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Acetaminophen / hydrocodone Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Acetaminophen / hydrocodone Xeljanz (tofacitinib) Methotrexate
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Acetaminophen / hydrocodone Xeljanz (tofacitinib) Methotrexate
Prescription only

Acetaminophen/hydrocodone may be used to treat moderate-to-severe pain that is unrelieved by nonopioid analgesics. However, its use is limited by the dependence and addiction potential of the... View more

Prescription only

Xeljanz is a Janus kinase (JAK) inhibitor that may be used to reduce inflammation associated with several conditions such as rheumatoid arthritis, psoriatic arthritis, ulcerative colitis, or... View more

Prescription only

Methotrexate may be considered for the treatment of psoriasis, rheumatoid arthritis, polyarticular juvenile idiopathic arthritis (pJIA), mycosis fungoides, and certain cancers, such as ALL or... View more

More about Acetaminophen / hydrocodone More about Xeljanz (tofacitinib) More about Methotrexate
Ratings & Reviews

Acetaminophen / hydrocodone has an average rating of 6.0 out of 10 from a total of 1315 ratings on Drugs.com. 49% of reviewers reported a positive effect, while 35% reported a negative effect.

Xeljanz has an average rating of 5.7 out of 10 from a total of 145 ratings on Drugs.com. 43% of reviewers reported a positive effect, while 40% reported a negative effect.

Methotrexate has an average rating of 6.5 out of 10 from a total of 335 ratings on Drugs.com. 52% of reviewers reported a positive effect, while 24% reported a negative effect.

View all 1315 reviews

View all 145 reviews

View all 335 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

View all Acetaminophen / hydrocodone side effects

View all Xeljanz side effects

View all Methotrexate side effects
Drug Class
Generic Availability

Lower cost generic

No lower cost generic approved

Lower cost generic
Pricing and Coupons * Prices are without insurance
Quantity 50 each
Strength 325 mg-10 mg
Per unit* $0.47
Cost* $23.53

View all Acetaminophen / hydrocodone prices

Quantity 240 mL
Strength 1 mg/mL
Per unit* $21.65
Cost* $5,196.55

View all Xeljanz prices

Quantity 20 each
Strength 2.5 mg
Per unit* $1.52
Cost* $30.31

View all Methotrexate prices

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Dosage Forms
  • Oral liquid
  • Oral solution
  • Oral tablet
  • Oral solution
  • Oral tablet
  • Injectable powder for injection
  • Injectable solution
  • Oral tablet
Brand Names
Xodol, Zyfrel Other tofacitinib brands include: Xeljanz Oral Solution, Xeljanz XR Jylamvo, Methotrexate LPF Sodium, Otrexup, Rasuvo, Trexall, Xatmep
Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

3.8 hours

3 hours

15 hours
CSA Schedule 1 View glossary of CSA terms
2
High potential for abuse

Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
Pregnancy Category
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.
X
Category X Not for use in pregnancy

See the full pregnancy warnings document.
Drug Interactions

A total of 679 drugs are known to interact with Acetaminophen / hydrocodone:

  • 217 major drug interactions (801 brand and generic names)
  • 451 moderate drug interactions (1917 brand and generic names)
  • 11 minor drug interactions (39 brand and generic names)

A total of 655 drugs are known to interact with Xeljanz:

  • 378 major drug interactions (1239 brand and generic names)
  • 266 moderate drug interactions (1023 brand and generic names)
  • 11 minor drug interactions (42 brand and generic names)

A total of 716 drugs are known to interact with Methotrexate:

  • 144 major drug interactions (664 brand and generic names)
  • 557 moderate drug interactions (2717 brand and generic names)
  • 15 minor drug interactions (47 brand and generic names)
Alcohol/Food/Lifestyle Interactions
  • Do not use alcohol or medications that contain alcohol while you are receiving treatment with... View more

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.
  • Caffeine may reduce the effectiveness of methotrexate in the treatment of arthritis. If you are... View more
  • Methotrexate may cause liver problems, and using it with other medications that can also affect the... View more
Disease Interactions
First Approval Date

May 03, 1982

November 06, 2012

December 07, 1953
WADA Class View classifications

N/A

N/A

N/A
More Information
Patient Resources
Professional Resources
Related Treatment Guide

1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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