Rexulti for Major Depressive Disorder User Reviews (Page 3)

• Catzz
• Taken for 2 to 5 years
• August 28, 2019

"Rexulti help save my life! I have been on it since 2014. Thanks to this drug I have only had 2 episodes of MDD.. I have suffered from depression since I was in my late teens & I am 57 years old now. I had my first experience with MDD., in Oct. of 2013 & my 2nd one sometime in 2016. My 2nd episode of MDD was a lot milder and I was able to recognize that I was battling another bout of it. I owe that all to Rexulti! Rexulti helps the other Antidepressants that I am on to work better. I also have an awesome Psychiatrist and Psychologist that have really really been there for me over the years."

• uhhhhh
• Taken for less than 1 month
• February 15, 2020

"I hate this medication (I had an adverse reaction). A couple years back my psychiatrist gave me a free trial of Rexulti to replace my antidepressant (I don’t remember what mg). I took it for about a week and a half before I started to have strong, consistent suicidal ideations. A week later I put myself into a psychiatric hospital with the support of my therapist and psychiatrist. The hospital didn’t have any Rexulti so I was forced to come off of it. After a week or so without taking it, the suicidal thoughts started to fade and I was back to the depressed-but-not-suicidal state I had been in beforehand. I would give Rexulti 0/10 if I could."

• Doone
• Taken for 1 to 6 months
• April 4, 2017

"I would give this drug a 10 if it didn't make me gain a little weight. I have had depression my whole life and also have ADD and OCD. It seems to be helping with my depression AND my OCD. I am not taking any other anti-depressants and maybe that is the key. I know it's supposed to be an add on, but my Dr. said I could take it alone. I am also taking Sam e which only helps a bit. I have been taking Rexulti for only about a month. It started working after only a few days and I hope it doesn't stop working. I have taken so many other anti depressants all with side effects or they only worked for a while. I have even had Trans cranial Magnetic Stimulation and it didn't work for me. :("

• AJ63
• Taken for 1 to 6 months
• February 8, 2019

"I’ve been taking Rexulti for about 6 months now. I’m presently taking 1 mg/day. This medication has changed my life. I was on an SSRI ( Zoloft then Paxil) for almost 18 years. I had severe breakthrough depression with menopause about 5 years ago and the SSRIs were no longer working. In the past 5 years I have been on numerous medications including atypical antipsychotics, mood stabilizers (Lithium, lamotrigine), Lexapro, Latuda. Nothing was helping and I was so low I was having persistent suicidal thoughts at one point. My psychiatrist started me on Rexulti on a whim. I feel like a new person. More energy and zest for life. I also take Seroquel for sleep which I’m hoping to wean and Adderall 20mg in am. This combo works well for me. It is an expensive drug but you can print an online coupon from Rexulti website for maximum $15 monthly copay with insurance."

• FLTE
• July 16, 2016

"Have tried this med as an add on to Lexapro twice in past year. Both times I felt an immediate (within 3 days) change/improvement. Started on .5 mg and stopped bc of weight gain. Several months of unrelenting depression strong suicidal thoughts/intentions despite exercise, avoiding alcohol, etc and I knew I had to try it again. Now 1mg and feel quite good. Sleeping pretty much through the night, except when hormonal, but that has been a consistent experience. Overall, I do use less Xanax on this medication. Appetite has increased, but has leveled off. My physical exercise routine has also increased so I would say that I've only gained about 3-4 lbs total, whereas before I had gained about 7-9# previously."

• Rachel
• Taken for less than 1 month
• December 8, 2019

"I was on Rexulti (Nov/Dec 2019) for 28 days. The first week I felt great I had more energy, not staying in bed for 16 hours a day. My mood was back to being positive, more outgoing and sarcastically funny. Then I began to feel very short tempered and frustration that got stronger every day. My family was telling me I was acting and talking differently. I at one point sent an email to my brother saying if I ever won the lottery I was going to hire a some to "take care" of a few family members and that he didn't have to worry, he wasn't on my list. I would never talk like this. Another email from me to my psychiatrist earned me a surprise visit from the police to include a complimentary trip to the Crisis Center and then to a hospital for 48 hours. You have to be careful in the the words you use in an attempt to be sarcastically funny - it would have been funny 20 years ago but not in the world we live in today."

• Anonymous
• Taken for 1 to 2 years
• October 15, 2016

"Probably the best antipsychotic I have ever been. I have only responded to Abilify and yet I still had some intense residual depressive, obsessive compulsive, insomnia and anxiety symptoms not allowing me to function well half the time--the side effects of abilify were also too much. My doctor told me about rexulti and how it is a better and more cleaner version of abilify, therefore I agreed to try it. I have now been on it for a year and it has helped me in ways that I am glad that I switched to it. The only issue is that it still causes weight gain and diabetes but these are less severe than on abilify. It is worth dealing with those side effects because now I no longer have insomnia and can function thanks to rexulti."

• Jano
• Taken for 1 to 6 months
• September 17, 2019

"I've been anxiety ridden since 7 yrs old with depression. Would not take pysche meds until I finally had a severe breakdown with agoraphobia. Zoloft helped.. but, 5 yrs ago at 56, I needed inpatient care and outpatient programs. I tried over 15 additional meds, nothing worked. Abilify a bit, but too hyper. Rexulti has been great. Gets rid of anxiety fast and depression too. It does stimulate my appetite and I've gained 20lbs."

• Sophi...
• Taken for 1 to 6 months
• February 3, 2020

"Rexulti took time to start working and now I feel better than I have for awhile. I've lost my parents and my ESA in the last 6 years. The downside is the weight gain. I've gained 20 lbs in a short period of time. I can't afford to gain weight, I'm already big. I eat the same things, I don't snack. In comparison, before Rexulti I ate more than I do now and didn't gain weight. It's the weight gain that makes it problematic."

• Zippy
• Taken for 1 to 6 months
• October 14, 2016

"I'm taking this for Bipolar 2 with major depressive disorder that has been treatment resistant for over 5 years. Rexulti is the first drug that has ever worked for me. I have tried virtually everything previously with things making me a zombie, worse than I was or simply nothing at all. Rexulti has been a miracle drug for me. It does give me insomnia so I'm going to try to switch to taking it in the morning to see if that helps. I am on a 2 mg dose."

• Lauren
• Taken for 1 to 6 months
• October 16, 2020

"I have Bipolar II with major depressive & Borderline Disorder and I started on .5mg per day for two weeks. I couldn't handle it, brought on a lot side effects. Once doc reduced to .25mg/day, I am feeling very good. The side effects are almost gone. It has helped immensely improved my day to day life with depression which was causing anxiety and other triggers for my mood disorders. I was on lamictal and trileptal before this. I switched entirely to Rexulti 6 weeks ago. Great part of this is quick to help depression. Bad part, tolerance is a bit tricky. Restlessness, digestive, insomnia was horrible when I was on wrong dose. Also, HUNGER is huge. I see why people have gained weight. I don't think it's like SSRIs where it screws w/ your metabolism. It just makes you hungry. Try to get a schedule down for eating and only eat at those times normal amounts of food. This helped me avoid weight gain. Highly recommend."

• Sarah
• Taken for 1 to 6 months
• September 7, 2018

"I never thought I would feel alive again. I have struggled with major depressive disorder for six years. I’ve been on many medications hoping each time it would be the “magic pill.” When I started Rexulti it took about two weeks for me to feel the positive impact of the medication. I feel present and a part of life again. I can get out of bed and do things and be happy!!!! I am grateful for Rexulti and how it has helped me."

• Anonymous
• Taken for less than 1 month
• October 7, 2015

"I've just started the starter pack of Rexulti I am on day 3. It is replacing Ability in my meds. I feel a lift in the depression, however I am experiencing some agitation and anxiety. I'm hoping this improves. It is affecting my dreaming...they aren't nightmares, just very vivid and strange. I am hopeful for this medicine if we can just get the agitation to cease."

• Not...
• Taken for 1 to 2 years
• March 3, 2019

"Rexulti is amazing in two categories: 1) depression and 2) massive weight gain. The weight gain does NOT come off when you stop Rexulti. Four years later, I’m still struggling with the 40 lbs I gained."

• Inked...
• Taken for 1 to 6 months
• January 3, 2019

"I believe this drug has been the best to treat my depression, Bipolar, and PTSD. I went from having suicidal ideations on a daily basis and now I only have intrusive thoughts on occasion. I would recommend trying this drug if you get a chance, I tried Seroquel, Abilify and all they did was make me tired and gain weight. Rexulti has been a great addition to my Lamictal to help balance my Bipolar depression. I give Rexulti a 9/10."

• Kiara...
• November 15, 2016

"I was put on half a mg for a week, then titrated to 1 mg. Everything was cool until about the 3rd or 4th wk I started feeling overhwelmed and ridiculously tired to where I couldn't keep my eyes open. Then it progrogressed to full blown anxiety in my POV. I never thought it could be rexulti until I finally saw my doc who took me off straight away after seeing how anxious I was. I can hardly deal with my son or life. He sadly has to calm himself as noise and lots of energy around me exascerbate my anxiety. I've been completely off for a day but I'm wondering how long it will be before I'm not anxious. I hope not the 2-4 weeks my doc said. I can't keep living with all this anxiety and tiredness and wanting to cry all the time."

• ram...
• March 16, 2017

"I have been on rexulti for about a year. a lifesaver!! I'm no longer stricken by depression and doomed with sadness and unmotivated. Rexulti has given me life back and I actually want to leave the house and do things. great medication, not for everyone tho. I also did gain 30 pounds. only downside"

• Early...
• Taken for 6 months to 1 year
• July 28, 2019

"I have bipolar disorder, MDD, and GAD. I tried Abilify as an add on and it made me so tired all the time and I gained weight. We switched to Rexulti and I immediately felt fabulous. I was stable and optimistic! Soon after, I noticed I was eating non stop. It was like an addiction. I struggle with weight as it is. I take Vyvanse for ADHD and it helps curb my appetite a little but the Rexulti still makes me want to eat all the time. Also, I've noticed it makes me really restless and irritable. I think it actually induces hypomania in me. I end up having major outbursts of anger and rage. It's even taken a toll on my marriage. I had to stop. I feel a little depressed but it's better than being out of control."

• Sharl...
• January 5, 2017

"First couple weeks were good but after that had a lot of nervous energy and a lot of waking up thoroughout the night. About a month in a began having intrusive thoughts and had to be hospitalized. They took me off the Rexulti and the intrusive thoughts went away after about two days."

• Frank...
• Taken for less than 1 month
• June 28, 2018

"24 years old. 4 yrs of treatment. I've tried Transcranial magnetic stimulation (TMS), etc, MAOIs, SSRIs, SNRIs, DNRI, atypicals...nothing worked. I took Rexulti...boom. I never thought life would ever be this good. God bless the people that found this. Thank you so much. I am going to hang out with my friends and family first time in 4 years."

• Kelley
• Taken for 1 to 6 months
• February 27, 2016

"I haven't really seen much in the way of adverse effects from actual users being reported online, though I have tried to find them. My experience as I have been taking it for about 3 months is that it has worsened my depression, made me extremely anti-social and withdrawn, and very easily agitated. I stopped it a few days ago and have experienced a slight improvement in those symptoms already. Please use caution when taking this as there is very little information out there about this drug, or how it is affecting actual patients. I will not be taking this drug again."

• Saman...
• Taken for 1 to 6 months
• December 17, 2019

"I took this medication for a couple of months in high school, and it didn't help with my depression at all, and it caused me to gain serious weight. In four weeks I had gained two inches around my waist, which likely equated to about 15 to 20 lbs. My eating habits did not change, nor did my appetite at all. This medication caused me serious stress and was not worthwhile for me."

• sleep...
• Taken for 1 to 6 months
• December 5, 2016

"Can't say this med is helping after about 6 weeks. On 2mg daily, went off my Effexor XR I was on for over 10 years. I take 200mg Trazadone at bedtime and have for years and always slept fine. Nothing has helped the Schizo or major depression in all my adult life. This Rexulti? I have not slept one night since starting it! I go to sleep, then wake up in like an hour or two and am wide awake until my alarm clock goes off in the morning. What scares me is that I am like a zombie. A very tired zombie. Ugh"

• mengman
• Taken for less than 1 month
• March 11, 2016

"Prozac kept me "in check" for around 30 years until it "pooped out". When added to the 20 mg of Brintellix, the addition of 2 mg of Rexulti has significantly improved my MDD symptoms. I began with the starter pack and went from 1/2 mg for a week, 1mg for a week and then to 2mg which I have been taking for the last 3 weeks. I have not experienced any side effects and fortunately my Dr. has been providing samples to me until I can find a way to obtain this drug at an affordable cost."

• Kelsey
• Taken for 1 to 6 months
• October 24, 2018

"If I could give this medication a 0, I would. My psychiatrist prescribed me a low dosage of Rexulti to help boost my "regular" antidepressant. After beginning this medication I felt paralyzed from my body to my increase in anxiety. I had no control of my motor skills which was dangerous because while driving my foot would tremor/bounce off of the gas & break pedals. I couldn't move my hands or grasp things properly and it absolutely terrified me after reviewing the side effects because motor movements was one if them and it stated it might not be able to be reversed. I immediately ceased this medication, the craziness stopped, and I would never go near it again."