Praluent User Reviews & Ratings (Page 2)

• Gir...
• August 23, 2017

For High Cholesterol "I am a statin intolerant patient who was initially excited to try this new drug. It was easy to administer and seemed to be working with little side effects (minor cough and cold symptoms). Total cholesterol went from 203 to 98 after just two months. As I continued to use the drug, I developed severe shortness of breath and heart palpitations. Sadly, apparently I can't tolerate this drug either. After further research, there is little information on long-term side effects. My pharmacist told me that patients are reporting my same symptoms and even memory loss. Not the drug for me."

• Mel...
• Taken for 1 to 6 months
• March 27, 2018

For High Cholesterol "I'm a 53-year-old female. I've had two heart attacks back in 2015. I'm also diabetic and have other chronic illnesses. My doctor prescribed this medication about four months ago. At first, I didn't take it, something made me wary. I don't tolerate statins. Just this week, I took my third dose. The side effects are horrible, the pain is unbearable. My memory is a mess. I can't literally hold a cup in my hands. Lower back pain, legs are weak, if I move an arm, it feels like it's being broken. My shoulders hurt, my neck hurts, literally, I'm not able to function at all. I will not take this medication ever again. I'm calling my doctor tomorrow and letting him know that I'm practically in pain 24/7. I refuse to be this ill."

• Uni...
• June 23, 2020

For High Cholesterol "This is an update to my April 29th comments. My numbers are great vs. last December 2019: cholesterol overall: 153 vs. 250, HDL: 65 vs. 56, LDL: 67 vs. 162, triglycerides: 107 vs. 160. Side effects: frequent muscle spasms, shorter in duration than muscle cramps, occurred during daily activity. Bend to tie my sneaker; spasm in my butt. Stretch to clasp on my bra; spasm in my midriff. These have subsided somewhat. I still have the same kinds of excruciating thigh/muscle cramps at night that I got on statins. The big difference is they aren't as bad or long-lasting. I still get cramps in my feet and the calves of my legs but, again, not as bad. My feet get sore and tired when I take my walks, which never happened 3-4 months ago. Overall, I would say if these side effects don't get any worse, I will likely continue on the drug. The outstanding results for my cholesterol are worth it, since I have cardiovascular risks, as well."

• GPa...
• Taken for 1 to 6 months
• August 10, 2019

For Cardiovascular Risk Reduction "I am three shots in or 5 weeks. Progressive muscle and joint pain. Muscle cramps. Rapid heartbeat and palpitations. Brain fog. Burning eyes. Dry nose. Stuffy nose. Hoarse voice. Horrible GERD for several days post-injection. No more for me. This stuff is horrible."

• Fat...
• Taken for 1 to 6 months
• April 7, 2016

For High Cholesterol "My dad is taking this med as no statin drug was tolerable for his high cholesterol. As other reviewers have noted, his LDL decreased quickly from 144 to 34. However, his HDL also had a significant decrease. It is now 34. We have a concern with this medication lowering both 'good' and 'bad' cholesterol. I think all individuals using this med are part of a bit of a continued experimental process given the controversial recent approval by the FDA to release. Sharing info on sites such as this can be useful. Please share feedback if others have similar experiences. My dad's doc told him to return in 2 months. He didn't seem too concerned about the low HDL number."

• NUM...
• Taken for 1 to 2 years
• April 11, 2020

For Cardiovascular Risk Reduction "I started Praluent about a year ago... loved the results, LDL from 135 to 69, just awesome. I first noticed a tightness in my chest and diaphragm, as I continued to take it, I noticed increased difficulty in breathing deeply and freely. There was the loss of stamina and increased fatigue. I used up my supply of Praluent 5 weeks ago... restricted breaths stopped about 2 weeks ago. SCARED about going back on Praluent with coronavirus approaching. I'm 69 years old, that battle will be hard enough... Restart Praluent... YES or NO? I JUST DON'T KNOW!"

• Lui...
• Taken for 1 to 2 years
• January 18, 2025

For High Cholesterol "57-year-old woman, stent/heart attack 2 years ago. Been using Praluent 75 since May 2024. Bad side effects with statins. Cholesterol down from 4.8 to 2.8. Have a lot of pain in the lower back, hips, and legs. Issue with my eyes, also memory. Noticed after the injection I get headaches, very tiredness, hot flushes, bad stiffness, can’t walk properly, anxiety, elevated heartbeat sometimes. Difficulty talking, finding the words sometimes. I train every day for my heart, but it’s tough. No info on long-term effects."

• Frm...
• Taken for less than 1 month
• April 30, 2016

For High Cholesterol "My Cardiologist prescribed Praluent to control cholesterol. I had one injection in October of 2015. Within 24 hours, my joints swelled to the point where, for example, I could not safely grasp my steering wheel. My B/P rose by 52 points to 191/106. My Cardiologist made no diagnosis outside of it might not be the Praluent, but began to try every drug that was available. My new normal B/P is 161/98. I have contacted the manufacturer, talked generically for an hour, who cordially let me speak with their research person, and we but was unable to get any list of could be's or look for's. After perusing the Internet today, I find that the injection could have caused Vasculitis or Immunogenicity."

• Jwa...
• Taken for less than 1 month
• November 20, 2020

For High Cholesterol "Horrible. It has been 6 days since I could function. Severe neck and sinus pain. Arms so tired I can barely lift them. No fever. Bronchial pain and short of breath. Doctor said wait it out. Wait 3 weeks before next dose. There will NOT be another dose."

• Kri...
• Taken for 1 to 6 months
• September 24, 2016

For High Cholesterol "Praluent dropped my cholesterol quickly and significantly. Unfortunately, the last 3 injections have been followed within a couple of hours by a rapid, irregular heart rate. Has anyone else experienced this 'side effect'?"

• Ell...
• Taken for 1 to 6 months
• September 16, 2019

For High Cholesterol, Familial Heterozygous "The Praluent injections gave me a runny nose, chest muscle pain, and I would cough up little chunks of clear phlegm for a few days after every injection. Then the muscle pains and fatigue would set in until time for the next shot. Rinse and repeat. However, my cardiologist was ecstatic with my blood work. I had been on the injections for a couple of months when I got a real bad case of pneumonia and could do nothing but lay in bed and cough phlegm for 3 weeks. I went off the injections during this time. After 4 weeks of no injections, I got blood work done and it was absolutely horrible, so now, of course, I'm back on it just praying the muscle pain goes away and that I don't get pneumonia again. This is the only medication I have ever taken that I am afraid might kill me. But my cardiologist thinks it's a freaking miracle drug."

• jhb...
• Taken for 6 months to 1 year
• January 11, 2023

For High Cholesterol "After the second injection, the medicine made sores on my back, which are now scars. At the eighth month, I was developing arm pain and my hands were going numb. At ten months, I lost the ability to perform any physical manual labor, lots of pain in my arms, hands going numb at night, it was worse. I am a hard worker, and I could not pick things up, I had no strength in my hands, severe pain in my arms and hands. I contacted my doctor finally. She did lots of blood work, and everything was okay with that. I was advised there was no explanation for the pain I was going through. I am on no meds other than Praluent. I found an article in the Journal of Neurology Research that described exactly what I was experiencing from what a 57-year-old woman went through and was diagnosed with CIDP as an exclusion diagnosis. Praluent is pure poison for me at least. I have never hurt so badly in my life and just hope there is no permanent damage. I have not taken an injection for 3 weeks now and still hurt with numb hands and arms."

• FtM...
• Taken for 1 to 6 months
• March 4, 2016

For High Cholesterol "I have experienced debilitating leg pain, brought on by simple walking, and I'm not sure if it's related to Praluent. It began shortly after the first injection and has increased in severity. I have seen many doctors without success."

• Nan...
• Taken for 1 to 6 months
• October 1, 2019

For High Cholesterol, Familial Heterozygous "62 yr-old female with heterozygous familial on statins - 20 mg Crestor - and ezetrol. After strict diet and exercise, total cholesterol down from 6.8 to 2.1. Started on Praluent bi-weekly in June. Although my LDL plummeted to 0.06, severe muscle spasms, pain, and cramps kept increasing: knee, thigh, ankle, next leg, and eventually upper arm. No more gym, chronic pain, sleepless nights, painful to stand or walk. Requested to be taken off a week ago. 3 weeks since my last shot and improving each day. Please God let the statins work better."

• Anonymous
• Taken for 1 to 6 months
• October 14, 2021

For High Cholesterol "Horrendous. I called the FDA. I had side effects of horrendous fatigue, flu-like symptoms, muscles hurt, feel very weak, musculoskeletal issues, burning, bad sinuses, tired, tired, diarrhea after the 4th bi-weekly injection, and insomnia. I was on a great path before this, my diet is good, I was active. Now I can’t do walking and treadmill because I just feel horrible. To walk up stairs, my legs feel so heavy. Would not recommend this to anyone. What’s the point in having great cholesterol numbers if your quality of life is horrible? I’m just waiting for this stuff to leave my system and praying it does no long-term damage."

• Mik...
• Taken for 5 to 10 years
• September 23, 2020

For High Cholesterol, Familial Heterozygous "Had a heart attack 5 years ago at 38 years old due to hypercholesterolemia. Statins wrecked my body up until this came out. I’m allergic to almost everything, so I was happy to hear that this medicine didn’t have bad side effects for most people. This medicine has literally saved my life. I've had normal levels for a while now. The only noticeable thing I get is occasional urinary sensitivity. Surprised to see all the negative comments. This medicine costs me nothing."

• CMa...
• February 18, 2020

For High Cholesterol "I was on a statin for several years, but in 2015 I had to have 2 stents put in. When the cardiologist increased the statin, I had side effects, so I had to stop it. She urged me to try Praluent, saying it had little to no side effects. After 4 doses, I got a UTI that didn't respond to the usual antibiotics, and I ended up in the hospital for stronger antibiotics. Then, a few weeks later, I developed pain in my neck muscles that got so bad it woke me up, I also had pain in my hips and legs. I've been off the medication for 3 weeks, and symptoms have all but disappeared. The only good thing was my collateral went down almost 100 points."

• Unh...
• Taken for 1 to 6 months
• August 17, 2020

For High Cholesterol "So I have been on Praluent for a month. I was previously on Repatha doing great, however, my insurance doesn't want to pay for that and made me switch. 2nd dose now has UTI, muscle pain, and daily headaches. I go to my doctor in 2 weeks and see if I can go back to Repatha. I thought from the reviews they are the same, however, these side effects are telling otherwise. By the way, both give me a stuffy nose, but I can live with that one. The other side effects were what I had being on statins, and this is the low dose of Praluent."

• NJG...
• November 14, 2019

For Cardiovascular Risk Reduction "Took one dose of Praluent @ 3:00 PM and had a massive flush of symptoms throughout my whole body 15 minutes later. At the ER at 4:00, given a steroid shot, Benadryl shot, and finally epinephrine to stop the reaction 4 hours later. This is toxic and poison! It should be taken off the market."

• Bad...
• Taken for 1 to 6 months
• February 20, 2016

For High Cholesterol "So far, this drug is amazing! I did my first injection of 75 mg on 1-6-2016. I had a lipid panel drawn on 1-8-2016 to see what my starting baseline will be. In the 48 hours between the injection and the lipid panel, the results were nothing less than miraculous. My total cholesterol went from 222 to 170, LDL from 152 to 96! I can't wait to see the results at 30 days and on. The self-injection was virtually painless and quick. I didn't even have any injection site reactions like swelling or redness, and I always have those side effects from almost all shots. I'm not on the Praluent payroll, just a 68-year-old man who couldn't take statins and now has a great alternative drug. I hope you have the same results as I have."

• ele...
• Taken for 1 to 6 months
• October 21, 2021

For High Cholesterol "My mum (76) took Praluent 75 for some months and in a short time started complaining of elevated BP and feeling of ear pressure, something she never suffered from before. After some months, her total cholesterol showed a marginal reduction (200) but also a CPK elevation (245). Be aware of this drug, it is still quite experimental. Doctors will mostly deny its side effects as do the leaflets, but they are all there! Doctors only care about studies with a control group, but please also listen to the actual experiences from patients!"

• a w...
• January 18, 2016

For High Cholesterol "After three shots, my cholesterol came down over 100 points to 152, as did my LDL, down over 100 points. But I am not happy with the side effects of sinusitis and now earache. My whole face is throbbing from neck to face. Not sure if the pain in my arm is part of the side effects. I am fearing other side effects noted on the bladder infection. The first three shots were samples; the next will cost me about $50 a shot. Having problems with the prescription... pharmacy is still working with the pharmaceutical company. I will ask to discontinue, even if all other statins have not helped. I am a 79-year-old female."

• Fri...
• Taken for 1 to 2 years
• December 24, 2018

For High Cholesterol "Dramatic reduction in total cholesterol after about 1.5 years. 62-year-old female. Went from 250 down to now 107. Have gradually been getting more and more fatigued, weaker, and now to the point I can't do my walks. Going to call cardiologist after the holidays. This is how I felt on statins after just a few days. I'm disappointed. Very easy to use med."

• RSU...
• Taken for 1 to 2 years
• January 6, 2018

For High Cholesterol "Started Praluent 9/2015. Began cough/cold symptoms 1/2016. Injection every 2 wks. Symptoms got worse each time the med was injected. 7/2016 informed my Dr. who said symptoms were unrelated. Between 8/2016 and 1/2017 went to the ER 5 times and spent 20 days in the hospital. Bronchitis and autoimmune reaction. The med reduced LDL and destroyed my immune system. Had to receive infusion and still have very low IGG. Once I stopped it, took all of 2017 to start feeling a little better. Reported reaction to mfg and FDA. Thinking about seeking litigation advice."

• Lak...
• Taken for 1 to 2 years
• November 27, 2018

For Cardiovascular Risk Reduction "Have genetic high cholesterol plus cardiovascular risk. Taking statins caused myopathy, resulting in terrible muscle aches and pains. I have been on Praluent 75 mg twice monthly for approximately 2 years. I am a very active, soon-to-be 70 years old, however, after sitting at least 10 minutes, it is unbearable to raise my body and start walking, as my body is very stiff. Hard to get my feet to move...I ache from my lower back down to my feet...my insides feel very sore, and I have developed terrible nose sores! I am afraid if I take it much longer, I will be unable to walk. I was hoping that the Praluent was safe for me, and in the beginning of using Praluent, I was pleased with the thought of it lowering my cholesterol and having no side effects. Not sure what to do now!"