Bupropion / dextromethorphan and Fatigue: What Users Say

• STL...
• Taken for 1 to 6 months
• October 10, 2023

For Major Depressive Disorder "This drug was a lifesaver, literally if you know what I mean. Six months on Prozac (20 mg) after depression's sudden onset was a disaster with trembling, brain fog, chest-pounding anxiety, an eye floater, and gastrointestinal issues. Auvelity started to improve my mood within three days and got better once Prozac was out of the system over about a month. The early side effects were some weird tired feeling in my legs that went away after a few weeks. There is some mild shakiness a few times a day. Today, I tentatively feel like a normal person again and almost like who I was before the depression's onset after about 10 weeks of 1 tablet per day. Going to 2 gave me some anxiety, it seems 1 tablet is good enough for me. There is some fatigue associated with the drug, but it is mild and not every day. I was lucky to get prescribed Auvelity."

• CTC...
• Taken for less than 1 month
• April 24, 2023

For Major Depressive Disorder "For reference, I’ve been on Wellbutrin and Effexor for several years. I stopped the Wellbutrin when starting Auvelity and I just started weaning off the Effexor this weekend, so it’s too early to tell. However, since I do feel “lighter” already, I’m hopeful. The first couple of days at the full dose caused some dizziness and mania about two hours after taking, but both have decreased. I took the second dose a little later last night, and now I feel extreme fatigue, so I’m going to be more diligent about taking it earlier. The doctor said the side effects should go away soon, so I’ll update here. Again, I’m hopeful!"

• Bip...
• Taken for less than 1 month
• June 8, 2023

"I've been taking aripiprazole 10 mg and lamotrigine 300 mg for bipolar, but I need to add in an antidepressant, so my doctor recommended Auvelity. I've been on it about a week now and am 3 days into the higher dose. I've had fatigue, lightheadedness, tiredness, tingling skin, jaw clenching, and vision problems as side effects. After taking a dose, I usually feel somewhere between tipsy and drunk, which isn't good while you are working. Still, underneath all the side effects, I can feel that it's working. I don't have suicidal thoughts, I don't have intrusive thoughts, and I'm generally calmer. I'm going to stick this out for a little bit as I feel like I'm not far enough into the higher dose to decide to come off of it. I've been fortunate in that I haven't had insomnia (quite the reverse), but I haven't experienced the change in energy or motivation yet. I'm hopeful, however."