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Benadryl and Itching: What Users Say

Itching: mentioned by 5 users (6.3%)

Based on user experiences from 79 Benadryl reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

drowsiness 15.2%
nausea 8.9%
itching 6.3%
heart palpitations 5.1%
shortness of breath 5.1%
swelling 5.1%
allergic reaction 3.8%
anxiety 3.8%
dry mouth 3.8%
increased heart rate 3.8%

Reviews for Benadryl

  • Jus...
  • Taken for less than 1 month
  • May 9, 2020

For Allergic Reactions "This is an old thread but thought I would share. I was in the hospital in labor. I developed a reaction to the epidural that caused severe itchiness. They gave me something that didn't help, and after several hours of itching, a nurse gave me IV Benadryl. I immediately couldn't breathe and felt like someone kicked me in the chest. I was warm all over, nauseous, and on the edge of passing out. An EKG also showed I had a heart arrhythmia from it. I've taken oral Benadryl in the past with no problems. Now it's on my list of allergies, and I tell every doc I see. Most terrifying experience."

1 / 10
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36 Report
  • Con...
  • April 26, 2017

For Allergic Reactions "I have no rest every time I take Benadryl. I feel I have a really bad reaction as I feel restless, my body feels itchy, nauseous, and it makes me feel angry. Feeling restless really hurts my stomach. Am I allergic to it, or is it a bad reaction?"

2 / 10
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22 Report
  • Tal...
  • July 3, 2021

For Allergic Reactions "I took over-the-counter Benadryl for some minor reason, and hours later I started itching all over my body. The itch was deeply intense, from my scalp to my feet - a full body reaction. I started getting visible large hives, and my throat and face were swelling. I went to the ER, and they said it was impossible that I was allergic to Benadryl. The ER doctor was certain I was having a reaction to the pink dye in the pill. He injected me with clear liquid Benadryl to prove this to me. I immediately had a second reaction. They had to treat me with alternative medications; an injection in my bottom, prednisone to help with breathing, and another green pill of some sort to take home with me. I am allergic to Benadryl."

1 / 10
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7 Report

Frequently asked questions

  • Bit...
  • Taken for less than 1 month
  • June 24, 2021

For Allergic Reactions "I had been to the doctor for hives from an insect bite, and they told me to use Benadryl cream and medicine, but it didn't help. I used calamine lotion and everything else I could think of, even Cortisone 10 extra strength, it didn't help. I went to the doctor for the 2nd time, and they told me to use the same thing, no help at all. I was itching so badly, the hives were spreading, even the itching and burning sensations to my arm, ankles, burning feeling in my fingers, and hives spreading to my chest. I couldn't help but scratch them sometimes, that probably caused them to spread, but I couldn't help it. I went to see another doctor for the 3rd time, and he prescribed Prednisone and Hydroxyzine, and this is my 2nd day taking them, and I see a great difference. My arms and everything are clearing up, and I finally could rest. I recommend Prednisone. I give it a 10."

10 / 10
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0 Report
  • All...
  • Taken for 5 to 10 years
  • April 20, 2016

For Allergic Reactions "Best drug for me to wake up with good sleep and not have a headache. I have used it for 8 years for allergies (itchy eyes, bug reactions), and my house always has it in stock. Love the drug!"

10 / 10
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10 Report

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