Esomeprazole and Nausea: What Users Say

• RJN...
• Taken for less than 1 month
• December 17, 2019

Nexium (esomeprazole) for GERD "I developed terrible GERD and acid reflux where I had chest pressure and the feeling of a giant golf ball stuck in my throat. I was started on Omeprazole for about a week with no improvement. I was sleeping almost sitting down because laying down made the chest pressure so much worse. I was switched to Nexium 40 mg, which I took for 2 weeks. I had terrible nausea, diarrhea, sweating, and anxiety every day. I also developed a fear of suicidal ideations. Fear of dying and fear that something would make me jump from my balcony. I had to lock all my sliding doors and I currently moved to my mom's house. I also had moments where my mind would not stop racing and I would be in a daze. Everyone was talking around me and I would not be present. I stopped the Nexium for 1 day already. The nausea has stopped and so has the diarrhea. I also have not had any dazed our moments today and my thoughts of dying were much less today. I also developed crazy depression."

• Bil...
• Taken for 1 to 6 months
• June 8, 2019

Nexium (esomeprazole) for GERD "This drug is dangerous. I was given an 8-month prescription for acid reflux. At first, I didn't notice any bad side effects, but after about 3 months, things have really deteriorated. At first, I thought I was tired from pushing myself hard with my work and workout routine. But then I started feeling nauseous, and it persisted for three days. Then, I began having severe joint pains to the point where I could hardly walk. Also, feelings of panic, insomnia, and blood when I go to the toilet. But the worst has been MY HAIR FALLING OUT!!! I thought I was imagining it at first, but now my whole head has gone flaky/scabbing, and I've lost about a third of my hair. I'm going straight to my doctor on Monday for a blood test. Currently, I'm bedridden. Stay well away from this medication, it's not worth the risks."

• jay...
• Taken for 1 to 6 months
• December 30, 2020

Nexium (esomeprazole) for GERD "I bought Nexium after the Zantac warning. It helped with reflux but caused constipation fairly quickly. Next, I noticed dizziness, then feelings of nausea, followed by extreme tiredness during the day but insomnia, causing me to wake in the early hours and be unable to fall asleep again. I became extremely depressed and lost interest in everything. The final straw was noticing that my legs have started to swell and feel tight, and my feet are tingling and uncomfortable when I want to relax. The first few symptoms I could live with, but the swelling and twitching of my feet and legs is not acceptable, neither is the aching I am experiencing. I am concerned about this to the extent I will be contacting my doctor. I will not be taking any more Nexium, I will try to control acid with diet from now on."

• Kay...
• Taken for less than 1 month
• April 18, 2019

Nexium (esomeprazole) for GERD "I took one Nexium and had some frightening neurological or central nervous system response. I was trembling uncontrollably, broke out in a cold sweat, was weak, and nauseous. It terrified me! The only other time I have had a reaction like this was to a flu shot. I will never take either again!"

• MEa...
• Taken for 1 to 6 months
• January 15, 2020

Nexium (esomeprazole) for GERD "I had been taking this medication, Nexium, for 4 months. I didn’t realize it at first, but it slowly sucked away my energy. Near the end of the 4 months, I began to feel nauseous and dizzy, with pain in my back. I had labs done and am borderline anemic, low potassium, and kidney function is no longer optimal. I stopped the drug immediately and started to feel better-aside from the return of my gastritis. Three days ago, I began taking it again: same symptoms, except this time with diarrhea, too. Make sure your vitamins and electrolytes are measured before and during use of this drug! It has been awful for me."

• Ash...
• January 18, 2016

Nexium (esomeprazole) for GERD "I have never in my life felt so horrible than what I do now. I have taken this med for 4 days. I have been nauseous every day, diarrhea, and my stomach hurts, gas, etc. I cannot believe this med would make me feel this way when it is supposed to help. Maybe some people do well on it, but I cannot do this anymore. I feel worse than what I did when I started it. I will just go back to taking my generic Famotidine every day. It works and works right away. I do not even care at this point that Famotidine does not heal, it just masks the symptoms. I do not care! I just know no more Nexium for me. It can all burn!! Like the feeling I have in my stomach right now from taking it. Thanks for letting me give my honest review. G'Day"

• Hor...
• Taken for 1 to 6 months
• November 16, 2021

Nexium (esomeprazole) for GERD "I have been taking this medication for the past 4 months, 20 mg but recently up to 40 mg. I wanted to stop taking it a while ago as I felt it wasn’t working, but the specialist insists on taking it. Since taking 40 mg, I have felt so nauseous, have headaches, and feel so dizzy. Since reading these reviews, I have only just put 2 and 2 together. This drug is the cause of all the weird symptoms I’ve been experiencing for the past few months. I’ve had multiple doctor visits due to having bad palpitations, chest tightness, and breathlessness very regularly for the past few months. Had heart ultrasound and multiple ECGs, doctors have said my heart is fine and it’s my anxiety, yet it has nothing to do with my anxiety. This is the best I have ever felt mentally. These symptoms just hit me randomly. Before this drug, I didn’t feel like this. It’s truly scary thinking about all the symptoms these drugs cause and doctors insist it’s fine. I’m going to stop taking this ASAP. NEVER AGAIN!"

• Bil...
• Taken for less than 1 month
• December 29, 2019

Nexium (esomeprazole) for GERD "So I got acid reflux to the point where it woke me up at night. I got the pills Nexium to help. It helped for two days before I noticed I was constipated and extremely gassy, making it feel like I was passing a kidney stone or had a hernia while it was just the gas build-up in my body. The next day, it felt so much worse, and I also got pukey, to the point where I couldn't sleep and just wanted to purge my body of Nexium."

• Tam...
• Taken for less than 1 month
• September 5, 2022

Nexium (esomeprazole) for GERD "I only got prescribed Nexium yesterday due to intense chest pressure/heartburn caused by the bacteria H. pylori. I took 2 doses at the hospital, one when I got home and one when I woke up as instructed by the doctor. The side effects are scary. I can’t get out of bed. I have zero energy. I keep throwing up. I have insane chills, I am either freezing or hot. And the worst of them all…ANXIETY. I can’t even catch my breath. This is the worst I’ve almost ever felt. I called the doctor, and he said it’s possible that the pill is doing this and to take Omerpradex instead. I hope this feeling will go away fast because I have never felt so ill before!!!"

• Bat...
• Taken for less than 1 month
• November 12, 2019

Nexium (esomeprazole) for GERD "After a couple of hours of taking Nexium, I began to feel nauseous, another hour or so later, I vomited. Then the diarrhea started. Watery and urgent, I couldn't leave the house. I have tried this medicine several times, and every time I have had the same reaction. It is the worst medicine I have ever been prescribed, and I am going to destroy the ones I have left. The dosage I was prescribed was 40 mg, and this may well be too much, but I will not try to take it again."

• Ber...
• Taken for 5 to 10 years
• January 8, 2020

Nexium (esomeprazole) for GERD "I started taking Nexium in my teens (20 years ago) for persistent acid reflux. At the time, it relieved the nausea I was experiencing, and I used it on and off for about 7 years before stopping completely. One thing I did suffer with during those 7 years was chronic diarrhea, which at the time was diagnosed as IBS. After I stopped Nexium completely, the pattern of chronic diarrhea went away. That is until this past year when I was re-prescribed Nexium to deal with heartburn. When it works, Nexium is great, and I have no problem tolerating the side effects to gain what relief I can from reflux. However, I've noticed this time around it's working very slowly to alleviate my heartburn pain, if it alleviates it at all, and it's made dealing with any side effects increasingly frustrating."

• hpy...
• December 1, 2009

Nexium (esomeprazole) for Helicobacter Pylori Infection "Being on this medicine for the first 5 days was hard, felt sicker than ever with symptoms of mild diarrhea, some hives, worst nausea, fatigue. This started to improve day 6. After being on it for a week, am almost back to normal. Felt like the drugs had to work on the H. Pylori, then the body had to work on getting the drug out of the body."

• Ger...
• Taken for less than 1 month
• July 10, 2021

Nexium (esomeprazole) for GERD "I took this 20 mg twice a day as recommended by my doctor, and within 4 days I had palpitations, insomnia, extreme anxiety, dizziness, nausea, and pins and needles in my neck and legs. Worse was at night when trying to lie down, when there would be pressure in my head and chest, and violent dizziness and nausea. I had two weeks of only sleeping 2 hours a night and peaked with 2 successive nights of no sleep and a visit to Accident & Emergency. Suddenly realized it was the tablets and stopped them, effects slowly going and sleeping at last."

• GER...
• May 20, 2011

Nexium (esomeprazole) for NSAID-Induced Gastric Ulcer "It helps so much. Before this, my life was miserable with the morning nausea, then vomiting tons of acid straight from the stomach. It is not a way to live. We need to be grateful we have resources such as Nexium and other options to help and to treat these conditions. I know for sure in my case!"

• Bom...
• July 27, 2021

Nexium (esomeprazole) for GERD "I've been on over-the-counter Nexium 20 mg for 6 daily doses, as I hadn't been able to pick up my omeprazole prescription. My God, I thought I was dying! Massive panic attack yesterday, nausea, dizziness, and early morning insomnia, followed by crazy thoughts, diarrhea, and eye twitches. I still have waves of nausea, had no idea what it was until I visited these shared experiences. I'm off it now, and this review site has settled my nerves! This stuff is utterly toxic! Steer clear! Thank you all."

• Tja...
• Taken for less than 1 month
• October 7, 2019

Nexium (esomeprazole) for GERD "I had been taking Somac (brand of pantoprazole) for a possible ulcer. Then a pharmacist suggested Nexium. Within hours, I had bad nausea. The next day, I read it causes bad nausea. I went back to the pharmacy, and the chemist confirmed nausea and sweating. I had both, so no more for me."

• Ril...
• Taken for 1 to 6 months
• June 16, 2024

For Gastritis/Duodenitis "I had suspected gastritis after a stomach bug, with burning under my rib cage. The gastritis itself was causing me to feel shaky, and I had one episode of pounding heart and probably something of a panic attack. This happened right after diarrhea and me taking Pepto-Bismol. So, the doctor put me on esomeprazole 40 mg, and it quickly addressed the acid burning, and I do think it's helped me heal. However, I'm currently tapering off this after six weeks of use because I've been getting the anxious, lightheaded, dizzy nausea feelings described by others and they're getting to me. I've not yet had the rebound acid, hopefully, I won't. I just take a couple of Tums here and there. I'm just hoping and praying the dizzy, pre-fainting feelings go away soon. God bless all of you, take care of your guts!"

• Gin...
• Taken for less than 1 month
• September 28, 2021

Nexium (esomeprazole) for GERD "My cardiologist noticed that I had a cough and thought it might be acid reflux. I filled the script that day (40 mg). The next day my gut was tender, I was lightheaded, had diarrhea. Three days in, the pain was worse, my migraines had become daily and acutely painful, nausea persisted, I was flatulent, and even that caused severe gut pain. I felt nausea but thought it was a migraine-related problem. I reasoned all my symptoms could not have been from 10 capsules that were supposed to help my cough. After I looked online, I stopped the pills, thinking that would be the end of my pain, but six days later I am still dealing with some side effects, and the pain is just now easing up. Thanks to this site, I finally put it all together. Never take ESOMEPRAZOLE, the generic for Nexium. I have never had a side effect to anything that was this painful, this hard to pinpoint, and took this long to clear up."

• Cau...
• Taken for less than 1 month
• February 1, 2022

Nexium (esomeprazole) for GERD "Was given Nexium 40 mg for GERD. First week was great. Felt relief after 3 days. Second week it stopped working as well and nasty side effects. The worst being anxiety (crying all day), painful muscle cramps, and it made my chronic pain (fibromyalgia) worse! But also insomnia, stomach pain, headaches, trembling, watery diarrhea, nausea, insomnia, weakness, and fatigue. I'm asking the doctor tomorrow for something else. Never taking this again."

• Etk...
• Taken for 1 to 6 months
• November 5, 2020

For GERD "I had been on another PPI, my insurance would not cover it, so my gastro doc changed me to Nexium. It worked okay from another pharmaceutical company. When I received my 90-day refill, they changed pharmaceuticals to Camber. Unfortunately, things went south. Within a week of taking it, I noticed different changes: nausea, no appetite, and sore throat. I continued taking it for 3 weeks, and then issues became really bad. I called my gastro and ENT docs, got into see my ENT, and I developed ulcerated laryngitis and ulcers through my esophagus and duodenum (confirmed by tests). Unable to take this Camber esomeprazole product, perhaps some quality control should be done."

• Sta...
• Taken for less than 1 month
• March 9, 2022

For NSAID-Induced Gastric Ulcer "I’m glad to see these reviews, I thought I was going insane. I have been taking esomeprazole for the past 7 days, and I have been experiencing weird side effects. My doctor thinks I may have created an ulcer from all the pain relievers from when I had COVID and prescribed me this medication also for all the acid reflux, and it hasn’t been easy. I have been getting a lot of nausea, lack of appetite, really bad back pains, constipation, heart palpitations, fatigue, and even shortness of breath. Sometimes I get a dry mouth, and I have to drink tons of fluids and still feel like I’m not drinking enough. I thought it was maybe the ulcer, if I even do have one, causing all of this, but reading the reviews and putting it all together, it seems like it is the medication. I keep feeling really sick right after I take it. I want to stop taking it and try something else, but my doctor still hasn’t called me."

• JoJ...
• November 24, 2021

For GERD "Was taking Pantium up to a month ago and then switched to this drug. Have been feeling so nauseous the last 10 days, and now I know why, because it's all down to this tablet. Never again will I take this. My anxiety and stress levels are through the roof."

• Ecr...
• Taken for less than 1 month
• March 11, 2025

"Got prescribed 20 mg daily for inappropriate hunger, but I did not use it then. A few months later, I got the green light from another doctor to use it for stomach pain after eating. I took one every morning, and it reduced the heartburn and nausea following breakfast but stopped working after that. In fact, it worsened indigestion, stomach cramping, and diarrhea for the rest of the day. Stopped it after 10 days. I do not have H. pylori and was never diagnosed with GERD or other stomach conditions."

• Siz...
• Taken for 1 to 2 years
• November 5, 2016

For GERD "I have had GERD for almost one year, and this med is the only one that seems to be working for me. As always, it's not 100% effective since I still have night symptoms sometimes, but it's way better than any other med out there (I've tried out omeprazole and lansoprazole, and none of them were efficient for me). On the other hand, I didn't notice any important side effects, the only one mentionable is some queasiness when I'm in the bus or car and I'm not watching the road (I'm looking at the phone), which is something I've experienced very rarely before starting the esomeprazole treatment."

• Jer...
• February 17, 2011

Nexium (esomeprazole) for GERD "After 3 days on Nexium, my reflux is completely gone. But I now have nausea, body aches, constant mild headache, rash, tiredness, dizziness, and worst-ever stomach cramps."