Wellbutrin XL for Major Depressive Disorder User Reviews (Page 3)

• Butte...
• January 24, 2017

"I've only been on this medication since the 18th of this month, but one thing that I have noticed with this medication is that it is helping me to not have a constant appetite. I was not only needing help with depression, but I was also needing help with weight loss and at this point I don't know how the weight-loss will/will not work with med, but I do know that I do not have an appetite like before taking this. And for that I am very grateful. I also understand that it could take 3 to 4 weeks before I notice the effects for the depression. I am hopeful!"

• Inser...
• Taken for 1 to 2 years
• September 22, 2015

"I was on generic for about a year. Didn't really do anything. I recently (a little over a month ago) went back to get a different prescription. Doctor decided to put me on name brand, at 300mg. Night and day difference. I can't remember the last time I didn't hate everything about life. It's been at least 6 years I've had major depression. I've been suicidal for about 4. It sucked. But this drug really has helped me. I actually enjoy things now, my life has color again, and I have more energy and a less difficult time focusing. It's really great."

• hackg...
• September 13, 2017

"In the last 6 years I have taken a few meds for my depression. Started with Lexapro which helped but caused very quick weight gain. Switched to Cymbalta which caused rash. Switched quickly to Prozac which caused horrible dreams and sexual issues!! Was then put on Wellbutrin by a psych NPR because of my issues with weight gain and sexual side effects. Drug was a miracle for me!!! Lost 45lbs in 2 years after starting it and sexual side effects disappeared!! Started out on 150mg a day but upped to 300mg a day when I had a depressive episode!! Since upping dose have had no issues other than unusual dreams, but can live with that!! Nothings perfect!!!"

• Guerra...
• Taken for less than 1 month
• December 2, 2017

"I have been quite depressed with extreme anxiety, obsessive and compulsive behaviors, Extremely hard addiction to nicotine and some dissociative-psychotic features since 2016 and tried a whole different variety of SSRIS, SNRIS, Mood Stabilizers, but this one at 225mg XL 7 Day is like a custom-made pill for me! 0 desire to smoke, 100 desire to live, socialise, feel empathy and have healthy relationships, the anxiety I can't say for sure it's completely away but i can say for sure that it has lowered at least 65% I feel like I had gone to sleep in 2015 and waked up in december 2017, no side effects so far."

• Color...
• February 17, 2021

"I’m on day 3 of Wellbutrin XL 150mg prescribed for ADHD. I was really nervous to start it because I don’t take any medications and live a very natural lifestyle. And I was worried about side effects. I had a very mild hint of a headache on day one( I also didn’t drink much water that day) and I feel that my head rage during exercise is a bit more excitable and fast but my resting heart rate remains 58-62. I’ll get my blood pressure checked later today. I never have much of an appetite so that hasn’t changed. I’m more focused, my intrusive rapid random thoughts seem to be getting caught by my internal filter instead of me just saying them, I’m more at ease, not as anxious or irritable, I’m able to slow down to go fast, feel happier, and just overall like I’m crushing life (no not in a manic way) I take it at 7-8am and find that I am more awake in the daytime and into the evening. I’ve been using a CBD gummy to help me sleep."

• Lola
• Taken for less than 1 month
• June 4, 2020

"I did not have a great experience with this medication overall. It ended up being the cause of my vivid dreams, not being able to tell what was reality or not. I was feeling more physically and emotionally drained. It might help some, it was just most definitely not for me."

• Justice...
• January 25, 2017

"This did nothing for me, as far as I'm concerned, I think its a placebo.. I was very depressed because I felt awful everyday, I could barely get out of bed, I felt exhausted, foggy mind, body ached, and long list of other debilitating symptoms.. I knew I wasn't just feeling these things physically for no reason. I'm only 30yrs old and when I started having memory problems I knew that it wasn't just Depression!! My primary doc did blood work and found I had some severe vitamin deficiencies! I got some prescription vitamins and changed my diet.. I feel better physically and mentally!! This may not help everyone but I encourage you to make sure your doc does a lot of tests tests to rule out others health issues before before blaming depression"

• KARD
• Taken for 5 to 10 years
• April 13, 2023

"Been on Welbutrin XL 450 mg (300 mg am 150 mg pm) for years and it seems to work better than all the others I’ve tried. It’s not a miracle drug by any means. Every day, I tell myself “Get up, get going.” Depression is a horrible disease but it’s also a teacher and it has taught me that I have a lot of strength and courage. Never ignore depression or underestimate it because unless I am vigilant it will run me down. I think this drug affects my sleep but I have always had insomnia so at least I am less depressed. It has not caused weight gain but I have not lost weight on it. Other antidepressants caused so much weight gain that I couldn’t tolerate the extra 20 plus and more pounds. My weight shot up to 162 lbs and that was unacceptable. I am 5’4”. Try Wellbutrin. It helps me stay motivated and I can do my artwork, keep my house reasonably clean, stay sexually active, and have emotions."

• Susie
• September 8, 2018

"I have major depression disorder & panic moments (that’s what I prefer to call them). I take 10mg of Escitalopram & 150 mg of Wellbutrin XL spaced out by 2hrs . Wellbutrin was added as Escitalopram does not last 12 hours. I’ve been taking Wellbutrin for 2 weeks now, no side effects 1st week however this week I’ve had: headache, nausea, my big toe gets a numbness or tingle. (I’m a runner so this bugs me) frequent urination, a slight loss in appetite, I also get nauseous & gassy after I eat or drink coffee and I seem to have more bowel movements but not diarrhea. Not sleeping thru the night has happened twice. I can still have a panic moment if I think about things too much so I use Clonazepam or Lorazepam when needed. I do not “feel” any different (in a bad way) since I’ve started taking it. I did try Zoloft and it was a nightmare, so I know the difference. I would recommend trying it, but stoping if any wild side effects begin."

• Sunny...
• Taken for 1 to 6 months
• August 2, 2016

"I was 26 years old and taking Wellbutrin for about 5 months. Within those 5 months I became increasingly unmotivated, less energetic, and my depression worsened. I had terrible mood swings and was generally unpleasant to be around. My thoughts were not my own anymore, as I had horrific thoughts that were scary and confusing to me. Then came the night that I swallowed an entire prescription bottle of it. My thoughts were that either it would finally work and make me happy or it would just kill me so I wouldn't suffer anymore. I am obviously still here and I am so grateful for that! I stopped it and was put on Paxil. So much better for me! I'm a happy girl again!"

• Bee
• Taken for 1 to 2 years
• December 4, 2019

"I take 450mg wellbutrin for MDD and other meds for bipolar 2, and no other antidepressants worked for me. Some of my other meds made me tired on top of depression making me exhausted and this gave me the energy I needed and pulled me back up out of it. It kills my appetite which is good because I’m guilty of stress eating. It’s knownnot chnaging your libido but my other meds do that so idk But overall this medication has been great for me"

• Lucy
• Taken for 2 to 5 years
• June 21, 2020

"Wellbutrin has done wonders for me. I was diagnosed with Major Depressive Disorder in high school and was on a few different meds before being put on this one in college. It's helped me so much--if I ever feel myself getting into a "slump," I'm able to fight it off so much easier since starting this med."

• John
• Taken for 5 to 10 years
• December 9, 2020

"Seven years ago the anti-depressant I was on stopped working, and I crashed into horrible major depressive disorder. My new doctor, guessing (wrong) that I had Bipolar Depression (I didn't), took me off anti-depressants and put me on Latuda, an "atypical anti-psychotic" often used to control Bipolar Depression. Not only didn't help the depression but also made me pace uncontrollable. I switched doctors, and the new one put me on Wellbutrin XL (long-acting). Eventually, my depression cleared, and I've been relatively depression-free (there are bad patches with any drug) for the past 7 years. I've had no noticeable side-effects, and I take it with first thing in the morning breakfast so it doesn't interfere with my sleep. I highly recommend it. (Full disclosure: I also take Imipramine, an old "tricyclic" anti-depressant, a couple of hours before bedtime. Helps me sleep well but dry-mouth side effect is annoying & bad for my teeth.)"

• Chron...
• Taken for 5 to 10 years
• June 23, 2023

"Chronic, major depression throughout my adult life and it is a ceaseless battle to try and juggle meds to get me in a place where I am more than okay. At the moment, I'm not so okay, but this is after many years of taking bupropion (Wellbutrin) 300XL. Disclaimer: this is always the #1 antidepressant I recommend to others. Out of all I've tried, this, by far is the most successful and hasn't left me lethargic. In fact, when I first took it, I was more eager to wake up, more energetic and actually happier. Over time or perhaps circumstance, it has worked less effectively. Admittedly, I am over 5 years on this med and it is not being accompanied by therapy--that is essential. I do not have time for therapy because I'm a caregiver, but I will say--no side effects for this one, no weight gain and initially much happier. Worked well for years. Should have been in therapy at the same time, but telehealth wasn't a thing then and insurance only covered psychiatry and not psychotherapy."

• Tano
• September 27, 2019

"I have been struggling with depression and anxiety for a long time every little task felt so overwhelming and when I had my baby it was just to much , Dr prescriped cipralex then zoloft and it didn't help much then I asked for wellbutrin. So my thoughts so far when the zoloft finally left my body and I got to 300mg of wellbutrin I had so much energy I accomplished a lot my libido skyrocketed I felt great a few weeks later I think it caused me to be manic, I felt high even my pupils in the mirror were tiny I felt super confident and sexual and I did whatever I wanted and did not care who I hurt. Then I came down and went back into a horrible depression and attempted ending it all over the way I acted when I was feeling so great , now that the sadness has leveled out I'm just irritable and snappy over nothing or laughing my ass off at things that aren't that funny I either get a bunch done or can't be motivated to move.."

• Kotil...
• December 16, 2015

"I started taking bupropion XL 150mg a day I took that for a month, the first 3 weeks I felt kind of cloudy/lost, had a little bit of anxiety and had some pretty bad ups and downs with my depression but by the end of the month I felt a lot better and didn't even feel like I was on a medication at all. I just started my second month and was upped to a 300mg dose. I'm on my 5th day and so far have had really bad anxiety attacks feeling like I'm losing control/ stuck in my own head most of the time and sleeping a lot. I'm hoping I can stick it out like with the 150 and start feeling normal again. I almost quit in the first 3 weeks of 150 but I stuck it out after reading positive reviews and it got better. I'm hoping that happens with the 300mg."

• Happy...
• Taken for 1 to 2 years
• October 26, 2022

"This medication Wellbutrin XL has been my saving grace after a decade of trying different meds, from Lexapro, Luvox, Prozac, Lithium, Abilify, and many others I can not remember. They either had no effect, or made me worse. I attempted suicide many times. Therapy made me feel worse. After a week on Bupropion XL I felt something I hadn’t felt for years. Happy. I went from antisocial and scared of the outside world, to having a large group of friends and going on outings. I suddenly enjoyed going to work everyday. My life became a DREAM! I still felt negative emotions but they were easier to work through and they were always situationally appropriate feelings. This medication gave me my life that had been gone for so long. My only regret is not finding this medication sooner because it truly changed everything for me. I haven’t had a single suicidal thought since starting this medication."

• Ms J
• Taken for 1 to 6 months
• August 6, 2023

"I have been on several antidepressants since 2004. I have slowly moved up the latter of medications. I’ve taken single doses and combination doses, but Wellbutrin XL has done wonders for me. I have not had the low days like I once had on the other medications. That’s awesome! I haven’t felt useless or have the lack motivation. When I first began taking Wellbutrin XL, I did experience a little dizziness if I over exerted myself. I also would experience a slight disorientation when I would take it in the morning, for a little, but it passed within several minutes. I still am not sleeping well. I do have to take a sleeping pill in order to sleep for at least 4 hours, but my insomnia has been an issue for a long time. I have noticed I actually eating more on Wellbutrin XL( I’m only on 150mg). I have gained weight on this and I do not like it. However, I will gladly take the extra pounds over feeling like I’m useless and depressed 5/7 days in the week."

• Unemo...
• November 30, 2015

"January 2015 I was on Remeron 15mg by April 2015 I was at 45mg Remeron. I felt normal and happy but I gained 26lbs. Sept 2015 I was switched to Effexor 150mg because of issues caused by the weight. By October I was on 300mg Effexor. Today is day two of 150mg Wellbutrin. I am suffering headaches from going from Effexor to Wellbutrin. Tomorrow I increase to 300mg Wellbutrin. I can say that day two on Wellbutrin and I am not feeling as numb (unemotional) as I was two days ago. That's a positive. This is definitely a rollercoaster ride in trying to find the right meds to help with my major depressive disorder, anxiety/panic attacks and insomnia. My only regret is that I didn't get help sooner. Instead I suffered alone for years."

• David
• Taken for less than 1 month
• December 20, 2019

"I started welbutrin 150 xl and I've been sick ever since. I vomit each time I eat and I feel real withdrawn. Now, almost 3 weeks into in today is the only day I haven't vomited after eating and I still feel good. I think I'm getting better each day. I gave it a 3 because I've never felt more sick in my life than I did when I started welbutrin."

• Lo...
• June 12, 2017

"I am currently using wellbutrin xl (150mg) a day as an add on to trintellix. I have been on every medication under the sun & always seem to have negative side effects. My biggest struggle with my depression is fatigue & no energy. I've only been on wellbutrin 5 days & I feel a tremendous difference. I am awake in the morning & don't feel like I am going to fall asleep at random times during the day. I also haven't taken a nap in 5 days either which is huge considering I always nap. I am a little anxious sometimes & am also dealing with sleeping issues so I may talk to my Dr about switching to the SR. I am also dealing with a lot of muscle spams but this always happens when I adjust a dose or try a new medication. Wish I tried this sooner!"

• Remem...
• September 19, 2018

"I am a 25 yo female. I started taking Wellbutrin XL150mg after being diagnosed with MDD in April. I have done CBT in conjunction with taking medication. On Wellbutrin I feel more energetic, focused, & present. The black haze I saw my life in cleared and I feel normal. The main side effects I feel are: -increased energy soon after I take it -insomnia -appetite suppression. - some impulsivity -some forgetfullness -irritability sometimes -during high stress events I felt a build up of nervous energy & a 'drunk' feeling. I did try other doses. -75mg once daily did nothing for me. -100mg of an instant release once daily for a month. I felt an instant energy & focus in the mornings but by the evenings my mood would fall very deeply & found evenings difficult to get through. @100mg I didn't experience appetite suppression, insomnia, irritability or impulsivity. I plan to continue 150mg wellbutrin xl and may elect to take an SSRI to help with anxiety."

• Tomnik
• Taken for 1 to 6 months
• May 12, 2019

"Wellbutrin was a terrible medication for me. It gave me a lot of anger, my mood worsened much more and loss of libido. But the worse side effect was a MAJOR and TOTAL loss of memory. Never taking anymore."

• Enska
• Taken for 10 years or more
• October 10, 2019

"I've been on Wellbutrin for years along with Celexa and Abilify. It seems like now I'm not even taking it. I think it worked pretty well at the beginning, but for me it has just lost most of its effectiveness. I have been having really low functionality with my depression for a couple years now, and my doctors keep saying that my energy and motivation should be fine because of the Wellbutrin (I take the highest dose too), but I think the depression is just stubborn now after so many years. Additionally, I have stopped taking it a number of times and I didn't have withdrawal, AND I didn't get more depressed. So it's like I'm taking nothing."

• Mandy
• May 9, 2017

"I live with depression and anxiety. Generic Wellbutrin has given me none of the sexual side effects I experienced with SSRIs like Zoloft. Seems to help me get out of the house. I'm on 150mg every morning and I'm trying 200mg soon. 300mg was too much for me."