Hyaluronidase Side Effects

Medically reviewed by Drugs.com. Last updated on Apr 2, 2025.

Applies to hyaluronidase: solution.

Common side effects of hyaluronidase

Some side effects of hyaluronidase may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

• bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site

Serious side effects of hyaluronidase

Along with its needed effects, hyaluronidase may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking hyaluronidase:

Rare side effects

• cough
• difficulty swallowing
• dizziness
• fast heartbeat
• hives or welts
• itching
• large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• redness of the skin
• skin rash
• tightness in the chest
• unusual tiredness or weakness

Get emergency help immediately if any of the following symptoms of overdose occur while taking hyaluronidase:

Symptoms of overdose

• blurred vision
• chills
• confusion
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• fast, pounding, or irregular heartbeat or pulse
• nausea or vomiting
• redness of the skin
• sweating
• swelling
• unusual tiredness or weakness
• unusually warm skin

For healthcare professionals

Applies to hyaluronidase: injectable powder for injection, injectable solution.

Hypersensitivity adverse events

• Rare (less than 0.1%): Allergic reactions (e.g. urticaria, angioedema), anaphylactic-like reactions following retrobulbar block or intravenous injection^[Ref]

Local

• Postmarketing reports: Local injection site reactions^[Ref]

Other

• Postmarketing reports: Enhancement of adverse events of co-administered drugs; edema (reported most frequently in association with hypodermoclysis)^[Ref]

Frequently asked questions

• Do Herceptin (trastuzumab) injections hurt?

Further information

Hyaluronidase side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer