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Acetaminophen / hydrocodone for Pain User Reviews (Page 2)

Brand names: Xodol Zyfrel

Acetaminophen / hydrocodone has an average rating of 6.2 out of 10 from a total of 708 reviews for the treatment of Pain. 52% of reviewers reported a positive experience, while 31% reported a negative experience.

Reviews for Acetaminophen / hydrocodone

  • Real...
  • Taken for 2 to 5 years
  • September 13, 2021

Norco (acetaminophen / hydrocodone) "With brand Norco or Watson Hydrocodone at one a day, I experienced occasional itchy nose, occasional mild nausea, occasional constipation. Now at six Mallinckrodt brand Hydrocodone, I have no side effects. Along with minimal pain relief. Billions of dollars are being spent on these inferior drugs. People's money, insurance companies, taxpayers' money in the trash, and people suffering! What a joke the FDA is. Time for a federal lawsuit against the FDA and Mallinckrodt, as well as anyone else who stood by while this is going on. This is not the solution to a few bad apples that misuse/abuse their medication. There are many more people who have been using it responsibly, and it's not hard to distinguish the addicts from the people who want to be able to live their lives without agony and depression from constant pain. It may be sad when abusers overdose, but it's worse when honest, deserving patients give up due to no pain relief."

1 / 10
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  • M 367
  • April 21, 2022

Norco (acetaminophen / hydrocodone) "It pains me to see my mother suffer, to have been naive enough that I believed all generics are created equal and to have accused her of addiction and abusing her medicine. For a 10-month period in 2021, she had a better generic and her emotional, physical, and social health exceeded what I had assumed possible. Now back on bad generics, she is yellow, lethargic, and incoherent as well as needing more to ease pain. FDA do your job; you’re damaging my mother."

1 / 10
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  • LCano
  • September 15, 2018

Norco (acetaminophen / hydrocodone) "I used to take the 10/325 'yellow' pills, but now most pharmacies dispense white pills made by Watson, Mallinckrodt (“M”) or Amneal. Watson worked best for me, but not as well as the yellow pills. Walgreens just signed a contract with M and that's all they carry now. I can definitively say this past month has been awful. The M brand did not help my pain and made me very irritable. It's as if M put out a placebo or sugar pill. I refuse to take more pills due to the lack of efficacy of the M pills. I learned independent pharmacies often carry several brands at one time. One near me carries three -- including PAR (the yellow ones!) I hate to sound excited, but I thought they stopped making those and have been suffering through sub-par (pun intended) substitutions. The pharmacist told me Par costs twice as much to order than other brands. My guess is that's because it actually works. If you find a brand that works for your body, it can definitely improve quality of life."

9 / 10
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  • Fools...
  • Taken for 10 years or more
  • June 20, 2022

Norco (acetaminophen / hydrocodone) "Manufacturers of opioid pain relief medications must have gotten orders from healthcare leaders to reformulate these life saving medications. There is a recent drastic change in how they work and the cause most likely is they want you to ask for higher dosage to label you, which does no good due to the reformulate. Legitimate pain patients should just keep complaining to elected officials. Farmland states Dept. of Health may have different priorities because of the physical work needed for farm work. Bottom line, if you have daily pain because of a career in daily physical labor jobs with radiological images and medical proof of the pain condition, healthcare leaders couldn't care less."

2 / 10
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  • Jgano
  • Taken for 10 years or more
  • June 26, 2019

"I have 2 degrees in nursing and have been taking the yellow Norco for well over 15 years. Sometimes I only take 1/2 pill and obtain relief. CVS has changed the manufacturer to Lupin. Probably cheaper; stockholders will be happy but I am not. Minimal pain relief. I picked them up on the 22nd and am so angry. If I knew where I could get these generics analyzed, I would do it. Now that I get no pain relief and I have Part D insurance through CVS, I will be dumping them during open enrollment and hopefully find one that is honorable. Osteoarthritis. Shame on CVS!"

1 / 10
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  • Gandy...
  • Taken for 10 years or more
  • March 20, 2022

Norco (acetaminophen / hydrocodone) "Seems the physical dimensions of the product has changed with the formula. This med is supposed to be semi synthetic and may be less of the semi (natural opioid) and more of the cheap synthetic now. My same R/x that I have been taking for years, two a day max, fit in the smaller vial whereas 3 years ago they would not fit. They also do not have the same pain relief from that time. My heart disease is getting worse without the pain control. Please be cautious with this med if my suspicion is correct that the formula changed, because that cheap drugs are dangerous stuff. It is a shame how the medical community has changed and doesn't care about seniors who built all of what everyone enjoys today. Be safe policies are changing very fast."

2 / 10
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  • MLB
  • Taken for 10 years or more
  • October 4, 2020

"Those with concerns regarding current generic pain medications are not imagining anything. After a gunshot left me with debilitating pain close to 20 years ago, I was hesitant to begin opioid therapy. I was initially given numerous non-opiate meds to try and control the pain (Elavil, Neurontin, etc). After a few years, I ultimately ended up being prescribed Norco 10/325. Norco 10/325 worked wonders for me for years. All of a sudden, around the end of 2017, I filled my prescription and was notified that the pharmacy carries a new 'manufacturer's' brand. Ok, I thought no big deal, right? Well, it was a very big deal. That first generic I tried did zero except make me nauseous, so I changed pharmacies. The 2nd generic just made me feel weird & anxious. I stuck with the 3rd generic, Mallinckrodt, which is okay sometimes (very hit & miss, no stability). My physician has offered to prescribe me stronger meds, and despite my hesitation, I may need to change. Best of luck to you all!"

5 / 10
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  • mbeau
  • February 24, 2019

"I truly believe the FDA and the pharmaceutical companies are working together to make our hydrocodone pills less effective. I have been taking two 10/325 hydrocodone pills per day for the last several years since I have psoriatic arthritis. At first, I was able to get the yellow Par pills and they worked really great! When I moved to FL, I could only get the Watson brand and they worked pretty well. In Sept 2018, Walgreens switched to TRIS and they are horrible. Then I tried the Mallinckrodt from Walmart and they're worthless. Then 3 months ago, I tried Aurobindo from Costco and found them to work pretty well. However, I picked up my latest prescription on Thursday and they must have changed the ingredients as now they offer no pain relief at all. I agree with the folks who have written that we need to complain to the FDA concerning the quality of the hydrocodone pills we are receiving. This is extremely upsetting that there isn't one single brand available to help with our pain!"

2 / 10
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114 Report
  • Realt...
  • Taken for 2 to 5 years
  • April 3, 2019

"My pain issues are Severe Congenital Spinal Stenosis of Cervical and Lumbar, Degenerative Disc Disease, Scoliosis, and peripheral neuropathy. The stenosis is causing my spine to flatten. I'm new to writing reviews, so please bear with me. My pain management doctor prescribed Norco 10/325. I've always received the brand Lupin Pharmaceuticals, which relieves my pain tremendously. Until recently, I was given Amneal Pharma and today Mallinckrodt Pharma, both from my CVS Pharmacy. These two companies are distributing trash! If I were to submit Lupin Pharmaceuticals Norco, Amneal, and Mallinckrodt to a chemist, he/she would respond with the same results. Those companies, Amneal and Mallinckrodt, are using some type of fillers that have caused their pain medication to be worse than a baby aspirin! It shouldn't matter what company manufactures Norco. They should all be the same; however, that's not the case! They'll end up causing people to take more than prescribed because there's no pain relief! Quit screwing with pain medication! How do these people sleep at night knowing their product is junk! Thank you Lupin Pharmaceuticals for not being part of the monopoly the government has created for patients with chronic pain!"

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  • KTano
  • Taken for 2 to 5 years
  • April 26, 2021

"I have been taking 5/325 mg and on occasion 7.5/325 mg generic Norco. I changed pharmacy one time and was given Mallinckrodt Pharmaceuticals brand (M366 on pill). I have had some psychological disturbances since starting this current round of meds from this company. Not sure if it is coincidence but I am extremely concerned!!! Someone, anyone who reads these reviews, can we investigate this company? I see other people have mentioned this as well. What is going on? Thank you."

7 / 10
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  • Sarah
  • Taken for 6 months to 1 year
  • October 29, 2018

Norco (acetaminophen / hydrocodone) "Norco worked pretty well for me at the right dose and when rx'd with muscle relaxers. However, I was originally rx'd long-acting opioids because I had liver damage due to Halothane toxicity and taking a single-ingredient opioid was safer. With the new 'guidelines,' I can't even find a doctor who's okay with rxing Norco so I'm back to taking high doses of acetaminophen. The govt has really screwed chronic pain patients."

7 / 10
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115 Report
  • EddieZ
  • Taken for 10 years or more
  • January 9, 2022

"Full Stop. Do not complain here or with your physician. Send a FDA MEDWatch Complaint form 3500 and FAX it to the FDA. Only and only if we have enough complaints will the FDA actually run an assay to establish the FDA required 80-120% of a Brand medication value. We all know that the medication we are receiving is sub therapeutic and not one person is listening. The only way we can get relief for REAL Pain patients is to keep sending the Medwatch FDA form 3500 to the government. FDA/Medwatch/3500 form and print and fax. Do it now!!!"

1 / 10
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62 Report
  • keller
  • Taken for 2 to 5 years
  • January 28, 2020

"Feeling sick for over a year now from hydrocodone ingredient change by the manufacturers. Heart racing, insomnia, chest pains. Where can we have these pills analyzed to tell what is in them? I clearly have suffered immensely. We just have to find a lab that is not paid off by the government."

1 / 10
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  • Pattyc
  • Taken for 5 to 10 years
  • March 25, 2023

Norco (acetaminophen / hydrocodone) "Norco is extremely effective - I have used it over the years after having 3 back surgeries. I have never experienced any negative side effects or withdrawal symptoms. Norco has been in use for over 60 years and has not caused a public health crisis. We have oxycontin to thank for that - a drug that should never have been approved. Oxycontin is no more effective than Norco but is five times more addictive by design. The FDA should be ashamed of itself, and generic manufacturer Mallinckrodt should do us all a favor and go out of business. It is simply a waste unless you're looking for a medication that causes you to throw up. I would rate Norco a 10 and Mallinckrodt a 1. Oxycontin is an abomination. Meanwhile, millions of us with moderate to severe pain every day have nowhere to turn."

10 / 10
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37 Report
  • Drew
  • Taken for 10 years or more
  • June 13, 2023

Norco (acetaminophen / hydrocodone) "I used to take the colored Watson Norco and it worked great but ever since they switched to this white generic one it doesn’t do anything for me and has been the same for friends. The Percocet still works but not the hydrocodone."

3 / 10
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  • Berry...
  • Taken for 2 to 5 years
  • June 3, 2022

Norco (acetaminophen / hydrocodone) "After reading some of these reviews I am not alone. I actually thought maybe it's just me thinking the medicine doesn't work at times when I take it. WTH? What is going on? I have neck pain, neck fused with 2 cadaver discs. Now it's the back of my neck. The pain management center Dr. just lowered dose quite quickly I might add. Maybe because I'm on medicare now they got audited? I know that happens cause I worked in a Dr. office!! It's like no one cares about your chronic pain. Even after a tendon repair surgery on my hand the nerve block wore off after 18 hrs. and it felt like my hand went through a tree shredder. I literally had to BEG for a few to get through at least 2 days after surgery. All because of an opioid crisis thanks to the drug addicts .Now people who suffer genuine pain have to suffer."

6 / 10
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  • Anonymous
  • October 27, 2009

Vicodin (acetaminophen / hydrocodone) "I started taking this after my knee surgery. I found it to be great. My recovery time was fast. I had no pain and lots of energy. It started with 3 or 4 pills a day, then after that it got to be 5 or 6 a day. I then had foot surgery. I had to take more for the pain to go away. This went on for 5 years. By the time I got help, I was taking 20 to 25 pills a day. I now know that God is watching over me because if he wasn't, I wouldn't be here now. I am now off of all painkillers, but it took a lot of hard work. I'm letting you know this because it creeps up on you before you even know it. Vicodin may help you at first and you may be able to control it. I thought I could. I'm just asking you, please be careful with this medicine."

10 / 10
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220 Report
  • Gandy...
  • Taken for 10 years or more
  • June 23, 2022

Norco (acetaminophen / hydrocodone) "Mallinckrodt Norco is the only generic brand Walgreens carry. The last 2-3 years they have been rubbish. The Walgreen pharmacist tells me they cannot get any other brand. I have decided July 2022 will be my last AARP Walgreen Part D insurance premium payment and will drop the coverage. If anyone asks, I will explain one of my medications is nontherapeutic as the cause."

1 / 10
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  • EddieZ
  • Taken for 10 years or more
  • December 2, 2021

Norco (acetaminophen / hydrocodone) "Call the FDA Voluntary report of AE event, such as product is not AB Rated anymore. Use NDC 00406-0125-01 on form 3500B from FDA.Gov. Request proof from independent Lab assay that this NDA meets or exceeds 80/20 bioavailability. We need 100,000 reports to make the FDA listen to Pain patients we number nearly 77 million in the USA."

2 / 10
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59 Report
  • Low...
  • Taken for 5 to 10 years
  • July 28, 2022

Norco (acetaminophen / hydrocodone) "These sub par bioequivelent generic pain meds are simply causing the ones who medically need pain relief to have to suffer. Why can't I have the opportunity to consult with my pain management dr get a prescription for a name brand pain medication only to discover that the production of name brand are priced extremely expensive and this has resulted in the untreated severe chronic pain I have due to sub par bioequivelent generics flooding the pharmaceutical market. Hopefully the truth behind this abomination will surface soon and needless suffering will be addressed with compassion not concerns of profits."

2 / 10
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45 Report
  • Bazin...
  • June 12, 2021

Norco (acetaminophen / hydrocodone) "This opioid is TRASH! I was prescribed it after a tonsillectomy and it has provided ZERO relief. I’m 18 and have never taken pain pills in my life so I definitely don’t have a tolerance, this stuff is just bogus. Thanks gov’t, I’m glad I get to suffer for 2 weeks since you can’t give us pain relief!"

1 / 10
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63 Report
  • Anonymous
  • March 19, 2008

Lortab (acetaminophen / hydrocodone) "I have an unusual side effect to this drug. It takes the pain away (YEAH) but it also wires me. It should make me sleepy but it speeds me up. So not only is the pain gone but my house gets clean too. YEAH!"

10 / 10
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214 Report
  • Fed...
  • Taken for 2 to 5 years
  • September 6, 2021

Norco (acetaminophen / hydrocodone) "Generic Norco used to work great when pharmacies carried the good quality brands, but now with the poor quality brands available, it is difficult to get pain relief. I am fed up with the so-called overdose epidemic causing chronic pain patients to suffer! States have sued the Pharmaceutical companies over it and as a result, the Pharm companies filed bankruptcy and had to sell off their sub-companies that manufactured the good quality generics! Goodbye Watson, Qualitest, Par, Teva, etc.! Hello unrelieved crippling pain! I changed pharmacies from CVS who dispensed worthless Caracao, to a private pharm who dispenses Amneal or Mallinckrodt. Mallin is very weak and causes terrible side effects and Amneal works at about half strength. Tris from Walgreens doesn’t work at all! It’s so frustrating, we need pain relief and can’t get it anymore."

5 / 10
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58 Report
  • Colie
  • May 2, 2014

Norco (acetaminophen / hydrocodone) "I used to be on Vicodin 10/500 for my severe pain due to rheumatoid arthritis, psoriatic arthritis, fibromyalgia, and spinal issues. My pain is chronic and severe. I've been on Norco for 4 months now and did not feel any difference from the Vicodin. Last month, my pharmacy gave me a different brand. It was amazing! First time in a few years that my pain was less. I even found myself missing a dose because I was feeling okay. Believe me, all generics don't work the same way."

8 / 10
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150 Report
  • Anonymous
  • October 29, 2013

Norco (acetaminophen / hydrocodone) "Dating back to 1960, it seems like I've been plagued with pain every day of my life. Most of the time a small amount of aspirin will eliminate the issue. But there are days when almost nothing will end the pain. Since I began taking Norco 3-4 years ago - up to three, 10-325 mg tablets a day, life has been a genuine pleasure. I'm still experiencing daily pain. But it is very seldom severe. And when it is, that's only because I forgot I'm 74 years old and spent the day working in the yard like an 18 year old. I can't begin to name all the pain killers I've used in my life. But Norco is, by far, the most effective."

10 / 10
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155 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.