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Nexium and Insomnia: What Users Say

Insomnia: mentioned by 11 users (5.2%)

Based on user experiences from 211 Nexium reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

anxiety 11.8%
diarrhea 11.4%
nausea 10.0%
headaches 9.0%
fatigue 7.1%
dizziness 5.7%
heart palpitations 5.7%
insomnia 5.2%
constipation 4.7%
tremors 4.7%

Reviews for Nexium

Commonly mentioned side effects
  • Bil...
  • Taken for 1 to 6 months
  • June 8, 2019

For GERD "This drug is dangerous. I was given an 8-month prescription for acid reflux. At first, I didn't notice any bad side effects, but after about 3 months, things have really deteriorated. At first, I thought I was tired from pushing myself hard with my work and workout routine. But then I started feeling nauseous, and it persisted for three days. Then, I began having severe joint pains to the point where I could hardly walk. Also, feelings of panic, insomnia, and blood when I go to the toilet. But the worst has been MY HAIR FALLING OUT!!! I thought I was imagining it at first, but now my whole head has gone flaky/scabbing, and I've lost about a third of my hair. I'm going straight to my doctor on Monday for a blood test. Currently, I'm bedridden. Stay well away from this medication, it's not worth the risks."

1 / 10
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86 Report
  • jay...
  • Taken for 1 to 6 months
  • December 30, 2020

For GERD "I bought Nexium after the Zantac warning. It helped with reflux but caused constipation fairly quickly. Next, I noticed dizziness, then feelings of nausea, followed by extreme tiredness during the day but insomnia, causing me to wake in the early hours and be unable to fall asleep again. I became extremely depressed and lost interest in everything. The final straw was noticing that my legs have started to swell and feel tight, and my feet are tingling and uncomfortable when I want to relax. The first few symptoms I could live with, but the swelling and twitching of my feet and legs is not acceptable, neither is the aching I am experiencing. I am concerned about this to the extent I will be contacting my doctor. I will not be taking any more Nexium, I will try to control acid with diet from now on."

1 / 10
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58 Report
  • Anonymous
  • February 27, 2012

For GERD "Nexium was moderately effective at reducing my GERD symptoms, but the side effects made it not worth taking. I had trouble sleeping, felt very lethargic and fatigued, found it difficult to think through complex problems (which, in my job, is a serious concern). I felt constantly run-down and had no energy, but could not get a good night's sleep."

5 / 10
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76 Report

Frequently asked questions

  • Anonymous
  • February 27, 2012

For GERD "Nexium was moderately effective at reducing my GERD symptoms, but the side effects made it not worth taking. I had trouble sleeping, felt very lethargic and fatigued, found it difficult to think through complex problems (which, in my job, is a serious concern). I felt constantly run-down and had no energy, but could not get a good night's sleep."

5 / 10
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  • Gri...
  • Taken for less than 1 month
  • April 15, 2018

For GERD "I took Nexium for 14 days for GERD problems...first week noticed a difference in my GERD symptoms. The only side effect in my first week with Nexium was diarrhea. In the second week, my side effects got bad...every day headache day and night, feeling tired all day, muscle pain in my back, my shoulders, my neck, and my cheekbones, trouble falling asleep at night...hope all these bad side effects go away soon."

1 / 10
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40 Report

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  • Anonymous
  • Taken for less than 1 month
  • July 6, 2012

For GERD "Little to no heartburn after taking Nexium for 3 days now, but high blood pressure, tingly cramps in my stomach that bring me to the verge of throwing up, light headache, difficulty sleeping, throat's constrictive. Not sure if I can keep taking Nexium."

6 / 10
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  • Eso...
  • Taken for less than 1 month
  • June 28, 2022

For GERD "Omg, I am so glad I found this website!! I took Nexium 20mg 24hr for 2 weeks, then my GI put me on 40mg, and after taking it for 1 week, I thought I was going crazy with all these horrible side effects such as anxiety, muscle twitches, bloating, belching, insomnia, heart palpitations, and much more!! Ended up in the ER, did an ultrasound and bloodwork, and nothing came up, so they must have thought I was faking it. It raises my blood pressure, makes me so fatigued that some days I couldn’t even get out of bed. My mouth and eyes were so dry, brain fog, and confusion…. Just HORRIBLE!! I’m so glad I went on here and found all these reviews, I will stop taking it!"

1 / 10
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11 Report
  • Ger...
  • Taken for less than 1 month
  • July 10, 2021

For GERD "I took this 20 mg twice a day as recommended by my doctor, and within 4 days I had palpitations, insomnia, extreme anxiety, dizziness, nausea, and pins and needles in my neck and legs. Worse was at night when trying to lie down, when there would be pressure in my head and chest, and violent dizziness and nausea. I had two weeks of only sleeping 2 hours a night and peaked with 2 successive nights of no sleep and a visit to Accident & Emergency. Suddenly realized it was the tablets and stopped them, effects slowly going and sleeping at last."

1 / 10
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14 Report
  • Bom...
  • July 27, 2021

For GERD "I've been on over-the-counter Nexium 20 mg for 6 daily doses, as I hadn't been able to pick up my omeprazole prescription. My God, I thought I was dying! Massive panic attack yesterday, nausea, dizziness, and early morning insomnia, followed by crazy thoughts, diarrhea, and eye twitches. I still have waves of nausea, had no idea what it was until I visited these shared experiences. I'm off it now, and this review site has settled my nerves! This stuff is utterly toxic! Steer clear! Thank you all."

1 / 10
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9 Report
  • Cau...
  • Taken for less than 1 month
  • February 1, 2022

For GERD "Was given Nexium 40 mg for GERD. First week was great. Felt relief after 3 days. Second week it stopped working as well and nasty side effects. The worst being anxiety (crying all day), painful muscle cramps, and it made my chronic pain (fibromyalgia) worse! But also insomnia, stomach pain, headaches, trembling, watery diarrhea, nausea, insomnia, weakness, and fatigue. I'm asking the doctor tomorrow for something else. Never taking this again."

2 / 10
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  • ksa...
  • Taken for less than 1 month
  • March 21, 2018

For GERD "My side effects were insomnia, fatigue, and abdominal pain. It helped my condition, for best results, use it for 4 weeks. Modifying diet is very important."

8 / 10
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12 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.