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Hyaluronidase and Dry Eyes: What Users Say

Brand names: Hylenex, Vitrase, Amphadase, Hydase

Dry eyes: mentioned by 8 users (10.7%)

Based on user experiences from 75 Hyaluronidase reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

burning 18.7%
skin issues 12.0%
dry eyes 10.7%
pain 9.3%
swelling 8.0%
nerve damage 6.7%
blurred vision 5.3%
bruising 5.3%
tight skin 5.3%
hair loss 4.0%

Reviews for Hyaluronidase

Commonly mentioned side effects
  • Ano...
  • Taken for less than 1 month
  • June 11, 2021

For Dissolution of Dermal Filler "I had Hyaluronidase injections used on my face to dissolve filler, and it has caused nerve damage, pain, and burning sensation. I experienced dry eyes, blurred vision, and it damaged my skin permanently. I have experienced volume loss, skin laxity, sunken eyes, changes in skin texture, and pain in the left side of my jaw. I am unable to open my mouth properly because my jaw clicks and locks. I had the injection over a year ago, never had any of these problems before, and it is still ongoing. It was an awful experience."

1 / 10
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136 Report
  • PAE...
  • November 5, 2021

Hyaluronidase "I was told by my doctors that it would not spread and it does not damage tissue. It did both. From injections around my mouth to my eyes, scalp, hands, feet... I was scared for my vision at one point. Six months out and this has been a living nightmare. I can’t believe the FDA is allowing this to happen to so many women. Most may not relate it to the dissolver... like joint problems, dry eye, etc. Manufacturers should have a warning label like Botox."

1 / 10
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32 Report
  • RBK...
  • Taken for 1 to 6 months
  • August 1, 2022

For Dissolution of Dermal Filler "If your doctor tells you it's safe, run! I thought I could take a risk, that it's used all the time. I saw these reviews, but my doctor promised he's never seen any side effects. These past two months have been hell. I've had face burning, head burning, eye burning, dry eye, fatigue, terrible eye bags, volume loss, saggy skin. I don't recognize myself anymore. I am getting tested for nerve damage this week. If things don't get better, I don't know how I can live like this."

1 / 10
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19 Report

Frequently asked questions

  • Sad...
  • Taken for less than 1 month
  • August 22, 2022

For Dissolution of Dermal Filler "I really got lied to right to my face and asked repeatedly if it could hurt my eyes. I specifically asked because they shoot it with a cannula right towards your eyes to remove eye filler. Then later talked down to by another nurse injector. Vitrase ruined my eyes and stole my vision. It's left me with constant eye itching, and I cannot wear makeup. Dry eye and corneal inflammation. Skin inflammation that doesn't stop. I am so sad. They didn't tell me anything like this could even happen. That it was safe for the eyes, well it isn't, I have read lots of articles about the damage it can do to the cornea. Not to mention what it's done to my face and self-confidence. And now I cannot even see, even with glasses. It is not even FDA approved for this use. It's also cost me more money than I can say because of all the medications and doctors to try and fix my eyes."

1 / 10
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13 Report
  • Eve...
  • Taken for 1 to 2 years
  • June 27, 2022

For Dissolution of Dermal Filler "I experienced a nightmare from hyaluronidase. A year ago, I had hyaluronidase in my face to reduce fillers. After that, I felt a burning sensation and terrible nerve pain. Dry eyes, nose, mouth, tachycardia, etc. It's been a year, and I'm still suffering from pain, especially dryness in the mucous membranes. Right now, I can see dots and lines and blurry. Please don't use hyaluronidase, even if the doctors say it has no side effects. I used to be healthy and never had any problems."

1 / 10
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10 Report

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  • Ano...
  • Taken for 10 years or more
  • August 21, 2022

For Dissolution of Dermal Filler "Vile, vile, vile drug. I’m not sure it’s even legal to use! Destroyed my face and my immune system! My skin just melted after the doctor used this! My skin suffered huge indentations, sunken eyes, dry eyes, and saggy skin. My natural elasticity just disappeared over a few weeks. This injection is awful! And it seems to cause much longer-term issues. I had this injected about 10 years ago and there is still no research into the long-term side effects, because those injecting it are making too much profit, so sadly don’t want to invest in the impact of those suffering!"

1 / 10
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9 Report
  • HA ...
  • Taken for 1 to 6 months
  • December 20, 2022

For Dissolution of Dermal Filler "The so-called surgeon used more than 1,000 IU in one session to dissolve the remaining filler in lips and nose, which caused immediate and visible change in the appearance of fat on the face. One day after, my face looked saggy and as if I would’ve lost weight overnight. After one week, I looked terrible, my eyes started sinking, all the fat in my left cheek disappeared, I developed under-eye bags and folds in my upper eyelids, and also fine lines around my eyes appeared. It’s been one month, and I don’t see any improvement. To the contrary, I am worried because now my eyes look even more sunken, and they are dry. Fine lines under my eyes look each day worse. Stay away from this product."

1 / 10
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6 Report
  • Wor...
  • Taken for less than 1 month
  • August 21, 2022

For Dissolution of Dermal Filler "I had my cheeks dissolved 4 days ago, and so far, so good. I am not experiencing anything that has been described above. No burning, no dry eyes, no overly aggressive volume loss or dents. I feel the dissolver did what it was supposed to do. I had a large amount of Juvéderm Voluma in my cheeks for over 2 years that had started to harden and look very odd when I smiled. Getting them dissolved was the best thing I have done. I look like myself again. It was done by a board-certified PS, 75 units in each cheek diluted with lidocaine. I’m very happy with the results."

10 / 10
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7 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.