Fosinopril / Hydrochlorothiazide Side Effects

Medically reviewed by Drugs.com. Last updated on Feb 6, 2025.

Applies to fosinopril / hydrochlorothiazide: oral tablet.

Important warnings This medicine can cause some serious health issues

Oral route (tablet)

Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus.

Discontinue therapy as soon as possible when pregnancy is detected.

Other side effects

Some side effects of fosinopril / hydrochlorothiazide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

• cough

Less common side effects

• body aches or pain
• diarrhea
• difficult breathing
• ear congestion
• fever
• headache
• loss of voice
• muscle or bone pain
• nausea and vomiting
• runny or stuffy nose
• sneezing
• sore throat

Serious side effects

Along with its needed effects, fosinopril/hydrochlorothiazide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking fosinopril / hydrochlorothiazide:

Less common side effects

• blurred vision
• chest pain or discomfort
• chills
• cold sweats
• confusion
• decreased urination
• dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
• dry mouth
• fainting
• fast, slow, or irregular heartbeat
• muscle cramps or pain
• numbness, tingling, pain, or weakness in the hands or feet
• rapid breathing
• seizures
• sunken eyes
• sweating
• thirst
• trembling
• unusual tiredness or weakness
• weakness and heaviness of legs
• wrinkled skin

Incidence not known

• persistent non-healing sore
• pink growth
• reddish patch or irritated area
• shiny bump
• white, yellow or waxy scar-like area

For healthcare professionals

Applies to fosinopril / hydrochlorothiazide: oral tablet.

General adverse events

The most common adverse reactions were cough, headache, upper respiratory infection, dizziness, weakness, musculoskeletal pain, pharyngitis, and fatigue.^[Ref]

Respiratory

• Common (1% to 10%): Cough, upper respiratory infection, pharyngitis, rhinitis, sinus abnormality, tracheobronchitis
• Uncommon (0.1% to 1%): Congestion, dyspnea, epistaxis, sneezing
• Frequency not reported: Sinus congestion

Fosinopril:

• Common (1% to 10%): Cough, pharyngitis, rhinitis, upper respiratory infection
• Uncommon (0.1% to 1%): Sinus abnormality, tracheobronchitis
• Frequency not reported: Bronchospasm, laryngitis/hoarseness, epistaxis

Hydrochlorothiazide:

• Frequency not reported: Respiratory distress, pneumonitis, pulmonary edema^[Ref]

Gastrointestinal

• Common (1% to 10%): Dyspepsia/heartburn, gastroenteritis, nausea/vomiting, epigastric pain
• Uncommon (0.1% to 1%): Abnormal stool, constipation, diarrhea, abdominal distention, dry mouth, gastritis, oral lesion, intestinal obstruction, abdominal pain, eructation, halitosis
• Frequency not reported: Esophagitis

Fosinopril:

• Common (1% to 10%): Dyspepsia/heartburn, gastroenteritis, nausea/vomiting, epigastric pain
• Frequency not reported: Pancreatitis, dysphagia, abdominal distention, flatulence, dry mouth

Hydrochlorothiazide:

• Frequency not reported: Pancreatitis, sialadenitis, vomiting, diarrhea, cramping, nausea, gastric irritation, constipation^[Ref]

Nervous system

• Common (1% to 10%): Headache, dizziness, vertigo
• Uncommon (0.1% to 1%): Syncope, neuropathy entrapment, memory impairment, numbness, somnolence, paresthesia
• Frequency not reported: Tinnitus

Fosinopril:

• Common (1% to 10%): Dizziness, headache
• Frequency not reported: Cerebrovascular accident, memory disturbance, tremor, taste disturbance

Hydrochlorothiazide:

• Frequency not reported: Vertigo, lightheadedness, headache, paresthesia^[Ref]

Genitourinary

• Common (1% to 10%): Sexual dysfunction, urinary tract infection
• Uncommon (0.1% to 1%): Menstrual disorder, urination abnormality, prostate disorder, vaginal bleeding
• Frequency not reported: Urinary frequency, dysuria

Fosinopril:

• Uncommon (0.1% to 1%): Sexual dysfunction, urinary tract infection

Hydrochlorothiazide:

• Frequency not reported: Glycosuria^[Ref]

Immunologic

• Common (1% to 10%): Viral infection, influenza
• Uncommon (0.1% to 1%): Allergy

Fosinopril:

• Common (1% to 10%): Viral infection, influenza

Hydrochlorothiazide:

• Frequency not reported: Anaphylactic reactions^[Ref]

Other

• Common (1% to 10%): Fatigue, weakness
• Uncommon (0.1% to 1%): Edema, breast disorder, chest pain, chills, fever, cold sensation, malaise, extremity swelling, ear abnormality, ear infection, hearing abnormality
• Frequency not reported: Breast mass, edema lower extremity

Fosinopril:

• Common (1% to 10%): Fatigue, weakness

Hydrochlorothiazide:

• Frequency not reported: Weakness^[Ref]

Musculoskeletal

• Common (1% to 10%): Musculoskeletal pain
• Uncommon (0.1% to 1%): Limitation of movement, muscle cramp, musculoskeletal trauma, musculoskeletal chest pain, tendonitis, extremity weakness
• Frequency not reported: Myalgia

Fosinopril:

• Common (1% to 10%): Musculoskeletal pain
• Frequency not reported: Arthralgia

Hydrochlorothiazide:

• Frequency not reported: Muscle spasm^[Ref]

Cardiovascular

• Common (1% to 10%): Orthostatic hypotension
• Uncommon (0.1% to 1%): Rhythm disturbance, flushing, hypertension, non-angina cardiac chest pain, hot flashes

Fosinopril:

• Frequency not reported: Angina, myocardial infarction, hypertensive crisis, hypotension, claudication

Hydrochlorothiazide:

• Frequency not reported: Orthostatic hypotension, necrotizing angiitis^[Ref]

Dermatologic

• Uncommon (0.1% to 1%): Acne, dermatitis, ecchymosis, extremity erythema, bacterial skin infection, pruritus, rash, skin discomfort, hyperhidrosis, angioedema

Fosinopril:

• Frequency not reported: Urticaria, photosensitivity

Hydrochlorothiazide:

• Frequency not reported: Stevens-Johnson syndrome, purpura, urticaria, rash, photosensitivity^[Ref]

Psychiatric

• Uncommon (0.1% to 1%): Libido change, depression, emotional lability/disturbance, insomnia

Fosinopril:

• Frequency not reported: Confusion, mood change, sleep disturbance

Hydrochlorothiazide:

• Frequency not reported: Restlessness^[Ref]

Metabolic

• Uncommon (0.1% to 1%): Polydipsia, appetite decreased, appetite increased, weight loss

Fosinopril:

• Frequency not reported: Gout, appetite/weight change

Hydrochlorothiazide:

• Frequency not reported: Anorexia, hyperglycemia, hyperuricemia^[Ref]

Hepatic

• Uncommon (0.1% to 1%): Hepatitis

Fosinopril:

• Frequency not reported: Hepatitis, transaminases elevated, lactate dehydrogenase elevated, alkaline phosphatase elevated, serum bilirubin elevated

Hydrochlorothiazide:

• Frequency not reported: Intrahepatic cholestatic jaundice^[Ref]

Hematologic

• Frequency not reported: Neutropenia, hematocrit decreased, hemoglobin decreased, eosinophilia

Fosinopril:

• Frequency not reported: Lymphadenopathy, eosinophilia, hemoglobin decreased, leukopenia

Hydrochlorothiazide:

• Frequency not reported: Aplastic anemia, agranulocytosis, leukopenia, thrombocytopenia, hemolytic anemia^[Ref]

Renal

• Frequency not reported: BUN elevated, creatinine elevated

Fosinopril:

• Frequency not reported: Renal insufficiency, BUN elevated, creatinine elevated^[Ref]

Ocular

Fosinopril:

• Frequency not reported: Vision disturbance, eye irritation

Hydrochlorothiazide:

• Frequency not reported: Transient blurred vision, xanthopsia^[Ref]

Further information

Fosinopril/hydrochlorothiazide side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer