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Where is the best place to inject Mounjaro?

Medically reviewed by Kristianne Hannemann, PharmD. Last updated on March 12, 2025.

Official answer

by Drugs.com

Recommended Injection Sites

Mounjaro is administered as a subcutaneous (under-the-skin) injection. The three recommended injection sites are:

  • Stomach (abdomen): Avoid the 2-inch area around the belly button.

  • Thighs: Inject in the upper outer thigh area.

  • Upper arms: The back of the upper arm is an option if someone else is administering the injection.

Rotate injection sites weekly to prevent irritation and lumps (lipohypertrophy). Avoid injecting in the same spot consecutively.

How to Inject Mounjaro

Mounjaro is available in two forms: single-dose vials (requiring a syringe) and pre-filled pens. Follow these steps based on your chosen method:

Single-dose vial instructions:

  1. Wash your hands with soap and water.
  2. Prepare the dose – Remove the vial cap, clean the top with an alcohol swab, and draw up the medication with a syringe.
  3. Inject the medication – Pinch a fold of skin and insert the needle at a 90-degree or 45-degree angle. Push the plunger down to administer the dose. Hold for 5 seconds to ensure full delivery.
  4. Dispose of the needle – Remove the needle at the same angle and place it in a sharps container.

Related questions

Pre-filled pen instructions:

  1. Wash your hands with soap and water.
  2. Inspect the pen – Ensure the medication is clear and not frozen or discolored.
  3. Prepare for injection – Remove the base cap and place the clear base flat against your skin.
  4. Administer the dose – Unlock the pen, press and hold the injection button for up to 10 seconds. A first click signals the start of the injection; a second click indicates completion.
  5. Dispose of the pen – Remove it from the skin and place it in a sharps container.

Is One Injection Site Better Than Another?

Mounjaro is equally effective whether injected into the stomach, thigh, or upper arm. Choose a site that feels comfortable and rotate locations each week for optimal results.

This is not all the information you need to know about Mounjaro (tirzepatide) for safe and effective use and does not take the place of your doctor’s directions. Review the full product information and discuss this information and any questions you have with your doctor or other health care provider.

References

Mounjaro [package insert]. Revised 09/2023. Eli Lilly and Company - https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d2d7da5d-ad07-4228-955f-cf7e355c8cc0

Mounjaro (tirzepatide) https://www.drugs.com/mounjaro.html

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