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Acetaminophen / hydrocodone for Pain User Reviews (Page 3)

Brand names: Xodol Zyfrel

Acetaminophen / hydrocodone has an average rating of 6.2 out of 10 from a total of 708 reviews for the treatment of Pain. 52% of reviewers reported a positive experience, while 31% reported a negative experience.

Reviews for Acetaminophen / hydrocodone

  • shelly...
  • Taken for 2 to 5 years
  • May 2, 2023

"I agree with everyone about the switch though I doubt the FDA will do anything. After two hip and neck surgeries, the meds don't give me pain relief now like the earlier ones. I'm fatigued more and these pills don't seem to work."

1 / 10
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30 Report
  • WeAre...
  • Taken for less than 1 month
  • October 6, 2022

"I did a little "investigating" a few years ago about this. I found that some of these manufacturers are legally able to put a certain percentage of the ACTIVE ingredient in some of these meds. So, some people might get 85% of the active ingredient while others may get 90, 95, 100%.... I also found many MANY pharmacies don't even carry brand name, only generic. I also found that they can charge more for 325 mg of the APAP than they do for 300mg of the same. Or maybe it's the other way around....anyway, you get the gist.... I've also found that some pharmacists or techs look all googgle-eyed at you if you ask for name brand, like you were stabbing a kitten at their cash register or something. And they have basically more say-so than your doctor. I've simply decided to take BC powders and have my insides eaten up. I don't have insurance. I hope good people aren't being made to suffer needlessly."

1 / 10
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40 Report
  • Mrs...
  • Taken for 5 to 10 years
  • July 18, 2014

Norco (acetaminophen / hydrocodone) "I was diagnosed with Fibromyalgia about seven years ago. I have taken Norco as prescribed by my physician along with other medications. Norco has improved my quality of life 100% as it allows me to manage down my pain level so that I am capable of conducting everyday living without that heavy narcotic side effects i.e., feeling 'high', sleepiness, nausea, abdominal discomfort. I think I have developed a mild physical or mental dependence due to the length of time that I've been on the medicine. First and foremost I take the medicine as directed and I do not wait until my pain level is at a 10 before I act otherwise its effects are limited. Norco has been very helpful in giving me my life back!"

10 / 10
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141 Report
  • Curley
  • June 10, 2020

"This acetaminophen/hydrocodone Camber brand yellow pill with the number T259 (325 mg/10 mg). This must have come from the black market because it is worthless. I have to stay in pain all month long. It is wrong to have your insurance pay for this pill. No more for me. I have to find out what is in this pill. My pain is too great. Camber, fix this medication."

1 / 10
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72 Report
  • Dee
  • Taken for 10 years or more
  • January 6, 2022

Lortab (acetaminophen / hydrocodone) "I have taken this medication for 30 years this is by far the worst ! One month ok, the next month like I'm taking nothing! When Watson brand was available I did not have this problem. It's extremely frustrating and painful!"

2 / 10
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Are you taking this medicine?

  • wraym...
  • March 11, 2008

Norco (acetaminophen / hydrocodone) "I have had a severe back injury and have been off work since Nov '06. I was first on Vicodin, which didn't work anymore, so they put me on Norco to manage the pain. It works wonders, and I take 1-2 every 4 hours. However, it has become very habit-forming, and I don't see an easy end to trying to cut back or get off these pills. They work great for pain, but be careful!"

10 / 10
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198 Report
  • Greg
  • Taken for 5 to 10 years
  • February 29, 2020

"I just got a script yesterday for the 1st time for these generic pills acetaminophen & hydrocodone. I've been taking 10/325 Norco's for over 6 years due to all my health issues along with OxyContin. I totally feel the difference with these pills. The yellow ones are actually the best I have ever taken, but these are garbage like everyone is saying. I just don't know how to file a complaint? Good luck everyone!"

2 / 10
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71 Report
  • Anonymous
  • December 11, 2019

"I have Fibromyalgia, neck herniated discs, plantar fasciitis. What is going on? They've been changing the generics, so they don't work. Why are they doing this to us? We are not the criminal junkies overdosing on illegal drugs. I have been taking the same Tris Pharmaceutical brand of acetaminophen with hydrocodone for several years at work okay until last year they changed it, so now it does not work. I know they changed it because I had some old pills left and they looked different. I got my new prescription and it's even worse than it was before. I am devastated. I have to support myself and I won't be able to with this pain being untreated. I can no longer clean my home or care for my sick cat. I am scared to death. Why is the government doing this to us? We need to file a complaint with the drug manufacturer and FDA. Maybe enough people are not complaining to the FDA and that is why all these companies have gotten away with it for so many years, as this all started about 6 years ago, when the Watson brand changed from yellow to white. Please file an FDA complaint."

1 / 10
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  • Anonymous
  • Taken for 5 to 10 years
  • March 6, 2019

"Are all of you that are complaining about Mallinckrodt? Have you already filed complaints with the FDA? I sure hope so because that's the only way they will be stopped. So, sure, complain here BUT PLEASE FILE COMPLAINTS TO THE FDA! Also, do complaints on Tris. They changed their formula and it no longer works; this is sickening! I am gonna be homeless as I had to quit my job due to no pain relief! I know they changed it because I had saved a few pills from the prior month and when I took even HALF, I felt a night and day difference. Yet I called Tris, and they lie and say nothing changed. They are doing something probably illegal, and it also makes my heart race. They are playing with people's health and lives, and it's sickening."

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  • skeeter
  • Taken for 5 to 10 years
  • February 7, 2019

"Like everyone else, I was on Watson brand till they sold out. Mallinckrodt is now what every major pharmacy has in our town of 200,000: Walmart, CVS, HEB, to name a few. First of all, if you call trying to find another brand, they treat you like a drug addict. I'm 70 years old, a retired teacher. What is this country coming to when you can't buy a pain reliever that works but you can get all the marijuana you need? The manufacturer of this Mallinckrodt should be investigated. No one in the government seems to care. Big surprise! I have a prescription for brand name only - guess what? The pharmacy won't even order the brand name. I still don't understand that, so you can't order the brand name. Someone answer that one."

1 / 10
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80 Report
  • Scarlet
  • Taken for 10 years or more
  • June 15, 2019

"I'm part of the acetaminophen with hydrocodone generic saga. I have had the same bad experience with Lupin brand of acetaminophen with hydrocodone. I've been a long-time, non-addict user of Hydrocodone for my Ehlers-Danlos pain. Recently, I got my first bottle of Lupin's acetaminophen/hydrocodone from CVS and went into withdrawal, increased pain, and my Mast Cell Disorder spiked. Two weeks later I was back to my normal manufacturer and went back to my normal. Today I got Lupin meds again and I'm tanking. This manufacturer is not providing the correct dosage and should be removed from the market."

1 / 10
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75 Report
  • Jax
  • March 29, 2019

Norco (acetaminophen / hydrocodone) "Both Norco and it’s Generic Actavis version 5-300 mg (White Scored Tablets) caused such a reaction that I turned in both prescriptions in to local Police Department Med Drop. CVS noted I could not take Norco, yet one month later they filled a prescription with the Generic form by Actavis, once again I was violently ill. For me Mallinckrodt White Oval Scored Tablet 5-300 mg is a marvel. No side effects whatsoever, just absolute pain relief in 30-45 minutes. Effective up to 5 hours, even 1/2 tablet is effective within an hour lasts perhaps 4-4:30 hours. CVS now only carries LUPIN Pharmaceuticals for Generic Hydrocodone/Acetaminophen 5-300 mg. Agh ! Massive headache, waves of nausea and dizzying lightheaded~No Pain Relief ."

1 / 10
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76 Report
  • 2 cents
  • Taken for 10 years or more
  • December 8, 2019

"Shocked that I have been taking generic Norco (acetaminophen with hydrocodone) and wondering why IT ISN’T HELPING. I used to get enough relief with the Watson brand to function enough, but that changed in [maybe] 2018. I didn’t know why, and I thought I just had to suffer to the point of being bedridden. I wasn’t aware of the change in manufacturer until now. Mallinckrodt brand of acetaminophen and hydrocodone DOESN’T WORK. I cannot believe that doctors are prescribing this new brand of garbage and allowing severely debilitating pain patients to suffer. I am so glad that I looked at the label on my generic Norco today. Thank you to everyone here who took the time to write about this maddening situation. Thank you so much."

10 / 10
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67 Report
  • Teri...
  • October 1, 2015

Norco (acetaminophen / hydrocodone) "I have severe Fibromyalgia with migraine/tension headaches and Chronic Fatigue. I also have osteoarthritis in my hips and lower back. I've already had one SI joint fusion. I am on disability because of the Fibromyalgia. I have used Norco 10/325 for several years. It controls the pain well, and at this point, I am able to manage with only 1-2 tablets a day. I have to manage my pain to be able to function; otherwise, depression sets in with the pain, and I just want to stay in bed. I may be somewhat dependent on Norco now, but it's worth it to have a life."

10 / 10
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108 Report
  • Vegas
  • Taken for 5 to 10 years
  • June 10, 2022

Norco (acetaminophen / hydrocodone) "I moved and switched pharmacies. Still the same chain, just different location. I was receiving 180 10/325 Norco with the imprint m367 those worked great, little to no side effects most days and pain relief. The new pharmacy gave me a different brand white pill with 10 on one side and n 358 on the other. I filled them Tuesday, today is Friday, I started the new ones last night. Almost immediately I realized there was a problem. Broke out in hives and my tongue started to swell. Zero pain relief. I called my on call nurse and she advised me to take benadryl and if my symptoms get worse or I can't breathe to call 911. I have been up all night in pain as well as fighting the rash, luckily the more time that passes the less I'm itchy. I don't understand how I'm allergic to one brand and not the other. At this point I don't even think this brand even has tylenol in it. These new pills are extremely fragile and turn into mush on your tongue before you can even take a sip of water."

1 / 10
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  • Half...
  • February 28, 2019

"I have tried a lot of brands of different pain meds for my migraines. Both hydrocodone and oxycodone. There are so many fake medications going around. Not just opiates, heart medication, diabetic meds, blood clot meds, etc. Currently I am getting the A 40 10/325 made by KVK. They are a hit and miss. Some pills will work and others won't, and they are the same pills in the same prescription bottle received from the pharmacy! They even dissolve differently. Some won't melt if you have to hold them in your mouth a second to get a drink, others will melt into a foamy/chalky substance almost instantly! These pharmacies are being allowed to buy from other countries that are not regulated nor have clean working conditions. They sell medicine for dirt cheap and most meds are fake and either have less than the active ingredient or none of it. Even worse, they are allowed to put any fillers or binders they want in it and OUR PHARMACEUTICALS ARE BUYING THEM TO SAVE MONEY AND COSTING PEOPLE THEIR LIVES!"

4 / 10
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74 Report
  • Anonymous
  • Taken for less than 1 month
  • January 9, 2019

"Actavis is now Watson and works. I was forced to take Mallinckrodt and had so many awful side effects and didn’t even help with pain, which were new to me since I’ve taken Watson since my first failed neck surgery years ago. I never understood why people abuse these medications since I didn’t have side effects or a 'high' from them, but I also take them responsibly. I made the pharmacy give me a list of all the ingredients since doctors say they are all the same; they are not. Mallinckrodt needs to be taken off the market. Too many fines, recalls, and lawsuits."

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75 Report
  • Bober...
  • June 17, 2021

Norco (acetaminophen / hydrocodone) "Vicodin and Norco seem consistent and without adverse side effects. I was able to work, go to school, take care of all the necessities of a busy and productive life, even with pain from Spondylosis. There has been a supply issue with the inception of the "Opioid Crisis". Legitimate Patients are unable to fill their prescriptions. Mallinckrodt brand gave me what can be described as flu-like symptoms. Nausea, ringing in my ears, headache, and general malaise. I checked the ingredients list to see if there was anything I was allergic to in the filler. I see nothing amiss. This is a mystery indeed. NORCO is unavailable at any pharmacy I have inquired to and the preferred generic from Camber Pharmaceuticals is also not available. Whether this is a manufacturing issue, a supply issue or a corporate issue (higher profits from offering a cheaper generic), I do not know."

8 / 10
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48 Report
  • CasAu...
  • Taken for 2 to 5 years
  • September 17, 2019

"Chronic Pain escalated to the point it was unbearable. Chronic fatigue & constant malaise. Arthritis Specialist & Pain Mgt had no answers. Manufacturer for the medication acetaminophen with hydrocodone that I was taking was LUPIN, previously I'd used Watson. I had a few reserve Watson's & tried one. THERE WAS A DRASTIC DIFFERENCE in the Watson and LUPIN!!!! IMMEDIATELY the sleepiness left, the Watson was effective and lasted Long enough to complete chores with a pain level of 2 verses 8 I felt on LUPIN. The next day I tried LUPIN, once again I had serious side effects. Watson is no longer in business. MY CVS Pharmacy Manager found a Manufacturer that manufactured pain medication that is effective without all the serious side effects of LUPIN. Be sure to file concerns with all parties involved. BEST TO ALL PAIN SUFFERS❤️"

8 / 10
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67 Report
  • shadow
  • Taken for 1 to 2 years
  • September 10, 2019

"I refilled my prescription a week ago for my regular acetaminophen with hydrocodone, and the pharmacy gave me these pills Mfg is Lupin imprint is n 358 and 10 on reverse side. This is the first time using this brand of pills and they are awful!!! I constantly have a headache and nausea, so much so I actually vomited after taking one. I thought I had a stomach bug or something but I realized it started when I started my new bottle of hydros. and nothing as far as pain relief. Also I feel more tired and depressed. FDA needs to take these off the market."

1 / 10
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  • Nana
  • Taken for 10 years or more
  • June 11, 2019

"I want to share my experience with these pain medications from Lupin. About five months ago, I believe I got a bad batch of this medication. I asked my pharmacist at CVS why I wasn't getting any relief from my medications. I was treated like I was imagining it. I spoke with my pain management doctor, and he said he didn't know why this was happening. So I got more injections. They just don't work for me. The next month, I picked up my prescription, and it was Lupin again. I was so upset. I took my first dose, and I had pain relief. So I thought, maybe I injured myself or it was just me. Well, I'm two days in on the prescription, and here we go again, no relief at all. I have headaches and muscle aches. I don't get it. I'm wondering if I'm just getting bad batches with little or no medication in them. I have been on the same doses for years, so I know my dose works for me."

1 / 10
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69 Report
  • Lola
  • Taken for 5 to 10 years
  • January 9, 2019

"I have been having trouble with my hydrocodone 7.5/APAP325 made by Mallinckrodt for a while but had no idea why. I have herniated discs in my neck and back along with arthritis, migraines, fibromyalgia, and inflammatory bowel disease. When I started taking the one made by Mallinckrodt, I saw a significant increase in my inflammatory bowel symptoms, more joint and muscle pain, and an increase in my migraines. I thought it might be the inactive ingredients, and that might be part of it, but there is no way to find out. When I asked my pharmacist, they said to contact the manufacturer. You can’t contact the manufacturer either; there is no information on how to reach them. It makes me so angry because that information is important to someone like me who has a lot of food and drug allergies. I am definitely going to report this to the FDA and to Mallinckrodt."

3 / 10
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  • poppy...
  • Taken for 6 months to 1 year
  • January 27, 2020

"I suffer from severe spinal pain, both neck & lower back disc deterioration & nerve damage. I started 10/325 hydrocodone with acetominophen by Rhodes . This medication would bring my pain from a 10 to a 5 and allowed me to function. This last refill however was changed to Sun Pharma & I get absolutely NO pain relief !!! I feel as if this company is is not putting any hydrocodone at all in this medication. FDA do your job & monitor what goes into our medicine."

2 / 10
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62 Report
  • Anonymous
  • Taken for 6 months to 1 year
  • October 7, 2018

Norco (acetaminophen / hydrocodone) "I've always taken the yellow Norco. I fractured my hip and my back. They stopped prescribing the yellow, and now they give me white Norco, and it doesn't work at all. Before, I was taking half of a yellow Norco, which worked fine. Now I take the white one, which sucks - it doesn't take my pain away. I don't know what the differences are, and I don't know where to buy the yellow brand. It is driving me crazy. The first time I took the white one, it gave me nightmares. Is there something wrong with the manufacturing process? Are there QA tests on these?"

10 / 10
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74 Report
  • Jimbo
  • July 17, 2020

"I have pain from Failed back surgery. I've found a WALGREENS in Illinois that will special order the par brand of acetaminophen/hydrocodone (qualitiest) Norco 10/325 for me. These are the LAST of the yellow acetaminophen/hydrocodone, and as such the last that work. (Unless you want to send insane money on name brand Norco). Also, I used to be on Fentanyl patches, and this same Walgreens ordered Sandoz brand Fentanyl. Sandoz is manufactured in the same facility and on the same line as name Brand Duragesic. The point being here, if you can make friends with your local Walgreens pharmacy manager, they can order a LOT of the specialty generic brands that are so much more effective then the IP 109/110 or the M367 garbage that every other pharmacy seems to dispense. I don't think Watson even manufactures Norco anymore."

8 / 10
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56 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.