Prolia and Fatigue: What Users Say (Page 2)

• Can...
• April 20, 2017

For Osteoporosis "Days after receiving my Prolia injection, I experienced vertigo, high blood pressure, and fatigue. Now I am on meds for the high blood pressure, and vertigo. It has been a month, and the vertigo is not controlled enough for me to continue my Yoga classes. I will never get another shot."

• Mar...
• Taken for 6 months to 1 year
• August 10, 2017

For Osteoporosis "I had my first Prolia injection in November 2016. Within a few weeks, I gained 10 lbs very rapidly, but I put it down to changing the time of taking Prednisolone meds that I am on long-term for Polymyalgia. I had the 2nd injection in May 2017, and I can only say that since then, I feel like I've been run over by a bus! I experienced bad insomnia, fatigue, neck pain, pain in upper legs, and upper arms. I also had numbness in my face, which is very annoying, especially near my eye, as it feels like something is too close to my eye! I will not take this drug again and am mad at myself that I did not check out the side effects beforehand. I took the word of my consultant that it was the greatest thing!"

• Flo...
• Taken for 6 months to 1 year
• September 4, 2024

For Osteoporosis "I would not recommend this drug. I have had my second shot, and I regret it. I have experienced joint pain, extreme fatigue at times. Sometimes I feel like I can't breathe. I've had abdominal pain, lower leg edema. I've been miserable at times after taking this drug. It is the worst drug I've ever taken. My cholesterol has gone up, I feel like every week I'm getting sick with an upper respiratory illness. I'm a kidney transplant patient, and after I read the reviews, I told my doctor I didn't want to take this drug, but he insisted I would be fine. Well, he was wrong. I will not take another injection. I was totally fine without this drug. Again, I do not recommend!!!"

• Joa...
• Taken for 1 to 6 months
• April 21, 2019

For Osteoporosis "Within 4 days of the Prolia injection, I had severe skin reactions. Within one week, my body became weak, and I experienced sleep difficulties. I have continued to be weak, experience bone pain, and have fatigue. Now I feel like I have some cancer in my organs, none of them are functioning right. This is a hideous drug that should be removed from the market."

• Gin...
• April 24, 2023

For Osteoporosis "I had my first injection on August 22 in 2022. I started having severe muscle spasms in my toes and calves. Headaches and fatigue. Then I started having pain in the lower and upper muscles in my legs. A little at first, and it has increased to where I am in tears when this happens. I had my second injection and now, along with that, I’m waking in the night with a severe rapid heartbeat. Can’t sleep and have such bad body weakness that it just overwhelms me. I would never recommend this poison to anyone. I have had test after test and been in the hospital several times. No answers. Not thinking about Prolia being so bad, I said let’s take a look at the side effects of Prolia. There it was in print: everything that was happening to me. It also said these side effects could continue on. Prolia is supposed to stay in your body for about four months, but it can be longer."

• Ann...
• Taken for 1 to 2 years
• August 23, 2018

For Osteoporosis "Where do I start, rash on face, loss of hair at one stage, fatigue, jumping out of bed at night with severe cramps in the legs, itchiness all over, pain in the knee, pain in the joints, pain in the side of the head, pain in the feet and big toes, sick in stomach, hearing loss, general weakness, mood change very angry, frequent urinating, weight gain, breathing difficulty, aware of heart rate changing, slight soreness in the mouth nose run-off and on like sinus problem, numbness in hands and arms, I have just had my third shot wish I never did"

• Jan...
• Taken for 1 to 6 months
• August 24, 2019

"Bone scans showed osteopenia at age 66, so my doctor decided I should have this. It isn't even indicated for osteopenia, only osteoporosis. I also don't have a strong immune system due to an accident a couple of decades ago. I had one Prolia at the end of February. Constant side effects started after about 2 weeks, just about all mentioned in the literature. Then in April, I developed shingles, which I've also had twice since. I was thinking not to have another dose, which is due this coming week. I also had a very heavy cold that I can't shake, but I didn't connect it until a couple of days ago while thinking about my immune system. Apparently, Prolia is not ideal if your immune system isn't good, which surely the doctor should have known. Last week, I developed severe burning pain in my ribs and back, and red skin - the last few days I can barely move - and fatigue. I was hoping the side effects would go away, but here I am at the end of the first and only dose in agony."

• JCa...
• February 12, 2019

For Osteoporosis "+10 lb. weight loss"

• Rud...
• Taken for 2 to 5 years
• June 6, 2023

For Osteoporosis "Well, it scares the crap out of me reading many of the reviews. I have had five Prolia shots so far and thought I was okay. My T-score was very poor and is now in the 'osteopenia' range, which, according to the guy who did the scan, is not too far from normal for a 72-year-old male in this area. I have hopes for even better results next time. However, in hindsight, I have had symptoms that might be related to Prolia. I've experienced slight headaches, although very slight, which I initially blamed on sinusitis. I have also been feeling like I am 'down a quart' for quite a while. So, my GP sent me for a blood test and ECG, and everything came back okay. Now I'm wondering if this fatigue is actually a side effect of Prolia. I have an appointment with the rheumatologist in August and will discuss the possibility of weaning off the medication. Does anyone know if lower doses of Prolia are given? I would rate the drug 7/10 for improving my bone mass, but if the way I feel is caused by it, then the rating drops. I am in Canada, so I'm not sure if this will be displayed."

• 505...
• Taken for 1 to 2 years
• March 17, 2019

For Osteoporosis "I’m 50 years old with a lumbar dexascan -3.8, left hip -3.0. I had my first Prolia injection, and for a few weeks, nausea with some aches, but it stopped, and I did awesome. 2nd injection, nausea, lower back aches, and some aches in bilateral hips. After a few weeks, I was great. 3rd injection almost 90 days late due to insurance, and I received the injection 10 days ago. This is the worst for me. I had nausea and vomiting, which has subsided. I have bad aches in the lower back, both wrists, and elbows. My left elbow is sore to touch and loss of strength. To pick something up with my left hand is painful to the elbow. After sitting, when I stand, I have pain in both knees. I’m severely fatigued! On a positive note, I just had a dexascan, hips are -1.9, but lumbar is -3.5. The injection is working but not in all areas. I’m unsure of what to do at this point. More injections could improve my lumbar possibly or not, and side effects could be worse or not. The doctor said he treats 27 people, and they do not have any issues, and what I’m having is the Prolia. Ok?"

• Joa...
• May 3, 2021

For Osteoporosis "After a severely painful experience with a Reclast infusion (which are once per year), I was put on Prolia injections every six months. After a yearly infusion of Reclast and two 6-month intervals of Prolia, I have pain in my joints, muscles, groin, tendonitis in my Achilles tendons and thumb, headaches, nausea, confusion, weakness, fatigue, at least 40 pounds of weight gain, and severe back and hip pain. Before, I was on the go all the time, walking, exercising, and busy constantly, now I don't feel like doing anything because I never feel good and hurt all the time. Needless to say, I canceled my next injection and will take nothing for the osteoporosis. Even though I have a pretty good chance, even more so now, of having a fracture since I took the injections. Can you believe this? When you stop taking Prolia, you are more at risk than you were before you took it! Thanks to all the doctors that only think of how much money they can make off of someone instead of thinking of their health."

• Lou...
• March 4, 2018

For Osteoporosis "I received the injection in December '17, and the shot was easy to take. I initially had no local side effects to the injection. Three weeks after receiving the injection of Prolia, I started to feel numbness and tingling all over my body, and I developed diarrhea. I ended up going back to my doctor, who took my calcium level, and it dropped to 7.1. I started increasing my calcium intake, and it went back to normal after two weeks. I still have multiple spasms in my body. The diarrhea really did resolve in two weeks, and after losing my appetite, it came back after three weeks. I am now 2 1/2 months into the shot and still getting quivering and spasms all over my body, including my arms, legs, and face, especially around my mouth, hands, and feet. There are times I feel foggy and extremely fatigued. The feelings do come and go. This drug is a nightmare. I would not waste my time taking this drug, I already lost two months of my life. Too bad there is not a way to reverse it."

• Mel...
• Taken for less than 1 month
• April 16, 2018

For Osteoporosis "Just received the first injection two weeks ago. After reading the comments above, I'm afraid my misery has only begun. Had to start using my cane again due to increased pain and fatigue. Odd though, this afternoon took a nap only to awake to high-frequency noise in both ears; that was six hours ago; haven't noticed any comments about the ears except one."

• San...
• February 26, 2023

For Osteoporosis "I have experienced increased fatigue, joint pain, and GI upset. I never should have agreed to take this. I also have lupus and achalasia. Will not go through with the fourth dose. Will request other medication. Have yet to have a follow-up on bone density."

• Anonymous
• May 4, 2021

For Osteoporosis "Wish I had read this first. Will never see my doctor who recommended this drug again. Just got my first injection and experiencing shortness of breath and feeling like I can’t breathe. Lots of fatigue. Could have had Reclast again. Feel I just ruined my health."

• Unh...
• Taken for 1 to 6 months
• June 10, 2022

For Osteoporosis "Terrible side effects-first and ONLY shot. Persistent bone pain-legs, ankles, wrists, arms, back, hips, neck, and shoulder pain. Muscle pain, extreme fatigue x 2 months so far. Side effects persist. Vague information from doctor. Was not advised regarding danger to people without all intestines, they are not supposed to use this drug-I had intestinal surgery 30 years ago, had no idea this was contraindicated. Not advised about dangers if the drug is stopped: increased chance of bone breaks, especially in spine. Must take other drugs if you stop it. Be informed. Read all information on side effects found on this site, some are serious and may be more common than reported-report all side effects to Amgen. Bone pain in back and other areas is COMMON. Per Amgen-they did not study bone loss in other areas that might occur as it takes calcium from some areas and moves to others. I do not recommend this drug."

• dam...
• Taken for 1 to 6 months
• December 7, 2021

For Osteoporosis "After a bone density test showed that I was on the brink of osteoporosis, I was prescribed an injection of Prolia late in September 2021. I began to experience mild pain in my arms, neck, and thighs. These increased in severity, and I developed nausea. I then developed bronchitis, another stated side effect, and feel, after two months, fatigued with continuing bone pain. My hair is falling out. I feel no benefit from this drug, and the quality of my life has been severely impaired in every way. I shall never use this medication again. I have lost my appetite, and my legs are swollen."

• Jas...
• Taken for 2 to 5 years
• September 17, 2021

For Osteoporosis "I have scleroderma. I have had 5 injections, starting on March 17, 2019. My last was March 17, 2021. I am scheduled for one on September 17, 2021. WON'T have it. I have had scleroderma for 14 years and was doing quite well. My bones were getting weak due to extensive time on prednisone. When the rheumatologist mentioned it, I asked her if it would help and did not give it another thought until two months ago (July 2021). My general practitioner, during my regular checkup, asked me if I was still taking Prolia. I said yes, and she did not comment. I had been declining in the past 2 1/2 years and was begging my doctors for help with the pain in my muscles, weakness, fatigue, stuffy nose (never had allergies), loss of hearing, spent $5,500.00 on hearing aids that do not help, blurry eyes, dizziness. Had my eyes checked and no problems, hair loss, I have curled fingers due to the scleroderma attack, but all of a sudden I was loaded with ulcers and calcium deposits on all of my fingers and thumbs.. continued."

• Suf...
• Taken for 1 to 6 months
• August 1, 2021

For Osteoporosis "The day after having the Prolia injection, I developed a 3-day headache, followed by chronic fatigue and vertigo. A week later, all my joints-neck, shoulders, elbows, wrists, hips, knees, and ankles-all started cracking. In the third week, I developed sciatica on my right side. I was unable to sit, I could only stand, walk, or lay flat. Sitting was unbearably painful. I have been medicated with Tramadol for pain. I have tried acupuncture, therapeutic massage, and hot mineral springs. Nothing has helped. I take natural vitamin supplements and calcium, nothing helps. I have read that Prolia weakens the immune system, so there is no way I would ever have the Covid vaccine in my situation. My body is very compromised. I would caution anyone considering Prolia. I had no ill health symptoms before I had this, and now I’m incapacitated."

• She...
• Taken for 1 to 6 months
• August 2, 2021

For Osteoporosis "Horrible drug. I felt my doctor was overbearing and wanted me to take Prolia. I have been miserable ever since. Bone, joint, muscle pain, difficulty walking. Extreme fatigue. Some days I feel like I am actually dying, nausea, bowel problems. My quality of life is definitely worse. Never again. Only took one injection."

• yox...
• Taken for 6 months to 1 year
• September 30, 2021

For Osteoporosis "I wish I didn't start on Prolia. I started feeling fatigue, dry eyes and skin, and itchy skin rashes. I didn't realize these symptoms were connected to the medication. I thought the cause was the hot summer. However, these symptoms remained in the fall. I feel my skin either burning or itching all the time. I cannot sleep, mostly because of my skin discomfort."

• Nic...
• March 8, 2016

For Osteoporosis "Headaches, lower back pain, visual problems, increased reflux, foot swelling, fatigue"

• Bug...
• May 25, 2017

For Osteoporosis "Insomnia, fatigue, confusion."

• una...
• April 10, 2018

For Osteoporosis "I have only had one shot of Prolia, but I haven't felt well since then. My symptoms are intermittent fever, shivers, bone and joint pain, severe fatigue, and jaw pain."

• 177...
• Taken for less than 1 month
• January 15, 2018

For Osteoporosis "Great fatigue and back pain. I doubt I'll do the second shot. Sad as I thought this would help. I have osteopenia, so hopefully, there's something else."