kept telling me there are no side effects! Glad I am not making it up as has been implied. There has to be quality to life, not just quantity."

• MJ ...
• Taken for less than 1 month
• February 6, 2025

Inclisiran for High Cholesterol "The drug does work to lower LDL, but for me, the side effects aren’t worth the risk. I experienced the following: The injection pain lasted 20 min, but very painful! Severe shoulder pain 2 days after injection, lasted 2 days. Some joint pain, slight, but irritating cough ever since the first week. I had a very, very painful blood clot in my leg that lasted 2 weeks. My eyes became somewhat red, like they were bleeding. It was scary. The biggest factor for me was a big jump in my glucose fasting level. I knew this because I had blood work a week before the injection. I had blood work again 2 weeks after the shot. I’m not going to continue taking the drug. I’m eating clean, and I’ll take my chances. I don’t want to exchange one problem for numerous others."

• cel...
• Taken for 1 to 2 years
• January 27, 2024

For High Cholesterol, Familial Heterozygous "I've had 3 injections, last one early December. Straight away, it floored me: headache, blurred vision, feeling weak all the time, muscle and joint pain, can't walk far, so much pain in hips, shivers, like I had influenza all the time. Quality of life-I was an energetic person. I had this injection. On a positive side, reduced cholesterol level in half. I'm due for another injection in June 24, not having it. My life has changed so much. I'll take my chances in exchange for the quality of life to return to what it was!"

• Sou...
• Taken for less than 1 month
• June 4, 2024

Inclisiran for High Cholesterol, Familial Heterozygous "This is in regards to side effects of Leqvio. Had the first injection about five days ago. No pain or redness at the injection site. A bit of soreness at the injection site for about 24 hours. A lethargic feeling off and on since the injection. A small amount of muscle or joint pain in the first 72 hours after the injection. No diarrhea as yet. Slightly loose BMs. No fever. Have experienced periods of being 'light-headed', i.e. feeling faint. Have not communicated this to my physician yet. Will do so later this week. I am hopeful this injectable medication will lower my LDL and thus, my total cholesterol number."

• Sta...
• Taken for 6 months to 1 year
• March 14, 2024

Inclisiran for High Cholesterol, Familial Heterozygous "I could not take statins without side effects. Sore muscles, aching joints. I was crying at night, could not sleep. After using Leqvio for 2 doses, I don't even need to take any statins. I also changed the way I eat."

• rog...
• Taken for 6 months to 1 year
• May 19, 2024

Inclisiran for High Cholesterol "Not sure if this is related to Leqvio or not, however, since beginning the Leqvio regimen I have experienced an increased level of muscle and joint pain and reduced mobility."

• Jay...
• Taken for 1 to 6 months
• September 5, 2024

Inclisiran for High Cholesterol "Painful joints when moving around after sitting. Troublesome cough. Feeling nauseous frequently, especially in the morning before breakfast."