Eszopiclone Side Effects

Medically reviewed by Drugs.com. Last updated on Apr 23, 2023.

Applies to eszopiclone: oral tablet.

Important warnings This medicine can cause some serious health issues

Oral route (tablet)

Complex sleep behaviors including sleep-walking, sleep-driving, and engaging in other activities while not fully awake may occur following use of eszopiclone.

Some of these events may result in serious injuries, including death.

Discontinue eszopiclone immediately if a patient experiences a complex sleep behavior.

Serious side effects of eszopiclone

Along with its needed effects, eszopiclone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking eszopiclone:

More common side effects

• chills
• cough
• fever
• hoarseness
• lower back or side pain
• painful or difficult urination
• sleepiness or unusual drowsiness

Less common side effects

• bladder pain
• bloody or cloudy urine
• confusion
• diarrhea
• discouragement
• fear or nervousness
• feeling sad or empty
• frequent urge to urinate
• general feeling of discomfort or illness
• headache
• irritability
• joint pain
• lack of appetite
• loss of interest or pleasure
• muscle aches and pains
• nausea
• nerve pain
• runny nose
• seeing, hearing, or feeling things that are not there
• shivering
• sore throat
• sweating
• trouble concentrating
• trouble sleeping
• unusual tiredness or weakness
• vomiting

Get emergency help immediately if any of the following symptoms of overdose occur while taking eszopiclone:

Symptoms of overdose

• change or loss of consciousness
• difficult or troubled breathing
• irregular, fast or slow, or shallow breathing
• pale or blue lips, fingernails, or skin
• sleepiness or unusual drowsiness

Other side effects of eszopiclone

Some side effects of eszopiclone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

• bad, unusual, or unpleasant (after) taste
• belching
• change in taste
• dizziness
• dry mouth
• heartburn
• indigestion
• pain
• stomach discomfort, upset, or pain

Less common side effects

• abnormal dreams
• accidental injury
• decreased interest in sexual intercourse
• inability to have or keep an erection
• pain, cramps, or heavy bleeding (females)
• rash
• swelling of the breasts or breast soreness (in both males and females)

Incidence not known

• change in sense of smell
• loss of memory
• problems with memory

For healthcare professionals

Applies to eszopiclone: oral tablet.

General adverse events

The most commonly reported side effects included unpleasant taste, headache, somnolence, and infection.^[Ref]

Nervous system

• Very common (10% or more): Unpleasant taste (up to 34%), headache (up to 21%)
• Common (1% to 10%): Dizziness, migraine, neuralgia, somnolence
• Uncommon (0.1% to 1%): Ataxia, decreased reflexes, difficulty concentrating, hypertonia, hypesthesia, incoordination, memory impairment, nystagmus, paresthesia, vertigo, vestibular disorder
• Rare (less than 0.1%): Abnormal gait, hyperesthesia, hypokinesia, neuritis, neuropathy, stupor, tremor
• Postmarketing reports: Dysosmia^[Ref]

A dose-response relationship appears to exist for dizziness and unpleasant taste.

Headache was reported in 21% of non-elderly patients given 2 mg orally for 6 weeks, and in 17% of non-elderly adults given 3 mg orally for 6 weeks.

In patients 65 to 86 years of age, headache occurred in up to 15% of patients given 1 mg, and unpleasant taste occurred in up to 12% of patients given 2 mg orally for 2 weeks.

Dizziness and neuralgia commonly occurred in patients aged 65 years of age or older. Somnolence has also been reported in this patient population.^[Ref]

Psychiatric

• Common (1% to 10%): Abnormal dreams, anxiety, confusion, decreased libido, depression, hallucinations, nervousness
• Uncommon (0.1% to 1%): Abnormal thinking, agitation, apathy, emotional lability, hostility, insomnia, neurosis,
• Rare (less than 0.1%): Euphoria^[Ref]

A dose-response relationship appears to exist for confusion, decreased libido, and hallucinations.

Abnormal dreams and nervousness commonly occurred in patients aged 65 years of age or older.^[Ref]

Gastrointestinal

• Common (1% to 10%): Diarrhea, dry mouth, dyspepsia, nausea, vomiting
• Uncommon (0.1% to 1%): Halitosis, melena, mouth ulceration, ulcerative stomatitis
• Rare (less than 0.1%): Colitis, dysphagia, gastritis, rectal hemorrhage, stomach ulcer, stomatitis, tongue edema
• Frequency not reported: Abdominal pain^[Ref]

A dose-response relationship appears to exist for dry mouth.

Diarrhea, dry mouth, and dyspepsia commonly occurred in patients aged 65 years of age or older. Abdominal pain and nausea have also been reported in this patient population.^[Ref]

Genitourinary

• Common (1% to 10%): Dysmenorrhea, urinary tract infection
• Uncommon (0.1% to 1%): Amenorrhea, breast engorgement, breast enlargement, breast pain, cystitis, dysuria, female lactation, hematuria, mastitis, menorrhagia, metrorrhagia, urinary frequency, urinary incontinence, uterine hemorrhage, vaginal hemorrhage, vaginitis
• Rare (less than 0.1%): Urethritis^[Ref]

Urinary tract infections commonly occurred in patients aged 65 years of age or older.^[Ref]

Dermatologic

• Common (1% to 10%): Pruritus, rash
• Uncommon (0.1% to 1%): Acne, alopecia, cellulitis, contact dermatitis, dry skin, eczema, photosensitivity, skin discoloration, sweating, urticaria
• Rare (less than 0.1%): Erythema multiforme, furunculosis, hirsutism, maculopapular rash, vesiculobullous rash^[Ref]

A dose-response relationship appears to exist for rash.

Pruritus commonly occurred in patients aged 65 years of age or older. Abdominal pain has also been reported in this patient population.^[Ref]

Other

• Common (1% to 10%): Accidental injury, pain
• Uncommon (0.1% to 1%): Ear pain, face edema, fever, hernia, malaise, otitis externa, otitis media, tinnitus
• Rare (less than 0.1%): Hyperacusis
• Frequency not reported: Asthenia^[Ref]

A dose-response relationship appears to exist for accidental injury and pain.

Accidental injury and pain commonly occurred in patients aged 65 years of age or older. Asthenia and pain have also been reported in this patient population.^[Ref]

Cardiovascular

• Common (1% to 10%): Chest pain, peripheral edema
• Uncommon (0.1% to 1%): Heat stroke, hypertension
• Rare (less than 0.1%): Thrombophlebitis^[Ref]

Immunologic

• Common (1% to 10%): Infection, viral infection
• Rare (less than 0.1%): Herpes zoster
• Frequency not reported: Flu syndrome^[Ref]

A dose-response relationship appears to exist for infection.^[Ref]

Hypersensitivity

• Uncommon (0.1% to 1%): Allergic reaction^[Ref]

Endocrine

• Common (1% to 10%): Gynecomastia^[Ref]

Musculoskeletal

• Uncommon (0.1% to 1%): Arthritis, bursitis, joint disorder, joint pain, joint swelling, joint stiffness, leg cramps, myasthenia, neck rigidity, twitching
• Rare (less than 0.1%): Arthrosis, myopathy
• Frequency not reported: Back pain, myalgia^[Ref]

Metabolic

• Uncommon (0.1% to 1%): Anorexia, hypercholesterolemia, increased appetite, thirst, weight gain, weight loss
• Rare (less than 0.1%): Dehydration, gout, hyperlipemia, hypokalemia^[Ref]

Respiratory

• Uncommon (0.1% to 1%): Asthma, bronchitis, dyspnea, epistaxis, hiccup, laryngitis
• Frequency not reported: Pharyngitis, rhinitis^[Ref]

Ocular

• Uncommon (0.1% to 1%): Conjunctivitis, dry eyes
• Rare (less than 0.1%): Iritis, mydriasis, photophobia, ptosis^[Ref]

Renal

• Uncommon (0.1% to 1%): Kidney calculus, kidney pain
• Rare (less than 0.1%): Oliguria, pyelonephritis^[Ref]

Hematologic

• Uncommon (0.1% to 1%): Anemia, lymphadenopathy^[Ref]

Hepatic

• Uncommon (0.1% to 1%): Cholelithiasis
• Rare (less than 0.1%): Hepatitis, hepatomegaly, liver damage^[Ref]

Oncologic

• Uncommon (0.1% to 1%): Breast neoplasm^[Ref]

Frequently asked questions

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Further information

Eszopiclone side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer