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Cholecalciferol and Anxiety: What Users Say

Brand names: Vitamin D3, D3, Decara, Enfamil D-Vi-Sol, Maximum D3, Replesta, D2000, Celebrate Vitamin D3 Quick-Melt, D3-50, D 1000 IU, Delta D3, D3-5, Ddrops, D-Vita Drops, Replesta Children's, Replesta NX, Thera-D 2000, Thera-D 4000, Carlson D, Bio-D-Mulsion, Bio-D-Mulsion Forte, BProtected Pedia D-Vite, Thera-D Rapid Repletion, D400, UpSpringbaby D, Wellesse Vitamin D3 …show all brand names

Anxiety: mentioned by 8 users (16.0%)

Based on user experiences from 50 Cholecalciferol reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

dizziness 18.0%
anxiety 16.0%
heart palpitations 14.0%
increased heart rate 12.0%
nausea 10.0%
tiredness 10.0%
cramps 8.0%
pain 8.0%
constipation 6.0%
depression 6.0%

Reviews for Cholecalciferol

Commonly mentioned side effects
  • Ver...
  • Taken for 1 to 6 months
  • January 22, 2021

Cholecalciferol for Vitamin D Deficiency "I struggle badly with Vitamin D supplements. Don't ever let a doctor tell you it's not the supplement! The only thing I do like about it is for me it's almost like a sleeping pill. I pass out very quickly after taking it every time. However, the next day I always feel tense, dizzy, short of breath, headaches, muscle aches, anxiety, stomach pains, constipation, and have acid reflux issues. This ALWAYS goes away when I stop the supplement. I've tried adding magnesium and it doesn't help."

1 / 10
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  • Ver...
  • Taken for 1 to 6 months
  • January 22, 2021

Cholecalciferol for Vitamin D Deficiency "I struggle badly with Vitamin D supplements. Don't ever let a doctor tell you it's not the supplement! The only thing I do like about it is for me it's almost like a sleeping pill. I pass out very quickly after taking it every time. However, the next day I always feel tense, dizzy, short of breath, headaches, muscle aches, anxiety, stomach pains, constipation, and have acid reflux issues. This ALWAYS goes away when I stop the supplement. I've tried adding magnesium and it doesn't help."

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  • Ano...
  • May 3, 2019

For Vitamin D Deficiency "I was feeling fine until I was diagnosed with vitamin D deficiency (4.6). I took 8000 IU of vitamin D3 once a week for a month. The first time I took it after 3 hours I felt sick all of a sudden, with terrible palpitations, extreme dizziness, nausea, and confusion. I thought I was dying! My doctor said it was impossible vitamin D caused this, so he told me to keep taking the drug. The second week I ended up in the ER, but everything was negative, and they told me it couldn't be vitamin D. I took it 4 times, once a week, until I asked my pharmacist about my symptoms, and he told me to stop immediately. During that month I had constipation, loss of appetite, extreme weight loss, dizziness, fatigue, muscle pain, anxiety, depression, high blood pressure, and scary palpitation episodes (10 times), all symptoms I never had before. Now it's been a month since I've stopped taking vitamin D, and my health is slowly improving. Now my vitamin D level is 16, so I guess the drug worked, but I would never take it again with all those side effects."

2 / 10
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53 Report
  • Cin...
  • Taken for less than 1 month
  • February 17, 2021

For Vitamin D Deficiency "Decided to begin taking Vit D3 as I'm 73 years old and have been reading they help during COVID. I purchased 1000 IU. I took that dose for 3 days and hardly slept a wink on those nights, so I cut them in half. Have been taking the 500 IU dose for 4 days and feel awful: dry mouth, bloating, feel anxious and irritable, light-headed. Don't know if anyone else has had these problems. Seems such a small dose. I think, sadly, I will have to stop taking them for a while and see what happens."

1 / 10
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  • Eri...
  • Taken for less than 1 month
  • August 22, 2021

For Vitamin D Deficiency "I was advised to take 2,000 IUs of cholecalciferol daily after being diagnosed with a vitamin D deficiency. About 6 hours after my first pill, I noticed my heart was racing, and I started having palpitations. Then the anxiety set in. At this point, I didn’t make the connection with the cholecalciferol, but after continuing to take it over the following days, the anxiety turned to absolute sweaty panic and dread, as well as insomnia. By day 4, I was horribly depressed, had no appetite, and was nauseous. I don’t think my doctor believed me when I told her the cholecalciferol was causing this, but I know that’s what it was. I later learned that cholecalciferol creates serotonin in your brain by increasing the enzyme tryptophan hydroxylase 2. If you get too much serotonin, you develop serotonin syndrome - and my experience aligned exactly with the symptoms of serotonin syndrome. Hopefully, this is helpful to others. For now, I’ll just keep my vitamin D deficiency."

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  • Eri...
  • Taken for less than 1 month
  • August 22, 2021

For Vitamin D Deficiency "I was advised to take 2,000 IUs of cholecalciferol daily after being diagnosed with a vitamin D deficiency. About 6 hours after my first pill, I noticed my heart was racing, and I started having palpitations. Then the anxiety set in. At this point, I didn’t make the connection with the cholecalciferol, but after continuing to take it over the following days, the anxiety turned to absolute sweaty panic and dread, as well as insomnia. By day 4, I was horribly depressed, had no appetite, and was nauseous. I don’t think my doctor believed me when I told her the cholecalciferol was causing this, but I know that’s what it was. I later learned that cholecalciferol creates serotonin in your brain by increasing the enzyme tryptophan hydroxylase 2. If you get too much serotonin, you develop serotonin syndrome - and my experience aligned exactly with the symptoms of serotonin syndrome. Hopefully, this is helpful to others. For now, I’ll just keep my vitamin D deficiency."

1 / 10
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  • Anonymous
  • Taken for less than 1 month
  • August 29, 2021

Cholecalciferol for Vitamin D Deficiency "I had low vitamin D. My doctor put me on 50,000 IU/week. After the first dose, I have been to the ER twice. Dizzy, lightheaded, real high, anxiety, massive headaches, twitchy, coordination loss, high heart rate, photo and audio oversensitivity, mental confusion, spinning, eye pressure, 'pre-dreaming,' just shutting my eyes. I have to avoid light, sounds, movement. I make myself eat 'cause nausea and weight loss. Doctors dismiss it, but I have read about serotonin and other levels being too high. I regret taking this and currently waiting for my body to be deficient again just so I can feel OK. First 15 hours bad. Doctor said 2-3 days, but it's been my 6th day. Read after 15 days, vitamin D is down to 50%. 25% by 30 days. I avoid light, any vitamin D foods, anything to cause serotonin levels to go up. I was better off in my level mental state. Hope this may help calm you if you are having effects."

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  • Big...
  • Taken for 1 to 6 months
  • April 6, 2021

For Vitamin D Deficiency "30/10/2020 prescribed 400,000 IU for ten days, 20K once weekly for six more weeks. After 10 days of the 400K severe colon pain, chronic bloating, alternating between diarrhea and constipation, so it was like the symptoms of IBS or bowel cancer. I had nerve pain, bone pain, severe back pain, chronic stress, depression and anxiety, weakness, exhaustion. The doctor denies any possible connection with vitamin D and suggested IBS. Then after a full blood count, suggested diverticulitis. And suggested I need to address my state of mind as opposed to the body. Now four months later, I am just about starting to feel slightly better."

1 / 10
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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.