Rezdiffra Side Effects

Generic name: resmetirom

Medically reviewed by Drugs.com. Last updated on Nov 10, 2024.

Note: This document provides detailed information about Rezdiffra.

Applies to resmetirom: oral tablets Side Effects associated with resmetirom. Some dosage forms listed on this page may not apply specifically to the brand name Rezdiffra.

Applies to resmetirom: oral tablets.

Side effects include:

Most common adverse reactions with resmetirom (the active ingredient contained in Rezdiffra) (reported in ≥5% of patients and more frequently than placebo) are diarrhea, nausea, pruritus, vomiting, constipation, abdominal pain, and dizziness.

For healthcare professionals

Applies to resmetirom: oral tablet.

General adverse events

The most common adverse reactions reported in at least 5% of patients included diarrhea, nausea, pruritus, vomiting, constipation, abdominal pain, and dizziness.^[Ref]

Cardiovascular

• Frequency not reported: Arrythmia, palpitations

Dermatologic

• Very common (10% or more): Pruritus (up to 10%)
• Frequency not reported: Urticaria, rash, erythema

Endocrine

• Very common (10% or more): Decreased prohormone free T4 (up to 17%)

Gastrointestinal

• Very common (10% or more): Diarrhea (up to 33%), nausea (up to 18%)
• Common (1% to 10%): Constipation, vomiting, abdominal pain
• Frequency not reported: Cholelithiasis, acute cholecystitis, obstructive pancreatitis (gallstone), flatulence, abnormal feces, dysgeusia

Genitourinary

• Frequency not reported: Abnormal uterine bleeding

Hepatic

• Very common (10% or more): ALT greater than 3 times the upper limit of normal (3 x ULN; up to 13%), AST greater than 3 x ULN (up to 12%)
• Common (1% to 10%): ALT greater than 5 x ULN, AST greater than 5 x ULN, total bilirubin elevations greater than 2 x ULN
• Frequency not reported: Hepatotoxicity

Hypersensitivity

• Frequency not reported: Hypersensitivity reactions

Metabolic

• Frequency not reported: Hypoglycemia

Musculoskeletal

• Frequency not reported: Tendinopathy

Nervous system

• Common (1% to 10%): Dizziness
• Frequency not reported: Vertigo

Other

• Frequency not reported: Decreased appetite

Psychiatric

• Frequency not reported: Depression

Further information

Rezdiffra side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer