Benadryl Alternatives Compared
Benadryl (diphenhydramine) | Loratadine | Hydroxyzine |
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Benadryl (diphenhydramine) | Loratadine | Hydroxyzine |
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Prescription and OTC
Benadryl is an antihistamine that can be used to treat allergic reactions, relieve motion sickness, as a sleep aid, and relieve some symptoms of Parkinson's disease. Sedation is a common side effect... View more |
Prescription and OTC
Loratadine is an antihistamine that effectively treats allergic-type reactions such as hay fever, that is unlikely to cause drowsiness. Prescribed for Allergic Rhinitis, Urticaria, Physical... View more |
Prescription only
Hydroxyzine may be used to relieve anxiety or itching; however, it causes sedation so can affect a person's ability to drive or operate machinery. It should not be used during pregnancy or while... View more |
Related suggestions |
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More about Benadryl (diphenhydramine) | More about Loratadine | More about Hydroxyzine | ||||||||||||||||||||||||
Ratings & Reviews | ||||||||||||||||||||||||||
Benadryl has an average rating of 7.3 out of 10 from a total of 79 ratings on Drugs.com. 65% of reviewers reported a positive effect, while 18% reported a negative effect. |
Loratadine has an average rating of 4.7 out of 10 from a total of 138 ratings on Drugs.com. 36% of reviewers reported a positive effect, while 55% reported a negative effect. |
Hydroxyzine has an average rating of 5.8 out of 10 from a total of 1397 ratings on Drugs.com. 47% of reviewers reported a positive effect, while 35% reported a negative effect. |
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Drug Class | ||||||||||||||||||||||||||
Side Effects | ||||||||||||||||||||||||||
Generic Availability | ||||||||||||||||||||||||||
N/A |
Lower cost generic |
Lower cost generic |
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Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all Benadryl prices |
View all Loratadine prices |
View all Hydroxyzine prices |
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Dosage Forms Available | ||||||||||||||||||||||||||
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Brand Names | ||||||||||||||||||||||||||
Other diphenhydramine brands include: Aler-Dryl, Aler-Tab, Aller-G-Time, Allergia-C, Allermax, Altaryl, Aurodryl Children's Allergy, Banaril, Banophen, Beldin, Belix, Ben-Tann, Benadryl Allergy, Benadryl Children's Allergy, Benahist-10, Benahist-50, Benoject-50, Buckley's Bedtime, Bydramine, Calm-Aid, Complete Allergy Relief, Compoz Nighttime Sleep Aid, ConRx Allergy, Dicopanol, Diphedryl, Diphen, Diphen AF, Diphen Cough, Diphenadryl, Diphendryl, Diphenhist, Diphenmax, Diphenydramine Quick Melt, Diphenyl, Diphenylin, Dormin, DPH, Dytan, Dytuss, Genahist, Help I Can't Sleep, Histaprin, Hydramine, Hydramine Compound, Hydramine Cough Syrup, Hyrexin, Miles Nervine, Nytol, Nytol Caplet, Nytol QuickCaps, Pharbedryl, Scot-Tussin Allergy, Siladryl Allergy, Silphen Cough, Simply Sleep, Sleep Tab II, Sleep-ettes D, Sleepinal, Sleepwell 2-nite, Snooze Fast, Sominex, Sominex Maximum Strength Caplet, Trux-adryl, Twilite, Unisom Liquid, Unisom SleepGels, Unisom SleepMelts, Unisom SleepMinis, Valu-Dryl, Vanamine PD, Vicks QlearQuil Nighttime Allergy Relief, Z-Sleep, ZzzQuil View more | Alavert, Allergy Relief 24 Hour, Allergy Relief Tablets, Bactimicina Allergy, Children's Allergy Relief 24 Hour, Children's Claritin Allergy, Claritin, Claritin 24 Hour Allergy, Claritin Reditabs, Clear-Atadine Children's, Help I Have Allergies, Loratadine Reditab, ohm Allergy Relief, Tavist ND, Wal-itin View more | Vistaril | ||||||||||||||||||||||||
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||||||||||
9.3 hours |
18 hours |
7 hours |
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CSA Schedule ** View glossary of terms | ||||||||||||||||||||||||||
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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Pregnancy Category | ||||||||||||||||||||||||||
Category B
No proven risk in humans
See the full pregnancy warnings document. |
Category B
No proven risk in humans
See the full pregnancy warnings document. |
Category N
Not classified
See the full pregnancy warnings document. |
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Drug Interactions | ||||||||||||||||||||||||||
A total of 445 drugs are known to interact with Benadryl:
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A total of 104 drugs are known to interact with Loratadine:
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A total of 579 drugs are known to interact with Hydroxyzine:
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Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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Disease Interactions | ||||||||||||||||||||||||||
First Approval Date | ||||||||||||||||||||||||||
March 04, 1946 |
April 12, 1993 |
April 12, 1956 |
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WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||||||||||
N/A |
N/A |
N/A |
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More Information | ||||||||||||||||||||||||||
Patient resources | ||||||||||||||||||||||||||
Professional Resources | ||||||||||||||||||||||||||
Related Treatment Guide | ||||||||||||||||||||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.