Skip to main content

Clozapine and Depression: What Users Say

Brand names: Clozaril, Clopine, Clozapine Synthon, Denzapine Versacloz

Depression: mentioned by 3 users (3.8%)

Based on user experiences from 78 Clozapine reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

weight gain 25.6%
constipation 7.7%
hallucinations 7.7%
drooling 6.4%
drowsiness 5.1%
depression 3.8%
fatigue 3.8%
memory loss 3.8%

Reviews for Clozapine

  • Edn...
  • May 25, 2019

For Schizophrenia "Yet another useless drug that has turned my spouse into a vegetable. Less energy, reduced mental capacity, dizzy spells where he falls over. Increased depression. OMG, the horrifying facial tics, and the doctor won't do a thing. Sleeps his life away. Developed GERD as well. I personally believe this drug is harming him."

1 / 10
Was this helpful?YesNo
67 Report
  • Mom...
  • July 29, 2019

For Schizophrenia "My son was diagnosed with schizophrenia at age 17. He was even hospitalized for 3 and 1/2 months because of this horrible disease. He tried many different medicines, and none worked until clozapine. Clozapine helped him a lot with the voices, but the weight gain is horrible. He gained over 100 lbs in 6 months! Now he is depressed and won’t leave the house because of his sudden weight gain and is refusing to take the med because of it, so now we are back to square one. It’s a no-win situation /: feeling helpless."

6 / 10
Was this helpful?YesNo
58 Report
  • I W...
  • Taken for 5 to 10 years
  • January 14, 2016

For Borderline Personality Disorder "I took this medicine for 6 years as a teenager for 'bipolar' (which we found out was a misdiagnosis). This medication made me miserable. I felt like I had died and somehow was still walking the Earth. For the first couple of years, I became extremely paranoid, which I had never had a problem with before taking the medicine. The depression was still there. As the dose was gradually decreased, I felt a bit better but still had that feeling of dread. You eat everything. You sleep all the time. You don't care about anything. Coming off of the medicine is almost as bad as being on it! I had severe headaches and nausea, and I lost 10 pounds almost instantly. Clozapine has its place, but you should think hard before taking it."

2 / 10
Was this helpful?YesNo
42 Report

Are you taking this medicine?

Your review helps others make informed decisions.
Write a review
Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.