Benadryl Interactions
There are 448 drugs known to interact with Benadryl (diphenhydramine), along with 8 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 15 are major, 430 are moderate, and 3 are minor.
- View all 448 medications that may interact with Benadryl
- View Benadryl alcohol/food interactions (1)
- View Benadryl disease interactions (8)
Most frequently checked interactions
View interaction reports for Benadryl (diphenhydramine) and the medicines listed below.
- acetaminophen
- albuterol
- amlodipine
- aspirin
- atorvastatin
- Claritin (loratadine)
- cyclobenzaprine
- famotidine
- Flonase (fluticasone nasal)
- gabapentin
- hydroxyzine
- ibuprofen
- levothyroxine
- lisinopril
- losartan
- melatonin
- metformin
- omeprazole
- ondansetron
- pantoprazole
- prednisone
- tramadol
- trazodone
- Tylenol (acetaminophen)
- Vitamin B12 (cyanocobalamin)
- Vitamin C (ascorbic acid)
- Vitamin D3 (cholecalciferol)
- Xanax (alprazolam)
- Zofran (ondansetron)
- Zyrtec (cetirizine)
Benadryl alcohol/food interactions
There is 1 alcohol/food interaction with Benadryl (diphenhydramine).
Benadryl disease interactions
There are 8 disease interactions with Benadryl (diphenhydramine) which include:
- depression
- anticholinergic effects
- asthma/COPD
- cardiovascular
- renal/liver disease
- glaucoma
- liver disease
- resp depression
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More about Benadryl (diphenhydramine)
- Benadryl consumer information
- Compare alternatives
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- Reviews (79)
- Drug images
- Latest FDA alerts (3)
- Side effects
- Dosage information
- Patient tips
- During pregnancy
- Support group
- Drug class: anticholinergic antiemetics
- Breastfeeding
- En español
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
